• Bulletin of the Korean Space Science Society
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• 2009.10a
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• pp.41.1-41.1
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• 2009

한국천문연구원은 2008년 10월 IVS(International VLBI Service for Geodesy and Astrometry) 통합분석센터로 선정되어 현재 정규운영을 위한 준비 작업을 진행하고 있다. IVS 통합분석센터는 개별 IVS 분석센터에서 산출한 산출물을 통합하여 개별 분석 센터 산출물의 품질을 검증하고 국제 지구기준좌표계 구성에 필요한 입력 데이터를 제공하는 기능을 한다. 이 연구에서는 IVS통합분석센터로서의 역할과 향후 IVS 통합분석센터의 운영계획에 대해 초점을 맞춘다. VLBI 산출물 통합을 위해 다른 IVS 통합분석센터와 차별화하여 GPS 자료처리 소프트웨어 Bernese 5.0에서 제공하는 정규방정식 단계 통합 프로그램인 ADDNEQ2를 활용할 계획이다. 이와 관련하여 VLBI 데이터 처리에 적합하도록 ADDNEQ2를 수정 보완한 사항과 수정된 ADDNEQ2로 통합한 예비 결과에 대해 집중적으로 논의한다. 이와 더불어 산출한 예비 결과를 각 개별 IVS 분석센터 산출물을 바탕으로 비교 검증한 결과를 소개한다.

• Bulletin of the Korean Space Science Society
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• 2011.04a
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• pp.21.4-22
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• 2011

IVS (International VLBI Service for Geodesy and Astrometry) 통합분석센터는 개별 IVS 분석센터의 산출물을 통합하고 그 결과물을 IERS (International Earth Rotation and Reference Systems Service)에 제공하여 국제 지구기준좌표계를 구축하고 지구회전파라미터를 결정하는데 핵심적인 역할을 한다. 한국천문연구원(KASI)은 2008년 10월 IVS 통합분석센터로 선정되어 현재 통합 분석 시스템을 구축하고 있다. 정규운영에 앞서 통합용 분석 소프트웨어를 정비하고, KASI 통합분석센터의 통합해를 타 IVS 통합분석센터 통합해와 비교 검증하는 것은 필수적이다. 이 연구에서는 통합분석처리를 위해서 GPS 자료처리 소프트웨어인 Bernese 5.0을 IVS 산출물 형식에 맞추어 수정 보완한 후 활용한다. 이 발표에서는 1984년부터 현재까지의 IVS 분석센터의 장기간 산출물을 수집하고 Bernese 5.0을 이용하여 지구회전파라미터(X-극, Y-극, UT1-UTC와 각각의 시간변화율)의 통합해를 산출한 결과를 소개한다. 또한, 타 IVS 통합분석센터의 통합해와 비교 검증결과를 논한다.

• Information Systems Review
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• v.10 no.2
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• pp.71-96
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• 2008

Interactive Video Service(IVS) is a new type of media service that enables users to interact with others in the process of casting and watching videos in a system. 'Timing flexibility', which divides IVS into real-time IVS and non-real-time IVS, is one of the significant factors of interactivity. The objective of this study is to identify critical factors of interactivity in IVS and to compare their effects in terms of timing flexibility. To achieve the objective, prior literature has been reviewed to establish a theoretical framework, and twelve active users of IVS have been interviewed to develop research model of IVS. Finally, an online survey has been conducted to verify the research model. The results indicate that Technical Factor, Communication Factor, and Contents Factor of IVS are found to be the important interaction factors in IVS; and their impacts on the intention to use IVS were found to be affected by timing flexibility. This paper ends with theoretical and practical implications of study results.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.1
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• pp.91-96
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• 2013

