• The Transactions of the Korea Information Processing Society
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• v.4 no.9
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• pp.2185-2196
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• 1997

The existing information retrieval systems utilize thesaurus in order to search and retrieve the desired information even when the query is not accurate. However the cost for implementing and maintaining thesaurus is very high and it can not guarantee complete success of search/retrieval operation. Thus in this paper, Information Retrieval System using Keyword Network(KNetIRS) which was designed and implemented to solve these problem is introduced. Keyword Network composed of keywords which were extracted from documents. KNetIRS finds the appropriate documents by using the Keyword Network which is based on the concept of "inverted file". In addition, KNetIRS can carry out query expansion by using the Keyword Network Browser, and deal with the conjunction of "정보 검색", "정보", and "검색", by defining and implementing spilt function.

• Nutrition Research and Practice
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• v.11 no.3
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• pp.198-205
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• 2017

BACKGROUND/OBJECTIVES: The anti-diabetic activity of pear through inhibition of ${\alpha}-glucosidase$ has been demonstrated. However, little has been reported about the effect of pear on insulin signaling pathway in obesity. The aims of this study are to establish pear pomace 50% ethanol extract (PPE)-induced improvement of insulin sensitivity and characterize its action mechanism in 3T3-L1 cells and high-fat diet (HFD)-fed C57BL/6 mice. MATERIALS/METHODS: Lipid accumulation, monocyte chemoattractant protein-1 (MCP-1) secretion and glucose uptake were measure in 3T3-L1 cells. Mice were fed HFD (60% kcal from fat) and orally ingested PPE once daily for 8 weeks and body weight, homeostasis model assessment of insulin resistance (HOMA-IR), and serum lipids were measured. The expression of proteins involved in insulin signaling pathway was evaluated by western blot assay in 3T3-L1 cells and adipose tissue of mice. RESULTS: In 3T3-L1 cells, without affecting cell viability and lipid accumulation, PPE inhibited MCP-1 secretion, improved glucose uptake, and increased protein expression of phosphorylated insulin receptor substrate 1 [p-IRS-1, ($Tyr^{632})$)], p-Akt, and glucose transporter type 4 (GLUT4). Additionally, in HFD-fed mice, PPE reduced body weight, HOMA-IR, and serum lipids including triglyceride and LDL-cholesterol. Furthermore, in adipose tissue, PPE up-regulated GLUT4 expression and expression ratio of p-IRS-1 ($Tyr^{632})/IRS$, whereas, down-regulated p-IRS-1 ($Ser^{307})/IRS$. CONCLUSIONS: Our results collectively show that PPE improves glucose uptake in 3T3-L1 cells and insulin sensitivity in mice fed a HFD through stimulation of the insulin signaling pathway. Furthermore, PPE-induced improvement of insulin sensitivity was not accompanied with lipid accumulation.

• Journal of the Korean Society for information Management
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• v.34 no.2
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• pp.47-80
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• 2017

The purpose of this study is to develop an adoptive model of institutional repositories (IRs) by identifying the key factors affecting adoptive intention of IRs and explaining the relations among these factors. Through a survey of 270 researchers and 12 in-depth interviews in the field of physics, mathematics, and life science in Korea, performance expectancy, perceived risks, socio-organizational influence, and individual characteristics were found to have substantial influences on the adoptive intention of IRs. Among the key factors, individual characteristics showed the greatest effect on the adoptive intention of IRs, followed by performance expectancy and other socio-organizational influences except for the perceived risks. Strategies to enhance the adoptive intention of IRs based on analyses of the results were suggested, in terms of the reformation of research assessment system at the national level, strengthening of role of the operational institution, and the need for voluntary scientists-participating service.

