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Nectandrin A Enhances the BMP-Induced Osteoblastic Differentiation and Mineralization by Activation of p38 MAPK-Smad Signaling Pathway

  • Kim, Do Yeon;Kim, Go Woon;Chung, Sung Hyun
    • The Korean Journal of Physiology and Pharmacology
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    • v.17 no.5
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    • pp.447-453
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    • 2013
  • Osteoblastic activity of nectandrin A was examined in C2C12 cells. Nectandrin A enhances the BMP-induced osteoblastic differentiation and mineralization, manifested by the up-regulation of differentiation markers (alkaline phosphatase and osteogenic genes) and increased calcium contents. In C2C12 cells co-transfected with expression vector encoding Smad4 and Id1-Luc reporter, nectandrin A increased Id1 luciferase activity in a concentration-dependent manner, when compared to that in BMP-2 treated cells, indicating that Smad signaling pathway is associated with nectandrin A-enhanced osteoblastic differentiation in C2C12 cells. In addition, nectandrin A activated p38 mitogen-activated protein kinase (MAPK) in time- and concentration-dependent manners, and phosphorylated form of pSmad1/5/8 and alkaline phosphatase activity were both decreased when the cells were pretreated with SB203580, a p38 MAPK inhibitor, suggesting that p38 MAPK might be an upstream kinase for Smad signaling pathway. Taken together, nectandrin A enhances the BMP-induced osteoblastic differentiation and mineralization of C2C12 cells via activation of p38 MAPK-Smad signaling pathway, and it has a therapeutic potential for osteoporosis by promoting bone formation.

An Experimental Study on Mode Switching from Air-firing to Oxy-firing in Pilot-scale Combustion Systems (미분탄 순산소 연소 운전 모드 전환 과정에 대한 Pilot 규모 설비에서의 실험적 연구)

  • Choi, Chong-Gun;Na, Ik-Hwan;Lee, Jae-Wook;Chae, Tae-Young;Yang, Won;Kim, Young-Ju;Kim, Jong-An;Seo, Sang-Il
    • Journal of the Korean Society of Combustion
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    • v.16 no.3
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    • pp.12-20
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    • 2011
  • Oxy-coal combustion for $CO_2$ capture in coal power plants entails a mode switching from air-firing to oxyfiring. In this study, procedure of the mode switching was investigated and discussed through experiments in pilot scale facilities: (1) a 0.3 $MW_{th}$ furnace with a vertical single burner and a FGR(Flue Gas Recirculation) system (2) a 1 $MW_{th}$ furnace with horizontal 4 burners and a FGR system. Principle of the mode switching was established and performed with control of FD fan, FGR fan, ID fan and oxygen flow rates. We have found that equivalence ratio in the oxy-firing mode should be increased more than that in the air-firing to achieve stable mode switching. Control of FD, ID and FGR fans should be performed carefully in the mode switching, in the sense of complete combustion and flame attachment. Moisture contents in the ash and the flue gas recycled to the primary oxidizer stream should be removed to prevent condensation, corrosion and duct clogging.

Proposal of optical subscriber access network to eliminate multiple access interference using 2 dimensional optical frequency and time domain CDMA method (동시 사용자의 간섭을 제거한 광 주파수 및 시간 영역 광 CDMA를 이용한 광 가입자 망의 제안)

  • Park Sang-Jo;Kim Bong-Kyu
    • The KIPS Transactions:PartC
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    • v.13C no.2 s.105
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    • pp.161-166
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    • 2006
  • In this paper, we propose optical subscriber access network to eliminate multiple access interference using 2 dimensional(D) optical frequency and time domain CDMA method. We have numerically analyzed the characteristics of proposed system. It is seen that the excess intensity noise is the major limiting factor to the system. Also it is seen that the number of simultaneous subscribers is four times as large as the conventional ID optical system under the same bit error ratio.

