• Title/Summary/Keyword: IPF

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Rule-Based Classification Analysis Using Entropy Distribution (엔트로피 분포를 이용한 규칙기반 분류분석 연구)

  • Lee, Jung-Jin;Park, Hae-Ki
    • Communications for Statistical Applications and Methods
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    • v.17 no.4
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    • pp.527-540
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    • 2010
  • Rule-based classification analysis is widely used for massive datamining because it is easy to understand and its algorithm is uncomplicated. In this classification analysis, majority vote of rules or weighted combination of rules using their supports are frequently used in order to combine rules. We propose a method to combine rules by using the multinomial distribution in this paper. Iterative proportional fitting algorithm is used to estimate the multinomial distribution which maximizes entropy constrained on rules' support. Simulation experiments show that this method can compete with other well known classification models in the case of two similar populations.

The Heat Exchangers Performance Experiment for a Field Application Ice Slurry Cooling System (현장 적용 아이스슬러리 시스템의 열교환기 성능 실험)

  • Lee, Sang-Hoon;Yoo, Ho-Seon;Lee, Yoon-Pyo
    • Proceedings of the SAREK Conference
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    • 2009.06a
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    • pp.1002-1007
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    • 2009
  • The research are performed to check the characteristics of the ice slurry transport system for the district cooling. The system are installed at the 1st floored building which is as large as the $1204\;m^2$ ($86\;m{\times}14\;m$). Three kinds of heat exchanger are selected, such as, plate, spiral and shell & tube type, to apply to the ice slurry systems. Experiment was done in the two cases. The first case, circulation water flow fixed at the design conditions for the state to change the flow of the supply of ice slurry. The second case, Ice slurry flow fixed at the design conditions for the state to change the flow of circulation water. Both side of Energy balance was calculated. The performance of plate heat exchanger is higher than others and it's enthalpy effectiveness is higher too.

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An Experimental Study on the Heat Transfer Characteristics during the Freezing Process of Water in the Vertical Multi Tube Type Ice Storage Tank (수직다발관형 빙축열 탱크내 물의 응고과정시 열전달특성에 관한 연구)

  • Kim, Y.K.;Yim, C.S.
    • Solar Energy
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    • v.18 no.3
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    • pp.95-105
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    • 1998
  • In this study, basic design data which were required for development of highly efficient ice storage system with low temperature latent heat were experimentally obtained. The ice storage system considered in this study was the one that has been widly used in the developed country and called the ice-on-coil type. Using the system, the ice storage performance for various design parameters which were the flow direction and the inlet temperature of the secondary fluid was tested. In addition, the timewise variation of the interface profiles between the solid and the liquid were visualized, and the heat transfer characteristics of the Phase Change Material(PCM) in the ice storage tank were Investigated. During the freezing processes in the ice storage tank with several vertical tubes, decrease of the heat transfer area and the heat resistance of the ice layer made the increasing rate of ice packing factor(IPF) less. The total freezing energy for the upward flow of the secondary fluid was higher than that for the downward flow. The average ice storage efficiency for the upward flow of the secondary fluid was higher than that for the downward flow.

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An experimental study on ice slurry creation by injection of an aqueous solution (수용액 분사에 의한 아이스 슬러리의 제조에 관한 실험적 연구)

  • Lee, Yong-Koo;Oh, Cheol
    • Journal of Navigation and Port Research
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    • v.34 no.1
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    • pp.71-75
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    • 2010
  • This study is experimented to observe an influence of experimental conditions on production characteristics of slurry ice by injection operating water to cooling plate. And at this experiment it used ethylene glycol-water solution and the concentration is 10 to 20wt%. The experimental apparatus was constructed of ethylene glycol-water solution and slurry ice storage tank, brine tank, pumps for ethylene glycol-water solution and brine circulating, a mass flow-meter, data logger for fluid temperature measuring and a vertical circular tube with single copper plate as test section. The experiments were carried out under various conditions, with mean velocity of fluid at the entry ranging from 1.0 to 2.0m/s and the cooling temperature of $-17^{\circ}C$ to $-10^{\circ}C$.

