• Biotechnology and Bioprocess Engineering:BBE
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• 제6권4호
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• pp.231-236
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• 2001

How much do we know about the biology of aging from cell culture studies Most normal somatic cells have a finite potential to divide due to a process termed cellular or replicative senescence. A growing body evidence suggests that senescence evolved to protect higher eu-karyotes, particularly mammals, from developing cancer, We now know that telomere shortening due to the biochemistry of DNA replication, induces replicative senescence in human cells. How-ever in rodent cells, replicative senescence occurs despite very long telomeres. Recent findings suggest that replicative senescence is just the tip of the iceberg of a more general process termed cellular senescence. It appears that cellular senescence is a response to potentially oncogenic in-sults, including oxidative damage. In young orgainsms, growth arrest by cell senescence sup-presses tumor development, but later in life, due to the accumulation of senescent cells which se-cret factors that can disrupt tissues during aging, cellular senescence promotes tumorigenesis. Therefore, antagonistic pleiotropy may explain, if not in whole the apparently paradoxical effects of cellular senescence, though this still remains an open question.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.537-550
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• 2014

The actual burden of head and neck cancer in India is much greater than reflected through the existing literature and hence can be regarded as a 'tip of iceberg' situation. This has further been evident by the recent reports of 'Net-based Atlas of Cancer in India'. South-east Asia is likely to face sharp increases of over 75% in the number of cancer deaths in 2020 as compared to 2000. Since the percentage increase of Indian population has been nearly twice that of the world in last 15 years there is a likelihood of increase in cancer burden with the same proportion. The distribution of population based cancer registries is grossly uneven with certain important parts of the country being not represented at all and hence the current cancer burden is not reflected by registry data. However, the pathetic situation of health care system in major parts of the country as also emphasized by the World Bank, is not suitable to provide anywhere near accurate data on cancer burden. Head and neck cancer (including thyroid lesions) is third most common malignancy seen in both the sexes across the globe but is the commonest malignancy encountered in Indian males. Also oral cavity cancer is the most prevalent type amongst the males and one of the highest across the globe. This article reviews the latest global and national situation with an especial emphasis on head and neck cancer. Furthermore this review focuses on burden in different sub sites at national and global levels.

• Journal of Ship and Ocean Technology
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• 제12권1호
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• pp.35-44
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• 2008

As arctic energy resource is attracting public attention, arctic shipping market will also be growing in large as expected to increase in LNG trade from Arctic area to the western countries by shipping. During the voyages through such routes, collision with icebergs may be possible. In the present report, ice collision analyses are carried out from a practical point of view to verify the safety of hull structural strength of LNG carriers equipped with GTT $MKIII^{TM}$ membrane type cargo containment system. From the results of collision analyses and the operation-friendly design concept of no-repairing of cargo containment system, a safe operating envelope against ice collision is proposed for LNG carriers of membrane type cargo containment system. Based on the currently proposed safety criteria, it is concluded that LNG carriers with membrane tank type can operate safely with regard to the integrity of CCS in regions where collision between LNG carrier and iceberg is expected.

• Preventive Nutrition and Food Science
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• 제9권4호
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• pp.289-294
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• 2004

The antioxidant activity of forty two kinds of salad vegetables grown in Korea was evaluated. Methanol extract of freeze-dried vegetable was assayed by radical scavenging activity using 1,2-diphenyl-2-picrylhydrazyl (DPPH) and Fe^{2+}$-catalyzed lipid peroxidation inhibition by TBA method. Total phenolics were determined colorimetrically using Folin-Ciocalteu reagent. The highest radical scavenging activity was expressed by perilla leaf, followed by dandelion leaf, red and green leafy lettuce, of which $IC_{50}$ was less than 0.10 mg/mL. Angelica leaf showed the highest inhibitory action for lipid peroxidation with $95\%$, and then dandelion leaf, water spinach, and perilla leaf inhibited over $80\%$. However, lettuce (Iceberg) and young Chinese cabbage exhibited the lowest antioxidant activity based on both assay methods. Highly positive correlations between antioxidative activities and total phenolics were observed (p < 0.001). The results suggested that salad vegetables, especially perilla leaf, leafy lettuce, dandelion or angelica, could be used for easily accessible sources of natural antioxidants.

• 동의신경정신과학회지
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• 제30권4호
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• pp.305-317
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• 2019

Objectives: The purpose of this study was to analyze domestic qualitative research papers of the Satir Transformational Systemic Therapy and suggest the possibility of applying it to Korean medicine counseling. Methods: Domestic research papers were gathered by keywords 'Satire Counseling' or 'Satir Transformational Systemic Therapy' and 'Qualitative Research' in RISS (http://www.riss.kr/), KISS (http://kiss.kstudy.com/), OASIS (http://oasis.kiom.re.kr/). The results were seven papers. Seven papers were selected based on grounded theory and case studies. Researchers analyzed the phenomena during the course of counseling to discuss the mechanism of the Satir Transformational Systemic Therapy and consider its applicability to Korean medicine psychotherapy. Results: The Satir Transformational Systemic Therapy has three points: 'Self', 'Communication', and 'Family'. Positive changes such as 'Self-recovery', 'Consistent communication', and 'Recovery of relationships' are derived from these three points. And techniques such as iceberg exploration, family maps, three-members in a born family, and the family sculpture are also effective means. Conclusions: The Satir Transformational Systemic Therapy is valuable in the clinical fields of Korean medicine counseling, especially relative to problems stemming from relationships.