Background: p53 alterations have been implicated in the development of many cancers, such as gastric cancer, but there is no evidence of p53 intron alterations in gastritis lesions. The aim of this study was to investigate the p53 intron alterations in gastritis along with p53 and mismatch repair protein expression and microsatellite status. Materials and Methods: PCR-sequencing was conducted for introns 2-7 on DNA extracted from 97 paired samples of gastritis lesions and normal adjacent tissue. Abnormal accumulation of p53 and mismatch repair proteins was investigated using immunohistochemistry. In addition, microsatellite status was evaluated with reference to five mononucleotide markers. Results: Gastritis cases included 41 males and 56 females in the age range of 15-83 years, 87.6% being H.pylori positive. IVS2+38, IVS3ins16 and IVS7+72 were the most polymorphic sites. Their minor allele frequency values were as follows: 0.38, 0.21 and 0.06, respectively. Samples with GG genotype at IVS2+38 and CT at IVS7+72 had no insertion. Moreover, most of the stable samples (91.9 %) had a G allele at IVS2+38. All of the samples were IHC negative for p53 protein, microsatellite stable and expressed mismatch repair proteins. p53 alterations were prominent in the H. Pylori+ group, but without statistical significance. Conclusions: According to our results, some p53 polymorphisms such as IVS2+38, IVS3ins16 and IVS7+72, because of their correlations together or with microsatellite status may contribute to gastritis development. However, so far effects on p53 expression and function remain unclear. Therefore, a comprehensive survey is needed to delineate their biological significance.

• Journal of Dental Anesthesia and Pain Medicine
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• v.16 no.2
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• pp.89-94
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• 2016

Anxiety and phobia in dental procedures are common deterrents for patients visiting the dental care unit. For these individuals, procedural sedation may aid in completion of dental treatments. In most cases, the patients are conscious during sedation, thereby allowing spontaneous ventilation. Intravenous sedation (IVS) is widely used during dental treatment to relieve patient anxiety. IVS is the most effective route of administration to achieve this goal, but it requires advanced training, more than that provided during undergraduate education. During IVS, rapid onset, repetitive drug administration, easy titration, and rapid recovery from sedation can be achieved. However, conscious sedation during IVS can result in deep sedation that can cause respiratory and cardiovascular depression. Therefore, the characteristics of intravenous sedatives should be known. The purpose of this review is to discuss the characteristics and usage of intravenous sedatives currently used for dental procedures.

• Environmental Analysis Health and Toxicology
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• v.28
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• pp.12.1-12.5
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• 2013

Objectives The role of genetic polymorphisms of tumor necrosis factor-alpha (TNF-${\alpha}$) for lung cancer development was evaluated. Methods Genotypes of the TNF-${\alpha}$ polymorphisms, -1210C>T, -487A>G, -417A>G, IVS1+123G>A, and IVS3+51A>G, were determined in 616 lung cancer cases and 616 lung cancer-free controls. Results After adjusting for body mass index and smoking, each TNF-${\alpha}$ genotype or haplotype composed of five TNF-${\alpha}$ single nucleotide polymorphisms did not show an association with lung cancer risk (p>0.05). The statistical power was found to be 88.4%, 89.3%, 93.3%, 69.7%, and 93.9% for 1210C>T, -487A>G, -417A>G, IVS1+123G>A, and IVS3+51A>G, respectively. Furthermore, the effects of each SNP or haplotype on lung cancer risk were not found to be different according to the cell type of lung cancer (p>0.05). In the repeated analysis with only subjects without other diseases related to inflammation, there was also no association between polymorphisms or haplotypes of the TNF-${\alpha}$ gene and lung cancer risk (p>0.05). Conclusions This study found no association between common variants of the TNF-${\alpha}$ gene and lung cancer risk.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.3
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• pp.897-902
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• 2015

PTEN (phosphatase and tensin homologue), as a tumor suppressor gene, plays a significant role in regulating cell growth, proliferation, and apoptosis. Results from published studies for association between the PTEN IVS4 I/D (rs3830675) polymorphism and cancer risk are inconsistent and inconclusive. We therefore conducted a meta-analysis to evaluate the potential association between PTEN IVS4 I/D polymorphism and risk of cancer in detail. We searched PubMed (Medline) and EMBASE web databases to cover all relevant studies published until December 2013. The meta-analysis was carried out and pooled odds ratios (ORs) and 95% confidence intervals (95%CIs) were used to appraise the strength of association. A total of 1,993 confirmed cancer cases and 3,200 controls were included from six eligible case-control studies. Results from overall pooled analysis suggested a significant effect of the PTEN IVS4 I/D polymorphism and cancer risk in all genetic models, i.e., allele (I vs D: OR=0.743, 95%CI=0.648 to 0.852, p=0.001), homozygous (II vs DD: OR=0.673, 95%CI=0.555 to 0.816, p=0.001), heterozygous (ID vs DD: OR=0.641, 95%CI=0.489 to 0.840, p=0.001), dominant (II+ID vs DD: OR=0.626, 95%CI=0.489 to 0.802, p=0.001) and recessive (II vs DD+ID: OR=0.749, 95%CI=0.631 to 0.889, p=0.001). Significant publication bias was detected during the analysis. The present meta-analysis suggests that the PTEN IVS4 I/D polymorphism is significantly associated with reduced risk of cancer. However, future larger studies with other groups of populations are warranted to clarify this association.

