• 한국기후변화학회지
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• 제9권3호
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• pp.209-221
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• 2018

The characteristics of heat wave events in Seoul are analyzed using weather station data from Korea Meteorological Administration (KMA) and European Centre for Medium-Range Weather Forecast (ECMWF) ERA-Interim reanalysis data from 1979 to 2016. Heat waves are defined as events in the upper 10th percentile of the daily maximum temperatures. The associated synoptic weather patterns are then classified into six clusters through Self-Organizing Map (SOM) analysis for sea-level pressure anomalies in East Asia. Cluster 1 shows an anti-cyclonic circulation and weak troughs in southeast and west of Korea, respectively. This synoptic pattern leads to southeasterly winds that advect warm and moist air to the Korean Peninsula. Both clusters 2 and 3 are associated with southerly winds formed by an anti-cyclonic circulation over the east of Korea and cyclonic circulation over the west of Korea. Cluster 4 shows a stagnant weather pattern with weak winds and strong insolation. Clusters 5 and 6 are associated with F?hn wind resulting from an anti-cyclonic circulation in the north of the Korean Peninsula. In terms of long-term variations, event frequencies of clusters 4 and 5 show increasing and decreasing trends, respectively. However, other clusters do not show any long-term trends, indicating that the mechanisms that drive heat wave events in Seoul have remained constant over the last four decades.

• 생명과학회지
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• 제27권11호
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• pp.1315-1323
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• 2017

본 연구의 목적은 울금의 발효를 통해 쓴맛의 관능적 기호도를 향상시키면서, 발효 울금의 항산화 및 항염효능 검증을 위한 것으로, 발효 울금의 관능적 기호도 확인을 위해 맛센서 분석과 항산화 평가를 위해 총 폴리페놀 및 플라보노이드 함량 및 DPPH radical 소거능, 지표성분 검출을 위해 HPLC분석을 진행하였고, 항염증평가는 RAW 264.7 세포에서 LPS에 의해 유도되는 염증인자인 NO, $PGE_2$, iNOS, COX-2, $NF-{\kappa}B$, IL-6와 $TNF-{\alpha}$에 대한 감소효과를 측정하였다. 실험결과 Rhizopus oryzae로 울금의 발효가 진행 될수록 쓴맛이 감소함을 보였다. 총 폴리페놀, 플라보노이드 함량과 DPPH radical 소거능은 비 발효 울금보다 울금 발효 1, 3일차에 증가함을 보였다. 발효 기간별 발효 울금은 10, 50, $100{\mu}g/ml$ 모든 농도에서 세포독성이 나타내지 않았다. RAW 264.7 세포에 LPS로 유도된 염증인자인 $NF-{\kappa}B$, IL-6와 $TNF-{\alpha}$ 생성량이 발효 기간별 발효 울금의 염증인자 생성억제를 평가한 결과 $NF-{\kappa}B$와 IL-6에서 발효 울금 $100{\mu}g/ml$에서 현저히 생성량이 억제되었다. LPS로 유도된 cytokines 억제효과를 보인 발효 기간별 발효 울금($100{\mu}g/ml$)의 NO, $PGE_2$ 생성억제를 평가한 결과, 대조군과 비교해 LPS를 처리한 군에서 NO, $PGE_2$의 생성이 현저히 증가되었고, 울금 에탄올 추출물에 의해 유의성 있는 생성억제효과를 보였고 비 발효에 비해 발효 울금의 생성억제 효과를 보였다. 또한 COX-2와 iNOS의 단백질 발현 억제효과를 확인한 결과, 대조군과 비교해 LPS에 의해 증가 된 COX-2와 iNOS의 단백질발현이 발효 울금에 의해 감소됨을 확인하였다. 위 결과 발효 울금은 RAW 264.7 세포에서 LPS에 의해 유도되는 NO와 $PGE_2$의 생성억제, iNOS와 COX-2의 발현을 억제시켰으며, $NF-{\kappa}B$, IL-6와 $TNF-{\alpha}$의 분비량도 억제시켰다. 이는 발효 울금의 항산화와 항염증성을 입증하기 위한 기초자료로 활용이 가능하다고 사료된다.

• Asian-Australasian Journal of Animal Sciences
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• 제29권9호
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• pp.1280-1286
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• 2016

This study was aimed to evaluate the in vitro effects of medicinal herb extracts (MHEs) on ruminal fermentation characteristics and the inhibition of protozoa to reduce methane production in the rumen. A fistulated Hanwoo was used as a donor of rumen fluid. The MHEs (T1, Veratrum patulum; T2, Iris ensata var. spontanea; T3, Arisaema ringens; T4, Carduus crispus; T5, Pueraria thunbergiana) were added to the in vitro fermentation bottles containing the rumen fluid and medium. Total volatile fatty acid (tVFA), total gas production, gas profiles, and the ruminal microbe communities were measured. The tVFA concentration was increased or decreased as compared to the control, and there was a significant (p<0.05) difference after 24 h incubation. pH and ruminal disappearance of dry matter did not show significant difference. As the in vitro ruminal fermentation progressed, total gas production in added MHEs was increased, while the methane production was decreased compared to the control. In particular, Arisaema ringens extract led to decrease methane production by more than 43%. In addition, the result of real-time polymerase chain reaction indicted that the protozoa population in all added MHEs decreased more than that of the control. In conclusion, the results of this study indicated that MHEs could have properties that decrease ruminal methanogenesis by inhibiting protozoa species and might be promising feed additives for ruminants.

