• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.897-902
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• 2015

PTEN (phosphatase and tensin homologue), as a tumor suppressor gene, plays a significant role in regulating cell growth, proliferation, and apoptosis. Results from published studies for association between the PTEN IVS4 I/D (rs3830675) polymorphism and cancer risk are inconsistent and inconclusive. We therefore conducted a meta-analysis to evaluate the potential association between PTEN IVS4 I/D polymorphism and risk of cancer in detail. We searched PubMed (Medline) and EMBASE web databases to cover all relevant studies published until December 2013. The meta-analysis was carried out and pooled odds ratios (ORs) and 95% confidence intervals (95%CIs) were used to appraise the strength of association. A total of 1,993 confirmed cancer cases and 3,200 controls were included from six eligible case-control studies. Results from overall pooled analysis suggested a significant effect of the PTEN IVS4 I/D polymorphism and cancer risk in all genetic models, i.e., allele (I vs D: OR=0.743, 95%CI=0.648 to 0.852, p=0.001), homozygous (II vs DD: OR=0.673, 95%CI=0.555 to 0.816, p=0.001), heterozygous (ID vs DD: OR=0.641, 95%CI=0.489 to 0.840, p=0.001), dominant (II+ID vs DD: OR=0.626, 95%CI=0.489 to 0.802, p=0.001) and recessive (II vs DD+ID: OR=0.749, 95%CI=0.631 to 0.889, p=0.001). Significant publication bias was detected during the analysis. The present meta-analysis suggests that the PTEN IVS4 I/D polymorphism is significantly associated with reduced risk of cancer. However, future larger studies with other groups of populations are warranted to clarify this association.

• Biotechnology and Bioprocess Engineering:BBE
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• 제11권5호
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• pp.408-413
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• 2006

We assessed the ability of a Pseudonocardia sp. from soil samples to bioconvert vitamin $D_3$. The optimal culture conditions for the bioconversion of vitamin $D_3$ to active $1{\alpha}$,25-dihydroxyvitamin $D_3$ were investigated by varying the carbon and nitrogen sources, the metal salt concentrations, the initial pH, and the temperature. Microbial transformations were carried out with the addition of vitamin $D_3$ dissolved in ethanol. They were sampled by extraction with methanol-dichloromethane and the samples were examined by HPLC. Optimum culture conditions were found to be 0.4% yeast extract, 1% glucose, 3% starch, 1% fish meal, 0.2% NaCl, 0.01% $K_2HPO_4$, 0.2% $CaCO_3$, 0.01% NaF, and pH 7.0 at $28^{\circ}C$. The optimal timing of the addition of vitamin $D_3$ for the production of calcitriol by Pseudonocardia autotrophica ID9302 was concurrent with the inoculation of seed culture broth. Maximum calcitriol productivity and the yield of bioconversion reached a value of 10.4mg/L and 10.4% respectively on the 7th day in a 75L fementer jar under the above conditions.

• 한국재료학회지
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• 제31권8호
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• pp.439-444
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• 2021

The oxidation resistance of the diffusion aluminide bond coat (BC) is compromised largely by interdiffusion (ID) effects on coated turbine blades of aeroengines. The present study is designed to understand the influence of ID on βNiAl coatings or BC. In this regard, nickel substrate and CMSX-4 superalloy are deposited. In total, four sets of BCs are developed, i.e. pure βNiAl (on Ni substrate), simple βNiAl (on CMSX-4 substrate), Zr-βNiAl (on CMSX-4 substrate) and Pt-βNiAl (on CMSX-4 substrate). The main aim of this study is to understand the interdiffusion of Al, Zr and Pt during preparation and oxidation. In addition, the beneficial effects of both Zr and platinum are assessed. Pure βNiAl and simple βNiAl show Ni-out-diffusion, whereas for platinum inward diffusion to the substrate is noticed under vacuum treatment. Interestingly, Zr-βNiAl shows the least ID in all BCs and exhibit stability under both vacuum and oxidation treatments. However, its spallation resistance is slightly lower than that of Pt-βNiAl BC. All BCs show similar oxide growth trends, except for Zr-βNiAl, which exhibits two-stage oxidations, i.e. transient and steady-state. Moreover, it is suggested that the localized spallation in all BCs is caused by βNiAl - γ'-Ni₃Al transformation.

