• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• v.26 no.1
• /
• pp.53-58
• /
• 2000

Treatment of oral cancers with chemotherapeutic agents are evaluated as an effective method for remission to reduce cancer proliferation nowadays. But, minimization of side-effects such as bone marrow suppression, gastrointestinal toxicity and renal damage is another problem to be solved. Thus, a possible approach to develop a clinically applicable chemotherapeutic agents is to screen anticancer activity among traditional medicinal plants which have been used for thousands of years with very low side-effects in orient. In this study we focused on screening anti-oral cancer activities among 14 traditional medicinal plant extracts that revealed anticancer activities on other solid tumors. The results were as follow : 1. Methanol extract of Lepidium apetalum showed the highest anti-oral cancer activity against A253 cells. At concentration of $4{\mu}g/ml$, the cell viability was 48% under our experimental condition. $IC_{50}$ value obtained was $4{\mu}g/ml$. 2. Methanol extract of Coptis japonica and Solanum nigrum were effective on KB cells. Cell viability observed were 62% and 67% at concentration of $4{\mu}g/ml$, and $IC_{50}$ values were $12{\mu}g/ml$ and $10{\mu}g/ml$ respectively. 3. When the methanol extract of Lonicera caerule was combined with $2{\mu}g/ml$ of cisplatin, the anticancer activity was synergistically increased. One hundred ${\mu}g/ml$ of Lonicera caerule showed 92%(alone) or 59%(combined with cisplatin) cell viabilities. $IC_{50}$ value of Lonicera caerule extract against KB cells was reduced from $301{\mu}g/ml$ to $126{\mu}g/ml$ when combined with $2{\mu}g/ml$ of cisplatin. 4. Medicinal plant extracts effective on both A253 and KB cells were Coptis japonica, Lepidium apetalum, Solanum nigrum, Caesalpiniae Lignum, Curcuma aromatica.

• The Journal of the Korea institute of electronic communication sciences
• /
• v.15 no.2
• /
• pp.357-362
• /
• 2020

The TMFT, a sub-system of TINC, provides voice calls, data transmission and reception, and multimedia services to individual users. At the time of development in 2011, the power circuit of the TMFT was designed to electrical power supply to each device via a charger IC. However, the newly improved power supply circuit allows power to be supplied to each device through the PMIC without configuring the charger IC separately. In this paper, the power circuit design structure of TMFT applied in the development stage and the improved power circuit design structure were compared. And we verified through experiments whether the improved power circuit can be applied to TMFT. The experimental method was verified by directly comparing the current consumption test, charge time comparison test, and rising temperature test during charging each of before and after improvement terminals.

• The Transactions of the Korean Institute of Electrical Engineers B
• /
• v.54 no.2
• /
• pp.88-93
• /
• 2005

To develop a 100 hp high temperature superconducting(HTS) motor with high efficiency first in Korea, we fabricated a HTS field winding and test. HTS field winding is composed of sixteen HTS race track shaped coils wound with stainless steel-reinforced Bi-2223 tape conductor by react and wind fabrication method. Nomex paper was used for electrical insulation. Each of four magnet pole assemblies was constructed with four double pancake sub-coils, mechanically stacked and electrically in series. Four magnet assemblies were fixed on an aluminum support structure to make effective heat transfer. The Critical current (Ic) was 41.5A at 77K and self field. However the lowest Ic value of sub-coils was 35A. Joule heat generated by each joints between sub-coils was lower than 1mW at 77K and 34A. And Joule heat generated by the joints between field coils was lower than 10mW at 77K and 34A. Joule heat of the whole field winding was 1W at 77K and 32A. And so, the lowest Ic value of sub-coils was more important than Joule heats generated by all joints. The operating current must be lower than the lowest Ic of all the sub-coils. In this paper, design, construction and testing of HTS field winding, Joule heat generated by the joints, and operating current were discussed.

