• 대한한방내과학회지
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• 제37권4호
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• pp.653-660
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• 2016

Objectives: The purpose of this study was to investigate the effects of Korean medicine on patients with idiopathic Parkinson’s disease.Methods: The charts of 47 patients diagnosed with idiopathic Parkinson’s disease in the Department of Internal Korean medicine, Stroke and Neurological Disorders Center, Kyung Hee University Hospital, Gangdong between August 2012 and July 2016 were reviewed. The Unified Parkinson’s disease rating scale (UPDRS) was administered before and after treatment with Korean medicine.Results: Thee average UPDRS Ⅱ+Ⅲ, UPDRS Ⅱ, and UPDRS Ⅲ of the 47 patients decreased significantly from 22.26±15.15, 10.19±7.53, and 12.06±8.35, respectively, pretreatment to 16.96±13.63, 7.47±6.44, and 9.49±7.73, respectively, post-treatment. The average postural instability and gait difficulty (PIGD), tremor, and bradykinesia also significantly improved post-treatment.Conclusions: These results provide evidence that Korean medicine can improve the activities of daily living and motor function of patients with idiopathic Parkinson’s disease. In particular, Korean medicine may be effective for the treatment of PIGD, tremor, and bradykinesia.

• 음성과학
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• 제12권3호
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• pp.19-33
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• 2005

Tremor is a main factor of parkinsonism. Voice tremor may be the first, later or the only symptom of a neurological disease and its frequency, amplitude, and regularity may differ among the diseases of different neural subsystems. Differential diagnosis between idiopathic Parkinson's disease (IPD) and multiple system atrophy (MSA) has been difficult. This study included three groups: (1) 6 IPD patients; (2) 6 MSA patients; and (3) 20 ageand sex-matched normal controls. The MDVP (Multidimensional Voice Program) was used to analyze the sustained /a/phonation. The results were as follows: (1) frequency perturbation parameters (jitter, sPPQ, Vf0) and FTRI of tremor parameter of two patient groups were statistically different from those of the controls (p < .01); (2) measures were higher in short-term and long-term f0 and amplitude perturbation in MSA than IPD; (3) however, any acoustic parameters between IPD and MSA were not statistically different; except for the rate of frequency tremor, 4$\sim$5 Hz in IPD, 5$\sim$11 Hz in MSA and (4) the pattern of regularity for voice tremor through histogram indicated that amplitude of IPD was irregular while both f0 and amplitude of MSA were irregular. In conclusion, F0, rate of frequency tremor, and pattern of f0 regularity may be predictors for differential diagnosis. These findings might signify that voice tremor of parkinsonism was resulted from modulation of f0.

• 동의신경정신과학회지
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• 제28권2호
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• pp.95-107
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• 2017

Objectives: This study was performed to review studies on Essential Tremor (ET) in Traditional Chinese medicine (TCM). Methods: We reviewed papers in the China National Knowledge Infrastructure (CNKI) from 2007~2016. Search keywords were 原发性震颤, 特发性震颤, essential tremor and idiopathic tremor, and excluded non-clinical studies, non-related to ET or TCM studies, theses for degrees and non-Randomized Controlled Trial (RCT). The quality of the articles was assessed by Jadad scale and the Risk of Bias (RoB). Results: Thirteen studies were selected. 'Criteria for the diagnosis of ET' was most frequently used as diagnostic criteria. 'Tremor rating scale' was primarily used for outcome measurement. Meta-analysis of nine trials revealed the effective rate of acupuncture and Western medicine (WM+Acu) groups was significantly higher compared to the WM group (RR: 1.48, 95 percent CI: 1.20 to 1.82, p=0.0002, $I^2=0$ percent) and tremor rating scale was also significantly decreased in the treatment group (MD: -1.35, 95 percent CI: -2.17 to -0.54, p=0.001, $I^2=0$ percent). Also, effective rates of Electro-acupuncture (EA) and Chinese herbal medicine (CHM) groups were significantly higher than that of the WM group {(RR: 1.53, 95 percent CI: 1.22 to 1.92, p=0.0003, $I^2=0$ percent) in EA vs. WM and (RR: 1.35, 95 percent CI: 1.16 to 1.57, p<0.0001, $I^2=0$ percent) in CHM vs. WM}. However, the quality of selected clinical studies was poor. Conclusions: Treatment of ET in TCM may be more effective and safe than in Western medicine. Therefore, we hope this study will lead to further clinical research on treatment of ET in Korean medicine.

