• Journal of Internet Computing and Services
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• v.25 no.4
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• pp.97-108
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• 2024

Ethical and technical problems are becoming serious as the industrialization of artificial intelligence robots becomes active, research on risk is insufficient. In this situation, the researcher developed 52 verified indicators that can measure the body, rights, property, and social risk of artificial intelligence robots. In order to develop measurement indicators for each type of risk of artificial intelligence robots, 11 experts were interviewed in-depth after IRB deliberation. IIn addition, 328 workers in various fields where artificial intelligence robots can be introduced were surveyed to verify their fieldwork, and statistical verification such as exploratory factor analysis, reliability analysis, correlation analysis, and multiple regression analysis was verifyed to measure validity and reliability. It is expected that the measurement indicators presented in this paper will be widely used in the development, certification, education, and policies of standardized artificial intelligence robots, and become the cornerstone of the industrialization of artificial intelligence robots that are socially sympathetic and safe.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.43 no.1
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• pp.43-52
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• 2017

EtOAc fractions of Magnolia obovata (M. obovata) Bark extracts were studied for the potential ingredient as a safe and effective whitening cosmetic material. The concentration of active substances honokiol was determined by HPLC. In vitro, the fractions reduced the extracellular and intracellular melanin contents in B16F10 cells in dose dependently and inhibited extracellular melanin secretion ($IC_{50}=11.05{\mu}g/mL$). The $12.5{\mu}g/mL$ treatment of maximum concentration effectively inhibited up to about 60% to the amount of extracullular melanin. Also, the $12.5{\mu}g/mL$ treatment of maximum concentration effectively inhibited up to about 59% to the amount of intracullular melanin ($IC_{50}=10.85{\mu}g/mL$). The $IC_{50}$ value of ${\alpha}-arbutin$ used as a positive control was $59.99{\mu}g/mL$. So, EtOAc fractions of M. obovata Bark extracts showed whitening effect when compared with the non-treatment group. In case of in vivo study, Cosmetic cream with EtOAc fractions of M. obovata Bark extracts was approved by Ethics committee of KDRI (IRB number: KDRI-IRB-1537). As a result in progress for skin sensitization as well as assessment of skin irritation through repeated patch test, skin allergens was identified as non sensitizing agents. Also, cosmetic cream with EtOAc fractions of M. obovata Bark extracts showed significant topical whitening effect and reliable skin safety when compared with the non-treatment group. In conclusion, EtOAc fractions of M. obovata Bark extracts may be a useful cosmetic ingredient for effective skin whitening.

• Health Policy and Management
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• v.19 no.2
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• pp.1-20
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• 2009

This paper examines some relations on national crisis management and bioethics. This study stars to discuss that chance and risk of biotechnology which is the 21st century's pioneering core technology. This study reviews the traditional method that a nation(law) copes with the new scientific technique. The study also examines some difficulties of social agreement on the problems of bioethics because of nature of the rational disagreement. Then this paper attempts to incorporate the crisis of biotechnology, especially bioethics, in the system of national crisis management. this paper reviews the contents of the domestic "Act on Bioethics and Safety" on the side of the protection and restoration of crisis management. And this paper proposes some changes to manage the crisis of bioethics better, as it were, some problems of IRB and schems for improvement of it.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.06a
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• pp.932-935
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• 2005

Three dimensional laser welding technology for light car body is studied. A robot, a seam tracking system and 4kW CW Nd:YAG laser are used for three dimensional robot laser welding system. The Laser system is used 4kW Nd:YAG laser(HL4006D) of Trumpf and the Robot system is used IRB6400R of ABB. The Seam tracking system is SMRT-20LS of ServoRobot. The welding joint of steel plate are butt and lap joint. The 3-D welding for Non-linear Tailored blank is performed after the observation experiments of bead on plate. Finally, the welding process for non-linear tailored blank and front side member is developed.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1995.10a
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• pp.1165-1168
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• 1995

This paper describes the evaluation of a robot based filament winding cell consisting of an industrial robot (ASEA IRB 6/2) and an in-house fabricated mandrel drive mechanism, both being coordinated by a personal computer. As in many manufacturing processes, tradeoffs exist between accuracy and speed. The accuracy versus speed relationships of the robotic winding cell were experimentally determined for discrete, fine and medium movement modes while traversing a segmented delivery eye path for a cylindrical mandrel in three configurations (in-line, offset and angled with respect to the axis of rotation). the results show that the robot winding cell is appropriate for very accurate winding of fibre strands if the mandrel axis is concentric with the mandrel drive axis and the discrete mode(i.e. low speed) of the robot is used.

