• Title/Summary/Keyword: IR36

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Improvement of Solubility and Dissolution of Ketoconazole by Inclusion with Cyclodextrin (시클로덱스트린과의 포접에 의한 케토코나졸의 용해성 및 용출 증가)

  • Park, Gee-Bae;Ann, Hong-Jik;Chang, Young-Soo;Seo, Bo-Youn;Lee, Kwang-Pyo
    • Journal of Pharmaceutical Investigation
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    • v.24 no.2
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    • pp.85-94
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    • 1994
  • Inclusion complexes of ketoconazole (KT) with ${\alpha}-$, ${\beta}-cyclodextrin$ (CD) and dimethyl-${\beta}-cyclodextrin$ $(DM{\beta}CD)$ in a molar ratio of 1:2 were prepared by freeze-drying and solvent evaporation methods. The interactions of KT with ${\alpha}-CD$, ${\beta}-CD$ and $DM{\beta}CD$ in aqueous solution and in solid state were investigated by solubility study, infrared (lR) spectroscopy and differential scanning calorimetry (DSC). The stability constant of $KT-DM{\beta}CD$ inclusion complex (lC) was found to be the largest among three inclusion complexes. Clear differences in IR spectra and DSC curves were observed between inclusion complexes and physical mixtures (PM) of KT-CDs. It was also shown by IR spectra and DSC curves that solvent evaporation method might be. superior to the freeze-drying method in preparing the inclusion complexes of KT-CDs. The dissolution rate of KT was markedly increased by inclusion complex formation with CDs in the buffer solution at pH 4.0 and pH 6.8. The mean dissolution time (MDT,min), which represents the rapidity of dissolution, was in the order of $KT-DM{\beta}CD$ IC (3.20) < $KT-{\beta}-CD$ IC (4.36) < $KT-{\alpha}-CD$ IC (6.99) < $KT-{\alpha}-CD$ PM (17.46)< $KT-{\beta}-CD$ PM (19.36) < $KT-{\beta}-CD$ PM (28.53). The dissolution rates of KT-CD ICsprepared by solvent evaporation method were faster than those of KT-CD ICs prepared by freeze-drying method.

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The Study on Synthesis and Application of Polymer Dispersion for Cement Modifier -The Waterproffing Effeet of Cement Mortar by Poly[DMA-co-DAMA] Emulsion- (시멘트 혼화용 폴리머 합성과 그 응용에 관한 연구 -Poly[DMA-co-DAMA] 에멀젼을 이용한 시멘트 모르타르의 방수성-)

  • Kim, Young-Geun;Herh, Dong-Seop;Park, Hong-Soo
    • Applied Chemistry for Engineering
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    • v.5 no.4
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    • pp.669-680
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    • 1994
  • DMA-co-DAMA were synthesized from 2-diethylaminoethyl metacrylate and dodecyl-metacrylate containing long chain hydrocarbon group with hydrophilic and hydrophobic radicals. To facilitate water emulsification,acrylic copolymer was cationized by acetic acid to produce acetated acrylic copolymer. The structures of the synthesized copolymer and acetated copolymers were confirmed by IR, NMR, and molecular weight was measured by GPC, and C. H. N elemental analysis. Acetated acrylic copolymers were perfectly emulsified in water and showed increased emulsion stability. Polymer dispersion for cement modifier(PDCM-PDD) was prepared by blending of the guaternized acrylic copolymer synthesized above sodium silicate sodium gluconate oleic acid and triethanol amine. The result with prepared polymer dispersion of cement modfier was examined, and it was found that excellent waterproffing effect; Water permeability ratio is 0.44 under the water pressure of $100g/cm^2$ and 0.55 under $3kg/cm^2$, and water absorption ratio is 0.36~0.47 and 1.02 compressive strength ratio at mixed ratio of water/PDCM-PDD is 45 times.

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Effect of two root activators [phthalamic acid and N(p - chlorophenyl) phthalamic acid] on Rice yield (근활력(根活力) 증진제(增進劑) [phthalamic acid 와 N(p - chlorophenyl) phthalamic acid] 의 수도증수(水稻增收) 효과(效果))

  • Park, Hoon;Mok, Sung-Kyun
    • Applied Biological Chemistry
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    • v.17 no.4
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    • pp.235-239
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    • 1974
  • Rice root activiators (phthalamic acid (PA) and p-chlorophenyl PA (PCPPA) were tested in pot culture for their effects on yield of IR667-Suwon 214 weak in root activity. The results were as follows: 1) Maximum percentage yield increase was 36.7% with organic matter applied and 13.3% without organic matter in 100 ppm (90ml/0.05$m^2$) of PCPPA treatment. 2) Root activators increased oxidizing power of root (root activity), consequently gave a balanced nutrient uptake, stimulated root growth and subsequent shoot growth. 3) Root activators increased number of panicle per hill, grain weight, filled grain ratio and effective tiller ratio.