• Bulletin of the Korean Chemical Society
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• 제10권1호
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• pp.50-57
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• 1989

A pressure effect of the dehydrogenation of ethylalcohol catalyzed by alcoholdehydrogenase was observed in Tris-HCl buffer, pH 8.8 from $25^{\circ}C$ to $35^{\circ}C$ under high pressure system by using our new theory. The theory makes it possible for us to obtain all rate and equilibrium constants for each step of all enzymatic reaction with a single intermediate. We had enthalpy and volume profiles of the dehydrogenation to suggest a detail and reasonable mechanism of the reaction. In these profiles, both enthalpy and entropy of the reaction are positive and their values decrease with enhancing pressure. It means that the first step is endothermic reaction, and its strength decrease with elevating pressure. At the same time, all activation entropies have large negative values, which prove that not only a ternary complex has a more ordered structure at transition state, but also water molecules make a iceberg close by the activated complex. In addition to this fact, the first and second step equilibrium states are controlled by enthalpy. The first step kinetic state is controlled by enthalpy but the second step kinetic state is controlled by entropy.

• 복식
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• 제62권4호
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• pp.91-106
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• 2012

The purpose of this study was to offer some directions for the design of men's knitwear and provide basic data helpful for design conception and product development for creative and unique men's knitwear. As for the methodology, the investigator examined the works of these following ten designers that consistently participated in the men's Milano Collection for the last ten years from 2001 S/S to 2010 F/W: Burberry Prorsum, Costume National, D & G, D squared, Dolce & Gabbana, Giorgio Armani, Gucci, Iceberg, Prada, and Vivien Westwood. We identified the design elements expressed in knitwear, categorized examples for each element, and reviewed their characteristics. The results of this study are as follows. The designers usually adopted the H-silhouette with some room until 2006, after which the slim tubular silhouette became prevalent. Most of the designers made knitwear with normal yarn and expressed them by dyeing or printing regardless of seasons, which meant the usage level of fancy yarn was low. The much usage of the basic pattern was particularly salient. The most popular basic structure was plain, which was followed by rib and color pattern, which included the jacquard and intarsia pattern. The designers presented thick outer items made of thick yarn for F/W seasons and many thin inner items made of thin yarn for S/S seasons. The popular colors were brown from the Red Group(R) and beige from the Orange Group (YR) regardless of seasons. When achromatic colors were used a lot, there was a development of various grey shades. For the most used basic structure, plain, the designers employed such technical methods as printing, pleat treatment, and dyeing in high frequency.

• 대한조선학회논문집
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• 제49권6호
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• pp.478-483
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• 2012

The speed performances of ice sea trial on the Arctic(2010 & 2011) area were shown different results depend on the ice floe size. Penetration phenomena of level ice was not happened on medium ice floe and tore up by the impact force because the mass of medium ice floe is similar to the mass of Araon which is Korean ice breaking research vessel and did not shut up by the ice ridge or iceberg. The sea trial on the Amundsen sea was performed at the big floe which is classified by WMO(World Meteorological Organization). Three measurements of ice properties and five results of speed trial were obtained with different ice thicknesses and engine powers. To evaluate speed of level ice trial and model test results at the same ice thickness and engine power, the correction method of HSVA(Hamburg Ship Model Basin) was used. The thickness, snow effect, flexural strength and friction coefficient were corrected to compare the speed of sea trial. The analyzed speed at 1.03m thickness of big floe was 5.85 knots at 10MW power and it's 6.10 knots at 1.0m ice thickness and the same power. It's bigger than the results of level ice because big floe was also slightly tore up by the impact force of vessel based on the observation of recorded video.

• 대한화학회지
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• 제36권1호
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• pp.28-32
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• 1992

몇 가지 요소-수용액에서 Dodecylpyridinium bromide의 임계미셀농도 변화를 1${\sim}$2000 bar 및 $25^{\circ}C$에서 전기전도도법으로 측정하였다. 수용액에 요소가 첨가됨에 따라 전압력 범위에서 임계 미셀농도가 증가하는 경향을 보였으며, 요소-수용액에서 압력의 증가에 따라 임계미셀농도가 증가하다가 어떤 압력이상에서는 압력의 증가에 따라 다시 감소하는 경향을 나타내었다. 한편 미셀 형성에 대한 분몰부피변화$({\Delta}V^m_o)$는 요소의 농도가 증가함에 따라 감소하는 경향성을 보였다. 이 결과로부터 단량체 상태의 계면활성제의 탄화수소사슬 주위의 물의 "icerberg" 구조가 요소에 의해 효과적으로 파괴된다는 것을 알 수 있었다.

• 정보화연구
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• 제9권4호
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• pp.455-464
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• 2012

최근 데이터의 폭발적인 증가로 인해 대규모 데이터의 분석에 대한 요구를 충족할 수 있는 방법들이 계속 연구되고 있다. 본 논문에서는 맵리듀스를 이용한 분산 병렬 처리를 통해 대규모 데이터 큐브의 효율적인 계산이 가능한 MRIterativeBUC 알고리즘을 제안하였다. MRIterativeBUC 알고리즘은 기존의 BUC 알고리즘을 맵리듀스의 반복적 단계에 따른 효율적인 동작이 가능하도록 개발되었고, 기존의 대규모 데이터 큐브 계산에 따른 문제인 데이터 크기와 저장 및 처리 능력의 한계를 해결하였다. 또한, 분석자의 관심 부분에 대해서만 계산하는 빙산 큐브 개념의 도입과 파티셔닝, 정렬과 같은 큐브 계산을 분산 병렬 처리하는 방법 등의 장점들을 통해 데이터 방출량을 줄여서 네트워크 부하를 줄이고, 각 노드의 처리량을 줄이며, 궁극적으로 전체 큐브 계산 비용을 줄일 수 있다. 본 연구 결과는 맵리듀스를 이용한 데이터 큐브 계산에 대해서 상향식 처리와 반복적 알고리즘을 통해 다양한 확장이 가능하며, 여러 응용 분야에서 활용이 가능할 것으로 예상된다.