• Clinical and Experimental Pediatrics
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• v.52 no.1
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• pp.1-5
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• 2009

Children are not small adults and there is a need to carry out specific trials that cannot be performed in adults. In general, children (minors) are unable to consent but their assent should be obtained using age appropriate information. Institutional Review Board (IRB) need paediatric expertise to balance the benefits and risks of research in children. The lack of consent has implications on the design, analysis and the choice of comparators used in the trials, which should only be performed by trained investigators with paediatric experience. Pain, fear, distress and parental separation should be prevented and minimised when unavoidable. The children requires even more careful review. Children represent a vulnerable population with developmental, physiological and psychological differences from adults, which make age- and development- related research important for their benefit. Finally, criteria for the protection of children in clinical trials therefore need to be laid down. Specific protection should be defined for research performed in children, at all stages and ages.

• Biomolecules & Therapeutics
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• v.6 no.4
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• pp.417-422
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• 1998

Loxoprofen sodium (sodium 2-[4-(2-oxocyclopentylmethyl)phenyl] propionate dehydrate) is a nonsteroidal antiinflammatory drug of $\alpha$-phenyl propionic acid derivative. To test the bioequivalence of loxoprofen, the pharmacokinetic parameters of new preparation of loxoprofen, LENOX was compared with LOXONIN as a reference drug. Fourteen healthy volunteers were entered to the stydy (Yonsei University College of Medicine, Severance Hospital IRB approval No. 9608). They were administered 60 mg of loxoprofen in 2$\times$2 cross-over design. There was one week of drug-free interval between doses. The blood sample was taken on schedule up to 8 hours, and the plasma concentration loxoprofen was measured by reverse phase high-performance liquid chromatography (HPLC) with UV-detector. There were no significant difference between two preparations when AUC, Cmax, and Tmax were compared by ANOVA. The mean differences of AUC, Cmax, and Tmax were within 20% of the reference drug: the values were 2.22,5.61, and 12.50%, respectively. The confidence limits of AUC and Cmax but not Tmax satisfied the bioequivalence criteria. These results suggest that the tested LENOX is bioequivalent to the reference drug.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2002.09a
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• pp.125-128
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• 2002

강변 여과 취수 방식을 활용한 국내 충적층 지하수의 이용을 위해서는 망간에 대한 수처리가 주요 사항인 것으로 나타났다. 강변 여과 방식 취수 원수의 망간 함량은 먹는 물 수질 기준을 부분적으로 상회하지만, 이러한 망간에 대한 저감 처리는 기존의 지표수를 취수하여 처리하는 수처리 공정에 비해서는 상대적으로 효율적인 것으로 판단된다. 실제로, 국내 최초의 강변 여과 방식 취수를 활용하는 창원시 대산 지구 원수는 공기 포기, 급속 여과, 활성탄 여과를 통해, 먹는 물 수질 기준을 상회하는 망간을 효과적으로 처리하고 있는 것으로 평가되었다. 특히, 활성탄 여과가 망간제거 효과를 보이는 점은 특이한 현상으로, 활성탄 내에서도 철 관련 박테리아에 의한 망간 처리 가능성을 시사하고 있다. 또한 망간과 함께 나타나는 철 성분은 망간의 침전 처리에 긍정적인 면으로 작용하는 것으로 판단된다. 한편, 고령군 다산면에서의 실증 플랜트 실험은 전염소처리와 망간접촉여과를 통해 먹는 물 기준 이하의 망간 함량을 확보하는 데는 성공하였으나, 이러한 처리 기작이 안정화되는데 까지는 약 3개월 내외의 시간이 요구되는 것으로 나타났다.

• Proceedings of the KWS Conference
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• 2007.11a
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• pp.67-69
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• 2007

Laser welding technology for automobile body is studied. Laser system, robot and seam tracking system are used for 3D laser welding system. The laser system is used 4kW Nd:YAG laser(HL4006D) of Trumpf and the robot system is used IRB6400R of ABB. The seam tracking system is SMRT-20LS of ServoRobot. The welding joints of steel plate are butt and lap joint. The 3 dimensional laser welding for non-linear pipe welding line is performed.

• Proceedings of the KWS Conference
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• 2005.06a
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• pp.103-105
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• 2005

Laser welding technology for automobile body is studied. laser system, robot and seam tracking system are used for 3D laser welding system The laser system is used 4kW Nd:YAG laser(HL4006D) of Trumpf and the robot system is used IRB6400R of ABB. The seam tracking system is SMRT-20LS of ServoRobot. The welding joints of steel plate are butt and lap joint. The 3-D welding for non-linear tailored blank is performed after experiments of bead on plate. Finally, the welding process for non-linear tailored blank is developed.