Discretization of Continuous-Valued Attributes for Classification Learning (분류학습을 위한 연속 애트리뷰트의 이산화 방법에 관한 연구)

  • Lee, Chang-Hwan
    • The Transactions of the Korea Information Processing Society
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    • v.4 no.6
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    • pp.1541-1549
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    • 1997
  • Many classification algorithms require that training examples contain only discrete values. In order to use these algorithms when some attributes have continuous numeric values, the numeric attributes must be converted into discrete ones. This paper describes a new way of discretizing numeric values using information theory. Our method is context-sensitive in the sense that it takes into account the value of the target attribute. The amount of information each interval gives to the target attribute is measured using Hellinger divergence, and the interval boundaries are decided so that each interval contains as equal amount of information as possible. In order to compare our discretization method with some current discretization methods, several popular classification data sets are selected for experiment. We use back propagation algorithm and ID3 as classification tools to compare the accuracy of our discretization method with that of other methods.

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Studies on enzootic bovine leukosis II. Survey for antibodies to bovne leukemia virus in the Holstein calves in a dairy farm (축우의 유행형 (지방병성) 백혈병에 관한 연구 II. 한 유우군에서 출생한 송아지에 대한 우백혈병 바이러스 항체 검사)

  • Kim, Chan-ju;Son, Jae-young;Ko, Ki-whan
    • Korean Journal of Veterinary Research
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    • v.30 no.3
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    • pp.343-348
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    • 1990
  • Total 51 calves born from both 28 seropositive and 23 seronegative dams were subjected to study both prenatal and postnatal infections of bovine leukemia virus (BLV), and the duration of passive colostral antibody by means of immunodiffusion (ID) test. All calves were tested for precolostral and postcolostral periods by 16 months of age. The results were as follows: 1. Of 28 precolostral sera of the calves born from infected dams, one appeared positive, indicating in utero BLV infection from the dam. 2. BLV-antibody test for the postcolostral sera of the calves born from seropositive or seronegative dams showed that the colostral antibody of the calves disappeared from 2 to 6 months of age, and the increase of the number of seropositive calves initiated from 3 to 4 months of age indicated postnatal infection.

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Heat Transfer Characteristics of R-407C During Condensing Inside Horizontal Smooth and Micro-Fin Tubes (수평 평활관 및 전열촉진관내 대체 냉매 R-407C의 응축 열전달 특성에 관한 연구)

  • Roh, Geonsang;Oh, Hookyu
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.23 no.2
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    • pp.210-217
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    • 1999
  • This paper reports the experimental results on heat transfer characteristics of R-22 and R-407C(HFC-32/125/134a 23/25/52 wt%) condensing inside horizontal smooth and finned tubes. The test condensers used In the study are double pipe heat exchangers of 7.5 mm ID, 9.5 mm OD smooth tube, and 60 finned micro-fin tube with 8.53 mm ID, 9.53 mm OD. Each of these tubes was 4 000 mm long tubes connected with an U-bend. These U type two-path test tubes are divided In 8 local test sections for the identification of the local condensing heat transfer characterisitcs and pressure drop, U-bend effects on condensing flows. Inlet quality is maintained 1.0, and refrigerant mass velocity is varied from 102.0 to $301.0kg/m^2{\cdot}s$. From the results, it was found that the pressure drop of the R-407C Increased, and heat transfer coefficient decreased compared to those of R-22. In comparison condensing heat transfer characteristics of micro-fm tube with those of smooth tube, increasing of condensing heat transfer coefficient was found outstanding compared to the increasing ratio of pressure drop. Furthermore, pressure drop In U-bend showed at most a 30 % compared to the total pressure drop in the test section.

