• 융합정보논문지
• /
• 제9권9호
• /
• pp.195-200
• /
• 2019

국민건강보험 청구자료는 급여 지급을 위한 자료로 질환에 대한 유병 및 발생자료는 아니므로 보건학적 연구 자료로 활용하기 위해서는 진료에피소드개념을 적용하여 재가공이 필요하다. 따라서 건강보험 청구자료의 보건학적 연구 자료로 활용하기 위한 시범적 진료에피소드 자료를 구축하는 것이 목적이다. 본 연구에서는 무진료기간을 퇴원한 당일 입원한 경우 월 단위 분리청구를 보정하기 위해 0으로 정의하였다. 서울지역에 한하여 호흡기계 질환(ICD10: J00-J99)및 심혈관계 질환(ICD10: I00-I99) 발생의 진료개시일부터 입원 이후 재입원까지 경향을 확인하였다. 무진료기간이 0일 일 때 자료 감소율은 건강보험청구자료의 월 단위 분리청구건으로 인한 것으로 판단된다. 또한 의료기간 종별에 따라 월 단위 분리청구 경향 차이가 있는 것으로 확인 하였다. 본 연구를 통해 구축된 시범적 진료에피소드자료는 기초적 역학정보를 산출하는 자료처리 기법으로 이용될 수 있을 것이다.

• Korean Circulation Journal
• /
• 제53권9호
• /
• pp.621-631
• /
• 2023

Background and Objectives: The morphology-voltage-P-wave duration (MVP) electrocardiography (ECG) risk score is a newly defined scoring system that has recently been used for atrial fibrillation (AF) prediction. The aim of this study was to evaluate the ability of the MVP ECG risk score to predict AF in patients with an implantable cardioverter defibrillator (ICD) and heart failure with reduced ejection fraction in long-term follow-up. Methods: The study used a single-center, and retrospective design. The study included 328 patients who underwent ICD implantation in our hospital between January 2010 and April 2021, diagnosed with heart failure. The patients were divided into low, intermediate and high-risk categories according to the MVP ECG risk scores. The long-term development of atrial fibrillation was compared among these 3 groups. Results: The low-risk group included 191 patients, the intermediate-risk group 114 patients, and the high-risk group 23 patients. The long-term AF development rate was 12.0% in the low-risk group, 21.9% in the intermediate risk group, and 78.3% in the high-risk group. Patients in the high-risk group were found to have 5.2 times higher rates of long-term AF occurrence compared to low-risk group. Conclusions: The MVP ECG risk score, which is an inexpensive, simple and easily accessible tool, was found to be a significant predictor of the development of AF in the long-term follow-up of patients with an ICD with heart failure with reduced ejection fraction. This risk score may be used to identify patients who require close follow-up for development and management of AF.

• 한국게임학회 논문지
• /
• 제20권1호
• /
• pp.107-120
• /
• 2020

세계보건기구의 ICD-11 개정 이래 인터넷게임이용장애에 대한 사회적 담론의 수위가 높아지고 있다. 그러나 기존의 연구는 게임이용장애 혹은 중독에 대한 용어와 인과관계조차 혼재되어 있는 실정이다. 본 연구는 인터넷게임중독에 초점을 두고 만 16~18세 고등학생을 대상으로 연구를 진행하였다. 분석 결과, 일상생활과 자아조절능력에 지장이 클수록 인터넷게임중독에 빠질 위험이 높은 것으로 나타났다. 본 연구는 전문의 자문과 설문을 통해 2차 검증을 실시한 연구로써 학술적, 실무적 의의를 가진다.

• BMB Reports
• /
• 제44권3호
• /
• pp.199-204
• /
• 2011

Ephrin signaling is involved in various morphogenetic events, such as axon guidance, hindbrain segmentation, and angiogenesis. We conducted a yeast two-hybrid screen using the intracellular domain (ICD) of EphrinB1 to gain biochemical insight into the function of the EphrinB1 ICD. We identified the transcriptional co-repressor xTLE1/Groucho as an EphrinB1 interacting protein. Whole-mount in situ hybridization of Xenopus embryos confirmed the co-localization of EphrinB1 and a Xenopus counterpart to TLE1, xTLE4, during various stages of development. The EphrinB1/xTLE4 interaction was confirmed by co-immunoprecipitation experiments. Further characterization of the interaction revealed that the carboxy-terminal PDZ binding motif of EphrinB1 and the SP domain of xTLE4 are required for binding. Additionally, phosphorylation of EphrinB1 by a constitutively activated fibroblast growth factor receptor resulted in loss of the interaction, suggesting that the interaction is modulated by tyrosine phosphorylation of the EphrinB1 ICD.

• 한국게임학회 논문지
• /
• 제21권3호
• /
• pp.91-106
• /
• 2021

본 연구는 게임 이용 장애 질병 코드화라는 맥락에서 게임에 대한 언론 보도의 특징을 살펴보고자 했다. 이를 위해 2019년 5월부터 2020년 8월까지 국내 5개의 종합일간지에 보도된 게임 기사 694건을 분석했다. 그 결과, 게임 산업에 대한 보도의 비율이 매우 높았으나 주로 산업 동향·기업사 경영 현황에 관한 보도였다. 정책 보도는 규제 정책이 압도적으로 많았고 특히 중독 관련 정책 보도가 주를 이뤘다. WHO의 질병 코드화를 찬성하는 의견만 다룬 보도는 매우 적었고 반대하는 의견만 다루는 보도와 찬반 의견을 모두 다루는 보도량이 비슷한 비율을 보였다. 반대 근거로는 산업계와 학계의 관점이 반영돼 있었다. 이용 효과 보도는 매우 낮은 비율을 보였으나 게임을 극단적인 범죄·일탈행위의 원인으로 보도하는 기존 관행을 그대로 따르고 있음을 알 수 있었다.

