• The Korean Journal of Nuclear Medicine
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• v.32 no.4
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• pp.374-381
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• 1998

Purpose: I-131 labeled (2'-deoxy-2'-iodo-${\beta}$-D-arabinofuranosyl) adenine (IAD) may be involved in DNA synthesis during active proliferation of tumor cells. We conducted this study to find out the biodistribution of IAD and it's feasibility for scintigraphic tumor imaging. Materials and Methods: Tosyl acetyl-adenosine was dissolved in acetonitrile, and I-131-NaI was added and heated to synthesize IAD. Female Fisher 344 rats innoculated with breast tumor cells were injected with 0.27 MBq of IAD. Rats were sacrificed at 0.5, 1, 2, 4, 24h and the % of injected dose per gram of tissue (%ID/g) was determined. For scintigraphy, rats bearing breast cancer were administered with 1.11 MBq of IAD and imaging was performed after 2 and 24h. Then, rat body was fixed and microtomized slice was placed on radiographic film for autoradiography. Results: %ID/g of tumor was 0.74 (0.5h),0.73 (1h), 0.55 (2h), 0.38 (4h), and 0.05 (24h), respectively. At 1h after injection, %ID/g of tumor was higher than that of heart (0.34), liver (0.42), spleen (0.47), kidney (0.69), muscle (0.14), bone (0.33) and intestine (0.51). However, %ID/g of tumor was lower than blood (1.06), lung (0.77), and thyroid (177.71). At 4h, %ID/g of tumor in comparison with other tissue did not change. Tumor contrast expressed by tumor to blood ratio was 0.69 and tumor to muscle ratio was 5.11 at 1h. However, these ratios did not improve through 24h. On autoradiogram and scintigraphy at 2 and 24 hour, the tumor was well visualized. Conclusion: This results suggest that IAD may have a potential for tumor scintigraphy. However, further work is needed to improve localization in tumor tissue.

• Environmental Mutagens and Carcinogens
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• v.22 no.2
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• pp.65-69
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• 2002

To elucidate the effect of microsphere coinjection on the administration of oligodeoxynucleotides (ODN), we have investigated biodistribution of ［S-35］-labeled antisense ODN targeted to cAMP-dependent protein kinase (PKA) RI-$\alpha$ subunit in nude mice xenografted with WiDr (human colon cancer, ATCC CCL218). The strategy of using microsphere has been proposed for cancer treatment as a carrier of therapeutic ODN so that it could offer an advantage with respect to maintaining constant ODN levels in blood and obtaining higher therapeutic ODN concentration at tumor sites. Comparative biodistribution studies were performed in nude mice (female, 20 g of body weight, n = 4-6) xenografted with WiDr cancer cells, when 0.1 $\mu$Ci (specific activity, 2.94 mCi/$\mu$mole) of ［S-35］-labeled RI-$\alpha$ antisense ODN was injected alone or with microsphere (PLG-18, polylactic copolymer with cationic surfactant DDAB18). Peak tumor uptake of ［S-35］-labeled ODN was significantly increased from 17.7% (at 6 h) of injected dose per gram of tissue (ID/g) to 42.5% (at 24 h) ID/g when microsphere was coinjected with ODN. The different biodistribution in the kidney accumulation (e.g., 100.2% ID/g for ODN alone and 54.9%/ID/g for microshpere coinjection) may contribute to higher blood concentration (e.g., 21.5%ID/$m\ell$ for ODN alone and 37.5%ID/$m\ell$ for microsphere coinjection) of radiolabeled ODN. Of importance is the fact that the whole body retention of radioactivity increased with microsphere coinjection from 50.8%ID/g to 68.0%ID/g after 24-h of injection. This decreased kidney accumulation and increased whole body retention of ［S-35］-labeled ODN resulted in a significant improvement of ODN targeting to the tumor site. In conclusion, the coinjection of microsphere appears to be an important carrier system in vehiculation of antisense oligonucleotide to the tumor tissue in vivo.

• The Korean Journal of Nuclear Medicine
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• v.28 no.3
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• pp.331-337
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• 1994

In order to develop a $^{18}F$-labelled myocardial perfusion agent(flow tracer) for PET, $^{18}F$-labelled organic ammonium cations were synthesized and evaluated in relation to their biodistribution. Five quaternary organic ammonium compounds were labelled with $^{18}F$ in a side chain with moderate to good yields by direct introduction of $^{18}F$-fluoride. Radiochemical yields have been achieved in 30-40min by the precursors (tosylates) in dimethylsulfoxide 15-60% (decay corrected). The reaction was found to be autocatalyzed. A remote controlled procedure was developed in these synthesis. $^{18}F$-Labelling and HPLC-purification of com-pounds needed about 60 min(Yield; 7-20%). Up to now the two compounds N-4-[$^{18}F$]fluorobutyl-pyridinium cation(1) and N, N dibenzyl-4(2-[$^{18}F$]fluoroethyl)piperidinium cation(2) were investigated in relation to their biodistribution in mice. Compound 1 showed at 1 min post injection the high uptake of 19.22% ID/g organ in the myocardium but a following fast decline to 1.12% ID/g organ after 40min. Uptake of compound 2 was after 1min in the heart 5.90% ID/g organ but after 40min at the relative high value of 4.33% ID/g organ. Heart:blood ratio for compound(1) at 1 min was 8.3, at 40 min 2.6 for compound II 2.0(1min) and 15.0(40 min). As data of compound 2 showed greater heart uptake, slower myocardial release, and higher heart: blood ratios, compound 2 is a good candidate for further evaluation.

