• Journal of Biomedical Engineering Research
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• v.22 no.4
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• pp.369-375
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• 2001

The statistical regression model is one of the most frequently used clinical analysis methods. It has basic assumption of linearity, additivity and normal distribution of data. However, most of biological data in medical field are nonlinear and unevenly distributed. To overcome the discrepancy between the basic assumption of statistical model and actual biological data, we propose a new analytical method based on artificial neural network. The newly developed multilayer perceptron(MLP) is trained with 120 data set (60 normal, 60 patient). On applying test data, it shows the discrimination power of 0.76. The diabetic risk factors were also identified from the MLP neural network model and the logistic regression model. The signigicant risk factors identified by MLP model were post prandial glucose level(PP2), sex(male), fasting blood sugar(FBS) level, age, SBP, AC and WHR. Those from the regression model are sex(male), PP2, age and FBS. The combined risk factors can be identified using the MLP model. Those are total cholesterol and body weight, which is consistent with the result of other clinical studies. From this experiment we have learned that MLP can be applied to the combined risk factor analysis of biological data which can not be provided by the conventional statistical method.

• Journal of Microbiology and Biotechnology
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• v.23 no.3
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• pp.329-334
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• 2013

Uridinediphospho-N-acetylglucosamine enolpyruvyl transferase (MurA, E.C. 2.5.1.7) is an essential bacterial enzyme that catalyzes the first step of the cell wall biosynthetic pathway, which involves the transfer of an enolpyruvyl group from phosphoenolpyruvate to uridinediphospho-Nacetylglucosamine. In this study, novel inhibitors of Haemophilus influenzae MurA (Hi MurA) were identified using high-throughput screening of a chemical library from the Korea Chemical Bank. The identified compounds contain a quinoline moiety and have much lower effective inhibitory concentrations ($IC_{50}$) than fosfomycin, a wellknown inhibitor of MurA. These inhibitors appear to covalently modify the sulfhydryl group of the active site cysteine (C117), since the C117D mutant Hi MurA was not inhibited by these compounds and excess dithiothreitol abolished their inhibitory activities. The increased mass value of Hi MurA after treatment with the identified inhibitor further confirmed that the active-site cysteine residue of Hi MurA is covalently modified by the inhibitor.

• Korean Journal of Food Science and Technology
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• v.30 no.3
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• pp.655-659
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• 1998

Bacterial strain showing the strong fibrinolytic activity (2.04 plasmin unit) was screened from Jeot-Gal, Korean salt-fermented fish collected from various region. For the identification, when the strain was characterized morphologically, culturally, and biochemically, it was identified to Bacillus pumilus. And, when the fatty acids composition of the strain was analyzed, it was identified to Bacillus atropheus. Finally, the 16S rRNA partial sequence (V3 region) showed that the fibrinolytic stain screened from Jeot-Gal was identified as Bacillus subtilis. So, we named it Bacillus subtilis KJ-48.

• Proceedings of the Korean Biophysical Society Conference
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• 2003.06a
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• pp.53-53
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• 2003

Calumenin was previously identified as a high affinity Ca$\^$2+/ binding protein in mouse cardiac sarcoplasmic reticulum (SR). For the present study, a 48 kDa skeletal homologue of calumenin was identified by sucrose-density gradient of rabbit skeletal SR membranes, concanavalin A treatment, 2D-gel electrophoresis, $\^$45/Ca$\^$2+/ overlay, Stains-all staining, and MALDI-TOF analysis. We attempted to clone the skeletal calumenin by RT-PCR based on mouse cardiac and human calumenin sequences. The deduced amino acid sequence (315 residues) of the skeletal calumenin showed high identity to mouse cardiac calumenin (90％). As seen in the cardiac calumenin, the deduced sequence contains a 19 amino acid N-terminal signal sequence and a HDEF C-terminal sequence, a putative retrieval signal to ER. Also, the skeletal calumenin contains one N-glycosylation site, three PKC phosphorylation sites, eight casein kinase 2 phosphorylation sites, and 6 EF-hand domains. GST-calumenin showed a conformational change and increased mobility in the presence of Ca$\^$2+/ in SDS-PAGE. Three calumenin interacting proteins (ryanodine receptor 1, glycogen phosphorylase, and phosphofructo kinase) were identified by pull-down assay with GST-calumenin and solubilized SR. All the interactions were Ca$\^$2+/dependent. The present results suggest that calumenin plays an important role in Ca$\^$2+/ homeostasis of muscle cells.

• Preventive Nutrition and Food Science
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• v.4 no.2
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• pp.88-91
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• 1999

Aroma components of tea processed from Korean chicory roots were isolated and identified. The model system of amino-carbonyl reaction was carried out to study the formation mechanism of aroma compounds of chicory tea during manufacturing process. The concentration extracts from chicory tea and model system were analyzed and identified by gas chromatography(GC) and GC-mass spectrometry. Twenty-nine compounds, including pyrazines, furans, acids, alcohols, pyrroles and lactones were isolated and identified in chicory tea. The main compounds were pyrazines including methyl pyrazine, 2,5-dimethyl pyrazine, 2, 6-dimethyl pyrazine, 2-ethyl-6-methyl pyrazine, 2-ethyl-3-methyl pyrazine, thrimethyl pyrazine, 3-ethyl-2-5-dimenthyl pyrazine, 5-ethyl-2-3-dimenthyl pyrazine, and 2-acetyl-3-methy pyrazine and pyrroles including acethl pyrrole and formlyl pyrrole ; and furans including furfural , acetyl furan, 5-methyl furan, 5-methyl furfuralm, and furfuryl alcohol. These pyrazine compounds of a roasted and nutty aroma may be important contributors to the flavor of chicory tea. The aroma concentrate of model system also had a roasted and nutty aroma and the main compounds were methyl pyrazine, 2, 5-dimetyl pyrazine, 2, 6-dimethyl pyrazine and trimethyl pyrazine.

