• The Korean Journal of Physiology and Pharmacology
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• v.2 no.3
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• pp.297-305
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• 1998

This study used in vivo intracellular recording in rat hippocampus to evaluate the effect of lidocaine and MK-801 on the membrane properties and the synaptic responses of individual neurons to electrical stimulation of the commissural pathway. Cells in control group typically fired in a tonic discharge mode with an average firing frequency of $2.4{\pm}0.9$ Hz. Neuron in MK-801 treated group (0.2 mg/kg, i.p.) had an average input resistance of $3.28{\pm}5.7\;M{\Omega}$ and a membrane time constant of $7.4{\pm}1.8$ ms. These neurons exhibited $2.4{\pm}0.2$ ms spike durations, which were similar to the average spike duration recorded in the neurons of the control group. Slightly less than half of these neurons were firing spontaneously with an average discharge rate of $2.4{\pm}1.1$ Hz. The average peak amplitude of the AHP following the spikes in these groups was $7.4{\pm}0.6$ mV with respect to the resting membrane potential. Cells in MK-801 and lidocaine treated group (5 mg/kg, i.c.v.) had an average input resistance of $3.45{\pm}6.0\;M{\Omega}$ and an average time constant of $8.0{\pm}1.4$ ms. The cells were firing spontaneously at an average discharge rate of $0.6{\pm}0.4$ Hz. Upon depolarization of the membrane by 0.8 nA for 400 ms, all of the tested cells exhibited accommodation of spike discharge. The most common synaptic response contained an EPSP followed by early-IPSP and late-IPSP. Analysis of the voltage dependence revealed that the early-IPSP and late-IPSP were putative $Cl^--and\;K^+-dependent$, respectively. Systemic injection of the NMDA receptor blocker, MK-801, did not block synaptic responses to the stimulation of the commissural pathway. No significant modifications of EPSP, early-IPSP, or late-IPSP components were detected in the MK-801 and/or lidocaine treated group. These results suggest that MK-801 and lidocaine manifest their CNS effects through firing pattern of hippocampal pyramidal cells and neural network pattern by changing the synaptic efficacy and cellular membrane properties.

• Information and Communications Magazine
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• v.17 no.9
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• pp.108-118
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• 2000

인터넷에서의 정보보호는 IPsec으로 대표된다. IPsec은 인터넷에서 필수적인 암호와 인증 서비스를 구조적으로 제공하면서 안전한 키교환이나 replay 공격등을 방어할 수 있는 메카니즘도 제공하고 있다. IETF IPsec과 IPsp워킹그룹에서는 패킷 기반의 비연결형 정보보호 서비스를 제공하기 위하여 두 개의 확장 헤더를 정의하였고, 헤더 처리를 위한 키교환 및 인증 프로토콜, 정보보호 정책기술, 그리고 정보보호 서비스 관리를 위한 MIB들을 정의하였다. IPsec은 다양한 플랫폼에서 구현되고 있어, 조만간 기존의 특정 어플리케이션 위주의 정보보호 기술들을 대체시킬 것으로 보인다. 이 논문에서는 인터넷 정보보호 서비스제공을 위한 프레임워크를 설정하고 각 주요 구성 요소에 대해 기술한다.

• The Korean Journal of Physiology and Pharmacology
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• v.14 no.6
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• pp.399-405
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• 2010

Gamma-aminobutyric acid (GABA)-ergic inhibition is important in the function of the visual cortex. In a previous study, we reported a developmental increase in $GABA_A$ receptor-mediated inhibition in the rat visual cortex from 3 to 5 weeks of age. Because this developmental increase is crucial to the regulation of the induction of long-term synaptic plasticity, in the present study we investigated in detail the postnatal development of phasic and tonic inhibition. The amplitude of phasic inhibition evoked by electrical stimulation increased during development from 3 to 8 weeks of age, and the peak time and decay kinetics of inhibitory postsynaptic potential (IPSP) and current (IPSC) slowed progressively. Since the membrane time constant decreased during this period, passive membrane properties might not be involved in the kinetic changes of IPSP and IPSC. Tonic inhibition, another mode of $GABA_A$ receptor-mediated inhibition, also increased developmentally and reached a plateau at 5 weeks of age. These results indicate that the time course of the postnatal development of GABAergic inhibition matched well that of the functional maturation of the visual cortex. Thus, the present study provides significant insight into the roles of inhibitory development in the functional maturation of the visual cortical circuits.

