• Proceedings of the Computational Structural Engineering Institute Conference
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• 2005.04a
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• pp.97-104
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• 2005

The seismic behavior of framed structure with Chevron-type bucking restrained braces were investigated and their behavior factors were evaluated following the procedure proposed in ATC-19 & ATC-34. Two types of structures, building frame systems and dual systems, with 4, 8, 12, and 16 stories were designed per the IBC 2000, the AISC LRFD and the AISC/SEAOC Recommended Provisions for BRBF. Nonlinear static pushover analyses were carried out to observe the plastic hinge formation and to identify the loads and the displacements at the yield and the ultimate states. Time history analyses were also carried out to compute the permanent displacement md the dissipated hysteretic energy. According to the analysis results, the response modification factors of model structures fumed out to be larger than what is proposed in the provision in low story structures, and a little smaller in medium-story structures. The dual systems, even though designed with smaller seismic load, showed superior static and dynamic performances.

• Journal of Veterinary Clinics
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• v.13 no.2
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• pp.163-170
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• 1996

This study was performed to analyse the common calls of poddle spectrographically : bark, growl, howl, snore, yelp and whine. The sonograms of 6 common calls were shown their own specific features. There were significant differences among each types of common callsin the parceter of minimun frequency of call (MIFC), maximun frequency of call (MAFC), duration of call (DC), interval between call (IBC), dominant frequency (DF), F1 formant, F2 formant and F3 formant (P<0.01). It was considered that it was possible to record the main common calls dogs by sonograms and it sould be applied to objective basic data for understanding the psychological stats of dogs, the social relationship among them and the relationship sith human being.

• Interdisciplinary Bio Central
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• v.2 no.2
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• pp.3.1-3.4
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• 2010

In the present research, we assessed the utility of the structural information of drugs for predicting human in vivo intrinsic clearance from in vitro intrinsic clearance data obtained by human hepatic microsome experiment. To compare with the observed intrinsic clearance, human intrinsic clearance values for 51 drugs were estimated by the classical methods using in vivo-in vitro scale-up and by the new methods using the in vitro experimental data and selected molecular descriptors of drugs by the forward selection technique together. The results showed that taking consideration of molecular descriptors into prediction from in vitro experimental data could improve the prediction accuracy. The in vitro experiment is very useful when the data can estimate in vivo data accurately since it can reduce the cost of drug development. Improvement of prediction accuracy in the present approach can enhance the utility of in vitro data.

• Interdisciplinary Bio Central
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• v.2 no.2
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• pp.6.1-6.5
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• 2010

Fragment molecular orbital (FMO) method provides a novel tool for ab initio calculations of large biomolecules. This method overcomes the size limitation difficulties in conventional molecular orbital methods and has several advantages compared to classical force field approaches. While there are many features in this method, we here focus on explaining the issues related to protein-ligand binding: FMO method provides useful interaction-analysis tools such as IFIE, CAFI and FILM. FMO calculations can provide not only binding energies, which are well correlated with experimental binding affinity, but also QSAR descriptors. In addition, FMO-derived charges improve the descriptions of electrostatic properties and the correlations between docking scores and experimental binding affinities. These calculations can be performed by the ABINIT-MPX program and the calculation results can be visualized by its proper BioStation Viewer. The acceleration of FMO calculations on various computer facilities is ongoing, and we are also developing methods to deal with cytochrome P450, which belongs to the family of drug metabolic enzymes.

• Interdisciplinary Bio Central
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• v.5 no.3
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• pp.6.1-6.7
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• 2013

Many insects such as mosquitoes cause life-threatening diseases such as malaria, yellow fever and West Nile virus. Malaria alone infects 500 million people annually and causes 1-3 million death per year. Volatile insect repellents, which are detected through the sense of smell, have long been used to protect humans against insect pests. Antifeed-ants are non-volatile aversive compounds that are detected through the sense of taste and prevent insects from feeding on plants. The molecular targets and signaling path-ways required for sensing insect repellents and antifeedants are poorly understood. Transient Receptor Potential (TRP) Ca2+-permeable cation channels exist in organisms ranging from C. elegans to D. melanogaster and Homo sapiens. Drosophila has 13 family members, which mainly function in sensory physiology such as vision, thermotaxis and chemotaxis. G protein-coupled receptors (GPCRs) initiate olfactory signaling cascades in mammals and in nematodes C.elegans. However, the mechanisms of G protein signaling cascades in insect chemosensation are controversial. In this review, I will discuss the putative roles of G protein-coupled receptors (GPCRs) and Transient Receptor Potential (TRP) channels as targets for insect repellents.

