• 대한세포병리학회지
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• 제1권1호
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• pp.74-84
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• 1990

Herpes simplex virus type 1 and 2(HSV-1, HSV-2) are the ubiquitous human pathogens responsible for a variety of afflictions. HSV-2 is one of the viruses that were suspected of promoting carcinogenesis in the uterine cervix. Certainly, there is a need for the more sensitive and accurate laboratory techniques for HSV detection. We examined total 80 cases of smears including 17 Tzanck smears of skin and 63 cases of Papanicolaou smears from total 77 patients with clinical impression of herpetic infections, from September, 1985 through August, 1989. Immunohistochemical typings for HSV-1 and HSV-2 were performed together with routine cytologic findings and compared. The results are as follows : 1) Patients were 9 males and 33 females, and age distribution was between 5 and 71 years. 2) Subjective symptoms such as ulceration, vesicle, vaginal discharge, pruritus, and pain were complained in 36 patients and 38 cases were genital herpes. Recurrence was noted in 11 cases. 3) Positive results were obtained in 42 among 80 cases. 4) Both routine cytology and immunohistochemical staining were positive in 13 cases and in 24 cases only immunohistochemical staining were positive. 5 cases were positive only in routine cytologic smears. 5) The cases that immunocytochemical stain had been performed were 37 cases, which were all positive in type 2. Among the above 37 cases, type 1 also were positive in 5 cases. The results show that the immunoperoxidase technique is one of the rapid and reliable method to confirm the herpetic infection when suspected and that it is particularly useful when the Papanicolaou smear findings are equivocal.

• Asian Pacific Journal of Cancer Prevention
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• 제17권8호
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• pp.4125-4129
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• 2016

Background: Chemotherapy-induced nausea and vomiting (CINV) places a significant burden on the patient. Herbal agents are the most commonly complementary therapies used among the public. This study was done to determine the effect of ginger and chamomile capsules on nausea and vomiting in cases undergoing chemotherapy for breast cancer (BC). Materials and Methods: In a randomized, double-blind and clinical trial study, 65 women with BC undergoing chemotherapy were referred to Breast Cancer Research Center, Tehran, Iran, between May 2013 to June 2014. Regimen for ginger group for 5 days before and 5 days after chemotherapy was: 2 times a day and 500 mg capsules of powdered ginger root in addition to a routine antiemetic regimen consisting of dexamethasone, metoclopramide and aprepitant (DMA) capsules. Chamomile group similarly was: 2 times a day and 500 mg capsules of Matricaria chamomilla extract in addition to a routine antiemetic regimen consisting of DMA capsules. Control group, routine antiemetic regimen consisting of DMA capsules. Results: There were no significant differences between the ginger, chamomile and control groups regarding age. Drugs used for chemotherapy were identical and duration of disease was also matched (1-4 months). Ginger and chamomile were both significantly effective for reducing the frequency of vomiting, there being no significant difference between the ginger and chamomile groups. Moreover, unlike the chamomile, ginger significantly influenced the frequency of nausea. Conclusions: According to the findings of this study, it should be declared that taking ginger capsules (1 g/day) might relieve CINV safely. Nurses dealing directly with cancer patients should be responsible for providing educational programs for patients and their families about how to deal with their drug regimens and associated side effects.

• 한국과학교육학회지
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• 제9권1호
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• pp.53-67
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• 1989

General Physics CAI Program was developed for university science and engineering student. The program was restricted in the field of mechanics and was mainly aimed for individual tutorial. This project was supported by Government. Department of Education, physics attending their general physics classes in university. The program was written in BASIC and constructed by frame, 4 professors and 6 graduate students were involved in the project. Summary of this study is as follows. 1. The theory of CAI was illuminated from a new point of view to enhance usefullness of CAI. Also the structure of frame type CAI was studied. 2. The program was developed as follows 1) The program consisted of main program, pretest routine, tutorial routine, final test routine, and several other routines for program control. Whole program was written in BASIC. 2) 20 problems for pretest, 90 problems and subsequent hints and solutions for tutorial, 20 problems for final test were developed. 3) According to student's pretest result, tutorial course was routed through several different courses which contain different number of problems 4) The expected rate of achievment for final test was set to 75%. 5) Data of students response to problems including number of tries and time used were recorded for the purpose of achievment analisys 3. 22 students went through whole course and the results were as follows. 1) Pretest marks were widly distributed from 20 points to 100. It means that achievement of high school physics course were not enough. 2) Throughout tutorial course, students who had got higher mark in pretest answered correctly in the first trial at a higher rate of 78 %. Overall rate of correct answer in the second trial was distributed appropriatly. 3) Average mark of final test was 78.8 points, rather a higher rate of achievement than expected. This means that the program was constructed well.

