• Journal of Pharmaceutical Investigation
• /
• v.31 no.2
• /
• pp.113-117
• /
• 2001

CKD602, a camptothecin derivative, is a synthetic and water-soluble anticancer agent possessing of topoisomerase I inhibiting activity. DPPC and DSPE-PEG liposomal formulations entrapped with CKD602 were developed. DSPE-PEG liposome, or PEGylated liposome, encapsulating CKD602 composed of dipalmitoylphosphatidylcholine (DPPC), cholesterol and distearoyl-N-monoethoxy poly (ethyleneglycol) succinylphosphatidylethanolamine $(DSPE-PEG_{2000})$ (22:11:2) was prepared by reverse-phase evaporation method. Formed liposomes were characterized in terms of the morphology, size and encapsulation efficiency. To elucidate the in vitro stability, PEGylated liposome was incubated in human plasma, and the adsorbed proteins onto the surface of liposomes were applied to the SDS-PAGE. In vitro cytotoxicity of CKD602 encapsulated in PEGylated liposome was studied in human cervical cancer cell line (HeLa). CKD602 in PEGylated liposome was found to be 40-fold more effective $(IC_{50}=1\;nM)$ than free CKD602 $(IC_{50}=40\;nM)$ in inhibiting the growth of HeLa cells in vitro.

• Proceedings of the IEEK Conference
• /
• 1998.06a
• /
• pp.235-238
• /
• 1998

This paper presents the detection of internal combustion engine's multiple misfire. The primary cause of air pollution by vehicles is imperfect conbustion of fuel. The CARB(California Air Resources Board) have imposed regulations for the detection of misfiring in automotive engines. The OBD-II regulations requir that misfire should be monitored by the diagnostic system, and that the goal of OBD-II is to alert the driver to the presence of a malfunction of the emission control system. Present invention based upon measurements of engine roughness as derived from crankshaft angular velocity measurements with special signal processing method. Crankshaft angular velocity signals are processed by walsh-fourier transform. Experimental work confims that it's possible to apply walsh-fourier transform for the detection of multiple misfires in no-load idle and road testing.

• 한국정보디스플레이학회:학술대회논문집
• /
• 2005.07b
• /
• pp.1436-1439
• /
• 2005

A novel current-type data driver for active matrix organic light emitting diode (AMOLED) is proposed for current uniformity enhancement among its output channels. New architecture is composed of shadow DACs that precharge output stages, a single-real DAC that correct the output level to a real target current level and output stages that operate in 3 states of sampling, correcting and driving. Simulation results show that the proposed driving method and circuits improve the current uniformity among output channels of a current-type driver IC.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.21 no.11
• /
• pp.2978-2990
• /
• 1996

With the advent of multimedia era, there are ever increasing interest in computer music and sound syntheis. An FM type sound synthesizing method makes possible the syntheis ofvarious sounds ofmusical instruments with a relatively simple hardware architecture. Therefore, in this paper, we designed a hardware architecture for real-time sound synthesizer and its logic gates. In this paper, we designed a basic sound generator for implementation of real-time logic gates, analzed characteristics of sounds synthesized in this architecture and extracted parameters of FM sounds of musical instruments by using the Csound software. The major bolkcs to build the hardware are a phase-generator, a singe-function-generator, an envelope-generator and a multiplier-part. Finally, logic circuits are designed and verified in VHDL and logic gates by 1.0um standard cell library, which will be easily implementable by the form of ASIC.

• Journal of the Korean Institute of Telematics and Electronics
• /
• v.26 no.6
• /
• pp.115-123
• /
• 1989

This paper describes a new method of mask compaction to formulate a mixed integer linear programming problem from a user defined stick diagram. By solving this mixed integer program, a compacted and design rule violation free layout is obtained. Also, a new efficient algorithm is given which solves the longest problem in the constraint graph.

• Proceedings of the Korean Society For Composite Materials Conference
• /
• 2002.10a
• /
• pp.273-275
• /
• 2002

In this studies, curing behavior and mechanical properties of tetrafunctional epoxy resin (4EP)/ fluorine-containing epoxy resin (FEP) blend systems was investigated with 4, 4'-diaminodiphenol methane (DDM) as a curing agent. The cure activation energies $(E_a)$) were studied by Flynn-Wall-Ozawa's equation with dynamic DSC method. For the fracture toughness of the casting specimens, the critical stress intensity factor ($K_{IC}$) and the specific fracture energy ($G_{IC}$) were determined by fracture toughness test.

• The Plant Pathology Journal
• /
• v.22 no.2
• /
• pp.164-167
• /
• 2006

An immunocapture reverse transcription-polymerase chain reaction (IC/RT-PCR) was developed for simultaneous detection of two pepper-infecting RNA viruses, Pepper mud mottle virus (PMMoV) and Tobacco mild green mosaic virus (TMGMV). The assay could be performed in a single tube for simultaneous and sensitive detection of these tobamoviruses. This detection system revealed thousand-fold increase in detection sensitivity compare to ELISA. This method could save time and reagent cost compare to common RT-PCR which needs several reactions and several procedures of viral RNA extractions for the same number of samples.

• Journal of the Korean Institute of Telematics and Electronics
• /
• v.26 no.2
• /
• pp.163-168
• /
• 1989

In this paper, Rayleigh wave velocity has been measured by detecting the backscattered signal generating near the Rayleigh critical angle in the elastic medium. The rotating system has been made for the measurment of Rayleigh angle. It has been shown that the measured velocity for the stainless steel, brass aluminum, copper has been good agreement with the theoretical value. The method of non-destructive evaluation using backscattering signal has been presented and the c-scan acoustic image for internal of IC sample has been displayed.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
• /
• 1996.05a
• /
• pp.220-223
• /
• 1996

Mechanical properties of Plasma-Enhanced Chemical Vapor Deposited (PECVD) silicon nitride thin film was studied to determine the feasibility of the film as a passivation layer over the aluminum bonding areas of integrated circuit chips. Ultimate strain of the films in thicknesses of about 5 k${\AA}$ was measured using four-point bending method. The ultimate strain of these films was constant at about 0.2% regardless of residual stress. Intrinsic and residual stresses of these films were measured and compared with thermal shock and cycling test results. Comparison of the results showed that more tensile films were more susceptible to crack- induced failure.

• Transactions of the Korean Society of Automotive Engineers
• /
• v.21 no.5
• /
• pp.1-7
• /
• 2013

The present paper relates to a development of the Gear Detection Sensor for automotive manual transmission. To detect air gap from control finger to detecting zone of sensor based on non-contacted method, permanent magnet and linear type Hall IC are mounted in this sensor. Control finger is machined to 3 step heights to detect 3 gear stages such as In-Gear, Normal and Rear. After conducting actual experimentation based on exclusive Jig and FEM, it is described to consider possibility for automotive application of Gear Detection Sensor.