• Journal of Elementary Mathematics Education in Korea
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• v.14 no.2
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• pp.315-335
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• 2010

The goal of this research was to study the effects of the Mathematical Problem Generating Program on problem solving ability and learning attitude. The experiment was carried out between two classes. One class was applied with the experimental program (treatment group), and the other continued with normal teaching and learning methods (comparative group). In this study, two 5th grade elementary classes participated in Seoul city. In this study, the students were tested their problem solving abilities by the IPSP test and learning attitude by the Korean Education Development Institute (KEDI) before and after use of the program. The collected results were t-tested to find any meaningful changes. The results showed the followings. First, use of the mathematical generating program showed meaningful progressive results in problem solving ability. Second, the students that used the program showed positive results in learning attitude. In conclusion, learning mathematics using the problem generating method helps students deeper understand and solve complex problems. In addition, problem solving abilities can be improved and the attitude towards mathematics can be changed while students are using an active and positive approach in problem solving processes.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.21 no.2
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• pp.309-315
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• 2017

Recently it has drawn much attention on the technologies about Internet of Things (IoT) which connects objects with constrained resource and heterogenous communication module in order to communicate information via internet. We propose a real-time sensor monitoring system based on IPv6 over Bluetooth Low Energy (BLE), which is included in Bluetooth 4.2 Specification. Since this system uses a publish-subsribe based IoT protocol, so called Message Queueing Telemetry Transport (MQTT), neither transforming network data nor any proxy server is needed in order to transmit data. Through the web client connected to this system, you can monitor sensor data sent by BLE device in real-time, intermediated via MQTT broker and then delivered to the client via HTTP and websocket protocol. In this paper we evaluated network capacity and availability of the implemented test platform. Thus by using this system it is possible to make development cost low and to construct IoT network with heterogenous devices easily.

• Asian-Australasian Journal of Animal Sciences
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• v.11 no.4
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• pp.445-449
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• 1998

Semen quality was compared between the local Katjang and the cross-bred (local Katjang ♀ ${\times}$ German Fawn ♂) bucks. There were on significant genotypic differences in semen characteristics of concentration (first ejaculate : $6.19{\pm}1.30$ -versus $6.33{\pm}1.40{\times}10^9/ml;$second ejaculate: $5.82{\pm}1.10$ - versus $5.68{\pm}1.45{\times}10^9/ml$, for Katjang and the cross-breds, respectively), percentage live (first ejaculate: $77.61{\pm}1.33%$ versus $77.81{\pm}0.53%$; second ejaculate: $81.97{\pm}1.59%$ versus $82.74{\pm}0.96%$, for Katjang and cross-breds, respectively) and percentage of normal sperms (first ejaculate: $12.54{\pm}3.88%$ versus $26.45{\pm}3.83%$; second ejaculate: $38.68{\pm}3.65%$ versus $28.54{\pm}4.38%$, for Katjang and cross-breds, respectively), with the exception of seminal volume and sperm motility. Means of all variables were within the values reported for other goat breeds, In contrast, the differences in semen characteristics between the first and second ejaculations of both genotypes were more distinct, the second ejaculations always had more volume, more normal sperms and better sperm motility but less sperm concentrations. Removing the seminal plasma and replacing it with tris-citrate buffer greatly prolonged the viability of sperms of both genotypes when stored at $5{^{\circ}C}$. Sperm motility seens to be a good indicator of sperm viability. However, the sperms of the corss-bred bucks withstood the washing process better and their swimming abilities were superior ($8.12{\pm}0.46mm/min$) when compared to those of the local Katjang breed ($5.42{\pm}0.49mm/min$). The higher content of calcium ions in their seminal plasma (first ejaculate: $10.5{\pm}0.8$ versus $10.6{\pm}0.8mg/100ml$;second ejaculate: $15.3{\pm}0.8$ versus $16.1{\pm}0.8mg/100ml$, for Katjang and cross-breds, respectively) means that in natural matings the sperms of the cross-breds would be at an advantage compared to those of the local Katjang, since calcium ions reportedly initiate acrosomal reactions.