• 대한유전성대사질환학회지
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• 제14권2호
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• pp.156-162
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• 2014

A 25-month-old boy was referred to the hospital due to large head detected on routine physical examination. At visit, dysmorphic facial appearances, including broad nose, prominent forehead, and coarse face, were noted. Nasal obstruction with nasal voice, prominent adenoids, and bilateral middle ear effusions were detected. His abdomen was distended, and liver and spleen were palpated about 3 finger and 2 finger breadths, respectively. He was operated for bilateral inguinal hernias. The motion of both elbow joints was mildly limited on supination and pronation. Urinary level of glycosaminoglycan was elevated and the enzyme activity of iduronate sulfatase in leukocytes was decreased. The mutational analysis of the gene iduronate 2-sulfatase (IDS) revealed c.263G>A (p.Arg88His) mutation. His developmental scale showed delayed development and there was cardiac valvular involvement (tricuspid regurgitation and mitral valve prolapse). After the diagnosis of Hunter syndrome, enzyme replacement therapy started on a weekly basis without progression of any clinical features. Here we report a case of early diagnosed Hunter syndrome detected by large head on routine examination. Thus, it is important to associate Hunter syndrome in the patient with large head especially, if there is the history of bilateral inguinal hernia and prominent adenoids to increase the possibility of early diagnosis and treatment.

• 센서학회지
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• 제6권4호
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• pp.307-315
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• 1997

본 논문에서는 센서교환이 용이하고 소량의 샘플을 요구하는 ISFET 센서용 전해질 분석기의 샘플챔버(sample chamber)를 설계하였으며, 이를 이용한 2점 교정방식의 4채널 전해질 분석기를 구현하였다. 샘플과 교정용액들의 사용을 최소화하기 위한 샘플의 로딩상태 감지회로를 제안하였으며 이를 실현하였다. 구현된 전해질 분석기는 제어계통과 액류흐름계통으로 구성되어 있으며 전해질 분석기의 효과적인 제어를 위하여 측정루틴, 교정루틴 및 세척루틴의 시스템 소프트웨어를 각각 개발하였다.

• Journal of Chest Surgery
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• 제22권4호
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• pp.705-708
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• 1989

Angiofollicular lymph node hyperplasia is a relatively rare benign lesion. It develops most often in the mediastinum, but also it found in other area of the body, usually where lymph nodes are normally found. There are histologically divided hyaline vascular type, plasma cell type and transitional type. The lesions were discovered most often on routine roentgenograms, and complete surgical excision is the treatment of choice. Recently, the authors experienced a case of angiofollicular lymph node hyperplasia, transitional type, located in the right hilar area. The lesion was removed and the patient is in good condition postoperatively. Now we report this case with review of previously reported literatures.

• 보건행정학회지
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• 제9권1호
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• pp.139-155
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• 1999

This study was performed to assess the practice behavior and the need for cancer screening in order to design the community projects in Suwon city. A random sample of urban married women was surveyed on knowledge, attitude, and practice of breast and cervical cancer screening by telephone from April 28th to May 19th. Four hundred two married women completed the questionnaire, and the results were as follows: 1. Urban women were not generally knowledgeable about symptoms, signs and etiology of breast and cervical cancer. Only 11.4% of respondents were fully aware of those subjects. 2. Two hundred eighty six repondents(71.1%) reported having had a mammogram or Pap smear, while 116 respondents(28.9%) reported never having had a mammogram nor Pap smear. 3. The rate of mammogram increased by age and income status significantly(p〈0.05). 4. The majority(73.1%) of women who had a mammogram reported that it was part of a routine physical examination and another 24.3% of the women reported that they had a mammogram for specific breast problems. Meanwhile, the reasons reported for never having a mammogram were as follows; never had any problems (72.1%), no chance(11.2%), no time(4.3%). 5. The main factors associated with adherence to mammography screening guidelines was monthly income status. 6. The majority(80.6%) of women who had a Pap smear reported that it was part of a routine physical examination and another 16.0% of the women reported that it was part of a routine physical examination and another 16.0% of the women reported that they had a Pap smear for specific uterus problems. Meanwhile, the reasons reported for never having a Pap smear were: never had any problems(69.0%) and no chance(11.5%) 7. Women with higher income status were most likely to have a Pap smear regularly (p〈0.01), and the rate of Pap smear increased by education level significantly(p〈0.05). The main factors associated with adherence to Pap smear screening guidelines were education level and monthly income status, similar to those of mammograph. These findings indicate that married women in Suwon city show a lower rate of breast and cervical cancer screening practice than that of developed countries. The rate of mammograph was especially low. It is, therefore, suggested that cost, environmental factors, process, and information for screening tests be considered more programmatically before designing a community project for breast and cervical cancer screening.

