• Title, Summary, Keyword: IND

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Genetic Diversity of Metallo-β-lactamase Genes of Chryseobacterium indologenes Isolates from Korea

  • Yum, Jong Hwa
    • Biomedical Science Letters
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    • v.25 no.3
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    • pp.275-281
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    • 2019
  • This study was performed to characterize the chromosomal metallo-${\beta}$-lactamases (MBLs) of Chryseobacterium indologenes isolated from Korea and to propose a clustering method of IND MBLs based on their amino acid similarities. Chromosomal MBL genes were amplified by PCR from 31 clinical isolates of E. indologenes. Nucleotide sequencing was performed by the dideoxy chain termination method using these PCR products. Antimicrobial susceptibilities were determined by the agar dilution method. PCR experiments showed that all 31 E. indologenes isolates contained all $bla_{IND}$ genes. DNA sequence analysis revealed that E. indologenes isolates possessed ten types of $bla_{IND}$ gene, including seven novel variants ($bla_{IND-8}$ to $bla_{IND-14}$). The most common combination of MBL was IND-2 (n = 18). Minimum inhibitory concentrations of imipenem and meropenem for the isolates harboring novel IND MBLs were ${\geq}16{\mu}g/mL$. IND MBLs were grouped in three clusters, based on amino acid similarities.

Post-treatment Enhancement of Ninhydrin-treated Fingermark Using 1,2-IND/Zn (1,2-IND/Zn를 이용한 ninhydrin으로 처리한 지문의 후속 증강 연구)

  • Park, Eun-Jee;Jung, Ha-Na;Hong, Sung-Wook
    • The Journal of the Korea Contents Association
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    • v.18 no.5
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    • pp.105-114
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    • 2018
  • Ninhydrin traditionally used to develop fingerprints on paper is often limited in its use depending on background color and its enhancement effect differs depending on reagent reaction condition. Recently 1,2-indanedione(1,2-IND), etc. which has no limitation of background color has been used to visualize the fingermark on paper. Therefore, this study was carried out for enhancement of fingerprints after 1,2-IND/Zn treatment on paper treated with ninhydrin. Comparison between 1,2-IND/Zn reaction after ninhydrin treatment and single ninhydrin reaction were conducted under various methods. Result shows the fingerprints were enhanced when ninhydrin-treated fingerprints were treated with 1,2-IND/Zn, and their enhancement was observed even after 6 months.

DW1350, a Newly Synthetic Anti-osteoporotic Agent: 2. Effect on Ovariectomized Osteoporosis Rat Model, a Histomorphometrical Aspect

  • Lee, Jin-Soo;Ku, Sae-Kwang;Jung, Da-Hee;Jin, Youn-Goo;Park, Jae-Hoon;Yang, Hee-Bok;Jung, Yong-Ho;Ryu, Jei-Man
    • Proceedings of the PSK Conference
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    • pp.155.1-155
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    • 2003
  • In the present study, the effect of DW-1350, a newly synthesized anti-osteoporotic agent, was evaluated in ovariectomized Rat. Female SD Rat mice underwent bilateral ovariectomy for prevention study that test article was administered from 2 days after ovariectomy for 6 weeks, for therapeutic study it was conducted from 6 weeks after ovariectomy for three months. (omitted)

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DW1350, a Newly Synthetic Anti-osteoporotic Agent: 1. DW-1350 Inhibited Bone Resorption and Promoted Bone Formation

  • Lee, Jin-Soo;Whang, Yun-Ha;Ahn, Seok-Hoon;PanSoo;Jin, Sang-Mi;Yi, Sun-Shin;Jung, Young-Ho;Suh, Hong-Suk;Ryu, Jei-Man
    • Proceedings of the PSK Conference
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    • pp.154.2-155
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    • 2003
  • Recently, we developed a new anti-osteoporotic agent, DW-1350, which not only inhibited osteoclast formation but also induced osteoblast differentiation through the in vitro randomized screening studies. We identified inhibitory activities of DW-1350 for each step of osteoclast differentiation, fusion and pit formation process in co-culture system with mouse bone marrow and primary osteoblasts. (omitted)