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
• /
• 2002.10a
• /
• pp.335-340
• /
• 2002

In recent years, the study of metal matrix composite has increased specially, aluminum alloy, research and development are briskly progress to find new metal matrix composite. this study is following the this purpose; This study is used metal matrix composite that was produced by matrix, AC4CH. and reinforcement $A_{18}B_4O_{33}$ metal matrix composite to add $Al_2O_3,\;TiO_2$ for strengthen of binding together among the Whisker. Each Metal matrix composite is produced using the squeeze casting method. Fracture tounghness test was in accordance with the provisions of ASTM E399; Specimen was produced half-size CT specimen W=25mm, B=12.5mm, Cross head speed 0.05mm/min in room temperature. The plane strain fracture toughness $K_{IC}$ is $8.7MPa-m^{0.5}$ for $Al_{18}B_4O_{33}$/AC4CH., $9.28MPa-m^{0.5}$ for $Al_{18}B_4O_{33}$/AC4CH added $TiO_2$. and $Al_2O_3$ but AC4CH alloy was violated the critical stipulated by ASTM standard for a valid measurement of $K_{IC}$. In case of, it was performed $I_{IC}$ test instead of $K_{IC}$ based on ASTM E 1820

• Analytical Science and Technology
• /
• v.33 no.6
• /
• pp.262-273
• /
• 2020

A fluorine content analysis method for krill oils, which is a representative oil formulation in foods, was developed in compliance with the Korea Food and Drug Ministry's "Guidelines for Validation of Testing Methods Related to Food". Using this method for krill oils, the presence of impurities was evaluated via combustion-ion chromatography (C-IC). A review of published technical data on fluorine in krill oils showed that while the traditional wet potentiometric method was typically used, it was not reliable. Moreover, there was no food testing/analysis laboratory in Korea to perform a fluorine test analysis on such an oil matrix. Therefore, we identified halogen (fluorine) tests, developed to national and international standards, and developed a test method suitable for krill oils by selecting a C-IC method that is sufficiently applicable to the oil matrix. Based on the characteristics of the oil matrix, the optimal test method was established through various experiments by reviewing the concerns related to loss and interference in the preparation and introduction of samples. The fluorine content test was carried out on 11 krill oil products that were purchased online. Most products (with the exception of only one) were found to contain less than the reporting limit obtained by the test method. Furthermore, after additional testing, a high fluorine content of approximately 2,000 ~ 3,000 mg/kg was detected on the krill surface, although the concentration varied depending on the area of the krill. A comparison with samples from two ISO/IEC 17025 testing laboratories confirmed that there was no significant difference in the statistical analysis results obtained by ANOVA among the three laboratories. A testing guide for fluorine content analysis was completed.

• Food Science and Preservation
• /
• v.21 no.3
• /
• pp.421-426
• /
• 2014

In this study, the antioxidant and pancreatic lipase inhibitory activities of aqueous methanolic (70% methanol) extract from the roots of Anemarrhena asphodeloides were investigated. The extracts of four solvent fractions (the n-hexane layer, EtOAc layer, n-BuOH layer, and $H_2O$ layer) of the 70% methanol extract were also investigated. Furthermore, the total phenolic content was quantified using a spectrophotometric method. All the tested samples showed dose-dependent radical scavenging and pancreatic lipase inhibitory activities. In particular, the pancreatic lipase inhibitory activity of the ethyl acetate soluble portion (the EtOAc layer) from the rhizomes of the A. asphodeloides was higher than that of the other solvent-soluble portions. The antioxidant property of the extracts was evaluated using radical scavenging assays with DPPH and $ABTS^+$ radicals. 1000 mg/ml of the n-BuOH layer extract showed 91.2% DPPH radical scavenging activity. The EtOAc layer extract and the n-BuOH layer extract showed $IC_{50}=20.5{\pm}1.7mg/ml$ and $IC_{50}=50.5{\pm}0.7mg/ml$ $ABTS^+$ radical scavenging activities, respectively. The anti-obesity efficacy of the A. asphodeloides extract was tested via porcine pancreatic lipase assay. A pancreatic lipase inhibitory activity ($IC_{50}$) of $31.3{\pm}0.1mg/ml$ was obtained from the EtOAc layer extract. These results suggest that A. asphodeloides can be considered a new potential source of natural antioxidant and anti-obesity agents.