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Influence of Cholesterol Derivatives on the Several Physicochemical Properties of Oleic acid (Oleic acid의 여러 물리화학적 성질에 미치는 Cholesterol계 유도체의 영향)

  • Ahn, Beom-Shu
    • Journal of the Korean Applied Science and Technology
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    • v.36 no.3
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    • pp.813-820
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    • 2019
  • The influence of cholesterol on the physicochemical properties of the oleic acid was clarified through the measurements of density, viscosity, IR, $^1H$ NMR, self-diffusion coefficient for the oleic acid samples containing a small amount of additives such as cholesterol, cholestanol, cholestane, cholesteryl oleate, benzene, and ethanol. Cholesterol, possessing one OH group and one double bond in its molecular structure, largely increased the viscosity and reduced the self-diffusion coefficient and the intramolecular movement of oleic acid. Oleic acid forms a complex with cholesterol as well as with ethanol. On the basis of these complex formations and the existence of the clusters composed of oleic acid dimers, it was known the role and the fundamental mechanism of cholesterol to the intermolercular and intramolecular movements of oleic acid in the liquid state.

Studies on Physiological Action of Ethylene in Rice Plants IV. Nitrogen Responses and Ethylene Evolution in Different Varieties (수도에 대한 Ethylene의 생리작용에 관한 연구 제4보 질소반응과 Ethylene생성의 품종간 차이)

  • Lee, M.H.;Lee, J.H.;Ota, Yasuo
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.28 no.1
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    • pp.89-93
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    • 1983
  • Rice plant was tested in the phytotron to know the varietal difference of ethylene production in different nitrogen levels. The high nitrogen concentrated varieties among tested varieties produced a large amount of ethylene. But high nitrogen concentrated leaf in the one variety produced less amount of ethylene. The varieties which produced a large amount of ethylene was remarkably increased ethylene in no nitrogen plot$(N_0)$ compare to standard level$(N_1)$. In contrast low ethylene producing varieties was remarkably decreased in double nitrogen level$(N_2)$.

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Varietal Difference of Viviparity and Germination - Inhibition of Rice Hull Extracts (벼 수발아의 품종간 차이와 왕겨 추출물질의 발아억제효과)

  • Kim, Bong Ku;Lee, Dong Jin
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.41 no.4
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    • pp.434-440
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    • 1996
  • This experiment were conducted to elucidate the damage by viviparity during grain filling on grain quality and hulling recovery and to understand the varietal differences of viviparity and the effect of extractive from rice hull of hardly viviparous varieties on seed germination and seedling growth. Ten rice cultivars, such as three indica, four japonica and three Tongil-type rices, were used in this study. The brown rice yield was decreased along with increasing the artificial viviparous treatment periods. At six days after treatment, brown rice yield of Daeseongbyeo was reduce 20% as compared with control. The ratio of head rice was 41.3% at six days after viviparous treatment with $25^{\circ}C$ temperature and over 95% relative humidity, while it was 99.5% in control. Varietal differences of viviparity in three rice groups were ranged from 1.1 to 5.2% in indica rices, 9.2 to 79.7% in japonica rices and 2.1 to 63.7% in Tongil-type rices. Methanol extractives from rice hull of IR36, Shinunbongbyeo and Jungwonbyeo inhibited significantly the germination of Deaseongbyeo.

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The Complete Chloroplast DNA Sequences of Viola selkirkii (뫼제비꽃(Viola selkirkii)의 엽록체 DNA 염기서열 분석)

  • Ah-Reum Go;Yun-Sun Lee;Kyung-Ah Kim;Kyeong-Sik Cheon;Ki-Oug Yoo
    • Proceedings of the Plant Resources Society of Korea Conference
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    • 2020.12a
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    • pp.55-55
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    • 2020
  • 뫼제비꽃(Viola selkirkii)의 엽록체 DNA 염기서열을 차세대염기서열분석법(NGS)을 이용하여 분석하였다. 재료는 강원도 화천군 일산과 제주도 한라산의 2개체를 사용하였다. 분석결과, 염기서열의 길이는 일산의 뫼제비꽃이 156,774 bp (GC content: 36.30%), 한라산의 뫼제비꽃이 157,451 bp(GC content: 36.30%)로 한라산 개체가 길게 분석되었다. 구간별로 LSC(Large single copy)지역은 한라산 개체(85,950 bp)가 일산 개체(85,930 bp)보다 20 bp 길었으며, SSC(Small single copy)지역은 한라산 개체(17,261 bp)보다 일산 개체가 17,982 bp로 길게 분석되었다. IR(Inverted repeat)지역은 한라산 개체가 27,120 bp로 일산 개체(26,431 bp)보다 길게 분석되었다. 이러한 염기서열 길이의 차이는 종내 개체 간 빈번하게 발생하는 현상으로 IGS와 intron 구간에서 확인 된 단순반복서열의 일부 누락과 IR지역 내의 수축과 확장에 의한 것으로 판단된다. 뫼제비꽃 2개체의 엽록체 게놈을 구성하는 유전자 수는 총 111개로 동일하였으며, protein coding gene 77개, tRNA(transfer RNA) gene 30개, 그리고 rRNA (ribosomal RNA) gene 4개로 구성되어 있었다. 이는 기 발표된 엽록체 DNA 전체 염기서열이 밝혀진 제비꽃속 (Viola) 종류들과 동일한 결과이다.

