• KSBB Journal
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• v.20 no.1 s.90
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• pp.46-49
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• 2005

Curdlan, a natural $\beta-1,3-glucan,$ has been studied as drug carrier due to its unique properties including its thermal gelling characters. In this study, curdlan was chemically acetylated for pH-sensitive drug delivery. Curdlan acetate microspheres(CAMs) were prepared by the solvent evaporation method. The size of the CAMs was below $200{\mu}m.$ The drug loading efficiency of microspheres was approximately $58.44\%$. In the swelling test, the CAMs showed pH-sensitive behavior. The swelling capacity of microspheres at pH 7.4 was much greater than at pH 1.4. Also, release rate of indomethacin(IND) at pH 7.4 from the CAMs was faster than that at pH 1.4. Therefore the CAMs have potential for the controlled release of IND over an extended period of time.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.52 no.4
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• pp.372-385
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• 2016

This present study investigated characteristics of distribution and community structure of macrobenthic invertebrates through the survey of commercial Danish seine fisheries from 2011 to 2013. In this study, a total of 28 species were sampled with a mean density of $32,568ind./km^2$ and mean biomass of $1,649.5kg/km^2$. The dominant species, comprising over 1.0% of the total number of individuals, were Chionoecetes opilio ($11,203ind./km^2$, 34.4%), Pandalus eous ($9,247ind./km^2$, 28.4%), Ophiuridae spp. ($5,750ind./km^2$, 17.7%), Argis lar ($2,631ind./km^2$, 8.1%), Neocrangon communis ($994ind./km^2$, 3.1%), Berryteuthis magister ($612ind./km^2$, 1.9%), Sepiola birostrata ($499ind./km^2$, 1.5%) and Strongylocentrotidae sp. ($424ind./km^2$, 1.3%). The dominant species, in terms of biomass, comprising over 1.0% of the total biomass, were C. opilio ($1,167.2kg/km^2$, 70.8%), B. magister ($130.3kg/km^2$, 7.9%), P. eous ($102.4kg/km^2$, 6.2%), Ophiuridae spp. ($84.6kg/km^2$, 5.1%), Enteroctopus dofleini ($45.5kg/km^2$, 2.8%), A. lar ($35.7kg/km^2$, 2.2%), Strongylocentrotidae sp. ($25.0kg/km^2$, 1.5%) and S. birostrata ($22.1kg/km^2$, 1.3%). Among them, S. birostrata, E. dofleini, Strongylocentrotidae sp. and Ophiuridae spp. were higher abundance and biomass in the shallow water (<200 meters in depth), whereas C. opilio, P. eous, A. lar, N. communis and B. magister were higher in the deep water (301 ~ 500 meters in depth). As the results of cluster analysis and non-metric multidimensional scaling (nMDS) analysis based on the Bray-Curtis similarity of fourth root transformed data for number of species and individuals, the macrobenthic invertebrates community by Danish seine survey was divided into two groups of station in the shallow water (<200 meters in depth, Group A) and the deep water (201 ~ 500 meters in depth, Group B). The major individual-dominant species was S. birostrata, Ophiuridae spp. and immature C. opilio in group A. But Group B was P. eous, A. lar, B. magister and mature C. opilio.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.29 no.3
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• pp.271-278
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• 1996

Daytime surface zooplankton were collected bimonthly from April 1993 to March 1994 at six stations around upwelling and adjacent areas of Cosan, western part of Cheju Island. This paper deals with the occurrence, biomass and some other characteristics of zooplankton in these areas. Copepods had two peaks in the abundance in June $(235\;ind./m^3)$ and November $(301\;ind./m^3)$, but were not especially abundant in upwelling area. While gelatinous organisms seldom occurred in the upwelling, and the outer area with high density of $75\;ind./m^3$ (in June) and $458\;ind./m^3$ (in November) at the intermediate area, seasonal values of biomass with mean of $35.8\;mg/m^3$ were the highest in November and the lowest in January. Abundance of chaetognaths (mainly Sagitta spp.) ranged $15\~37\;inds./m^3$ and carcasses of Sagitta occurred very highly in the upwelling area in June ($54\%$ of total Sagitta organisms) and November $(70.5\%)$. Especially $48\~77\%$ of Sagitta individuals in upwelling area in November was attached by Oncaea mediterranea, O. venusta and Candacia bipinata. Pteropods with shells were sampled only in the upwelling area during strong upwelling season (November, $27\~64\;ind./m^3$), indicating the characteristics of ascending behavioral adaptation from the bottom water by upwelling.

• Journal of the Korean Applied Science and Technology
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• v.11 no.1
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• pp.71-77
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• 1994

In order to review industrial application of amphoteric surfactants, new types of hydroxy sulfobetaine, 3-(N, N-dimethyl N-dimethyl-N-alkylammonio)-2-hydroxy-1-propane sulfonate and 3-(N, N-dimethyl N-acylammonio)-2-hydroxy-1-propane sulfonate were prepared by the reaction of quaternized sodium 1-chloro-2-hydroxy-3-propane sulfonate with N, N-dimethyl-N-alkylamine and N, N-dimethyl N-acylamido propylamine that have a straight chain radical of 12, 18 carbon atoms respectively in the presence of alkali catalyst. All the reaction products could be separated by means of column and thin layer chromatography, and the yields of all products ranged in $85{\sim}90%$, the structure of them could be confirmed from IR and $^{1}H$-NMR spectra.