• 한국정보과학회논문지:소프트웨어및응용
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• 제26권11호
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• pp.1314-1323
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• 1999

컴퓨터의 사용이 일반화됨에 따라 데이타를 생성하고 수집하는 것이 용이해졌다. 이에 따라 데이타로부터 자동적으로 유용한 지식을 얻는 기술이 필요하게 되었다. 데이타 마이닝에서 얻어진 지식은 정확성과 이해성을 충족해야 한다. 본 논문에서는 데이타 마이닝을 위하여 퍼지 결정트리에 기반한 효율적인 퍼지 규칙을 생성하는 알고리즘을 제안한다. 퍼지 결정트리는 ID3와 C4.5의 이해성과 퍼지이론의 추론과 표현력을 결합한 방법이다. 특히, 퍼지 규칙은 속성 축에 평행하게 판단 경계선을 결정하는 방법으로는 어려운 속성 축에 평행하지 않는 경계선을 갖는 패턴을 효율적으로 분류한다. 제안된 알고리즘은 첫째, 각 속성 데이타의 히스토그램 분석을 통해 적절한 소속함수를 생성한다. 둘째, 주어진 소속함수를 바탕으로 ID3와 C4.5와 유사한 방법으로 퍼지 결정트리를 생성한다. 또한, 유전자 알고리즘을 이용하여 소속함수를 조율한다. IRIS 데이타, Wisconsin breast cancer 데이타, credit screening 데이타 등 벤치마크 데이타들에 대한 실험 결과 제안된 방법이 C4.5 방법을 포함한 다른 방법보다 성능과 규칙의 이해성에서 보다 효율적임을 보인다.Abstract With an extended use of computers, we can easily generate and collect data. There is a need to acquire useful knowledge from data automatically. In data mining the acquired knowledge needs to be both accurate and comprehensible. In this paper, we propose an efficient fuzzy rule generation algorithm based on fuzzy decision tree for data mining. We combine the comprehensibility of rules generated based on decision tree such as ID3 and C4.5 and the expressive power of fuzzy sets. Particularly, fuzzy rules allow us to effectively classify patterns of non-axis-parallel decision boundaries, which are difficult to do using attribute-based classification methods.In our algorithm we first determine an appropriate set of membership functions for each attribute of data using histogram analysis. Given a set of membership functions then we construct a fuzzy decision tree in a similar way to that of ID3 and C4.5. We also apply genetic algorithm to tune the initial set of membership functions. We have experimented our algorithm with several benchmark data sets including the IRIS data, the Wisconsin breast cancer data, and the credit screening data. The experiment results show that our method is more efficient in performance and comprehensibility of rules compared with other methods including C4.5.

• 한국멀티미디어학회논문지
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• 제18권4호
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• pp.499-505
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• 2015

Security supports are a significant factor in the design of mobile ad hoc networks. In the dynamic topology where the node changes frequently, private key generation and revocation for newly joining and leaving nodes must be considered. In addition, the identities of individual nodes must be protected as well in mobile networks to avoid personal privacy concerns. This paper proposes ID-based private key revocation scheme and non-interactive key agreement scheme in anonymous MANETs. The proposed scheme provides the user privacy using pseudonyms and private key generation and revocation schemes with consideration of dynamic user changes. Therefore, our schemes can be applied in dynamic and privacy-preserving MANETs which are helpful to share multimedia data.

• Carbon letters
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• 제10권4호
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• pp.300-304
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• 2009

Thermal emissivity of nuclear graphite was measured with its oxidation degree. Commercial nuclear graphites (IG-110, PECA, IG-430, and NBG-18) have been used as samples. Concave on graphites surface increased as its oxidation degree increased, and R value (Id/Ig) of the graphites decreased as the oxidation degree increased. The thermal emissivity increased depending on the decrease of the R (Id/Ig) value through Raman spectroscopy analysis. It was determined that the thermal emissivity was influenced by the crystallinity of the nuclear graphite.

