• Biomedical Science Letters
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• v.29 no.4
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• pp.231-241
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• 2023

Messenger RNA (mRNA)-based vaccines and treatments have recently emerged as a promising strategy. Naked mRNA presents various limitations for direct delivery. Therefore, in this paper, Lipid Nanoparticles (LNPs) were utilized for the delivery of mRNA. Lipid nanoparticle (LNP) mRNA systems are highly effective as vaccines, but their efficacy for pulmonary delivery has not yet been fully established. Additionally, research on effective delivery systems and administration methods for vaccines is required to resolve the stability and degradation issues associated with naked mRNA delivery. This study aimed to determine mRNA delivery efficiency via the inhalation of a lipid nanoparticle (LNP) formulation designed specifically for pulmonary delivery. To this purpose, we built a library of seven LNP configurations with different lipid molar and N/P ratios and evaluated their encapsulation efficiency using gel retardation assay. Among the tested LNPs, LNP1, LNP2-2, and LNP3-2 demonstrated high transfection efficiency in vitro based on FACS analyses luciferase assays, and intracellular accumulation tests. The mRNA delivery efficiencies of the selected LNPs after inhalation and intravenous injection were compared and evaluated. LNP2-2 showed the highest mRNA expression in healthy mouse lungs when aerosolized and was found to be non-toxic. These results indicate that LNP2-2 is a promising carrier for lung mRNA delivery via inhalation.

• Journal of the Korean Society of Safety
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• v.37 no.1
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• pp.70-77
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• 2022

The total number of Korean restaurants using delivery applications has substantially increased from 7.6% in 2018 to 11.2% in 2019. In 2020, the gross sales in the food delivery service market reached approximately 17 trillion won; this amount is virtually six times that in 2017 (i.e., 2 trillion won). Meanwhile, the annual average death toll of motorcycle riders increased by 3.5%, whereas the number of deaths due to other traffic accidents decreased by 8.2%. Consequently, the foregoing has become a critical social problem. Despite the continuing increase in the number of delivery riders due to the rapid expansion of the delivery industry, no appropriate safety management system has been established. Moreover, the government is experiencing difficulties in assessing the exact situation because of the absence of competent authority. In this study, fundamental data on the characteristics of delivery work and motorcycle accidents were collected through surveys and interviews; then, the influencing factors of traffic accidents were analyzed. Different influencing factors were identified: work experience as a rider; number of deliveries; whether to accept delivery requests in transit; manner of accepting delivery requests; and traffic law violations, such as speeding (for faster delivery) and running a red light. Because the motorcycle delivery industry has a relatively low job-entry barrier (i.e., special qualifications are not required), the riding skills of riders must be improved, and delivery companies must be technically developed to achieve a safe working environment. The results of this study can be utilized as fundamental data for system development or structural improvement of the delivery industry.

• (The)Study of the Eastern Classic
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• no.69
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• pp.419-450
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• 2017

This study aims to discover the clue of the current modern postal system development by looking at the delivery patterns of Korean letters during the Joseon Dynasty. A letter is a text medium that the sender sends to a recipient by sending a message of news. The form and contents of the letter are influenced by the various surrounding factors and are adapted to circumstances. The study aims to clear up the method of delivery and the nature of the transmitter among the environmental factors which affects the format and contents of Korean letters. Depending on the public or private matters, the delivery method is divided into a public agency and a private messenger, or divided into one-phase delivery and the multi-phase delivery depending on whether or not a phase is divided into stages. It is also divided into a one-way and a round-transmission depending on whether or not it is round-switched. The transmitter is divided into a verbal communication, the letter and verbal communication, and the letter communication according to whether or not it is by verbal, and divided into the relational and the non-relational person according to the relationship with the sender. Also depending on whether the transmitter is exclusive or not, it is divided into the exclusive messenger and the messenger who deliver a letter incidentally while come and go. In the aspect of the delivery method, We can see the possibility of developing to a modern mail system through the public method, the multi-phase delivery, one-way delivery and in the aspect of the transmitter, we can see the possibility through the letter delivery, non-related transmitter, and the exclusive messenger.

