• Molecules and Cells
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• v.38 no.9
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• pp.781-788
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• 2015

Mutations of MYO15A are generally known to cause severe to profound hearing loss throughout all frequencies. Here, we found two novel MYO15A mutations, c.3871C>T (p.L1291F) and c.5835T>G (p.Y1945X) in an affected individual carrying congenital profound sensorineural hearing loss (SNHL) through targeted resequencing of 134 known deafness genes. The variant, p.L1291F and p.Y1945X, resided in the myosin motor and IQ2 domains, respectively. The p.L1291F variant was predicted to affect the structure of the actin-binding site from three-dimensional protein modeling, thereby interfering with the correct interaction between actin and myosin. From the literature analysis, mutations in the N-terminal domain were more frequently associated with residual hearing at low frequencies than mutations in the other regions of this gene. Therefore we suggest a hypothetical genotype-phenotype correlation whereby MYO15A mutations that affect domains other than the N-terminal domain, lead to profound SNHL throughout all frequencies and mutations that affect the N-terminal domain, result in residual hearing at low frequencies. This genotype-phenotype correlation suggests that preservation of residual hearing during auditory rehabilitation like cochlear implantation should be intended for those who carry mutations in the N-terminal domain and that individuals with mutations elsewhere in MYO15A require early cochlear implantation to timely initiate speech development.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.44 no.12
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• pp.1043-1053
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• 2016

In this paper, the application of Parallel Distributed Compensation (PDC) controller for fixed pitch rotary wing system was studied. For nonlinear modeling, T-S fuzzy model was utilized to advance system control including the tilt type UAV. PDC controller was designed through the Linear Matrix Inequality (LMI). Experiments for determining the applicability and feasibility of PDC were performed using the 1 axis attitude control equipment and simulation. To verify the performance and characteristics of the controller, Mathworks Co. Simulink was used. After then, the PDC controller performance was verified and the results with developed controller using a 1 axis attitude control equipment were compared. Verification of the feasibility of PDC controller for the fixed pitch rotary wing system and identification of the overall performance and improvement analysis was conducted based on the experimental results.

• Proceedings of the Korean Environmental Health Society Conference
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• 2004.06a
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• pp.92-106
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• 2004

Elemental dry deposition fluxes were measured using dry deposition plates from March to June 1998 in Seoul, Korea. During this spring sampling period several yellow sand events characterized by long-range transport from China and Mongolia impacted the area. Understanding the impact of yellow-sand events on atmospheric dry deposition is critical to managing the heavy metal levels in the environment in Korea. In this study, the measured flux of a primarily crustal metal, Al and an anthropogenic metal, Pb was used with two hybrid receptor models, potential source contribution function (PSCF) and residence time weighted concentration (RTWC) for locating sources of heavy metals associated with atmospheric dry deposition fluxes during the yellow-sand events in Seoul, Korea. The PSCF using a criterion value of the 75th percentile of the measured dry deposition fluxes and RTWC results using the measured elemental dry deposition fluxes agreed well and consistently showed that there were large potential source areas in the Gobi Desert in China and Mongolia and industrial areas near Tianjin, Tangshan, and Shenyang in China. Major industrial areas of Shenyang, Fushun, and Anshan, the Central China loess plateau, the Gobi Desert, and the Alaskan semi-desert in China were identified to be major source areas for the measured Pb flux in Seoul, Korea. For Al, the main industrial areas of Tangshan, Tianjin and Beijing, the Gobi Desert, the Alashan semi-desert, and the Central China loess plateau were found to be the major source areas. These results indicate that both anthropogenic sources such as industrial areas and natural sources such as deserts contribute to the high dry deposition fluxes of both Pb and Al in Seoul, Korea during yellow-sand events. RTWC resolved several high potential source areas. Modeling results indicated that the long-range transport of Al and Pb from China during yellow-sand events as well as non yellow-sand spring daytimes increased atmospheric dry deposition of heavy metals in Korea.

• Journal of Korean Society of Transportation
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• v.24 no.1 s.87
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• pp.19-28
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• 2006

To develop a crisis management for aviation safety, this study has defined crisis management includes risk management which is eliminates or lowers risks prior to accidents and emergency response after the accidents. This study takes a look at different kinds of crisis managements, risk managements and statistical methods of other nations and fields in order to develop a risk management model. Through surveys which have 102 risk factors that include air traffic control, maintenance and airport sectors, the weight of each risk factor was calculated and the probability was divided to develop a model for risk management. The risk management model of this study is conducted using four steps (risk management plan, risk factor identification, weight and probability analysis, decision making) and 4 standards of weight along with 5 standards of probability This study takes a look at Predictions through a quantitative method using a risk index for the risk management model An effective risk management model should have a wide and continuous collection of data and adopt various methods using this model. The crisis management could not be very effective only using a pre-active risk management. So it should also be conducted by using a pro-active response system to protect additional damage and to prevent accidents of the same nature. From the results, the most important points were the establishment of command and control accountabilities, and cooperation of related organizations.