• English Language & Literature Teaching
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• v.15 no.4
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• pp.265-290
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• 2009

The present data-driven study attempted to explicate nonnative English teacher trainees' foreign language teaching anxiety in microteaching settings from their perspectives. It is assumed that nonnative English teachers or teacher trainees may experience anxiety not only as foreign language learners but also as foreign language teachers. In order to inquire into their anxiety, the researcher had 172 teacher trainees perform extended microteaching tasks and reflect on their teaching and anxiety through group discussion. Based on the analysis of their discussion, three aspects related to nonnative English teacher trainees' anxiety were identified. First, teacher trainees identified three main types of anxiety-provoking situations: communicative-competence-threatening situations, unexpected situations, and instruction-hindering situations. Second, they identified three sources of anxiety: limited ability to use English, lack of English teaching skills, and fear of criticism. Third, they were aware that they used diverse strategies to lower anxiety before and while teaching for different purposes. From their identification and awareness of anxiety-provoking situations, sources of anxiety, and anxiety-lowering strategies, they could reflect on professional qualifications as a foreign language teacher.

• The Research Journal of the Costume Culture
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• v.28 no.5
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• pp.639-651
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• 2020

This study utilized data to classify and characterize the body types of plus-size adult men aged in their 30s and 40s. Diversity is an important factor in the era of inclusive design, and discussion about size diversity to include the plus size should be accommodated. Data from 493 adult men classified as obese (with a World Health Organization criterion ≥25 BMI) were used for the analysis. The results of the study are as follows. Six independent factors were extracted using factor analysis for cluster analysis, which were then classified into five types. Type 1 (29.01%) was identified as body type I with the smallest degree of obesity. Type 2 (15.4%) was identified as body type Y with wide shoulders and a thin waist. Type 3 (14.2%) was the largest body volume (body type O), while the fourth (19.27%) identified as body type H has a large height and upper body. Lastly, type 5 (22.11%) has a long lower body and a slim abdomen, referred to as body type X. This study presents a basis for the development of various clothing sizes utilizing the body shape characteristics of plus-size men in their 30s and 40s. Follow-up research is needed to develop patterns for plus size men and to design various products.

• Journal of Korean Academy of Nursing Administration
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• v.11 no.3
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• pp.233-241
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• 2005

Purpose: The purpose of this study was to understand the components of successful leadership and organizational structural barrier to apply leadership perceived by head nurses. Method: We collected the data using interviews from August 1 to August 31 in 2003. The participants of this study were 19 head nurses from two university hospitals in Pusan. Result: Three categories of successful leadership in nursing organization were identified; leadership, opportunity, authority. Leadership category included accepting nurses' opinions, providing comfortable work environment, and interpersonal harmony. Opportunity category included verbal convincing for professional development and emotional support. Authority category included accomplishment and competence. Head nurses included autonomy, incentives, and equal opportunity across to different discipline as power category. Barriers identified by head nurses were lack of opportunity and power from hospital level. They seem to be frustrated when they don't have enough support from hospital. Conclusion: We think that head nurses have to apply effective leadership to achieve organizational goal and harmonious nursing environment. Based on the barriers identified in the study, interdisciplinary managemental intervention can lead better quality of care and nurses' work satisfaction which could further enhance hospital productivity and quality of care.

• Korean Journal of Occupational Health Nursing
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• v.16 no.2
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• pp.177-187
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• 2007

Purpose: We were to identify the differences of "Job stress" and "Depression scores" in the divided groups by self-efficacy. And the factors affecting Depression scores were analyzed. Method: This study was conducted from July 2006 to September 2006. Collected 295 surveys were used in this study among 311 surveys since 16 surveys offered insufficient data. SPSS for Windows 10.0 was used to analyse the data. Result: We identified the factors of "Occupational climate", "Job control", "Job demand" as affecting the depression scores in the lower self-efficacy group by the multi-variables statistical analysis. And this statistical model had 12.5% explainable power. Also, the factors of "Occupational climate" were identified as affecting the depression scores in the higher self-efficacy group. And the statistical model had 9.0% explainable power. Conclusion: In the lower self-efficacy group, the scores of the job stress and depression were significantly higher. Therefore, in the lower self-efficacy group, the self-efficacy promotion programs should be needed for prevention of the related occupational diseases. The factors related job stress were identified as affecting the depression scores in both lower and higher self-efficacy groups. Therefore, job stress management program should be prepared for stress loading workers.

• Journal of the Korean Institute of Landscape Architecture
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• v.18 no.3 s.39
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• pp.143-154
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• 1990

This study aims at identifying factors and variables which have significant effects on users satisfaction with recreational activities and facilities in Apsan city natural park and therby establishing indicies of planning and / or development of urban forest. To test the causal models of this research, The data were gathered by self-administered questionnaires from 1,147 households in Taegu city which were selected by the multi-stage probabiling sampling method. The analysis of the data primarily consist of two phases : The first analysis dealt with exploratory factor analysis which identified major factors involved in satisfaction with recreational activities and facilities in Apasn city natural park and the second analysis tested the fit of causal models of this research to the data using LISREL methodology. The factor analysis identified that three significant factors are involved in satisfaction with recreational activities and five significant factors are inherent in satisfaction with recreational facilities. The second phase analysis tested the fit of the causal models for satisfaction with recreational activities and facilities to the data and identified statistically significant causal linkage among overall satisfaction with the park, other indogenous factors and exogenous variables. These significant relationships represent important factors and variables that should be considered in planning and/of development of the city natural park. On the basis of there significant causal relationships implications for planning and/or development of the city natural park were suggested.