• The Korean Journal of Nuclear Medicine
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• v.32 no.4
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• pp.374-381
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• 1998

Purpose: I-131 labeled (2'-deoxy-2'-iodo-${\beta}$-D-arabinofuranosyl) adenine (IAD) may be involved in DNA synthesis during active proliferation of tumor cells. We conducted this study to find out the biodistribution of IAD and it's feasibility for scintigraphic tumor imaging. Materials and Methods: Tosyl acetyl-adenosine was dissolved in acetonitrile, and I-131-NaI was added and heated to synthesize IAD. Female Fisher 344 rats innoculated with breast tumor cells were injected with 0.27 MBq of IAD. Rats were sacrificed at 0.5, 1, 2, 4, 24h and the % of injected dose per gram of tissue (%ID/g) was determined. For scintigraphy, rats bearing breast cancer were administered with 1.11 MBq of IAD and imaging was performed after 2 and 24h. Then, rat body was fixed and microtomized slice was placed on radiographic film for autoradiography. Results: %ID/g of tumor was 0.74 (0.5h),0.73 (1h), 0.55 (2h), 0.38 (4h), and 0.05 (24h), respectively. At 1h after injection, %ID/g of tumor was higher than that of heart (0.34), liver (0.42), spleen (0.47), kidney (0.69), muscle (0.14), bone (0.33) and intestine (0.51). However, %ID/g of tumor was lower than blood (1.06), lung (0.77), and thyroid (177.71). At 4h, %ID/g of tumor in comparison with other tissue did not change. Tumor contrast expressed by tumor to blood ratio was 0.69 and tumor to muscle ratio was 5.11 at 1h. However, these ratios did not improve through 24h. On autoradiogram and scintigraphy at 2 and 24 hour, the tumor was well visualized. Conclusion: This results suggest that IAD may have a potential for tumor scintigraphy. However, further work is needed to improve localization in tumor tissue.

• Journal of Korean Academy of Nursing
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• v.45 no.3
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• pp.357-366
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• 2015

Purpose: This study was done to develop an evidence-based incontinence care protocol through an adaptation process and to evaluate the effects of the protocol. Methods: The protocol was developed according to the guideline of adaptation. A non-randomized controlled trial was used for testing the effects of the new Incontinence Care Protocol. A total of 120 patients having bowel incontinence with Bristol stool type 5, 6, and 7 and admitted to intensive care units were recruited to this study. The newly developed incontinence care protocol was used with patients in the experimental group and conventional skin care was given to patients in the control group. Outcome variables were incontinence-associated dermatitis (IAD) severity, pressure ulcer occurrence and severity. Results: The experimental group had significantly less severe IAD (t=6.69, p <.001), lower occurrence of pressure ulcers (${\chi}^2=7.35$, p =.007), and less severity of pressure ulcers (Mann-Whitney=86.00, p =.009) than the control group. Conclusion: Use of this incontinence care protocol has the effects of preventing pressure ulcers and inhibiting worsening of IAD and pressure ulcers. Therefore, this incontinence care protocol is expected to contribute to managing IAD and pressure ulcers.

• Journal of the Korean Society of Radiology
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• v.10 no.2
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• pp.101-107
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• 2016

It was performed in this study to provide basic information on production of accurate gonadal shield by measuring pelvic indicators of TDP SD ISP IAD 1CDP and 2CDP. when pelvis ap and hip ap examination was taken, there is no exact position of the reference point of the shield and anatomically more difficult to shield gonad in the case of female infants than male. Results analyzed by height in 70~80 and 110~120 were approximately 30mm 13mm 19mm 20mm 2mm and 7mm difference in TDP SD ISP IAD 1CDP and 2CDP respectively. This value was statistically significant (P<0.05). Results analyzed by age of 2~3 and 6~7 were different on SD ISP IAD and 2CDP by 17mm 10mm 12mm 16mm respectively. it was also statistically significant. However 1CDP was not statistically significant(P>0.05). the difference was nearly about 1mm. Analysis of results by weight of less than 10 and more than 20 showed difference on TDP SD ISP IAD 1CDP and 2CDP by 28mm 14mm 11mm 20mm 3mm and 8mm. it was statistically significant (P<0.05). From the above results, female infants pelvic indicator measurement can be used as reference value for shielding production and especially IAD can present a reference point on the shielding position. Pelvis indicators of female infant has a close correlation. In addition, as it is showen in the statistical difference analysis to have an accurate ovarian shield, gonad shield would be produced and used by height, age and weight.

