• Journal of Korean Medicine for Obesity Research
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• v.10 no.2
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• pp.17-25
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• 2010

Objectives This study was performed to figure out the effects of I-razin in overweight children without any exercise or specific diet. Methods Twenty-eight children those who were diagnosed overweight have been recruited. They were randomly assigned treatment or control group under block randomization. Treatment group were treated with I-razin for 8 weeks, and control group were treated with placebo medication under same conditions. Anthropometry, fat computed tomography and blood test have been done before and after the treatment. Results Eleven subjects in treatment group and seventeen in control group were evaluated. BMI, waist circumference, glucose, total cholesterol, and triglyceride were decreased in the treatment group. And reduction of BMI, glucose, and triglyceride in the treatment group were greater than control group. But there was no statistically significance. No side effects have been notice during the study period and no adverse effect on liver has been observed. Conclusion This study could not demonstrate effect of I-razin compared with control group. However, treatment group has a tendency of weight loss without side effect. Additional studies with large population are thought to be necessary to clarify the effect of I-razin.

• The Journal of Pediatrics of Korean Medicine
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• v.30 no.3
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• pp.108-120
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• 2016

Objectives The purpose of this study is to investigate Korean clinical studies on treatment of childhood obesity and to propose for better treatment options for childhood obesity. Methods Based on RISS, KISS, OASIS, KMbase with the keyword 'childhood obesity', 'child obesity', 'obese child', 'overweight child', total of 21 randomized controlled trials (RCTs), 11 single clinical studies, 3 chart reviews and 3 case reports have been found, and were analyzed. Results and Conclusion 1. Some study subjects were classified based on their sex - only men or women in a group or sometimes both. Another way of classify the study subjects were based on their age - preschooler, primary school students, middle school students, and high school students. The diagnostic criteria of the subjects were BMI (body mass index), Body fat percentage, Obesity index, Weight and unknown criteria. 2. The treatments used in 38 studies were exercise alone, education alone, both exercise and education or herbal therapy. The 7 studies that used herbal therapy as part of their study intervention had a study group with herbal intervention only and the other 2 study group with herbal treatment in addition to exercise and education. 3. 9 studies included herb medicines, electroacupuncture, auricular acupuncture, cupping, aroma massage, infrared light, and abdomen pad. Herb medications used in 5 studies included Chegameuiin-tang 2 kinds, Sobieum, Biman-tnag, and I-razin. 4. The methods of assessment used in 38 studies were classified by 7 categories and anthropometry parameters which is the basic methods are used in all studies 5. Almost studies (29 studies in all 38 studies) were using anthropometric parameters results on significantly effectiveness of childhood obesity. 6. More studies are needed to prove true effectives from various treatments, especially herbal therapy for childhood obesity.