• 한국엔터테인먼트산업학회논문지
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• 제13권4호
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• pp.165-172
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• 2019

우연한 어떤 것을 기다리는 듯 단조롭게 반복되는 일상 속에 정지된 화면처럼 불쑥 등장하는 거리의 간판과 자연의 풍경(나무), 특별한 의미 없이 등장하고 사라지는 인물들, 상투적인 만남과 헤어짐을 반복하면서도 상투적인 것에서 벗어나라고 충고하고, 어떠한 결말도 제시하지 않으면서 다시 제자리로 돌아가는 인물들의 모습은 일상의 우연성과 의외성을 강조하면서도 너무나 익숙하기 때문에 간과되기 쉬운 일상의 순간들, 그러한 순간들 속에 잠재된 일상의 낯섦을 경험하게 한다. 잘 짜여진 캐릭터의 관습에서 벗어난 배우의 연기는 현장성이 강조된(계획되지 않고 다듬어지지 않은) 즉흥적인 연기로 영화라는 구조 속에 갇혀있지만 갇혀있지 않은 듯 자유로운 현실 속의 사람처럼 차별화된 캐릭터의 일상성을 표현하고, 마치 일상에 길들여진 듯 반복되는 인물들의 말과 행동, 예측할 수 없는 감정의 변화들은 만남과 대화가 중심이 되는 홍상수 감독의 영화에서 일상의 배경으로 제시되는 모든 것들과 일상의 형식을 이루며 이러한 일상은 어떠한 의미를 갖고 무엇을 발견하게 하는지 주목하게 한다. 또, 이러한 일상의 과정을 사실적으로 재현하기 위해 배우를 먼저 정하고 난 뒤에 이야기를 만들어간다는 홍상수 감독은 그의 영화에 반복적으로 등장하는 배우를 통해 캐릭터와 배우의 관계를 새롭게 설정하고, 사실적인 표현의 새로운 방법을 제시해 주었다는 점에서 본 연구는 홍상수 감독의 연출 스타일을 바탕으로 영화 <지금은 맞고 그때는 틀리다>의 일상적인 캐릭터와 연기를 분석해보았다.

• Tuberculosis and Respiratory Diseases
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• 제71권6호
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• pp.408-416
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• 2011

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a technique developed to allow mediastinal staging of lung cancer and also to evaluate intrathoracic lymphadenopathy. In a tuberculosis-endemic area, tuberculosis should be considered as an etiology of mediastinal lymphadenopathy. The aim of this study was to investigate the utility of the routine culture for tuberculosis from specimens of EBUS-TBNA. Methods: We prospectively performed routine culture for tuberculosis from aspiration or core biopsy specimens got from 86 patients who had undergone EBUS-TBNA due to mediastinal lymphadenopathy between March 2010 and March 2011. Results: A total of 135 lymph node aspiration and 118 core biopsy specimens were included in this analysis. We confirmed the malignancy in 62 (72.9%), tuberculosis in 7 (8.1%), sarcoidosis in 7 (8.1%), asperogillosis in 2 (2.3%) and pneumoconiosis in 2 (2.3%) patients. One lung cancer patient had pulmonary tuberculosis coincidentally and 5 patients had unknown lymphadenopathy. The number of positive culture for Mycobacterium tuberculsosis by EBUS-TBNA is 2 (1.5%) from 135 lymph node aspiration specimens and 2 (1.7%) from 118 core biopsy specimens. Out of eight patients confirmed with tuberculosis, only one patient had positive mycobacterial culture of aspiration specimen from EBUS-TBNA without histopathologic diagnosis. Conclusion: These results propose that routine culture for tuberculosis from EBUS-TBNA may not provide additional information for the diagnosis of coincident tuberculous lymphadenitis. However, if there is any possibility of tuberculous lymphadenopathy or pulmonary tuberculosis, it should be considered to perform EBUS-TBNA in patients who have negative sputum AFB smears or no sputum production.

• 한국임상수의학회지
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• 제32권3호
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• pp.219-223
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• 2015

Mycobacterium avium subsp. paratuberculosis (MAP)는 가축 및 야생동물에서 장 내 육아종성 감염증을 유발한다. 이 연구의 목적은 MAP 특이유전자 3개(IS900, F57 및 ISMAP02)의 빠른 검사를 위한 다중 실시간 중합효소연쇄반응기법을 개발하고 평가하는데 있다. 평가 결과 분석 민감도는 IS900이 150 cells/ml, F57이 1500 cells/ml, ISMAP02가 50 cells/ml로 확인되었다. 152개 소 분변시료를 대상으로 실시한 검사 결과 개발한 기법이 기존 검사방법보다 빠르고 적은 비용으로 동시검사가 가능한 것으로 확인되었다. 검사결과의 일치도는 94%로 나타났다. 불일치 결과는 개발한 기법이 양성으로 확인하였으나, 기존 검사에서는 음성으로 나타난 것 때문으로 확인되어, 개발한 기법이 더 높은 민감도를 갖는 것으로 나타났다. 개발한 다중 실시간 중합효소연쇄반응기법은 가축 및 야생동물에서 파라결핵 또는 요네병의 조사를 위한 빠르고 정확한 검사기법이 될 것이다.