• Journal of Korea Foundry Society
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• v.4 no.1
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• pp.21-31
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• 1984

IAD( Implicit Alternative Direction ) FDM을 사용하여 금형에서의 L형 순수알미늄 주물에 대하여 그 응고상황의 수치적 해석을 2차원적으로 시도하였다. 계산은 주형비 ( 주형의 부피/주물의 부피 )에 따라 금형 표면에서의 대류현상과 금형/주물계면에서의 Air-gap형성 현상을 고려에 넣은 경우와 그렇지 않은 경우로 나누어 각각 콤퓨터에 의해 계산하여 그 결과를 비교하였다. 또한 금형/주물 계면주위의 온도구배를 구함으로써 Air-gap이 열전달에 미치는 영향을 검토하였다. 이와같은 시도에 의하여 주물의 응고시간, 응고방향 Hot spot의 위치 등 주조에 있어서 매우 중요한 사항들을 알아내는데 Numerical Analysis 이 매우 유용한 방법임을, 특히 금형표면에서의 대류현상과 금형/주물 계면에서의 Air-gap형성현상을 고려에 넣은 경우에 더욱 정확한 결과를 기대할 수 있다는 것이 확인되었다.

• Journal of Korean Society of Transportation
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• v.36 no.1
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• pp.51-65
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• 2018

Intentional aggressive driving (IAD) is defined as a hazardous driving event that the aggressive driver intentionally threatens neighbor drivers with abrupt longitudinal and lateral maneuvering. This study developed a methodology for detecting IAD events based on the analysis of interactions between aggressive driver and normal driver. Three major aggressive events including rear-close following, side-close driving, and sudden deceleration were analyzed to develop the algorithm. Then, driving simulation experiments were conducted using a multi-agent driving simulator to obtain data to be used for the development of the detection algorithm. In order to detect the driver's intention to attack, a relative evaluation index (Erratic Driving Index, EDI) reflecting the driving pattern was derived. The derived IAD event detection algorithm utilizes both the existing absolute detection method and the relative detection method. It is expected that the proposed methodology can be effectively used for detecting IAD events in support of in-vehicle data recorder technology in practice.

• Microbiology and Biotechnology Letters
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• v.47 no.2
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• pp.242-249
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• 2019

Biosynthesis of indole-3-acetate (IAA) from L-tryptophan via indole-3-pyruvate pathway requires three enzymes including aminotransferase, indole-3-pyruvate decarboxylase, and indole-3-acetate dehydrogenase. To establish a bio-based production of IAA, the aspC, ipdC, and iad1 from Escherichia coli, Enterobacter cloacae, and Ustilago maydis, respectively, were expressed under control of the tac, ilvC, and sod promoters in C. glutamicum. Cells harboring ipdC produced tryptophol, indicating that the ipdC product is functional in this host. Analyses of SDS-PAGE and enzyme activity revealed that genes encoding AspC and Iad1 were efficiently expressed from the sod promoter, and their enzyme activities were 5.8 and 168.5 nmol/min/mg-protein, respectively. The final resulting strain expressing aspC, ipdC, and iad1 produced 2.3 g/l and 7.3 g/l of IAA from 10 g/l L-tryptophan, respectively, in flask cultures and a 5-L bioreactor.

• Proceedings of the Korean Institute of Landscape Architecture Conference
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• 2019.11a
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• pp.56-60
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• 2019

• Proceedings of the Korean Vacuum Society Conference
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• 1996.02a
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• pp.59-59
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• 1996

• Journal of the Korean Society of Radiology
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• v.10 no.1
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• pp.7-13
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• 2016

The goal of this study is to investigate corpus callosum and both internal capsule changes with the internet addiction disorder compared to control group using MR diffusion tensor imaging. A total of 22 teenager volunteers who had 10 high-risk group with internet addiction and 12 normal control group were conducted for this study. Imaging was conducted on a 3 T using a EPI sequence. Image evaluation was analysed of the FA, ADC($10^{-3}mm^2/s$), length(mm). We did select ROI for image tracking on corpus callosum of 5 and including 2(internal capsule). The data from these ROIs were compared statistically among the groups using independent t-test, correlation coefficient. There were significant inter-group differences(p<0.05) among FA, ADC($10^{-3}mm^2/s$) and length(mm). And also significantly negative correlations were fond between FA values of corpus callosum and IAD scale(p=0.000). DTI was shown significant changes of FA and ADC, LNF values in IAD compared to control group. Therefore, our results may provided clinical information for brain wite matter functions.

• Proceedings of the Korean Vacuum Society Conference
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• 1996.06a
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• pp.179-179
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• 1996