• Archives of Pharmacal Research
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• v.21 no.5
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• pp.610-614
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• 1998

DW-116, [1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquino-line-3-carboxylic acid hydrochloride}, is a new quinolone antibiotic with a broad antibacterial spectrum against G(+) and G(-) bacteria. DW-116 was evaluated for the immunomodulating activities, which is one of the efforts to investigate the mechanism of action related to the good in vivo antibacterial efficacy. The results of in vitro studies revealed there was no statistically significant increase in B and T lymphocyte proliferation. But the results of in vivo studies showed that the number of plaque forming cells (PFC), the amount of polyclonal antibodies and delayed-type hypersensitivity (DTH) were significantly increased after the repeat administration with 12 and 60 mg/kg of DW-116. Taken together, these results proposed that immunostimulting effect of DW-116 could be one of the action mechanisms for demonstrating in vivo antibacterial activities under these experimental conditions.

• Journal of Pharmaceutical Investigation
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• v.27 no.2
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• pp.133-137
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• 1997

Buccal absorption test of omeprazole in human was performed to determine the permeability of the drug molecule through oral mucous membrane. Oral mucosal adhesive tablets of omeprazole were prepared by compressing the omeprazole with a mixture of sodium alginate and hydroxypropylmethyl cellulose (HPMC) as bioadhesive polymers, magnesium oxide (MgO) as a stabilizer and sodium carboxymethyl cellulose (Na CMC) or cros-carmellose sodium (Ac-Di-Sol) as disintegrants. The bioadhesive force, stability in saliva and release characteristics of the tablets were evaluated. Omeprazole was absorbed about 23% in 15 min through human buccal mucous membrane. Furthermore, omeprazole was stable in saliva for more than 8 hrs when MgO was added to the tablet as the amount of 2.5 fold of omeprazole. The release rate of omeprazole was increased with increasing the amount of sodium alginate in the tablet. From these results, it is suggested that tablets composed of [omeprazole/HPMC/sodium alginate/MgO/Ac-Di-Sol and/or Na CMC (20/6/24/50/10) (mg/tablet)] are potential candidate for buccal drug delivery system.

• Biomolecules & Therapeutics
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• v.10 no.4
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• pp.236-239
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• 2002

The goal of this study was to evaluate the antidiarrheal efficacy of $Lacteol^{TM}$-loperamide combination against the mouse model of secretory diarrhea. Secretory dirrhea was induced in mice by p.o. administration of castor oil (0.3 ml). Antidirrheal effects of $Lacteol^{TM}$-loperamide combination were compared with each individual component. $Lacteol^{TM}$-loperamide combination was the most potent among these agents, eliminating diarrhea in 100% of mice at a dose 1360/4 mg/kg (Lacteol/loperamide, respectively). In this study, we also measured changes of bodyweight as another indicator of the dirrhea, based on the assumption that lower bodyweight loss represented reduced fecal passage. The bodyweight loss of $Lacteol^{TM}$-loperamide combination administered group was 4 times lower than that of vehicle control. These findings indicate that $Lacteol^{TM}$-loperamide combination may be more potent than individual component in its antidiarrheal action, so we are going to challenge this combination for further study and clinical evaluation.

• Proceedings of the Korean Society of Computer Information Conference
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• 2019.07a
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• pp.11-12
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• 2019

본 논문에서 에스컬레이터 기계실 내부 전동기, 감속기, 구동 체인의 IoT 소음 및 진동 센서를 부착하여 에스컬레이터 운영중 실시간 상태 감시가 가능한 IoT 기반 에스컬레이터 고장 예지 시스템을 제안한다. IoT 소음 및 진동 센서는 에스컬레이터 운영 중 발생하는 소음 및 진동 데이틀 수집하여 PHM(Prognostics and Health Management) 서버로 전송하며, 서버에서는 진단 알고리즘을 통해 고장 유 무를 판단한다. 소음 데이터를 이용한 체인 피치 길이 알고리즘을 검증하기 위하여 실제 체인의 길이를 측정한 결과 값과 비교한 결과 99.8% 정확도를 가지며, 진동 데이터를 이용하여 전동기, 감속기의 상태 판단을 위한 알고리즘 검증을 위해 AST 사의 진동 센서와 비교한 결과 약간의 오차는 발생하지만 ISO 10816-3을 기준으로 한 판단 결과 값은 동일한 결과 값을 가지는 것을 확인하였다.

• Applied Chemistry for Engineering
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• v.4 no.3
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• pp.505-514
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• 1993

Defined oligoglycerol monolaurate esters were synthesized by means of step by step synthesis methods, and monoglycerol monolaurate, diglycerol monolaurate, symmetrical triglycerol monolaurate and symmetrical tetraglycerol monolaurate were obtained in a rate of 85~95% yields. All the reacted products could be separated by means of column and thin layer chromatography, and the structure of products has been analyzed with IR, $^1H\;NMR$ spectra respectively.

• Journal of Ocean Engineering and Technology
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• v.1 no.1
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• pp.39-48
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• 1987

지금까지 건조된 jacket 중에서 가장 큰 것으로 알려진 미국 Exxon사의 Harmony jacket 이 현재 현대 중공업에 의해 제작되고 있다. Harmony jacket은 제작완료 후 울산으로부터 미국 California서안의 Santaynez해역으로 운송될 예정인데, 이와 같이 긴 해상운송시에 jacket과 seafasening 부재들은 피로에 의하여 상당히 손상을 입을 수 있다. 본 연구에서는 두가지의 가능한 운송항로에 대해, jacket과 tie-down 부재가 받는 피로에 의한 손상정도를 계산하고 그 결과를 비교 하였다. 몇 가지 가정하에 행하여진 해석 결과에 따르면, 피로에 의한 손상을 적게 주는 운송항로는 Hawaii를 경유하는 남쪽할로이며, 운송 barge와 인접하는 부분, 특히 barge 양단 부근의 jacket joint들이 손상을 받기 쉽다는 것을 알 수 있다.