• BMB Reports
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• v.37 no.1
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• pp.53-58
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• 2004

With advances in determining the entire DNA sequence of the human genome, it is now critical to systematically identify the function of a number of genes in the human genome. These biological challenges, especially those in human diseases, should be addressed in human cells in which conventional (e.g. genetic) approaches have been extremely difficult to implement. To overcome this, several approaches have been initiated. This review will focus on the development of a novel 'chemical genetic/genomic approach' that uses small molecules to 'probe and identify' the function of genes in specific biological processes or pathways in human cells. Due to the close relationship of small molecules with drugs, these systematic and integrative studies will lead to the 'medicinal systems biology approach' which is critical to 'formulate and modulate' complex biological (disease) networks by small molecules (drugs) in human bio-systems.

• Transactions of the Korean Society of Mechanical Engineers
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• v.19 no.1
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• pp.14-21
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• 1995

General Mechanical Structures have various and complex vibration transmission paths. In order to identify the mechanism of vibration transmission. The correct estimation of exciation forces and the exact modeling of transmission paths are required. In this paper, vector synthesis technique is employed to identify the characteristics of vibration input and it's transmission to body structure for the mounting system of a compressor in a refrigerator. Vibration reduction efficiency of each transmission path is evaluated by comparing individual vector components obtained before and after the paths from experimental research. The degree of effect is used to estimate the contribution of vibration input components to total output. And this paper presents a new technique based on simulation studies using vector synthesis dragram, by which the effects of change of the magnitude and phase of transmission paths can be predicted.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.24 no.6 s.177
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• pp.1593-1600
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• 2000

A method based on frequency domain approaches is presented for the nonlinear parameters identification of structure having nonlinear joints. The finite element model of linear substructure is us ed to calculating its frequency response functions needed in parameter identification process. This method is easily applicable to a complex real structure having nonlinear elements since it uses the frequency response function of finite element model. Since this method is performed in frequency domain, the number of equations required to identify the unknown parameters can be easily increased as many as it needed, just by not only varying excitation amplitude but also selecting excitation frequencies. The validity of this method is tested numerically and experimentally with a cantilever beam having the nonlinear element. It was verified through examples that the method is useful to identify the nonlinear parameters of a structure having arbitary nonlinear boundaries.

• Journal of Preventive Medicine and Public Health
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• v.12 no.1
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• pp.99-106
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• 1979

Accessibility to medical facilities and personnels has been known as one of important determinants of medical care utilization. This study attempted to identify the effects of medical accessibility in terms of geographical distance and occupational opportunity to the medical utilizations. Two-year-experiences of Yonsei University Health Insurance Cooperatives were used as the sources of data. Out patient utilization patterns of 713 members sampled from 4,352 members of Health Insurance Cooperatives were analyzed in order to identify the effects of medical accessibilities. Findings: 1 Average clinic visit rate of Yonsei Health Insurance is 1.66 per person per year. 2. The utilization rates of geographically more accessible group were 33% higher than that of less accessible group. 3. No marked difference in clinic visit rate were observed between medical and non-medical personnel and their family members. 4. Clinic visit rates among occupationally accessible group were slightly higher than those of less accessible. The utilization rate was more sensitively changed by the insurance policy changes in occupationally accessible group.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.14 no.3
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• pp.185-192
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• 2004

Vibration table is required to obtain high packing density in expendable pattern casting process. Packing density. which is an important manufacture factor, depends on the vibration pattern induced by vibration table. In general, circular vibration pattern is recognized as the best pattern. The existing vibration table is investigated to identify current vibration pattern and consider a countermeasure. Modal test is utilized to identify the dynamic characteristics of vibration table, and finite element method is used to propose the improved design. In simulation using finite element method, the position of stiffeners is obtained to satisfy the required dynamic characteristics.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2002.11b
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• pp.160-165
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• 2002

Vibration table is required to obtain high packing density in expendable pattern casting process. Packing density, which is an important manufacture factor, depends on the vibration pattern induced by vibration table. In general, circular vibration pattern is recognized as the best pattern. The existing vibration table is investigated to identify current vibration pattern and consider a countermeasure. Modal test is utilized to identify the dynamic characteristics of vibration table, and finite element method is used to present the improved design.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.20 no.6
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• pp.562-567
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• 2010

A passenger vehicle has various and complicated transmission paths of sound and vibration. In order to identify the mechanism of transfer path, estimation of excitation force and exact modeling of transfer path are required. In this paper vector synthesis technique is employed to identify the characteristics of road noise and its transmission to vehicle compartment through noise and vibration analysis. Vibration reduction efficiency of each transfer path is evaluated by comparing individual vector components obtained virtual simulation. The degree of effect is used to estimate the contribution of vibration input components to total output. And in this paper presents a new technique based on simulation studies using vector synthesis diagram and design of experiments, by which the effects of magnitude and phase change of input paths can be predicted.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 1998.04a
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• pp.582-589
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• 1998

This paper presents the analysis results of ex-core and in-core neutron noise, acceleration signals and pressure fluctuation measured at Ulchin Nuclear Unit 1 & 2 to identify and monitor the reactor internals vibration including fuel motion. A phase separation algorithm developed by authors was applied to the neutron noises to clearly identify the reactor internals vibratory motion. The beam mode frequency of the core support barrel was identified to be 8Hz and the shell mode to be 20Hz. The first frequency of the fuel assembly was also found to be 3Hz, while first two acoustic frequencies of the primary coolant system were 6 and 17.5Hz. By monitoring and analyzing these frequencies periodically, it is possible to diagnose the operating condition of reactor internals and to provide an early detection of faults for the predictive maintenance.

• Journal of Community Nutrition
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• v.7 no.1
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• pp.58-63
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• 2005

Identifying quality attributes with the greatest value to the residents is important if the Continuing Care Retirement Community (CCRC) is to increase the frequency of residents' dining. However, it is not known which specific attribute is relatively more important than others to evaluate foodservice. The purpose of this study is to identify the relative importance of food and service quality attributes in the evaluation of foodservice in CCRe. This study surveyed the independent living residents of three CCRCs in the Midwestern states. Respondents placed great importance on taste and flavor of food which has the highest percentage of utility range ($28.28\%$) and the second greatest on appearance of the server ($23.46\%$) . The important attributes were ultimately used to predict the most preferred choice of food-service for residents. Knowledge of the importance of the attributes would enable the foodservice managers in CCRCs to manipulate those attributes to enhance the residents' perceptions of quality and identify strategies for continuous improvement.

• Korean Management Science Review
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• v.23 no.2
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• pp.109-135
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• 2006

Despite much attention of strategy implementation, there is rarely a study focusing on the ways to evaluate the strategy implementation competence. Therefore, based on broad literature review, we suggested a simple model and procedure to evaluate the technology strategy implementation competence based on importance-Performance Analysis (IPA). The proposed model applied to the case of 'Company A' in order to examine the feasibility. We grasped the importance of strategic direction by surveying the employees in 'Company A', and also measured relative importance and performance of critical technology strategy implementation factor. By analyzing the results of the survey, we can identify the barriers to implementing the technology strategy in 'Company A'.