Integrity, Orbit Determination and Time Synchronisation Algorithms for Galileo

  • Merino, M.M. Romay;Medel, C. Hernandez;Piedelobo, J.R. Martin
    • Proceedings of the Korean Institute of Navigation and Port Research Conference
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    • v.2
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    • pp.9-14
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    • 2006
  • Galileo is the European Global Navigation Satellite System, under civilian control, and consists on a constellation of medium Earth orbit satellites and its associated ground infrastructure. Galileo will provide to their users highly accurate global positioning services and their associated integrity information. The elements in charge of the computation of Galileo navigation and integrity information are the OSPF (Orbit Synchronization Processing Facility) and IPF (Integrity Processing Facility), within the Galileo Ground Mission Segment (GMS). Navigation algorithms play a key role in the provision of the Galileo Mission, since they are responsible for computing the essential information the users need to calculate their position: the satellite ephemeris and clock offsets. Such information is generated in the Galileo Ground Mission Segment and broadcast by the satellites within the navigation signal, together with the expected a-priori accuracy (SISA: Signal-In-Space Accuracy), which is the parameter that in fault-free conditions makes the overbounding the predicted ephemeris and clock model errors for the Worst User Location. In parallel, the integrity algorithms of the GMS are responsible of providing a real-time monitoring of the satellite status with timely alarm messages in case of failures. The accuracy of the integrity monitoring system is characterized by the SISMA (Signal In Space Monitoring Accuracy), which is also broadcast to the users through the integrity message.

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Verification System Using NFT to Prevent Profile Impersonation Crime (프로필 사칭 범죄를 방지하기 위해 NFT를 이용한 검증 시스템)

  • Kim, Ho-Yoon;Lee, Won-Seok;Shin, Seung-Soo
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2022.10a
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    • pp.354-356
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    • 2022
  • Profiles are the most basic means of representing who you are, and you represent yourself. In SNS and chatting apps that use profiles the most, profiles are used to express their experiences, moods, and thoughts. However, in voice phishing, impersonation crimes, etc., they steal and impersonate a photo such as a profile, and then deceive the victim into committing a crime. In this paper, to prevent the crime of impersonation, the authenticity of the original is determined using NFT that can distinguish the original. Minting the original profile picture with NFT, registering it on the blockchain network, and storing the original file in off-chain IPFS. This is expected to be effective in preventing impersonation crimes because it is possible to easily determine the authenticity of the profile picture.

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Genistein alleviates pulmonary fibrosis by inactivating lung fibroblasts

  • Seung-hyun Kwon;Hyunju Chung;Jung-Woo Seo;Hak Su Kim
    • BMB Reports
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    • v.57 no.3
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    • pp.143-148
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    • 2024
  • Pulmonary fibrosis is a serious lung disease that occurs predominantly in men. Genistein is an important natural soybean-derived phytoestrogen that affects various biological functions, such as cell migration and fibrosis. However, the antifibrotic effects of genistein on pulmonary fibrosis are largely unknown. The antifibrotic effects of genistein were evaluated using in vitro and in vivo models of lung fibrosis. Proteomic data were analyzed using nano-LC-ESI-MS/MS. Genistein significantly reduced transforming growth factor (TGF)-β1-induced expression of collagen type I and α-smooth muscle actin (SMA) in MRC-5 cells and primary fibroblasts from patients with idiopathic pulmonary fibrosis (IPF). Genistein also reduced TGF-β1-induced expression of p-Smad2/3 and p-p38 MAPK in fibroblast models. Comprehensive protein analysis confirmed that genistein exerted an anti-fibrotic effect by regulating various molecular mechanisms, such as unfolded protein response, epithelial mesenchymal transition (EMT), mammalian target of rapamycin complex 1 (mTORC1) signaling, cell death, and several metabolic pathways. Genistein was also found to decrease hydroxyproline levels in the lungs of BLM-treated mice. Genistein exerted an anti-fibrotic effect by preventing fibroblast activation, suggesting that genistein could be developed as a pharmacological agent for the prevention and treatment of pulmonary fibrosis.

