• Title/Summary/Keyword: ICS

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Clinical Efficacy of Intra-Operative Cell Salvage System in Major Spinal Deformity Surgery

  • Choi, Ho Yong;Hyun, Seung-Jae;Kim, Ki-Jeong;Jahng, Tae-Ahn;Kim, Hyun-Jib
    • Journal of Korean Neurosurgical Society
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    • v.62 no.1
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    • pp.53-60
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    • 2019
  • Objective : The purpose of this study was to determine the efficacy of intra-operative cell salvage system (ICS) to decrease the need for allogeneic transfusions in patients undergoing major spinal deformity surgeries. Methods : A total of 113 consecutive patients undergoing long level posterior spinal segmental instrumented fusion (${\geq}5$ levels) for spinal deformity correction were enrolled. Data including the osteotomy status, the number of fused segments, estimated blood loss, intra-operative transfusion amount by ICS (Cell $Saver^{(R)}$, $Haemonetics^{(C)}$, Baltimore, MA, USA) or allogeneic blood, postoperative transfusion amount, and operative time were collected and analyzed. Results : The number of patients was 81 in ICS group and 32 in non-ICS group. There were no significant differences in demographic data and comorbidities between the groups. Autotransfusion by ICS system was performed in 53 patients out of 81 in the ICS group (65.4%) and the amount of transfused blood by ICS was 226.7 mL in ICS group. The mean intra-operative allogeneic blood transfusion requirement was significantly lower in the ICS group than non-ICS group (2.0 vs. 2.9 units, p=0.033). The regression coefficient of ICS use was -1.036. Conclusion : ICS use could decrease the need for intra-operative allogeneic blood transfusion. Specifically, the use of ICS may reduce about one unit amount of allogeneic transfusion in major spinal deformity surgery.

Improvement of Fringe Area using ICS Extremely Low Power Repeater (ICS 극소출력 중계기를 이용한 난시청 개선)

  • Choi, Soo-cheol;Cho, Ki-ryang
    • Journal of Broadcast Engineering
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    • v.21 no.1
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    • pp.97-104
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    • 2016
  • In this paper, in order to relieve the area of terrestrial DTV broadcasting, we watch the same channel DTV Repeater output ICS using nano field test and analysis of effect was proven. Interspersed throughout the blanket area(natural) and buildings(artificially) 7 established the field selected as the test area, and each station(KBS1, KBS2, MBC, SBS, EBS) Extremely Low Power ICS Repeater the same channel of the receiving field strength and after install, SNR(Signal to Noise Ratios) verify the equipment to measure the efficacy and minimal output for future ICS type nav should you wish to provide a research-based for the spread.

A Study on the Framework of Integrated Vulnerability Analysis of Domestic Nuclear Facilities (국내 원자력 시설 통합 취약점 분석 프레임워크 연구)

  • Mi-Joo Shin;Seong-su Yoon;Ieck-chae Euom
    • Convergence Security Journal
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    • v.22 no.1
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    • pp.11-17
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    • 2022
  • Cyber attacks on national infrastructure, including large-scale power outages in Ukraine, have continued in recent years. As a result, ICS-CERT vulnerabilities have doubled compared to last year, and vulnerabilities to industrial control systems are increasing day by day. Most control system operators develop vulnerability countermeasures based on the vulnerability information sources provided by ICS-CERT in the United States. However, it is not applicable to the security of domestic control systems because it does not provide weaknesses in Korean manufacturers' products. Therefore, this study presents a vulnerability analysis framework that integrates CVE, CWE, CAPE, and CPE information related to the vulnerability based on ICS-CERT information (1843 cases). It also identifies assets of nuclear facilities by using CPE information and analyzes vulnerabilities using CVE and ICS-CERT. In the past, only 8% of ICS-CERT's vulnerability information was searched for information on any domestic nuclear facility during vulnerability analysis, but more than 70% of the vulnerability information could be searched using the proposed methodology.

Blood Eosinophil Counts in Chronic Obstructive Pulmonary Disease: A Biomarker of Inhaled Corticosteroid Effects

  • Singh, Dave
    • Tuberculosis and Respiratory Diseases
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    • v.83 no.3
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    • pp.185-194
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    • 2020
  • Blood eosinophil counts have emerged as a chronic obstructive pulmonary disease (COPD) biomarker that predict the effects of inhaled corticosteroids (ICS) in clinical practice. Post-hoc and prospective analysis of randomized control trials have shown that higher blood eosinophil counts at the start of the study predict a greater response to ICS. COPD patients with frequent exacerbations (2 or more moderate exacerbations/yr) or a history of hospitalization have a greater response to ICS. Ex-smokers also appear to have a greater ICS response. Blood eosinophil counts can be combined with clinical information such as exacerbation history and smoking status to enable a precision medicine approach to the use of ICS. Higher blood eosinophil counts are associated with increased eosinophilic lung inflammation, and other biological features that may contribute to the increased ICS response observed. Emerging data indicates that lower blood eosinophil counts are associated with an increased risk of bacterial infection, suggesting complex relationships between eosinophils, ICS response, and the airway microbiome.