• Advances in pediatric surgery
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• v.14 no.2
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• pp.164-172
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• 2008

The survival rate for rhabdomyosarcoma (RMS) has significantly improved after the introduction of combined multimodality treatment. We report the 20-year treatment outcome of pediatric rhabdomyosarcoma in a single institution. The medical records of 16 patients treated for rhabdomyosarcoma between December 1986 and August 2007 at the Department of Pediatric Surgery, Seoul National University Children's Hospital, were retrospectively reviewed. Mean age at diagnosis was 7.1 years (range: 1.3 -14.2 years). Retroperitoneum was the most common primary site (n=7, 43.8 %), and embryonal type was predominant (n=11, 6 %). Before the treatment, most patients were in advanced TNM stage (stage III 50 %, IV; 25 %). The patient distribution according to the Intergroup Rhabdomyosarcoma Study Clinical Grouping System (IRS-CGS) was as follows; Group I 31.3 %, Group II 12.5 %, Group III 31.3 % and Group IV 25 %. Patients were classified into three groups according to the extent of resection of the primary tumor; complete resection (CR, n=5; 31.3 %), gross total resection (GTR, n=7; 43.8 %) and incomplete resection (IR, n=4; 25 %). Recurrence was observed in 9 patients (56.3 %) while there was no recurrence in CR patients. All patients with recurrence were identified as moderate or high-risk according to the IRS-V Risk Group. Pre-treatment TNM stage of RMS in our institution was advanced with aggressive clinical feature, however postsurgical conditions according to IRS-CGS were similar to the previous reports by IRS. This suggests that down-staging of IRS-CGS was achieved with multimodality treatment with CR or GTR. It also suggests that complete resection is the most important prognostic factor in the treatment of RMS in children. Patients classified as moderate or high-risk need close follow-up due to high recurrence rate. In case of localized recurrence, better outcome may be achieved with multimodality treatment including limited surgery.

• The Bulletin of The Korean Astronomical Society
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• v.39 no.1
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• pp.63.2-63.2
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• 2014

As a part of the "Dust, Ice, and Gas In Time" (DIGIT) key program on Herschel, we observed GSS30-IRS1, a Class I protostar located in Ophiuchus (d =125 pc), with Herschel/Photodetector Array Camera and Spectrometer (PACS). More than 70 lines were detected within a wavelength range from 50 ${\mu}m$ to 200 ${\mu}m$: CO lines from J = 14-13 to 41-40, several $H_2O$ lines of Eup = 100 K to 1500 K, 16 transitions of OH rotational lines, and two atomic [O I] lines at 63 and 145 ${\mu}m$. The [C II] line, known as a tracer of externally heated gas by the interstellar radiation field, is also detected at 158 ${\mu}m$. All lines, except [O I] and [C II], are detected only at the central spaxel of $9^{\prime\prime}.4{\times}9^{\prime\prime}.4$. The [O I] emission is extended along a NE-SW orientation, which is consistent with the known outflow direction, while the [C II] line is detected over all spaxels. One possible explanation of the detection of the [C II] line and no correlation of its spatial distribution with any other molecular emission is the existence of the enhanced ISRF nearby GSS30-IRS1. One interesting feature of GSS30-IRS1 is that the continuum emission is extended beyond the point-spread function (PSF), unlike the molecular line emission, indicative of significant external heating. The best-fit continuum model of GSS30-IRS1 with the physical structure including flared disk, envelope, and outflow shows that the internal luminosity is 11 $L_{\odot}$, and the region is also externally heated by a radiation field enhanced by a factor of 25 compared to the local standard interstellar field.

• Molecules and Cells
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• v.42 no.8
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• pp.604-616
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• 2019

Phosphoserine phosphatase (PSPH) is one of the key enzymes of the L-serine synthesis pathway. PSPH is reported to affect the progression and survival of several cancers in an L-serine synthesis-independent manner, but the mechanism remains elusive. We demonstrate that PSPH promotes lung cancer progression through a noncanonical L-serine-independent pathway. PSPH was significantly associated with the prognosis of lung cancer patients and regulated the invasion and colony formation of lung cancer cells. Interestingly, L-serine had no effect on the altered invasion and colony formation by PSPH. Upon measuring the phosphatase activity of PSPH on a serine-phosphorylated peptide, we found that PSPH dephosphorylated phospho-serine in peptide sequences. To identify the target proteins of PSPH, we analyzed the protein phosphorylation profile and the PSPH-interacting protein profile using proteomic analyses and found one putative target protein, IRS-1. Immunoprecipitation and immunoblot assays validated a specific interaction between PSPH and IRS-1 and the dephosphorylation of phospho-IRS-1 by PSPH in lung cancer cells. We suggest that the specific interaction and dephosphorylation activity of PSPH have novel therapeutic potential for lung cancer treatment, while the metabolic activity of PSPH, as a therapeutic target, is controversial.