• Mass Spectrometry Letters
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• 제11권4호
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• pp.108-112
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• 2020

A certified reference material (CRM) for the analysis of nutrient elements in an edible mushroom (Ganoderma lyceum) powder has been developed (KRISS CRM 108-10-011). The mass fractions of calcium (Ca), iron (Fe), and zinc (Zn) were measured by isotope dilution inductively coupled plasma mass spectrometry (ID ICP/MS). To dissolve the fungi cell wall of mushroom consisted of chitin fibers, sample preparation method by single reaction chamber type microwave-assisted acid digestion with acid mixtures was optimized. The mean measurement results obtained from 12 sample bottles were used to assign as the certified values for the CRM and the between-bottle homogeneities were evaluated from the relative standard deviations. The certified values were metrologically traceable to the definition of the kilogram in the International System of Units (SI). This CRM is expected to be used for validation of analytical methods or quality control of measurement results in analytical laboratories when they determine the mass fractions of elements in mushroom or other similar samples.

• 디지털산업정보학회논문지
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• 제16권4호
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• pp.29-42
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• 2020

SCADA (Supervisory Control and Data Acquisition) systems for remote monitoring, data acquisition and control are applied to major industrial infrastructures including power, water and railroad. Recently, there are many researches on key management scheme for secure communication due to change to the open network environment. These systems are located at far distances and are connected to the main control center through various types of communication methods. Due to the nature of these systems, they are becoming the significant targets of cyber attack. We propose an efficient key management scheme which is established on ID-based cryptosystem without an expensive computation on MTU (Master Terminal Unit), Sub-MTU, and RTU (Remote Terminal Unit). The proposed method is secure and effective in key management among multiple legitimate devices.

• 한국정보전자통신기술학회논문지
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• 제11권5호
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• pp.623-629
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• 2018

스마트 팩토리는 제 4차 산업혁명시대의 도래와 함께, 제조업과 정보통신기술의 결합을 통하여 사용자가 공장 내 설치된 장비의 시뮬레이션 및 시나리오 설계를 통해 자동으로 제품을 생산하는 시스템 개념으로 해외 주요국에서 이미 추진 정책 및 전략을 발표하고, 관련 기술개발에 주력하고 있다. 또한, 이러한 스마트 팩토리 구현을 위한 기반기술로서 저전력 친환경 LED 조명시스템에 대한 관심이 증대되고 있으며, LED를 활용한 통신, 위치인식 등 이른바 광 ID 관련 응용기술에 대한 연구가 활발히 진행중이다. 본 논문에서는 친환경 저전력의 LED 조명 기반의 광통신 기술을 생산설비 관리에 접목하여, 공장 내 고전압, 고전류, 발전기 등 전자기 간섭의 영향을 받지 않고, 물류 위치 및 부가정보를 안정적으로 식별할 수 있는 시스템을 제안하였으며, 기초 실험을 통해 근거리에서 8가지 컬러가변에 따른 컬러 ID 검출율이 98.8%~93.8% 수준으로 적용 가능성을 검증하였다.

• 한국멀티미디어학회논문지
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• 제12권4호
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• pp.540-549
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• 2009

Ad-hoc 네트워크는 모바일 디바이스가 무선 통신을 이용한 데이터를 전송 및 서비스를 제공한다. Ad-hoc 네트워크에서의 모바일 디바이스는 안전한 통신을 위해 인증과 암호 키 관리가 필요하다. 본 논문에서는 Ad-hoc 네트워크에서 인증과 그룹 키 관리의 동향에 대하여 알아보고, 아이디 기반의 상호 인증 및 그룹 키 설립 방안에 대하여 제안한다. 제안 방식의 아이디 기반의 상호 인증은 공유한 정보가 없는 상태에서 영지식을 이용하고, 세션 키 및 그룹 키를 설립하는데 활용된다. 또한 제안 방식을 Ad-hoc 네트워크에 적용하여 효율성 및 보안 기술에 대해 안전성을 높인다.