D.E.Cho : A Study on Smart City Data Security Model Using Blockchain Technology (블록체인 기술을 이용한 스마트시티 데이터 보안 모델 연구)

  • Do-Eun Cho
    • Journal of Platform Technology
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    • v.12 no.2
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    • pp.45-57
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    • 2024
  • Smart cities are the product of modern urban planning that seeks to innovate information and communication technology and improve the quality of urban life. For the efficient operation of smart cities, data collected, stored, and processed in real time is a key resource. Therefore, data from smart cities collected in various fields must be managed safely, and personal information protection is paramount. In this study, a smart city data security model using blockchain technology was proposed to safely manage smart city data. The proposed model integrates IPFS into the blockchain network to distribute and store data to ensure data confidentiality and integrity, and encrypts data using CP-ABE to efficiently control access to data from users. In addition, privacy was guaranteed while enhancing the usability of data by using Homomorphic Encryption with data access control policies.

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Management of Idiopathic Interstitial Pneumonia Treated only with Traditional Korean Medicine: a Case Report

  • Kang, Ji-Young;Han, Jong-Min;Kim, Jun-Young;Jung, In-Chul;Kang, Wee-Chang;Oh, Young-Seon;Lee, Jin-Woo;Park, Yang-Chun
    • The Journal of Korean Medicine
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    • v.35 no.4
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    • pp.104-109
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    • 2014
  • Objectives: To present the case of a 76-year-old man diagnosed with idiopathic interstitial pneumonias (IIPs) treated exclusively with traditional Korean medicine (TKM). Methods: The patient was treated with the revised Sasammaekmundong-tang (rSMT), acupuncture, and pharmacopuncture from September 2013 to May 2014 in our outpatient clinic. We prescribed rSMT three times a day for 4 months. Acupuncture and pharmacopuncture were performed twice a week for 9 months. To evaluate therapeutic efficacy, we recorded the patient's chief complaints at each visit, and pulmonary function test was performed at intervals of three months. Chest radiography and chest computed tomography were performed before and after treatment, respectively. Results: During the course of the treatment, dyspnea, cough, sputum, and overall pulmonary function improved. Conclusions: We suggest that traditional Korean medicine (TKM) for IIPs patients might be effective in the control of the main symptoms of IIPs and in the recovery of respiratory function.

Inhibition of Plasminogen Activator Inhibitor-1 Expression in Smoke-Exposed Alveolar Type II Epithelial Cells Attenuates Epithelial-Mesenchymal Transition

  • Song, Jeong-Sup;Kang, Chun-Mi
    • Tuberculosis and Respiratory Diseases
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    • v.70 no.6
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    • pp.462-473
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    • 2011
  • Background: Smoking is a risk factor for idiopathic pulmonary fibrosis (IPF), but the mechanism of the association remains obscure. There is evidence demonstrating that plasminogen activator inhibitor-1 (PAI-1) is involved in the progression of pulmonary fibrosis. This study was to determine whether the administration of small interfering RNA (siRNA) targeting PAI-1 or PAI-1 inhibitor to the cigarette smoking extract (CSE)-exposed rat alveolar type II epithelial cells (ATII cells) limits the epithelial-mesenchymal transition (EMT). Methods: ATII cells were isolated from lung of SD-rat using percoll gradient method and cultured with 5% CSE. The EMT was determined from the ATII cells by measuring the real-time RT PCR and western blotting after the PAI-1 siRNA transfection to the cells and after administration of tiplaxtinin, an inhibitor of PAI-1. The effect of PAI-1 inhibitor was also evaluated in the bleomycin-induced rats. Results: PAI-1 was overexpressed in the smoking exposed ATII cells and was directly associated with EMT. The EMT from the ATII cells was suppressed by PAI-1 siRNA transfection or administration of tiplaxtinin. Signaling pathways for EMT by smoking extract were through the phosphorylation of SMAD2 and ERK1/2, and finally Snail expression. Tiplaxtinin also suppressed the pulmonary fibrosis and PAI-1 expression in the bleomycin-induced rats. Conclusion: Our data shows that CSE induces rat ATII cells to undergo EMT by PAI-1 via SMAD2-ERK1/2-Snail activation. This suppression of EMT by PAI-1 siRNA transfection or PAI-1 inhibitor in primary type II alveolar epithelial cells might be involved in the attenuation of bleomycin-induced pulmonary fibrosis in rats.