• Journal of Korean Society for Atmospheric Environment
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• v.24 no.4
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• pp.439-454
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• 2008

The purpose of this study was to extensively identify $PM_{10}$ sources and to estimate their contributions to the study area, based on the analysis of the $PM_{10}$ mass concentration and the associated inorganic elements, ions, and total carbon. The contribution of $PM_{10}$ sources was estimated by applying a receptor method because identifying air emission sources were effective way to control the ambient air quality. $PM_{10}$ particles were collected from May to November 2007 in the Yongin-Suwon bordering area. $PM_{10}$ samples were collected on quartz filters by a $PM_{10}$ high-volume air sampler. The inorganic elements (Al, Mn, V, Cr, Fe, Ni, Cu, Zn, Cd, Pb, Si, Ba, Ti and Ag) were analyzed by an ICP-AES after proper pre-treatments of each sample. The ionic components of these $PM_{10}$ samples ($Cl^_$, $NO_3^-$, $SO_4^{2-}$, $Na^+$, $NH_4^+$, $K^+$, $Ca^{2+}$, and $Mg^{2+}$) were analyzed by an IC. The carbon components (OC1, OC2, OC3, OC4, OP, EC1, EC2 and EC3) were also analyzed by DRI/OGC analyzer. Source apportionment of $PM_{10}$ was performed using a positive matrix factorization (PMF) model. After performing PMF modeling, a total of 8 sources were identified and their contribution were estimated. Contributions from each emission source were as follows: 13.8% from oil combustion and industrial related source, 25.4% from soil source, 22.1% from secondary sulfate, 12.3% from secondary nitrate, 17.7% from auto emission including diesel (12.1%) and gasoline (5.6%), 3.1% from waste incineration and 5.6% from Na-rich source. This study provides information on the major sources affecting air quality in the receptor site, and therefore it will help us maintain and manage the ambient air quality in the Yongin-Suwon bordering area by establishing reliable control strategies for the related sources.

• Proceedings of the Korea Water Resources Association Conference
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• 2008.05a
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• pp.194-198
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• 2008

Significant soil erosion and water quality degradation issues are occurring at highland agricultural areas of Kangwon province because of agronomic and topographical specialities of the region. Thus spatial and temporal modeling techniques are often utilized to analyze soil erosion and sediment behaviors at watershed scale. The Soil and Water Assessment Tool (SWAT) model is one of the watershed scale models that have been widely used for these ends in Korea. In most cases, the SWAT users tend to use the readily available input dataset, such as the Ministry of Environment (MOE) land cover data ignoring temporal and spatial changes in land cover. Spatial and temporal resolutions of the MOE land cover data are not good enough to reflect field condition for accurate assesment of soil erosion and sediment behaviors. Especially accelerated soil erosion is occurring from agricultural fields, which is sometimes not possible to identify with low-resolution MOD land cover data. Thus new land cover data is prepared with cadastral map and high spatial resolution images of the Doam-dam watershed. The SWAT model was calibrated and validated with this land cover data. The EI values were 0.79 and 0.85 for streamflow calibration and validation, respectively. The EI were 0.79 and 0.86 for sediment calibration and validation, respectively. These EI values were greater than those with MOE land cover data. With newly prepared land cover dataset for the Doam-dam watershed, the SWAT model better predicts hydrologic and sediment behaviors. The number of HRUs with new land cover data increased by 70.2% compared with that with the MOE land cover, indicating better representation of small-sized agricultural field boundaries. The SWAT estimated annual average sediment yield with the MOE land cover data was 61.8 ton/ha/year for the Doam-dam watershed, while 36.2 ton/ha/year (70.7% difference) of annual sediment yield with new land cover data. Especially the most significant difference in estimated sediment yield was 548.0% for the subwatershed #2 (165.9 ton/ha/year with the MOE land cover data and 25.6 ton/ha/year with new land cover data developed in this study). The results obtained in this study implies that the use of MOE land cover data in SWAT sediment simulation for the Doam-dam watershed could results in 70.7% differences in overall sediment estimation and incorrect identification of sediment hot spot areas (such as subwatershed #2) for effective sediment management. Therefore it is recommended that one needs to carefully validate land cover for the study watershed for accurate hydrologic and sediment simulation with the SWAT model.