• 한국임상수의학회지
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• 제23권3호
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• pp.337-339
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• 2006

4년령의 중성화된 암컷 말티즈 견이 급성으로 발병하고 4일 동안 지속된 진신 진전 우측으로의 사경 수평성 안구진탕, 그리고 약간의 보행실조에 대한 평가를 위해 내원하였다. 환견은 의식이 뚜렷하고 외부자극에 잘 반응하였다. 신경계 검사 상에서 양안의 수평성-, 위치성 안구진탕 그리고 약간의 보행실조가 나타났다. 또한 양안의 위협반사가 소실된 상태였다. 중등도의 전신 긴장성 진전이 사지와 두부에서 특이적으로 관찰되었다. 혈액검사, 방사선, 그리고 자기공명영상에서 이상소견이 관찰되지 않았다. 뇌척수액의 세포학적 검사를 통해 약간의 비화농성 염증 소견을 확인하였다. 이와 같이 염증성 그리고 특발성의 특징을 가지고 있었기 때문에 스테로이드 반응성 진전 증후군이 강하게 의심되었다. 환견은 면역억제 용량으로 투여된 코르티코스테로이드에 매우 잘 반응하였다. 따라서 진전을 유발하는 다른 원인들을 배제하고, 임상증상 및 치료에 대한 반응에 근거하여 스테로이드 반응성 진전 증후군으로 최종 진단하였다. 이것은 국내에서 스테로이드 반응성 진전 증후군의 최초 보고이며, 이 질환의 임상적 그리고 신경학적 특징들을 기술하고 있다.

• 재활복지
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• 제18권4호
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• pp.237-255
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• 2014

특발성 파킨슨병(idiopathic Parkinson disease, IPD)은 알 수 없는 원인으로 인해 중뇌의 흑질신경세포가 손실되는 대표적인 퇴행성 신경계 질환이다. IPD 환자는 신체 운동 이상을 주로 호소하지만 이들 중 70~90%가 운동저하형 마비말장애(hypokinetic dysarthria)를 동반하는 것으로 알려져 있다. 진행된 심도의 IPD 환자의 운동 증상 호전에 가장 효과적인 치료 방법으로 알려진 시상밑부핵 심부뇌자극술(subthalamic nucleus deep brain stimulation, STN-DBS)은 말 산출에서는 그 효과가 일관되지 않게 보고된다. 이에 본 연구에서는 STN-DBS가 말 산출에 미치는 영향을 살펴보고, 연구에서 어떠한 말 평가 과제가 사용되었는지를 조사하기 위하여 medline을 통해 2012까지 이루어진 연구 논문을 수집하였다. 총 32편 중, 연구대상자들에서 술 후 말 상태의'호전'이 관찰된 논문은 42%,'악화'는 29%,'엇갈리는 결과'는 26%,'변화 없음'은 3%로 확인되었다. 말 효과 간에는 문맥발화(contextual speech)가 연구에 사용된 비중이 높을수록 술 후 말 상태는 부정적인 결과로 보고되었으며, 말 산출 단계 중 일부 단계(예: 호흡 및 발성만, 혹은 조음만)만이 반영된 평가 과제가 연구마다 선택적으로 사용되었음을 확인하였다. 이에 본 연구는 STN-DBS를 받은 IPD 환자의 말 평가는 말 산출 하부 단계를 모두 반영하는 문맥발화 과제를 통일적으로 사용할 것을 제안한다.