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Studies on the Mechanism of Varietal Resistance of Rice to the Brown Planthopper(Nilaparvata lugens $ST{\AA}L$ (벼멸구에 대한 수도품종(水稻品種)의 저항성기작(抵抗性機作)에 관(關)한 연구(硏究))

  • Kim, J.W.;Choi, S.Y.;Park, J.S.
    • Korean journal of applied entomology
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    • v.24 no.2 s.63
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    • pp.51-60
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    • 1985
  • This paper was performed to study the nature of varietal resistance of some Korean-new rice cultivars to the brown planthopper (BPH), Nilaparvata lugens ($ST{\AA}L$). The rice cultivars tested were Cheongcheong, Gaya, Hangangchal, Samgang, Nampoong and Yeongpoong which have been reported as having resistant genes for the BPH. The check varieties were Jinheung, Sangpoong and Chucheong for susceptible and IR-36 for resistant. The factors studied were referred to the seedling responses, preference in feeding and oviposition of BPH, antibiosis (nymphal development, adult emergence and sex ratio, adult body weight, population build-up, feeding amount and amylase activity), and chemical composition (inorganic components, chlorophyll contents, cell wall components, amino acids and esterase isozymes) of leaf- sheath and/or roots of rice plants. In conclusion, the natures of varietal resistance of rice cultivars to the BPH were not only correlated with the resistant reaction of rice plant, but also they were related with the non preference in feeding and oviposition and those resistant cultivars had the antibiotic effects to the insects. Their antibiotic effects of rice cultivars to the BPH would be related with some of the chemical components of rice plants, such as the contents of magnesium oxide (MgO), and chlorophyll and the different esterase isozymes.

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Yield Potential of Improved Tropical Japonica Rice under Temperate Environment in Korea

  • Lee, Kyu-Seong;Ko, Jae-Kwon;Kim, Jong-Seok;Lee, Jae-Kil;Shin, Hyun-Tak;Cho, Soo-Yeon
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.44 no.3
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    • pp.214-220
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    • 1999
  • Rice production in Korea has markedly increased during the last two decades due to newly developed high yielding varieties and improved production technology. This experiment was conducted to determine the potential of tropical japonica germplasm in enhancing the yield of temperate japonica. The yield performance of two tropical japonicas (IR 65597-29-3-2 and IR66154-52-1-2) and one temperate japonica (Dongjinbyeo) was compared at different plant densities and nitrogen levels under Korean environmental conditions. Although tropical japonicas showed low tillering habit and large panicles, they had similar leaf area index and dry weight at heading stage to Dongjinbyeo of the high tillering type indicating that there was not much difference between tropical and temperate japonica in terms of biomass production. The highest milled rice yield of 6.15 t/ha was obtained from Dongjinbyeo at a high nitrogen level with less planting density (220 kg N/ha and 30 $\times$ 15 cm). However, those of the two tropical japonicas were 5.36 t/ha at the condition of 165 kg N/ha and 30 x 10 cm planting density and 5.06 t/ha at the condition of 165kgN/ha and 15 x 15 cm planting density, respectively. Ripened grain of tropical japonicas ranged from 65 to 87%, while that Dongjinbyeo ranged from 82 to 97% under Korean conditions.

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Ultra-precision Machining of Space Telescope IR Camera Lens (초정밀 가공기를 이용한 적외선 우주망원경용 렌즈의 절삭가공기술개발)

  • Yang, Sun-Choel;Kim, Geon-Hee;Kim, Hyo-Sik;Shin, Hyun-Su;Hong, Kweon-Hee;Yoo, Jong-Sin;Kim, Dong-Rak;Park, Soo-Jong;Nam, Uk-Won
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.4 no.2
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    • pp.31-36
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    • 2005
  • Machining technique for optical crystals with single point diamond turning tool is reported in this paper. The main factors influencing the machined surface quality are studied and regularities of machining process are drawn. Optical crystals have been known to more and more important applications in the field of modern optics. Ge is more brittle material of poor machinability. The traditional machining method is polishing which has many shortcomings such as low production efficiency, poor ability to be automatically controlled and edge effect of the workpiece. The purpose of our research is to find the optimum machining conditions for ductile cutting of Ge and apply the SPDTM technique to the manufacturing of ultra precision optical components of Ge. As a result, the surface roughness is the best when cutting speed is 180m/min, feed rate is 2mm/min, depth of cut is $0.5{\mu}m$ and nose radius of tool is 0.8mm.

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