• Journal of Korea Water Resources Association
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• v.47 no.8
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• pp.671-684
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• 2014

Change point analysis is a efficient tool to understand the fundamental information in hydro-meteorological data such as rainfall, discharge, temperature etc. Especially, this fundamental information to change points to future rainfall data identified by reasonable detection skills can affect the prediction of flood and drought occurrence because well detected change points provide a key to resolve the non-stationary or inhomogeneous problem by climate change. Therefore, in this study, the comparative study to assess the performance of the 3 change point detection skills, cumulative sum (CUSUM) method, Bayesian change point (BCP) method, and segmentation by dynamic programming (DP) was performed. After assessment of the performance of the proposed detection skills using the 3 types of the synthetic series, the 2 reasonable detection skills were applied to the observed and future rainfall data at the 5 rainfall gauges in South Korea. Finally, it was suggested that BCP (with 0.9 posterior probability) could be best detection skill and DP could be reasonably recommended through the comparative study. Also it was suggested that BCP (with 0.9 posterior probability) and DP detection skills to find some change points could be reasonable at the North-eastern part in South Korea. In future, the results in this study can be efficiently used to resolve the non-stationary problems in hydrological modeling considering inhomogeneity or nonstationarity.

• Journal of the Korean Institute of Intelligent Systems
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• v.10 no.5
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• pp.487-496
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• 2000

In this paper, the Multi-FNN(Fuzzy-Neural Networks) model is identified and optimized using HCM(Hard C-Means) clustering method and genetic algorithms. The proposed Multi-FNN is based on Yamakawa's FNN and uses simplified inference as fuzzy inference method and error back propagation algorithm as learning rules. We use a HCM clustering and Genetic Algorithms(GAs) to identify both the structure and the parameters of a Multi-FNN model. Here, HCM clustering method, which is carried out for the process data preprocessing of system modeling, is utilized to determine the structure of Multi-FNN according to the divisions of input-output space using I/O process data. Also, the parameters of Multi-FNN model such as apexes of membership function, learning rates and momentum coefficients are adjusted using genetic algorithms. A aggregate performance index with a weighting factor is used to achieve a sound balance between approximation and generalization abilities of the model. The aggregate performance index stands for an aggregate objective function with a weighting factor to consider a mutual balance and dependency between approximation and predictive abilities. According to the selection and adjustment of a weighting factor of this aggregate abjective function which depends on the number of data and a certain degree of nonlinearity, we show that it is available and effective to design an optimal Multi-FNN model. To evaluate the performance of the proposed model, we use the time series data for gas furnace and the numerical data of nonlinear function.

• Journal of Digital Contents Society
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• v.9 no.4
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• pp.661-667
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• 2008

The dynamics of business cycles has been changed by the macroscopic economic forces because of the introduction of new technical know-how each year. These the dynamics of business has a significant influence on the investment of enterprise in the information communication field. Today, the most important goal of the IT investment is simply not to lower the production cost any more, but to improve the usefulness for the customers and partners in order to obtain the optimized mass products. Therefore, the enterprises have been concentrating their all abilities on the automation, integration, and optimization of business process using BPM. In addition, they are concentrating their efforts on the business expansion by approaching the technical aspect using RFID application system. However, in order to accomplish a successful enterprise ability, the technical view, business process view, and organization view must be considered together. We suggested the method considering organization view, via the technical element, i.e., RFID system for approaching the business process. Furthermore, we tried the optimization of assignment using Context Analysis methodology and proposed the method to reduce the element with respect to the time, human, and expense by applying the Case Study method that minimizes the iteration times through the transmitted processing procedure and type. The proposed method gave us the expectation that it will bring out the innovative improvement with respect to the time, expense, quality, and customer's satisfaction in the process from the analysis of business process to the analysis and design of system.

• Journal of Korea Water Resources Association
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• v.42 no.7
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• pp.525-535
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• 2009

In this paper a heuristic method for identifying individual pipes in water pipe networks to determine specific sections of the pipes that need to be replaced due to deterioration. An appropriate minimum pipe length is determined by selecting the pipe length that has the greatest variance of the average cumulative break number slopes among the various pipe lengths used. As a result, the minimum pipe length for the case study water network is determined as 4 m and a total of 39 individual pipe IDs are obtained. The economically optimal replacement times of the individual pipe IDs are estimated by using the threshold break rate of an individual pipe ID and the pipe break trends models for which the General Pipe Break Prediction Model(Park and Loganathan, 2002) that can incorporate the linear, exponential, and in-between of the linear and exponetial failure trends and the ROCOFs based on the modified time scale(Park et al., 2007) are used. The maximum log-likelihoods of the log-linear ROCOF and Weibull ROCOF estimated for the break data of a pipe are compared and the ROCOF that has a greater likelihood is selected for the pipe of interest. The effects of the social costs of a pipe break on the optimal replacement time are also discussed.