• Macromolecular Research
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• v.8 no.5
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• pp.199-208
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• 2000

The recent development of biodegradable polymers for drug delivery system (DDS) has been investigated. The biodegradable polymers for DDS are mainly discussed in two categories: one category is natural biodegradable polymers such as polysaccharides, modified celluloses, poly(${\alpha}$-amino acid)s, modified proteins, and microbial biodegradable polymers; the other is synthetic biodegradable polymers such as poly(ester)s, poly(ortho ester)s, poly(phosphazene)s, poly(anhydride)s, poly(alkyl cyanoacrylate)s, and multiblock copolymers. The bioconjugate polymeric drug delivery systems have been also proposed for the design of biocompatible polymeric controlled drug delivery.

• Journal of the Korea Safety Management & Science
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• v.2 no.3
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• pp.61-79
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• 2000

It is very important to delivery timely and safely items in logistics. So, the home delivery service system is introduced by many enterprises. Also, the beginning in 1990's, the rapid increase of automobile increased logistics cost and led to road stagnation. So, the railway transportation use in logistics can be considered. The railway transportation in home delivery service system can overcome the limit of transportation by land. This study evaluate railway transportation in home delivery service system by economical efficiency and timeliness.

• Journal of the Korean Dietetic Association
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• v.14 no.1
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• pp.77-86
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• 2008

In Korea, delivery of preterm has increased gradually, preterm delivery rate was 6.4% in 1995 and 9.8% in 2002. The purpose of this study is to provide guidelines for preventing preterm delivery in aspect of health factors and food habits. The health factors and dietary habits were compared between preterm delivery group and full-term delivery group on to recognize risk factor of delivering premature. The results obtained are summarized as follows. The full-term delivery group showed a high rate of professionals and the preterm delivery group showed a high rate of the service industry, showing differences in kinds of occupation(p<0.05). Heights were higher in full-term delivery group(p<0.05). Among the nutrition supplements, iron supplement consumption was the most, period of the intake of iron was significantly longer for the full-term delivery group than for the preterm delivery group(p<0.05). Also, prevalence of coffee was higher in preterm delivery group(p<0.001). The activity level was higher in full-term delivery group(p<0.005).

• Journal of Korean Society of Industrial and Systems Engineering
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• v.47 no.2
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• pp.176-189
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• 2024

Vertical takeoff and landing (VTOL) is a core feature of unmanned aerial vehicles (UAVs), which are commonly referred to as drones. In emerging smart logistics, drones are expected to play an increasingly important role as mobile platforms. Therefore, research on last-mile delivery using drones is on the rise. There is a growing trend toward providing drone delivery services, particularly among retailers that handle small and lightweight items. However, there is still a lack of research on a structural definition of the VTOL drone flight model for multi-point delivery service. This paper describes a VTOL drone flight route structure for a multi-drone delivery service using rotary-wing type VTOL drones. First, we briefly explore the factors to be considered when providing drone delivery services. Second, a VTOL drone flight route model is introduced using the idea of the nested graph. Based on the proposed model, we describe various time-related attributes for delivery services using drones and present corresponding calculation methods. Additionally, as an application of the drone route model and the time attributes, we comprehensively describe a simple example of the multi-drone delivery for first-come-first-served (FCFS) services.

