• The Korean Journal of Pharmacology
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• v.27 no.2
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• pp.135-144
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• 1991

Using T-lymphocytes obtained from rat peripheral blood, we found that the 44kD/pI6.8 protein was the major phosphoprotein of T-lymphocytes under basal condition, and that the 44kD/pI6.3 protein was a new phosphoprotein appeared in T-lymphocytes stimulated with ${\beta}-agonist$. The phosphorylation of the 44kD/pI6.3 protein was also induced by forskolin but inhibited by H-8 pretreatment. To clarify the character of the 44kD/pI6.3 protein, we used Con-A and kinase inhibitors, H-7 and W-7. Con-A stimulation induced phosphorylation of 44kD/pI 6.3 protein but that was inhibited by W-7 pretreatment. The phosphorytation of 44kD/pI6.3 protein was not induced by the PKC activator, PMA. Instead, the phosphorylation of 44kD/pI6.8 protein was reduced by H-7, a PKC inhibitor. From the above results,it can be concluded that the 44kD/pI6.3 protein can be a common substrate for A-kinase and CaM kinase. The two dimensional tryptic peptide mapping revealed that the 44kD/pI6.8 and 44kD/pI6.3 proteins are different.

• Communications of the Korean Mathematical Society
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• v.12 no.2
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• pp.251-256
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• 1997

We show that a strong system of derivations ${D_0, D_1,\cdots,D_m}$ on a commutative Banach algebra A is contained in the radical of A if it satisfies one of the following conditions for separating spaces; (1) $\partial(D_i) \subseteq rad(A) and \partial(D_i) \subseteq K D_i(rad(A))$ for all i, where $K D_i(rad(A)) = {x \in rad(A))$ : for each $m \geq 1, D^m_i(x) \in rad(A)}$. (2) $(D^m_i) \subseteq rad(A)$ for all i and m. (3) $\bar{x\partial(D_i)} = \partial(D_i)$ for all i and all nonzero x in rad(A).

• Korean Journal of Pharmacognosy
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• v.31 no.1
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• pp.34-38
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• 2000

Three compounds were isolated from the roots of Astragalus membranaceus (Leguminosae). On the basis of spectroscopic evidences, the structures were characterized as $3-0-{\beta}-D-xylopyranosyl-(2',3'-O-diacetyl)-6-0-{\beta}-D-glucopyranosyl-3{\beta},6{\alpha},16{\beta},25-tetrahydroxy-20(R)$,24(S)-epoxy-cycloartane(Astragaloside I), $3-0-{\beta}-D-xylopyranosyl-(2'-O-acetyl)-6-0-{\beta}-D-glucopyranosyl-3{\beta},6{\alpha},16{\beta},25-tetrahydroxy-20(R)$,24(S)-epoxy-cycloartane(Astragaloside II), $3-0-{\beta}-D-xylopyranosyl-(2',4'-O-diacetyl)-6-0-{\beta}-D-glucopyranosyl-3{\beta},6{\alpha},16{\beta},25-tetrahydroxy-20(R)$,24(S)-epoxycycloartane(Isoastragaloside I). Full data of NMR including HMBC and 1D-TOCSY experiment of these compounds were reported for the first time.

• Journal of applied mathematics & informatics
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• v.23 no.1_2
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• pp.517-523
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• 2007

Let R/I be an Artinian algebra of codimension 3 with Hilbert function H such that $h_{d-1}>h_d=h_{d+1}$. Ahn and Shin showed that A cannot be level if ${\beta}_{1,d+2}(Gin(I))={\beta}_{2,d+2}(Gin(I))$ where Gin(I) is a generic initial ideal of I. We prove that some certain graded Artinian algebra R/I cannot be level if either ${\beta}_{1,d}(I^{lex})={\beta}_{2,d}(I^{lex})+1\;or\;{\beta}_{1,d+1}(I^{lex})={\beta}_{2,d+1}(I^{lex})\;where\;I^{lex}$ is a lex-segment ideal associated to I.