• 동국한의학연구소논문집
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• 제4권
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• pp.81-98
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• 1995

This study is that examine and readjust cause-pathology, symptom, treatment, clinical reports recorded in western medicine, successive literatures of oriental medicine and recent literatures and journals of chinese medicine about Paralysis agitans. The results was followed ; 1. Paralysis agitans is similar with symptoms of Jinjeon, Qi, Gyeong, Gyejong, Lyeon and Pyengo, Tantan, Jungbu of Jungpung. 2. There are Pung, Hwa, Dam, Eo in the causes of disease, Gansinyinheo, Qihyeolyangheo, Jeokyeoldamhwa, Qichehyeoleo, Ganpungnaedong etc in clinical types, to be concerned with liver, kidney, heart and spleen in Jangbu, Gansinyinheo and Qihyeolyangheo are concerned wiyh idopathic paralysis agitans, Jeokyeoldamhwa and Qichehyeoloe successive it, Ganpungnaedongboth idiopathic and successive. 3. Treatments are Jayinjamyang, Pyeonggansikpung, Ikqiyanghyeol, Sikpunghwallak, Seoganhaewool, Hwalhyeoltonglak etc, and prescriptions are Yukmi, Chunmagudeongum, Paljintang, Tonggyuhwalhyeoltang, Hyeolbuchukeotang etc. 4. In caring, it is necessary to live pleasantly, to be temperate sexual intercourse, to control, diet, to do suitable exercises, for example Qigong, Physical exercises, Walking etc. 5. In clinical reports, this disease frequently-occurs more than 60 years, male is more than female, and there are many complications as hypertension and arteriosclerosis etc. The majority of causes are Gansinyinheo, Qichehyeoleo, and the others are Qihyeolyangheo, Damhwa, Ganpungnaedong, Qigiulche, Yeolyoesimsin etc, the majority of care Jabogansin, Yukyinsikpung, Hwalhy-eolhrwaeo, and the others Ikqiyanghyeol, Haldamtonglak, Seoganhaewool. Curing period is generally from 2 to 3 months. In effectiveness rate, successive Qichehyeoleo type is the highest, and idiopathic Qihyeolyangheo type is the lowest. Effectiveness of rigidity is higher than tremor.

• Journal of Korean Neurosurgical Society
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• 제30권8호
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• pp.976-980
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• 2001

Objectives : For Parkinsonian patients who had not reacted favorably on drug therapy are good candidate for ventroposterolateral pallidotomy, although not curative. We studied these patients after unilateral pallidotomy, to confirm the effectiveness and safety of this procedure. Methods : We evaluated the 17 patients with idiopathic Parkinson's diesease who had undergone unilateral posteroventral pallidotomy. All patients responded to levodopa initially. Mean age was 55 years(38-75years), and mean duration of disease was 9.8 years(3-20years). Pre-and postoperative evaluation at 3 month intervals included Unified Parkinson's Disease Rating scale(UPDRS) scoring, Hoehn and Yahr(H & Y) staging, and neuropsychological examinations. Results : Pallidotomy significantly improved parkinsonian symptom(tremor, rigidity, bradykinesia, dyskinesia, sensory symptom). Nine of 10 patients who showed dyskinesia preoperatively significant improvement. The mean dose of levodopa in 9 patients was lowered. The mean H & Y score and UPDRS score were improved in on and/or off time in 15 patients. Among patients who were not improved, one patient worsened, and the others showed no change. The mean overall UPDRS off score changed from 76 preoperatively to 44(33%) at 6 months and from 70 to 52(25%) at 1 year. Transient surgical morbidity was showen in four patients and included dysarthria, hypotonia and confusion. Conclusion : We conclude that pallidotomy is safe and effective in patients who have levodopa-reponsive parkinsonism with severe symptom fluctuation. Unilateral pallidotomy also considered helpful to ipsilateral symptom. Unilateral pallidotomy can improve all of parkinsonian's symptom and allow to reduce the levodopa medication. Most of patients show satisfactory results.