• Interdisciplinary Bio Central
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• v.5 no.4
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• pp.8.1-8.3
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• 2013

Unlike the traditional view, it is not mysterious about how G. Mendel chose the seven characters of the pea, Pisum sativum, that he studied. He first chose the pea that met three conditions he set up and repeated experiments for two years. Apparently, he knew that those characters were controlled by countable elements. Then, he derived the prediction on the basis of his idea about the elements, and selected the seven characters that satisfied the prediction. He knew "no prediction no science". In population genetics the Hardy-Weinberg principle is well known and cited in many papers and books. However, Mendel already derived the same principle in his paper, because he was acquainted also with physics and mathematics. Actually, the principle was trivial when they derived, but not at all when Mendel did. It is also well known that Mendel's laws were forgotten and rediscovered at the term of the 19th century. That may not be true either. His laws were internationally well known before the rediscovery. In fact, the 1881-year version of the Encyclopedia Britannica contains his laws.

• The Transactions of the Korean Institute of Power Electronics
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• v.19 no.2
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• pp.116-123
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• 2014

In this paper, a soft-switching scheme for the PWM interleaved buck converter(IBC) is newly proposed to obtain the advantages of both the conventional PWM interleaved buck and resonant converters such as ease of control, reduced switching losses and stresses, and low EMI. To obtain the soft-switching action, the proposed scheme employs an auxiliary circuit, which is added to the conventional interleaved buck converter and used to achieve soft-switching for both the main switches and the output diodes while not incurring any additional losses due to the auxiliary circuit itself. In this paper, the basic operations are discussed and design guidelines are presented. And through the experimental results, the usefulness of the proposed converter is verified.

• Proceedings of the Korea Concrete Institute Conference
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• 2003.11a
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• pp.140-143
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• 2003

Recently, many high-rise reinforced concrete (RC) bearing wall structures of multiple occupancy have been constructed, which have the irregularities of weak (or soft) story and torsion at the lower stories simultaneously. The study compared the eccentricity of such a building predicted by design codes, EC 8, IBC 2000 and UBC 97, and by the test results through a series of shaking table tests of 1:12 model. Based on the comparison of the predicted eccentricity and the test result, the conclusions are drawn as follow: Accidental torsion due to the uncertainty on the properties of structure can be reasonably predicted by using the dynamic analysis with the center of mass being shifted by 5 percent of the dimension of the building perpendicular to the direction of the excitations than by using equivalent lateral force procedure

• Interdisciplinary Bio Central
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• v.1 no.1
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• pp.2.1-2.3
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• 2009

There is evidence that cholesterol in the brain plays an important role in the neurotransmitter release. A decrease of the cholesterol level severely hampers the activity of the membrane fusion machinery, thereby inhibiting the release. Meanwhile, the results from several clinical studies suggest that a low cholesterol level is linked to the dysfunction of some brain activities. Because the neurotransmitter release underlies the basic brain function, the combined results lead to a testable hypothesis that the cholesterol-lowering drugs may inhibit the neurotransmitter release at the synapse. Such inhibition of the release could result in impaired brain function for a limited group of people. A molecular basis for the hypothesis is discussed.

• Interdisciplinary Bio Central
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• v.1 no.1
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• pp.4.1-4.7
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• 2009

Introduction: Histone modifications and DNA methylation are the major factors in epigenetic gene regulation. Especially, revealing how histone modifications are related to DNA methylation is one of the challenging problems in this field. In this paper, we address this issue and propose several plausible mechanisms for precise controlling of DNA methylation status at CpG islands. Materials and Methods: To establish the regulatory relationships, we used 38 histone modification types including H2A.Z and CTCF, and DNA methylation status at CpG islands across chromosome 6, 20, and 22 of human CD4+ T cell. We utilized Bayesian network to construct regulatory network. Results and Discussion: We found several meaningful relationships supported by previous studies. In addition, our results show that histone modifications can be clustered into several groups with different regulatory properties. Based on those findings we predicted the status of methylation level at CpG islands with high accuracy, and suggested core-regulatory network to control DNA methylation status.