Optimal Conditions for As(III) Removal by Filtration System Packed with Different Ratio of Iron-Coated Sand and Manganese-Coated Sand (철 및 망간코팅사 충전비를 달리한 여과시스템에서 3가 비소 제거의 최적 조건)

  • Chang, Yoon-Young;Kim, Kwang-Seob;Song, Ki-Hoon;Yang, Jae-Kyu
    • Journal of Korean Society of Environmental Engineers
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    • v.28 no.11
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    • pp.1186-1191
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    • 2006
  • Removal efficiency of As(III) through oxidation and adsorption in column reactors was investigated at different ratios of manganese-coated sand(MCS) and iron-coated sand(ICS) : MCS-alone, ICS-alone and both of ICS and MCS. The breakthrough of arsenic immediately occurred from a column reactor with MCS-alone. However, most of the arsenic present in the effluent was identified as As(V) due to the oxidation of As(III) by MCS. While five-times delayed breakthrough of arsenic was observed from a column reactor with ICS-alone. At a complete breakthrough of arsenic, the removed As(III) was 36.1 mg with 1 kg ICS. To find an optimum ratio of ICS and MCS in the column packed with both ICS and MCS, the removal efficiency of As(III) was investigated at three different ratios of ICS/MCS with a fixed amount of ICS. The breakthrough time of arsenic was quite similar in the different ratios ICS/MCS. However, much slower breakthrough of arsenic was observed as the ratio of ICS/MCS decreased. As the ratio of ICS/MCS decreased the concentration of As(III) in the effluent decreased and then showed below 50 ppb at an equal amount of ICS and MCS, suggesting more efficient oxidation of As(III) by greater amount of MCS. When a complete breakthrough of arsenic occurred, the removed total arsenic with an equal amount of ICS and MCS was 68.5 mg with 1 kg of filter material.

Design Challenges and Solutions for Ultra-High-Density Monolithic 3D ICs

  • Panth, Shreepad;Samal, Sandeep;Yu, Yun Seop;Lim, Sung Kyu
    • Journal of information and communication convergence engineering
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    • v.12 no.3
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    • pp.186-192
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    • 2014
  • Monolithic three-dimensional integrated chips (3D ICs) are an emerging technology that offers an integration density that is some orders of magnitude higher than the conventional through-silicon-via (TSV)-based 3D ICs. This is due to a sequential integration process that enables extremely small monolithic inter-tier vias (MIVs). For a monolithic 3D memory, we first explore the static random-access memory (SRAM) design. Next, for digital logic, we explore several design styles. The first is transistor-level, which is a design style unique to monolithic 3D ICs that are enabled by the ultra-high-density of MIVs. We also explore gate-level and block-level design styles, which are available for TSV-based 3D ICs. For each of these design styles, we present techniques to obtain the graphic database system (GDS) layouts, and perform a signoff-quality performance and power analysis. We also discuss various challenges facing monolithic 3D ICs, such as achieving 50% footprint reduction over two-dimensional (2D) ICs, routing congestion, power delivery network design, and thermal issues. Finally, we present design techniques to overcome these challenges.

Evaluation of Mental Status in High-Risk Neonates using Infants Coma Scale (고위험신생아의 의식수준 사정을 위한 Infants Coma Scale의 개발과 적용)

  • Ahn, Young-Mee;Sohn, Min;Lee, Sang-Mi
    • Journal of Korean Academy of Nursing
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    • v.40 no.4
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    • pp.561-570
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    • 2010
  • Purpose: This was a cross sectional descriptive study to introduce the Infants Coma Scale (ICS), describe mental status of high risk infants using ICS and explore the relationships between ICS and clinical variables in infants hospitalized in a neonatal intensive care unit of a university hospital in Korea. Methods: After ICS was developed and tested by the authors, a research nurse evaluated the mental status of the infants using the English version of ICS and obtained clinical information on the infants from their medical records. Results: Data from 88 infants were analyzed. About 60% were male, 90% were preterm births, and 40% had pathologic abnormalities. Their mean gestational age was 32.4 (${\pm}3.50$) weeks and the mean birth weight was 1,842 (${\pm}728.6$) grams. The Cronbach's alpha for the ICS was .78. There was a statistically significant positive correlation between ICS total score and five clinical variables including gestational age, birth weight, 1 and 5 min Apgar scores and respiration status. Conclusion: Mental status is an important parameter in nursing assessment. ICS is a valid and reliable instrument, which clinicians can easily use to evaluate the mental status of high risk infants.

