• 한국비블리아학회지
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• 제20권2호
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• pp.91-108
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• 2009

국립중앙도서관 디지털도서관(NDL)은 IC 공간 구축 전략을 통해 디지털 통합 서비스 및 다기능 복합 문화 공간 및 체계를 구축하였다. 본 연구는 NDL IC 모형의 공공도서관 적용을 위해 공공도서관의 IC 개념 정립과 IC 개념도입에 따른 공공도서관 건축 기본구상을 개발하는 것이다. 공공도서관에서 IC 개념의 성공적 도입과 구축을 위해서는 IC 공공도서관 공간개념과 구축방향, IC 공공도서관의 물리적공간과 도입 시설계획, IC 공공도서관에 대한 점진적 접근방법 등에 관한 기본구상이 선행되어야 한다.

• 정보관리연구
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• 제43권1호
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• pp.23-39
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• 2012

본 연구는 현대 정보화 시대에서 우려되는 디지털격차를 해결하는 대안이 IC(Information Commons)이며, IC의 가치가 OA(Open Acess)와 민주주의의 필수요소에 있다는 전제로 진행되었다. 그러한 가치 실현의 기반이 되는 물리적 공간을 선행연구를 토대로 6개로 구분하였고, 6개 IC공간의 이용행태를 조사, 분석하여 향후 공공도서관의 IC 적용 시 고려할 부분을 제안하였다.

• 한국실내디자인학회논문집
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• 제27권2호
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• pp.86-97
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• 2018

In modern times, pluralistic social phenomena in which various values are pursed and recognized appear. The modern society called hyper-connected, intelligence information and zero marginal cost society in which shared value is commonly emphasized faces a paradigm shift to shared society system. In particular, sharing-based activities related with intelligence information sectors more prominently emerge in the high-tech informatization which has been accelerated. The purpose of this study is to understand design factors related with how attribution of the sharing culture is expressed in library spaces and examine how sharing infrastructure is established in users' spaces. As a research method, it initially conducted theoretical consideration of the sharing culture and information spaces, which can be regarded as sociocultural phenomena in modern times. Then, it drew sharing culture-based spatial design factors-access, openness and plurality. It analyzed configuration of spaces for sharing information-Cultural Commons (CC), Information Commons(IC) and Learning Commons (LC) - and infrastructure of information spaces, for library cases-five domestic and foreign public libraries-. The findings show that modern library spaces reflect historical needs for the sharing culture and actively serve their roles through spatial infrastructure including contents (programs) and services for sharing knowledge. The study is determined to be valuable as basic data in establishing the infrastructure of information spaces reflecting modern social trends and cultural phenomena, in expecting spatial structures in which knowledge is reproduced and planning spaces of libraries in the future.

• Journal of Microbiology and Biotechnology
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• 제29권4호
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• pp.651-657
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• 2019

Although smallpox was eradicated in 1980, it is still considered a potential agent of biowarfare and bioterrorism. Smallpox has the potential for high mortality rates along with a major public health impact, eventually causing public panic and social disruption. Passive administration of neutralizing monoclonal antibodies (mAbs) is an effective intervention for various adverse reactions caused by vaccination and the unpredictable nature of emerging and bioterrorist-related infections. Currently, vaccinia immune globulin (VIG) is manufactured from vaccinia vaccine-boosted plasma; however, this production method is not ideal because of its limited availability, low specific activity, and risk of contamination with blood-borne infectious agents. To overcome the limitations of VIG production from human plasma, we isolated two human single-chain variable fragments (scFvs), (SC34 and SC212), bound to vaccinia virus (VACV), from a scFv phage library constructed from the B cells of VACV vaccine-boosted volunteers. The scFvs were converted to human IgG1 (VC34 and VC212). These two anti-VACV mAbs were produced in Chinese Hamster Ovary (CHO) DG44 cells. The binding affinities of VC34 and VC212 were estimated by competition ELISA to $IC_{50}$ values of $2{\mu}g/ml$ (13.33 nM) and $22{\mu}g/ml$ (146.67 nM), respectively. Only the VC212 mAb was proven to neutralize the VACV, as evidenced by the plaque reduction neutralization test (PRNT) result with a $PRNT_{50}$ of ~0.16 mg/ml (${\sim}1.07{\mu}M$). This VC212 could serve as a valuable starting material for further development of VACV-neutralizing human immunoglobulin for a prophylactic measure against post-vaccination complications and for post-exposure treatment against smallpox.