• Journal of Ginseng Research
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• v.33 no.2
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• pp.149-154
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• 2009

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation and progressive cartilage and bone erosion. Korean red ginseng (KRG) has been shown to have an anti-inflammatory effect by inhibiting the secretion of inflammatory cytokines like $TNF-{\alpha}$, IL-1, -6, and -8, and $IPN-{\gamma}$. In this study, whether KRG extract has an inhibitory effect on the collagen-inducible development of arthritis in DBA/1J mice was investigated. To induce arthritis, type II collagen emulsified in Complete Freund's Adjuvant was intradermally injected into the base of the tails of mice. Three weeks after the initial injection, a booster injection of type II collagen emulsified in Incomplete Freund's Adjuvant was administered. The oral administration of KRG extract for 8${\sim}$10 weeks at the dose of 300 mg/kg (three days a week) inhibited the development of arthritis in the experimental group, compared to the control group which was given saline. While the administration of KRG extract three times a week demonstrated both preventive and inhibitory effects, the administration of KRG extract once a week had little inhibitory effect. In other studies, the regimen of KRG administration has been shown to decrease the plasma level of inflammatory cytokines like IL-8 and TNF-${\alpha}$, but the plasma levels of these cytokines were not decreased in the present study. The results of the present study suggest that KRG has preventive and inhibitory effects on collagen-induced arthritis.

• Steel and Composite Structures
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• v.30 no.5
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• pp.483-492
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• 2019

In the current study, the influence of the initial lateral (sweep) shape and the cross-sectional twist imperfection on the lateral torsional buckling (LTB) response of doubly-symmetric steel I-beams was investigated. The material imperfection (residual stress) was not considered. For this objective, standard European IPN 300 beam with different unbraced span was numerically analyzed for three imperfection cases: (i) no sweep and no twist (perfect); (ii) three different shapes of global sweep (half-sine, full-sine and full-parabola between the end supports); and (iii) the combination of three different sweeps with initial sinusoidal twist along the beam. The first comparison was done between the results of numerical analyses (FEM) and both a theoretical solution and the code lateral torsional buckling formulations (EC3 and AISC-LRFD). These results with no imperfection effects were then separately compared with three different shapes of global sweep and the presence of initial twist in these sweep shapes. Besides, the effects of the shapes of initial global sweep and the inclusion of sinusoidal twist on the critical buckling load of the beams were investigated to unveil which parameter was considerably effective on LTB response. The most compatible outcomes for the perfect beams was obtained from the AISC-LRFD formulation; however, the EC-3 formulation estimated the $P_{cr}$ load conservatively. The high difference from the EC-3 formulation was predicted to directly originate from the initial imperfection reduction factor and high safety factor in its formulation. Due to no consideration of geometric imperfection in the AISC-LFRD code solution and the theoretical formulation, the need to develop a practical imperfection reduction factor for AISC-LRFD and theoretical formulation was underlined. Initial imperfections were obtained to be more influential on the buckling load, as the unbraced length of a beam approached to the elastic limit unbraced length ($L_r$). Mode-compatible initial imperfection shapes should be taken into account in the design and analysis stages of the I-beam to properly estimate the geometric imperfection influence on the $P_{cr}$ load. Sweep and sweep-twist imperfections led to 10% and 15% decrease in the $P_{cr}$ load, respectively, thus; well-estimated sweep and twist imperfections should considered in the LTB of doubly-symmetric steel I-beams.

• Journal of the Korea Society of Computer and Information
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• v.27 no.12
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• pp.209-217
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• 2022

Naval CMS(Combat Management System) is linked to various sensors and weapon equipment and use DDS(Data Distribution Service) for efficient data communication between ICU(Interface Control Unit) Node and IPN(Information Processing Node). In order to use DDS, software in the system communicates in an PUB/SUB(Publication/Subscribe) based on DDS topic. If the DDS messages structure in this PUB/SUB method does not match, problems such as incorrect command processing and wrong information delivery occur in sending and receiving application software. To improve this, this paper proposes a DDS message structure integrity verification method. To improve this, this paper proposes a DDS message structure integrity verification method using a hash tree. To verify the applicability of the proposed method to Naval CMS, the message integrity verification rate of the proposed method was measured, and the integrity verification method was applied to CMS and the initialization time of the existing combat management system was compared and the hash tree generation time of the message structures was measured to understand the effect on the operation and development process of CMS. Through this test, It was confirmed that the message structure verification method for system stability proposed in this paper can be applied to the Naval CMS.