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Cytotoxic Constituents form the Roots of Anthriscus sylvestris

  • Lim, Young-Hee;Leem, Moon-Jeong;Shin, Dong-Hyuk;Chang, Hwan-Bong;Hong, Seung-Woo;Moon, Eun-Yi;Lee, Dug-Keun;Yoon, Sung-June;Woo, Won-Sick
    • Archives of Pharmacal Research
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    • v.22 no.2
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    • pp.208-212
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    • 1999
  • Activity-guided fractionation of the roots of Anthriscus sylvestris resulted in the isolated and characterization of five cytotoxic compounds, deoxypodophyllotoxin (1), falcarindiol (2), and angeloyl podophyllotoxin (5) from the hexane soluble fraction and morelensin (3), bursehernin (4) from the choloroform soluble fraction. It is the first report of the occurrence of compound 5 in nature.

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Synthesis and Biological Evaluation of 4-Phenyl-1-(indoline-5-sulfonyl)-2-imidazolone Derivatives as Potential Antitumor Agents

  • Park, Dongrak;Lee, Jungah;Hyunsook Hwang;Lee, Dugkeun;Sungjune Yoon;Yongho Chung;Sanghun Jung;Lee, Moonsun
    • Proceedings of the Korean Society of Applied Pharmacology
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    • pp.73-73
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    • 1997
  • A series of 4-phenyl-1-(indoline-5-sulfonyl)-2-imidazolone derivatives has been synthesized starting from 2-bromoacetophenone. Reaction of 2-aminoacetophenone obtained from 2-bromoacetophenon by Delepin synthesis and potassium cyanate affords 1,3-dihydro-4-phenyl-2-imidazolone. This key intermediate was treated with sodium hydride and N-trifluoroacetyl-indoline-5-sulfonylchloride, and trifluoroacetyl group was deprotected to give 4-Phenyl-1-(indoline-5-sulfonyl)-2-imidazolone. Various substituents were introduced on the nitrogen of indoline. Antitumor activity of this series of compound was evaluated by MTT method. Nearly all of the compounds showed broad-spectrum activity.

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Macrobenthic Community on Angol Tidal Flat in Jinhae (진해 안골조간대에 서식하는 대형저서동물의 군집구조)

  • Paik Sang-Gyu;Yun Byoung Sun;Kim Kgu Hwan;Yun Sung Gyu
    • Korean Journal of Environmental Biology
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    • v.23 no.2
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    • pp.106-113
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    • 2005
  • This study was conducted to examine the community structure of macrobenthos on Angel tidal flat in Jinhae, south coast of Korea. Monthly samples were conducted at eight sites from March 1998 to February 1999. A total of 110 species were sampled with a mean density of 322ind. $m^{-2}$ and biomass of 98.4 wwt g $m^{-2}$. Of these species, there were 44 species of polychaetes $(40.0\%)$, 41 species of crustaceans $(37.3\%)$ and 16 species of molluscs $(14.5\%)$. The major density dominant species were a gastropod Batilaria cumingi (52ind. $m^{-2}$) and five polychaetes Ceratonereis erythraeensis (38ind. $m^{-2}$), Cirriformia tentaculata (32ind. $m^{-2}$), Capitella capitata (23ind. $m^{-2}$), Sigambra tentaculata (23ind. $m^{-2}$), Glycera chirori (17ind. $m^{-2}$). Cluster and MDS analysis showed that the study sites could be divided into two tidal elevation groups. According to the spatial distribution of dominant species and SIMPER analysis, the two groups were characterized by Sigambra tentaculata - Chaetozone setosa in upper species group and Ceratonereis erythraeensis-Cirriformia tentaculata-Capitella capitata in lower species group.