• 한국게임학회 논문지
• /
• 제19권1호
• /
• pp.135-146
• /
• 2019

2018년부터 국제보건기구의 게임 장애의 국제 질병 코드(ICD-11) 등재 계획이 본격화하면서 세계적으로 학자들 간에 뜨거운 토론이 있었다. 하지만 대한민국은 등재의 부당함에 대한 학문적 근거 제시 없이 회피만 해온 것 같다. 본 논문에서는 게임 중독/장애와 관련한 과거의 학술 연구의 쟁점과 연구 오류 및 왜곡 사례들을 뇌 사진 판독과 게임 중독/이상 진단 도구의 적절성 등을 중심으로 짚어 본다. 본 분석은 게임의 과도한 사용이 게임의 질병 코드 등재의 충분 조건이 아니며 대다수의 건강한 게이머들에게 부당한 낙인을 찍어버릴 위험이 있음을 밝힌다.

• Journal of Digestive Cancer Reports
• /
• 제9권2호
• /
• pp.57-59
• /
• 2021

Carcinoid tumor is called as neuroendocrine tumor and is classified into neuroendocrine tumor Grade 1, neuroendocrine tumor Grade 2, and neuroendocrine carcinoma based on the differentiation of tumors. Recently, the incidence of rectal carcinoid tumor has been increasing probably due to the increased interest on screening colonoscopy and the advancement of endoscopic imaging technology. As the rectal carcinoid shows a wide range of clinical characteristics such as metastasis and long-term prognosis depending on the size and histologic features, it is a challenge to give a consistent diagnostic code in patients with the rectal carcinoid. If the rectal carcinoid tumor is less than 1 cm in size, it can be given as the code of definite malignancy or the code of uncertain malignant potential according to International Classification of Diseases for Oncology (ICD-O) by World Health Organization (WHO). Because patients get different amount of benefit from the insurance company based on different diagnostic codes, this inconsistent coding system has caused a significant confusion in the clinical practice. In 2019, WHO updated ICD-O and Statistics Korea subsequently changed Korean Standard Classification of Diseases (KCD) including the code of rectal carcinoid tumors. This review will summarize what has been changed in recent ICD-O and KCD system regarding the rectal carcinoid tumor and surmise its clinical implication.

• Journal of Dental Anesthesia and Pain Medicine
• /
• 제23권1호
• /
• pp.45-51
• /
• 2023

Andersen-Tawil syndrome (ATS) is a rare genetic disease characterized by a triad of episodic flaccid muscle weakness, ventricular arrhythmias, and physical anomalies. ATS patients have various cardiac arrhythmias that can cause sudden death. Implantation of an implantable cardioverter-defibrillator (ICD) is required when life-threatening cardiac arrhythmias do not respond to medical treatment. An 11-year-old girl underwent surgery for an ICD implantation. For general anesthesia in ATS patients, anesthesiologists should focus on the potentially difficult airway, serious cardiac arrhythmias, such as ventricular tachycardia (VT), and delayed recovery from neuromuscular blockade. We followed the difficult airway algorithm, avoided drugs that can precipitate QT prolongation and fatal cardiac arrhythmias, and tried to maintain normoxia, normocarbia, normothermia, normoglycemia, and pain control for prevention of sympathetic stimulation. We report the successful application of general anesthesia for ICD implantation in a pediatric patient with ATS and recurrent VT.

• BMB Reports
• /
• 제56권5호
• /
• pp.275-286
• /
• 2023

Cancer immunotherapy has been acknowledged as a new paradigm for cancer treatment, with notable therapeutic effects on certain cancer types. Despite their significant potential, clinical studies over the past decade have revealed that cancer immunotherapy has low response rates in the majority of solid tumors. One of the key causes for poor responses is known to be the relatively low immunogenicity of solid tumors. Because most solid tumors are immune desert 'cold tumors' with antitumor immunity blocked from the onset of innate immunity, combination therapies that combine validated T-based therapies with approaches that can increase tumor-immunogenicity are being considered as relevant therapeutic options. This review paper focuses on immunogenic cell death (ICD) as a way of enhancing immunogenicity in tumor tissues. We will thoroughly review how ICDs such as necroptosis, pyroptosis, and ferroptosis can improve anti-tumor immunity and outline clinical trials targeting ICD. Finally, we will discuss the potential of ICD inducers as an adjuvant for cancer immunotherapy.

• 융합경영연구
• /
• 제4권4호
• /
• pp.1-16
• /
• 2016

In today's knowledge-based economy, measurement and disclosure (M&D) of intellectual capital (IC) are crucial for enhancing business performance and competitiveness. In the global world, M&D of IC are useful means to keep investors well-informed and reduce information asymmetry. At present, very few leading corporations in India have disclosed IC information on a 'voluntary' basis. Traditional accounting practices, therefore, will need to assimilate innovations that seek to meaningfully represent the 'true-value' of the intangible assets of the company. This is an exploratory study of IC M&D by 8 Indian companies over 5-year period, using 'content' analysis and market-value-added (MVA) as research methodologies. The annual reports of companies were collected from their respective websites. As part of present study, various statistical techniques have been used to analyze the data. The findings show that the sample companies, on an average, reported a positive value of IC, along with wide-disparity, low-level of ICD. Unfortunately, the omission of IC information may adversely influence the quality of decisions made by shareholders, or lead to material misstatements. Finally, we recommend to "the international accounting bodies, to take the lead by establishing a harmonized ICD standard, and provide guidance to the big listed-companies for proper measurement and disclosure of IC, both for internal and external users."