• Macromolecular Research
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• v.14 no.4
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• pp.473-477
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• 2006

The above described semi-transparent monochromators have been operational since 1997. Four units are permanently operating at the ESRF beam line ID14. Two units are in continuous operation at ID 10 and one unit is installed at the APS beamline 8-ID in USA. The water cooling of the crystals is currently being revised and above we showed that improvements most likely are possible by using micro fluidics techniques. Further tests will be performed in collaboration with the CEA-France and tested at ESRF. Parallel developments including nanofluids as coolants are under evaluation. Combination of nanofluidics and microfluidics cooling devices are under study. The authors are grateful to C. Gillot and J-A. Gruss for useful discussions and advices, and to S.Mcheik for his work on the thermal model.

• Geophysics and Geophysical Exploration
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• v.6 no.4
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• pp.180-186
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• 2003

We have developed an one-dimensional (ID) inversion program that can invert multiple frequency small-loop EM data from horizontal coplanar (HCP) and vertical coplanar (VCP) configurations. The inverse problem is solved using least-squares method with active constraint balancing (ACB) method and Jacobian matrix is calculated analytically. Tests using synthetic data from simple ID models indicate that conductivity and depth of each layer can be estimated properly when both real and imaginary data are used together.

• The Transactions of the Korea Information Processing Society
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• v.4 no.9
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• pp.2309-2314
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• 1997

The study introduces a neural network to predict the bankruptcy of insurance companies. As a method to optimize the network, a genetic algorithm suggests optimal structure and network parameters. The neural network designed by genetic algorithm is compared with discriminant analysis, logistic regression, ID3, and CART. The robust neural network model shows the best performance among those models compared.

• Communications of the Korean Mathematical Society
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• v.20 no.3
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• pp.611-621
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• 2005

This paper introduces an ID based authenticated two pass key agreement protocol of Smart[4] which used the Weil pairing. We propose other an ID based authenticated two pass key agreement protocol which using the Tate Pairing. We will compare protocol of Smart with this protocol.

• Review of KIISC
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• v.4 no.1
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• pp.20-29
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• 1994

Shamir가1984년 개인정보(ID)를 이용한 암호시스템의 개념을 제안한 이래 Fiat-Shamir방식을 필두로 하여 Ohta, Guillou 등이 개인정보에 기반을 둔 서명법과 영지식 대화형 증명방식을 조합한 각종 개인식별 방식 및 디지탈 서명 방식들이 제안되어 왔다. 또한, Okamoto 등이 개인 정보를 이용한 키분배 방식을 제안하였다. 본고에서는 지금까지 제안된 개인정보를 이용한 암호시스템의 대표적인 방식들에 대해 그들의 특징과 장단점을 비교 분석하였다.

• Review of KIISC
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• v.19 no.4
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• pp.36-43
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• 2009

키 교환은 이미 오래전부터 많이 연구되어 왔으나 끊임없이 변화하는 통신 환경과 그에 따른 새로운 위협에 따라 안전한 키 교환이 필요하게 되었다. 특히 키 교환을 수행하는 개체의 비밀키가 노출되었을 경우에도 안전한 키 교환 프로토콜이 필요하다. 또한 그룹의 구성원 수와 상관없이 상수 라운드를 가지는 효율적인 키 교환 프로토콜이 요구된다. 본 논문에서는 ID 기반의 그룹 키 교환 기법에 대한 기술 동향을 분석하고, 그룹 키 교환 환경에서의 다양한 공격 환경 및 공격자에 따른 안전성 모델에 대한 안전성을 분석한다.

• Proceedings of the Korea Multimedia Society Conference
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• 2003.11a
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• pp.1-4
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• 2003

최근에 침입 탐지 시스템은 네트워크 보안의 강화를 위해서 방화벽과 침입탐지 시스템 상호간의 연동으로 침입자의 연결 상태를 차단하는 방법도 개발되었다. 하지만 방화벽뿐만 아니라 침입탐지 시스템도 공격자에 의한 우회공격에 대해서는 아직 상당부분 방어할 수 없다. 또한 우회공격 탐지 모듈도 기존의 IDS와 Rule의 중복이 불가피하다. 본 논문은 취약점 진단 스크립트를 통해 IDS의 취약점 진단 후 IDS우회탐지공격 시스템의 Rule을 최적화 하여 우회공격을 효율적으로 탐지 해내는 시스템을 제안한다.