• Journal of Periodontal and Implant Science
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• v.30 no.1
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• pp.39-52
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• 2000

Polypeptide growth factor belong to a class of potent biologic mediator which regulate cell differentiation, proliferation, migration and metabolism. 1,25-dihydroxyvitamin $D_3$ decrease cell proliferation, and stimulate alkaline phosphatase activity which express in osteoblast during cell differentiation period. IGF-I is known to stimulate cell proliferation and differentiation too. 1,25-dihydroxyvitamin $D_3$ is known to increase IGF-I binding sites and IGF binding protein which inhibite the effect of IGF. The purpose of this study is to evaluate potential role of IGF-I as mediator that control the action of 1,25-dihydroxyvitamin $D_3$. MC3T3-E1 cell were seeded $5{\times}10^5/ml$ at 100mm culture plate in ${\alpha}-MEM$ containing 10% fetal bovine serum. After 48 hour incubation period, medium were changed ${\alpha}-MEM$ containing 5% fetal bovine serum. After 24 hours, $10^{-9}M$ 1,25-dihydroxyvitamin $D_3$ added. Total mRNA was extracted at 0, 6, 24, 48, 72 hour. PRPCR method was programed for the detection of IGF-I mRNA. In the both groups of 1,25-dihydroxy vitamin $D_3$ treated and control, alternative splicing form of IGF-I, IGF-IA and IGF-IB were expressed. In the 1,25-dihydroxyvitamin $D_3$ treated group, IGF-I mRNA expression was matained until 24 hour, there after expression was decresed. MC3T3-E1 cell were seeded $2.5{\times}10^4/ml$ at 24well plate in ${\alpha}-MEM$ containing 10% fetal bovine serum. After 48 hour incubation period, medium were changed ${\alpha}-MEM$ containing 3% fetal bovine serum. After 24 hours, $10^{-9}M$ 1,25-dihydroxyvitamin $D_3$ and 10 ng/ml IGF-I were added separately or together. Cell were cultured for 1 and 3 days, $2{\mu}Ci/ml\;[^3H]$ -thymidine was added for the last 24h of culture of each days. ${[^3H]}$-thymidine incorporation in to DNA was measured and expressed counter per minute(CPM). DNA synthetic activity was significantly decreased by 1,25-dihydroxyvitamin $D_3$ both at 1 day and 3 day, and in the combination group of 1,25-dihydroxyvitamin $D_3$ and IGF-I, DNA synthetic activity was also decreased both at 1 day and 3 days. IGF-I did not affect the DNA synthetic activity compared to control group both at 1 day and 3 day. From the above results, 1,25-dihydroxyvitamin $D_3$ was potent inhibitor of cell proliferaton in MC3T3-E1 cells. It assumed that the effect of 1,25-dihydroxyvitamin $D_3$ on osteoblast proliferation may be mediated in part by decreased level of IGF-I.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.11 no.2
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• pp.9-14
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• 2007

A signed 3-partite graph is a 3-partite graph in which each edge is assigned a positive or a negative sign. Let G(U, V, W) be a signed 3-partite graph with $U\;=\;\{u_1,\;u_2,\;{\cdots},\;u_p\},\;V\;=\;\{v_1,\;v_2,\;{\cdots},\;v_q\}\;and\;W\;=\;\{w_1,\;w_2,\;{\cdots},\;w_r\}$. Then, signed degree of $u_i(v_j\;and\;w_k)$ is $sdeg(u_i)\;=\;d_i\;=\;d^+_i\;-\;d^-_i,\;1\;{\leq}\;i\;{\leq}\;p\;(sdeg(v_j)\;=\;e_j\;=\;e^+_j\;-\;e^-_j,\;1\;{\leq}\;j\;{\leq}q$ and $sdeg(w_k)\;=\;f_k\;=\;f^+_k\;-\;f^-_k,\;1\;{\leq}\;k\;{\leq}\;r)$ where $d^+_i(e^+_j\;and\;f^+_k)$ is the number of positive edges incident with $u_i(v_j\;and\;w_k)$ and $d^-_i(e^-_j\;and\;f^-_k)$ is the number of negative edges incident with $u_i(v_j\;and\;w_k)$. The sequences ${\alpha}\;=\;[d_1,\;d_2,\;{\cdots},\;d_p],\;{\beta}\;=\;[e_1,\;e_2,\;{\cdots},\;e_q]$ and ${\gamma}\;=\;[f_1,\;f_2,\;{\cdots},\;f_r]$ are called the signed degree sequences of G(U, V, W). In this paper, we characterize the signed degree sequences of signed 3-partite graphs.