• Journal of the Korean Society of Industry Convergence
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• v.25 no.4_2
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• pp.655-662
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• 2022

Recently, with the increase in the use of UAV(unmanned aerial vehicles), research on horizontal maintenance stations that can take off and land in various environments has been actively conducted. These stations can safely land UAV through multiple DOF(degrees of freedom) or at least 2-DOF-based actuator actuation. Among them, many researchers are dealing with the multi-DOF stewart platform due to its high safety. However, the stewart platform requires high-precision control technology because it requires a lot of torque to actuate according to the load action. Therefore, in this paper, to solve the mentioned problem, a bevel gear-based 2-DOF horizontal maintenance station system is proposed. The proposed system is configured to prevent damage due to air resistance when maintaining ships and to install it in a small space. Also, in terms of system configuration, the bevel gear-based horizontal maintenance system has the main advantage of being able to take off and land UAVs of various sizes through the replacement of station pads. The driving of the system consists of a simple form that can control the motor by adjusting the rotation speed of the motor according to the sea waveform.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1999.10a
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• pp.214-224
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• 1999

The design response spectrum has been widely used in seismic design to estimate force and deformation demands of structures imposed by Earthquake Ground Motion (EQGM). Inelastic Design Response Spectra (IDRS) to specify design yielding strength in seismic codes are obtained by reducing the ordinates of Linear Elastic Design Response Spectrum (LEDRS) by strength reduction factor (R). Since a building is designed using reduced design spectrum (IDRS) rather than LEDRS in current seismic design procedures it allows structures behave inelastically during design level EQGM. Inelastic Response Spectra (IRS) depend not only on the characteristics of the expected ground motion at a given site, but also on the dynamic properties and nonlinear characteristics of a structure. However, it has not been explicitly investigated the effect of different hysteretic models on IRS. In this study, the effect of hysteretic models on IRS is investigated.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.16 no.10
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• pp.3256-3274
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• 2022

With the rapid development of information and communications technology, the construction of efficient, reliable, and safe Internet of Things (IoT) is an inevitable trend in order to meet high-quality demands for the forthcoming 6G communications. In this paper, we study a secure intelligent reflecting surface (IRS)-assisted IoT system where malicious eavesdropper trying to sniff out the desired information from the transmission links between the IRS and legitimate IoT devices. We discuss the system overall performance and propose a hybrid resource allocation scheme for maximizing the secrecy capacity and secrecy energy efficiency. In order to achieve the trade-off between transmission reliability, communication security, and energy efficiency, we develop a quantum-inspired marine predator algorithm (QMPA) for realizing rational configuration of system resources and prevent from eavesdropping. Simulation results demonstrate the superiority of the QMPA over other strategies. It is also indicated that proper IRS deployment and power allocation are beneficial for the enhancement of system overall capacity.

• International journal of advanced smart convergence
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• v.11 no.2
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• pp.205-210
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• 2022

To achieve the higher network capacity and mass connectivity in the forthcoming mobile network, revolutionary technologies have been considered. Recently, an upper bound on capacity of intelligent reflecting surface (IRS) transmissions towards the sixth generation (6G) mobile systems has been proposed. In this paper, we consider a tighter upper bound on capacity of IRS transmissions than the existing upper bound. First, using integration by parts, we derive an upper bound on capacity of IRS transmissions under Rician fading channels and a Rayleigh fading channel. Then, we show numerically that the proposed upper bound is closer to Monte Carlo simulations than the existing upper bound. Furthermore, we also demonstrate that the bounding error of the proposed upper bound is much smaller than that of the existing upper bound, and the superiority of the proposed upper bound over the existing upper bound becomes more significant as the signal-to-noise ratio (SNR) increases.