Association between Inhaled Corticosteroid Use and SARS-CoV-2 Infection: A Nationwide Population-Based Study in South Korea

  • Lee, Sang Chul;Son, Kang Ju;Han, Chang Hoon;Jung, Ji Ye;Park, Seon Cheol
    • Tuberculosis and Respiratory Diseases
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    • v.85 no.1
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    • pp.80-88
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    • 2022
  • Background: Although it is known that inhaled corticosteroid (ICS) use may increase the risk of respiratory infection, its influence on the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains unknown. Thus, the aim of this study was to investigate the association between ICS use and the positivity of SARS-CoV-2 infection among patients with chronic respiratory diseases. Methods: Nationwide data of 44,968 individuals with chronic respiratory diseases tested for SARS-CoV-2 until May 15, 2021 were obtained from the Ministry of Health and Welfare and Health Insurance Review and Assessment Service in Korea. The positivity of SARS-CoV-2 infection was retrospectively analysed according to the prescription, type, and dose of ICS taken one year before SARS-CoV-2 test. Results: Among 44,968 individuals tested, 931 (2.1%) were positive for SARS-CoV-2. A total of 7,019 patients (15.6%) were prescribed ICS one year prior to being tested for SARS-CoV-2. Low, medium, and high doses of ICS were prescribed in 7.5%, 1.6%, and 6.5% of total cases, respectively. Among types of ICS, budesonide, fluticasone, beclomethasone, and ciclesonide were prescribed in 3.7%, 8.9%, 2.3%, and 0.6% of total cases, respectively. A multivariate analysis showed no significant increase in infection with ICS use (odds ratio, 0.84; 95% confidence interval, 0.66-1.03). Moreover, there were no associations between the positivity of infection and the dose or type of ICS prescribed. Conclusion: Prior ICS use did not increase the positivity for SARS-CoV-2 infection. Moreover, different doses or types of ICS did not affect this positivity.

Bringing 3D ICs to Aerospace: Needs for Design Tools and Methodologies

  • Lim, Sung Kyu
    • Journal of information and communication convergence engineering
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    • v.15 no.2
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    • pp.117-122
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    • 2017
  • Three-dimensional integrated circuits (3D ICs), starting with memory cubes, have entered the mainstream recently. The benefits many predicted in the past are indeed delivered, including higher memory bandwidth, smaller form factor, and lower energy. However, 3D ICs have yet to find their deployment in aerospace applications. In this paper we first present key design tools and methodologies for high performance, low power, and reliable 3D ICs that mainly target terrestrial applications. Next, we discuss research needs to extend their capabilities to ensure reliable operations under the harsh space environments. We first present a design methodology that performs fine-grained partitioning of functional modules in 3D ICs for power reduction. Next, we discuss our multi-physics reliability analysis tool that identifies thermal and mechanical reliability trouble spots in the given 3D IC layouts. Our tools will help aerospace electronics designers to improve the reliability of these 3D IC components while not degrading their energy benefits.

Study on Thermal Characteristics of Smart LED Driver ICs Package (일체형 스마트 LED Driver ICs 패키지의 열 특성 분석)

  • Kang, Ey Goo
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.29 no.2
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    • pp.79-83
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    • 2016
  • This research was analyzed thermal characteristics that was appointed disadvantage when smart LED driver ICs was packaged and we applied extracted thermal characteristics for optimal layout design. We confirmed reliability of smart LED driver ICs package without additional heat sink. If the package is not heat sink, we are possible to minimize package. For extracting thermal loss due to overshoot current, we increased driver current by two and three times. As a result of experiment, we obtained 22 mW and 49.5 mW thermal loss. And we obtained optimal data of 350 mA driver current. It is important to distance between power MOSFET and driver ICs. If thhe distance was increased, the temperature of package was decreased. And so we obtained optimal data of 3.7 mm distance between power MOSFET and driver ICs. Finally, we fabricated real package and we analyzed the electrical characteristics. We obtained constant 35 V output voltage and 80% efficiency.