• Progress in Medical Physics
• /
• v.8 no.2
• /
• pp.45-57
• /
• 1997

It is mandatory to measure accurately the dose distribution and the total absorbed dose of fast neutron for putting it to the clinical use. At present the methods of measurement of fast neutron are proposed largely by American Associations of Physicists in Medicine, European Clinical Neutron Dosimetry Group, and International Commission on Radiation Units and Measurements. The complexity of measurement, however, induces the methodological differences between them. In our study, therefore, we tried to establish a unique technique of measurement by means of measuring the emitted doses and the dose distribution of fast neutron beam from neutron therapy machine, and to invent a standard method of measurement adequate to our situation. For measuring the absorbed doses and the dose distribution of fast neutron beam, we used IC-17 and IC-18 ion chambers manufactured by A-150 plastic(tissue-equivalent material), IC-17M ion chamber manufactured by magnesium, TE gas and Ar gas, and RDM 2A electrometer. The magnitude of gamma-contamination intermingled with fast neutron beam was about 13％ at 5cm depth of standard irradiated field, and increased as the depth was increased. At the central axis the maximum dose depth and 50％ dose depth were 1.32cm and 14.8cm, respectively. The surface dose rate was 41.6-54.1％ throughout the entire irradiated fields and increased as the irradiated fields were increased. Beam profile was that the horn effect of about 7.5％ appeared at 2.5cm depth and the flattest at 10cm depth.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.41 no.1
• /
• pp.49-56
• /
• 2021

The purpose of this study is to develop a methodology to select a cluster of night traffic accidents using CRP (Continuous Risk Profile) analysis. the other purpose of this study is to present the characteristics of the traffic accident cluster section selected at night using CRP analysis. The CRP analysis was performed considering traffic volume of target routes through traffic accident data. In addition, variables were set according to the freeway sections. the method of subtracting the daytime CRP from the nighttime CRP was used to analyze the nighttime traffic accident. As a result, Using the CRP analysis, the sections of hotspot were identified and plotted based on traffic accidents. Also, the sections where traffic accidents are frequent were those where IC or Tunnels were installed, and there was a deviation from the general section. In conclusion, CRP analysis could be used to calculate the frequent section of specialized traffic accidents at night, and it was selected as a point in need of improvement due to the frequent occurrence of specialized traffic accidents at night in the section where IC or tunnel facilities are installed. In addition, it is inferred that the number of specialized traffic accidents at night in the section where IC or tunnel facilities are installed is a factor in the problem of night visibility due to lighting facilities.

• Analytical Science and Technology
• /
• v.25 no.6
• /
• pp.350-363
• /
• 2012

To determine ionic species in snowpit samples using ion chromatography system, we described the performance of ion chromatography(IC) system, cleaning method of bottle, and interference by filtering procedure. The limit of detection, reproducibilities, and accuracies determined with BCR$^{(R)}$-408 were 0.01-0.26 ${\mu}g$/L, 0.4-17.4%, 4.5-12.0% for cations and 0.02-0.26 ${\mu}g/L$, 0.1-27.6%, 1.3-5.6% for anions, respectively. Lab blank test for sample bottle indicated that $CH_3CO_2{^-}$, $HCO_2{^-}$, and $NH_4{^+}$ can be easily contaminated in the lab environment. The positive interferences of $NO_3{^-}$ were partly attributed to the cleaning method of bottle. The filtering of melted snow sample should be carefully applied because it can positively affect the concentration levels of some ionic species. Finally, this method was applied to measure ionic species in snowpit samples from the upward area near NEEM camp and the uncertainties of measurement data of $F^-$ were also estimated.

• Korean Journal of Food Science and Technology
• /
• v.42 no.2
• /
• pp.130-135
• /
• 2010

Picrate, enzyme-picrate and instrumental analysis methods using IC (Ion Chromatography) and HPLC (High Performance Liquid Chromatography) were compared for their effectiveness in determining cyanide in extracts of Maesil, which is classified as a harmful substance. First, the picrate method showed the shortest analysis time (about 5 hr). The color of picrate paper changed at 0.01 mg/$200\;mL\;CN^-$. However, it was difficult to detect cyanide from amygdalin of glucosides. Second, we performed a qualitative analysis for total cyanide (free cyanide and cyanide from amygdalin) by the enzyme-picrate method using $\beta$-glucosidase and a quantitative analysis by spectrophotometry. Finally, analysis of cyanide by IC and HPLC required the longest determining time (about 17 hr) as well as pretreatment for each free cyanide and amygdalin. These results suggest that enzyme-picrate is the most effective analysis method for the detection of cyanide in Maesil extracts.