The Effectiveness of CRM Approach in Improving the Profitability of Korea Professional Baseball Industry Measured by Entropy of ID3 Decision Tree Algorithm

  • Oh, Se-Kyung;Gwak, Chung-Lee;Lee, Mi-Young
    • Journal of Information Technology Applications and Management
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    • v.18 no.3
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    • pp.91-110
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    • 2011
  • Korea professional baseball industry has grown to take the lion's share of the domestic sports industry, but still does not make break even. The purpose of this study is to examine the financial impact of adopting the Customer Relation Management (CRM) approach on the profitability of Korea professional baseball industry. We use a measuring tool called entropy used in ID3 decision tree algorithm. In the paper, we specify five the most important factors that affect spectator satisfaction based on the previous literature, perform survey analysis, calculate entropy values, and find the results. We predicted the change in revenues when we adopt CRM by checking the spectators' willingness to pay more when the conditions of each factor are improved. We find that we can reap significant fruits of the effect of CRM introduction through enhancing 'game content factor' and 'game promotion factor' among the five factors. We also find that we can increase the revenues of domestic professional baseball teams to 2.4 times or 2.1 times the current level if we manage intensively those two factors respectively. It is very surprising to see that the improvement in total revenues makes both ends meet for domestic professional baseball teams. This clearly demonstrates the effectiveness of CRM approach in improving the profitability of organizations.

A Study on the AVLS using VHF base on GPS faculty of Marine Electronic & Communication Engineering (GPS기반 VHF를 이용한 AVLS에 대한 연구)

  • Kim Chi-Yeon;Kim Geon-Ung;Choi Jo-Cheon
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.9 no.4
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    • pp.739-744
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    • 2005
  • For the structure of AVLS is required to the GPS-MDT for realtime acquisition the position reporting of vehicle and traffic management S/W. It is necessary that the MODEM using VHF transceiver base on GPS and monitoring program for display base on GIS the traffic status by vehicles position report in management system. The other wise, vehicles among management system that is required the automatic communications protocol for GPS information and mobile's ID. In his paper have studied the VHF modem for transmission the voice and data at same time and S/W for management system using GIS-tool.

A Survey of paratuberculosis by immunological methods in dairy and Korean native cattle (면역학적인 방법에 의한 한우와 유우의 요네병 발생조사)

  • Kim, Jong-man;Ahn, Jong-sam;Woo, Seung-roung;Jo, Dong-hee;Jo, Yun-sang;Park, Jeung-moon;Yoon, Yong-dhuk;Chang, Guk-hyun
    • Korean Journal of Veterinary Research
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    • v.34 no.1
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    • pp.93-97
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    • 1994
  • A immunological survey of paratuberculosis in dairy and Korean native cattles was conducted by enzyme linked immunosorbent assay(ELISA), complement fixation test(CFT), agar gel immunodiffusion test (AGID) and intradermal skin test(ID). Over all prevalence of pararuberculosis in cattles was 6.7%(109/1633) by ID, 7.5(205/2719) by AGID, 9.3% (245/2641) by CFT and 13.4%(363/2719) by ELISA. Prevalence in dairy cattle was higher than that of Korean native cattle. Of 70 ELISA-positive cattle, 23(28.6%) and 48(68.6%) cattles were classified as positive in the AGID and positive or suspect in CFT, respectively. Of 92 ELISA-suspect cattle, 32(34.9%) and 48(52.2%) cattles were classified as AGID-positive and CFT-positive or suspect, respectively. It was concluded that paratuberculosis is widespread in cattle of Korea.

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Efficient Methods for the Distributed Disaster Prevention Resources (효과적인 분산 방재자원 관리 방안)

  • Lee, Changyeol
    • Journal of the Society of Disaster Information
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    • v.7 no.4
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    • pp.294-304
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    • 2011
  • Disaster prevention resources consist of persons, equipments, goods, and facilities. Specially, equipments and goods are internally managed in the regional office, and may be leased to the inter-offices. National Disaster Management System(NDMS) managed the resources in the separated system. That is, one system is managed by regional disaster prevention system, the other is managed by the central disaster prevention system which receives the data from the regional disaster prevention system. Because the regional disaster prevention system updates the resource information quarterly, it is difficult to confirm the exact information. In this study, we propose the model which makes to supply in timely the resource to the disaster using the managed resource with RFID technology. Firstly, we classified the resources based on the resource types for the easily search. After then, we defined ID and attributes information of the resources. From the information, we described the management model for the real time resource.