• Journal of Integrative Natural Science
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• v.4 no.3
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• pp.197-201
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• 2011

3D-QSAR techniques including CoMFA have been used a lot for more than two decades now. For now, the perspective of 3D-QSAR has been changed. The realization of gorge activity cliffs and higher chance correlation with many independent variables (IVs) has changed the requirements. Some suggested the benchmarking datasets for 3D-QSAR. However, were they still useful for right reasons? Here, we propose the requirement of any general purpose 3D-QSAR benchmarking datasets for lead optimization, especially for feasibility test of any IVs. Specifically, we summarize the conceptual requirements for an ideal settings for 3D-QSAR especially CoMFA.

• Journal of Power Electronics
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• v.12 no.3
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• pp.439-447
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• 2012

In this paper, an input-series auxiliary power supply scheme is proposed, which is suitable for high input voltage and multiple-output applications. The power supply scheme is based on a two-transistor forward topology, all of the series modules have a common duty ratio, all the switches are turned on and off simultaneously, and the whole circuit has a single power transformer. It does not require an additional controller but still achieves efficient input voltage sharing (IVS) for each series module through its inherent transformer-integration strategy. The IVS process of this power supply scheme is analyzed in detail and the design considerations for the related parameters are given. Finally, a 100W multiple-output auxiliary power supply prototype is built, and the experimental results verify the feasibility of the proposed scheme and the validity of the theoretical analysis.

• Clinical and Experimental Pediatrics
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• v.46 no.5
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• pp.484-489
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• 2003

Purpose : To understand morphologic and hemodynamic variations in patients with pulmonary atresia with intact ventricular septum(PA/IVS), and to decide the best treatment modalities, we measured right ventricular volume, inflow, and outflow valvular annulus size in these patients and compared them with those of normal newborns. Methods : Eight patients with PA/IVS diagnosed by echocardiography from January to December 2001 were enrolled in this study. Among the total eight patients, five were male and three were female. The mean age of patients was 6.9 days(1-34 days), and the mean body weight was 3,343 gm (2,970-4,000 gm). Ten fullterm newborn infants with sepsis or hyperbilirubinemia without heart disease were enrolled as a control group. Echocardiographic and Doppler studies using Acuson Aspen (7Mh probe) were recorded on super-VHS videotape and later on, with review mode. We measured volumes of right and left ventricles, aortic, pulmonic, mitral and tricuspid valvular annulus sizes using an installed program, and then these parameters were compared with those of the control group. Results : Mean Z-value of tricuspid valvular annulus in PA/IVS was $-3.69{\pm}2.80$(-8.4--0.45), and tricuspid/mitral valvular annulus size ratio $0.68{\pm}0.15$(0.43--0.84). The more the tricuspid/mitral valvular annulus size ratio, the more Z-value of tricuspid valvular annulus(P=0.003, r=0.885). Those patients who underwent pulmonary valvuloplasty(balloon or surgical) had a tendency toward larger volume of the right ventricle, more Z-value of pulmonic and tricuspid valvular annulus, and more tricuspid/mitral valvular annulus size ratio than those patients who underwent a shunt operation. Conclusion : Compared to a measurement of the volume of the right ventricle, measurements of tricuspid/mitral valvular annulus size ratio and Z-value of tricuspid valvular annulus may be easier and better parameters to decide the treatment method and to predict prognosis in PA/IVS patients.