• Asian-Australasian Journal of Animal Sciences
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• 제31권10호
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• pp.1635-1642
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• 2018

Objective: This study was conducted to evaluate the effects of Rhus succedanea extract addition on in vitro ruminal fermentation and microbial growth. Methods: Two ruminally-fistulated steers consuming 600 g/kg timothy- and 400 g/kg cracked corn-based concentrate with free access to water and mineral block were used as rumen fluid donors. In vitro batch fermentation, with timothy as a substrate, was conducted for up to 72 h, with Rhus succedanea extracts added to achieve final concentrations of 0, 10, 30, 50, 70, and 90 mg/L. Results: Effective dry matter (DM) degradability rate linearly decreased (p = 0.046) depending on extract dosing levels. Total gas production after 24 to 72 h incubation tended to decrease following extract addition, beginning with 50 mg/L starting dose (significance of quadratic effects: p = 0.006, p<0.001, and p = 0.008 for 24, 48, and 72 h, respectively). Methane production decreased depending on dosing levels following 24 h (p<0.05) and 48 h (p<0.005) incubations and was the lowest with the 50 mg/L dose. The Rhus succedanea extracts increased the abundance of Fibrobacter succinogenes (p<0.05) and Ruminococcus flavefaciens (p = 0.0597) and decreased the abundance of methanogenic archaea (p<0.05) following 24 h incubation. Conclusion: Rhus succedanea was shown to reduce methane production and increase cellulolytic bacteria without any signs of toxic effects and with a minor effect on DM degradability.

• 대한토목학회논문집
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• 제38권6호
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• pp.839-850
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• 2018

집중호우에 의한 도시 유역의 침수 피해가 도시화에 따라 증가하는 추세이며, 이에 따라 정확하면서도 신속한 홍수예보 및 침수 예상도 표출이 필요하다. 특정 강우량에 따른 미지의 침수 범위를 예상하는 것은 도시 유역의 홍수에 대한 사전 대비에 매우 중요한 사안이며, 이를 위해 현재 홍수 예보와 관련된 정부기관에서 침수 피해 예상도를 주민들에게 제공하고자 하고 있다. 하지만, 특정 강우에 따른 정확한 침수 범위를 정량화하여 표출하는데 부족함이 있으며, 강우량과 지속시간에 따른 홍수의 크기에 대한 분석을 실시하고 수리학적 연계를 통한 준 실시간 침수범위 표출 방안을 고찰해야할 시기이다. 제시된 물리적 해석기반 자료를 이용하여 강우량-지속시간-침수량 관계곡선(Rainfall-Duration-Flooding quantity relationship curve, RDF)을 제시하고, 자율학습을 수행하는 자기조직화 특징 지도와 연계하여 미지의 침수 지도를 예측하였다. 예측한 침수 지도와 2차원 침수모형을 통한 결과를 비교하여, 제시된 방법론의 타당성을 검토하였다. 연구 결과를 통하여 중규모의 강우량 또는 빈도의 사상에 따른 미지의 침수범위를 제시하는데 용이할 것으로 판단된다. 더욱이 다양한 강우-월류량-홍수 양상을 내포하는 RDF 관계 곡선과 최적 침수예상도 데이터베이스를 구축함으로서 추후에 홍수예보의 기초자료로서 사용될 것이다.

• Tuberculosis and Respiratory Diseases
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• 제85권4호
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• pp.341-348
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• 2022

Background: An accurate diagnosis in patients with interstitial lung diseases (ILDs) by multidisciplinary discussion (MDD) based on histopathologic information is essential for optimal treatment. Transbronchial lung cryobiopsy (TBLC) has increasingly been used as a diagnostic alternative to surgical lung biopsy. This study aimed to evaluate the appropriate methods of TBLC in patients with ILD in Korea. Methods: A total of 27 patients who underwent TBLC were included. TBLC procedure details and clinical MDD diagnosis using TBLC histopathologic information were retrospectively analyzed. Results: All procedures were performed under general anesthesia with the fluoroscopic guidance in the operation room using flexible bronchoscopy and endobronchial balloon blocker. The median procedure duration was less than 30 minutes, and the median number of biopsies per participant was 2. Most of the bleeding after TBLC was not severe, and the rate of pneumothorax was 25.9%. The most common histopathologic pattern was alternative (48.2%), followed by indeterminate (33.3%) and usual interstitial pneumonia (UIP)/probable UIP (18.5%). In the MDD after TBLC, the most common diagnosis was idiopathic pulmonary fibrosis (33.3%), followed by smoking-related ILD (25.9%), nonspecific interstitial pneumonia (18.6%), unclassifiable-ILD (14.8%), and others (7.4%). Conclusion: This first single-center experience showed that TBLC using a flexible bronchoscopy and endobronchial balloon blocker with the fluoroscopic guidance under general anesthesia may be a safe and adequate diagnostic method for ILD patients in Korea. The diagnostic yield of MDD was 85.2%. Further studies are needed to evaluate the diagnostic yield and confidence of TBLC.