• Journal of Korean Academy of Nursing
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• v.32 no.5
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• pp.727-734
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• 2002

This study was to determine the effect of DHEA administration before, during, and after dexamethasone treatment on body weight and TypeI,II muscle weight of rat receiving dexamethasone treatment. Method: Wistar rats were divided into 6 groups: control(C), dexamethasone(D), DHEA administration for 3days after dexamethasone treatment for 7days(7D+3DH), dexamethasone treatment for 7days after DHEA administration for 3days(3DH+7D), DHEA administration during dexamethasone treatment for 4days after dexamethasone treatment for 3days(3D+4DDH), DHEA administration during dexamethasone treatment for 7days(7DDH). Dexamethasone was injected by subcutaneously daily at a dose of 5mg/kg. DHEA was orally administered daily at a dose of 5mg/kg for 7 days. Soleus(TypeI) muscle, and both plantaris and gastro- cnemius(TypeII) muscles were dissected on the 7th day of experiment. Result: Body weight of both 3DH+7D group and 3D+4DDH group increased significantly compared with that of 7D group. Body weight of 7D+3DH group decreased significantly compared with that of 7D group, 7DDH group, 3DH+7D group and 3D+4DDH group. Muscle weight of both plantaris and gastro- cnemius tended to decrease compared with that of 7D group. Muscle weight of 7DDH group, 3D+4DDH group and 3DH+7D group increased significantly compared with that of 7D+3DH group. Muscle weight of gastrocnemius of both 3DH+7D group and 3D+4DDH group increased significantly compared with that of 7D group. Conclusion: Based on these results, it can be suggested that DHEA administration before and during dexamethasone treatment can increase both body weight and mass of atrophied TypeII muscle induced by dexa- methasone treatment.

• Proceedings of the Korea Society for Simulation Conference
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• 2002.11a
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• pp.125-130
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• 2002

본 연구는 DEVS를 기반으로 개발된 교통류 시뮬레이션 시스템인 $\ulcorner$I$^3$D$^2$ 교통류 시뮬레이션 시스템$\lrcorner$(이하 I$^3$D$^2$)의 검증을 그 목적으로 한다. I$^3$D$^2$는 본 연구진이 DEVS를 기반으로 개발한 범용 시뮬레이션 도구로써, 이미 서울시 강남 신호교차로와 내부순환로를 대상으로 하여 개발된 내용을 발표한 바 있다. I$^3$D$^2$는 헌재 단속류에서의 최적신호 생성 및 대기행렬 예측 문제, 그리고 연속류 시설의 용량 산정 문제등을 시뮬레이션 할 수 있다. 하지만 아직 문헌자료나 현장 데이터를 토대로 한 충분한 검증이 수행되지 못한 문제가 있다. 따라서 본 연구에서는 문헌자료를 토대로, I$^3$D$^2$를 검증한다. 이를 위하여 고속도로 또는 도시고속도로와 같은 연속 교통류의 대표적인 효과척도인 $\ulcorner$교통량 - 밀도 - 평균주행속도 (시간)$\lrcorner$ 간의 상관관계를 이용하여 미국 HCM과 우리나라의 도로용량편람에 정의되어 있는 기준을 토대로 I$^3$D$^2$ 검증을 수행하였다. 모델링은 서울시 올림픽대로의 양화대교 - 성산대교 - 가양대교 구간을 대상으로 했으며, 검증은 교통량에 따라 크게 3가지 교통류 상태(random, intermediate, constant)를 기준으로 시뮬레이션이 각각의 교통상태에서 예측한 평균주행시간의 정확도를 측정하면서 수행하였다. 검증 결과 random 상태에서는 문헌자료에 부합되는 예측결과를 보여주었으나, intermediate와 constant 상태에서는 문헌보다 다소 낮은 속도를 보여주었다 이러한 속도차는 추후 현장 데이터를 수집하여 보다 실질적인 검증을 통하여 조정되어야 할 것으로 판단된다.

• Proceedings of the IEEK Conference
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• 2007.07a
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• pp.401-402
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• 2007

In this paper, we propose an automatic method to finding corresponding points. One 2D image can be changed 3D shape by 3D model. The main idea is using gabor wavelet values from 3D model. And Elastic Bunch Graph Matching algorithm is more stable in 3D model.

• Journal of applied mathematics & informatics
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• v.17 no.1_2_3
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• pp.605-614
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• 2005

We show that an Artinian O-sequence $h_0,h_1,{\cdots},h_{d-1},h_d\;=\;h_{d-1},h_{d+l}\;>\;h_d$ of codimension 3 is not level when $h_{d-1}\;=\;h_d\;=\;d + i\;and\;h{d+1}\;=\;d+(i+1)\;for\;i\;=\;1,\;2,\;and\;3$, which is a partial answer to the question in [9]. We also introduce an algorithm for finding noncancelable Betti numbers of minimal free resolutions of all possible Artinian O-sequences based on the theorem of Froberg and Laksov in [2].