• Journal of Distribution Science
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• v.14 no.3
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• pp.73-83
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• 2016

Purpose - The parcel delivery service(courier) industry all over the world has been expanding its market so far, but its growth has been declining in recent years. In this situation, most parcel delivery companies are having trouble with managing themselves because of the pressure from the customer to increase service level and decrease the rate. The purpose of this study is to provide ways to improve competitive advantages of the parcel delivery service industry by evaluating the multi-period operating efficiency of Korea, Japan and global service providers. Research design, data, and methodology - The data for the period of 2011 to 2014 were collected from the annual reports published by parcel delivery companies. In this study, we analyze the marketability (revenue), profitability (operating profits), and management conditions (net profits) of parcel service companies by combining information on human resources (number of employees) and material resources (total assets and equity). Therefore, the number of employees, total assets, and equity are selected as input variables, and revenue, operating profits, and net profits as the output variables. In this study, DEA (Data Envelopment Analysis) is used to measure the comparative efficiency and MPI (Malmquist Productivity Index) is used to analyze the trend of change of the efficiency for a multi-year period. Results - The operational efficiency scores of medium-sized parcel delivery companies in Korea are higher than other larger competitors such as Korean, Japan and Global larger companies. As of 2014, Logen(1.878) was found to be the most efficient parcel delivery enterprise, followed by KGB (1.224), and Kyoungdong(1.002). Otherwise, Hanjin(0.235), CJ(0.262), Hyundai Logistics(0.657), DHL(0.611), UPS(0.766), FedEx(0.498), TNT(0.350), Yamato(0.762) and Sagawa(0.520), larger sized companies, were done inefficiently. The productivity of parcel delivery companies is influenced by endogenous factors as well as exogenous ones such as changes in business environment and technological advances. Conclusions - Korean medium-sized companies have relatively high efficiency scores in operation. That is why they still survive the competitive market in Korea where market restructuring on the industry has been expected to be conducted for many years. The reason why medium-sized couriers had higher efficient scores than larger couriers is that most of couriers spend more operating expenses versus unit price of delivery which is the amount of money that is needed in order to send a package by parcel service. So the delivery unit price must be taken into account by all the expenses associated with the cost of fuel, labor and maintenance expenses for facilities, etc. therefore, the unit price must be increased to strengthen business competitive power. In order for the industry to have more competitive advantage, the companies need to make profits by increasing demand volume and raising the delivery rate to provide high-quality delivery service to customers. And both endogenous and exogenous change must take precedence in order to strengthen their competitiveness.

• Journal of the Korean Operations Research and Management Science Society
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• v.31 no.4
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• pp.35-47
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• 2006

This paper considers an integrated scheduling problem for consecutive production and delivery stages in a two-stage supply chain. The Production is performed on a single facility and then the finished products are delivered to the customer by capacitated multiple vehicles. The objective of this paper is to obtain job sequencing and delivery batching minimizing the total cost of the associated WIP inventory, finished product inventory and delivery. The inventory cost is characterized by the sum of weighted flowtime. The delivery cost is proportional to the required number of delivery batches. Some polynomial-solvable cases are derived. For the general case, two efficient heuristic algorithms are suggested, and then the heuristics are tested through some numerical experiments.

• Journal of Pharmaceutical Investigation
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• v.16 no.3
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• pp.89-100
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• 1986

Although insulin has been available for the treatment of diabetes mellitus for more than half a centry, the deficiency of conventional insulin therapy for diabetic patients have, to this date, not been satisfactorily overcome by any method. The development of potential delivery systems for insulin is highly important to prevent excessive fluctuation of plasma glucose levels, which results in long term complications in the diabetic. There are three major approaches toward development of glucose responding insulin delivery systems: A bioengineering approach is to devise mechanical components capable of releasing insulin in amounts appropriate to varying blood-glucose requirements. A biological approach relies upon cultured, living pancreatic beta cells encapsulated to constitute an insulin delivery unit. A biochemical approach is to synthesize a stable and biologically active glycosylated insulin that is complementary to the binding sites of lectin. This paper will cover several specific areas, including pancreatic transplantation(total or isolated islet cells), artificial pancreases(bioengineering or biological approach), controlled delivery system, glucose sensitive membrane systems, and a self-regulating insulin delivery system.