• Parasites, Hosts and Diseases
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• v.61 no.4
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• pp.405-417
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• 2023

Chagas disease, caused by Trypanosoma cruzi parasite, is a significant but neglected tropical public health issue in Latin America due to the diversity of its genotypes and pathogenic profiles. This complexity is compounded by the adverse effects of current treatments, underscoring the need for new therapeutic options that employ medicinal plant extracts without negative side effects. Our research aimed to evaluate the trypanocidal activity of Bidens pilosa fractions against epimastigote and trypomastigote stages of T. cruzi, specifically targeting the Brener and Nuevo León strains-the latter isolated from Triatoma gerstaeckeri in General Terán, Nuevo León, México. We processed the plant's aerial parts (stems, leaves, and flowers) to obtain a methanolic extract (Bp-mOH) and fractions with varying solvent polarities. These preparations inhibited more than 90% of growth at concentrations as low as 800 ㎍/ml for both parasite stages. The median lethal concentration (LC₅₀) values for the Bp-mOH extract and its fractions were below 500 ㎍/ml. Tests for cytotoxicity using Artemia salina and Vero cells and hemolytic activity assays for the extract and its fractions yielded negative results. The methanol fraction (BPFC3MOH1) exhibited superior inhibitory activity. Its functional groups, identified as phenols, enols, alkaloids, carbohydrates, and proteins, include compounds such as 2-hydroxy-3-methylbenzaldehyde (50.9%), pentadecyl prop-2-enoate (22.1%), and linalool (15.4%). Eight compounds were identified, with a match confirmed by the National Institute of Standards and Technology (NIST-MS) software through mass spectrometry analysis.

• Journal of the Korean Wood Science and Technology
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• v.27 no.2
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• pp.15-22
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• 1999

Polymeric meterials that are used for noise and vibration damper in wood/polymer/wood sandwich composites, must have a high loss factor(tan ${\delta}$), and at the same time the storage modulus(E) of $5{\times}10^7$ to $10^9$ dyne/$cm^2$ must withstand over a wide temperature and frequency ranges. In this study, the series of epoxy resinlpolyacrylate interpenetrating polymer networks(IPNs) were synthesized by simultaneous polymerization. Their dynamic tensile properties were measured at 110Hz using Rheovibron instrument. Composite damping factor(tan ${\delta}_c$) and dynamic bending modulus($E_c,\;E_^{\prime\prime}c$) of wood/polymer/wood sandwich composites were measured at 110Hz using a Rheovibron in bending mode of vibration. These dynamic tensile studies indicated that cured epoxy resin/polyacrylates IPNs were semicompatible in the sense that both the shifting of T($E^{\prime\prime}_{max}$) or T(tan ${\delta}_{max}$) and the broadening of glass transition temperature range were observed. Especially, the cured Epikote871/P(n-BMA) IPNs of composition 70/30 to 50/50 showed a relatively high tan a and appropriate E' value over a wide temperature range; consequently the tan a e curves of wood/IPNs/wood sandwich composites was broadened over a wide temperature range.

• Journal of the Korea Society of Computer and Information
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• v.27 no.12
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• pp.9-16
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• 2022

In this paper, we propose a plan to design and utilize the RDBS(Record Block Data file management System) so that data can be recovered when data files in the Combat Management System are mismatched. The CMS(Combat Management System) manages the same files in multiple IPN(Infomation Processing Node) repositories to support multiplexing. However, mismatches in data files can occur due to equipment maintenance or user immaturity. The existing CMS does not manage the history of changes in data files, and when a mismatch occurs, data file were synchronized based on the latest date. But, It is difficult to say that files with the latest date have the highest reliability, and once the file synchronization has progressed, it cannot be recovered with pre-synchronization data. To solve this problem, data was stored and synchronized in units of record blocks using RDBS proposed in this paper, and the Rsync algorithm was used to reduce the overhead of file synchronization due to units of record blocks. SW applied with RDBS was tested for performance in a simulated environment, and it was confirmed that it could be applied to CMS through normal operation confirmation.