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Effects of Dietary Prosomillet on cholesterol and Fatty Acid Metabolism in Rats Fed High Cholesterol Diets

  • Cho, Sung-Hee;Jung, Seung-Eun;Lee, Hye-Kyung;Ha, Tae-Youl
    • Nutritional Sciences
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    • v.3 no.1
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    • pp.25-30
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    • 2000
  • To study the effect of prosomillet (Panicum milaceum) on lipid metabolism, male Sprague-Dawley rats weighing 190$\pm$8g were fed six experimental diets for four weeks. The six diets based on AIN-76 composition consisted of one cholesterol-free(normal) and five 1%(w/w) cholesterol diets, i.e. control, two diets containing additional 0.3 and 0.6%(w/w) methanol extracts of prosomillet and another two diets containing 15 and 30% (w/w) prosomillet powder. There was no difference in weight gains between the groups but relative liver weights increased under the cholestrol diets. Plasma levels of total cholesterol and triglyceride(TG) decreased by 23-27% and by 37-52%, respectively, in the four prosomillet diet groups compared to those of the normal and control groups. Whereas in the liver, only TG levels decreased in the prosomillet diet groups. Fecal excretions of bile acid and cholesterol significantly with methanol extracts of prosomillet. There was a significant increase in the activity of hepatic microsomal cholesterol 7$\alpha$-hydroxylase when feeding 1% cholesterol but prosomillet in the diet, either as in the form of powder or methanol extract, appeared to have only slight additional effects, namely increases in enzyme activity. The activity of liver cytosolic glucose-6-phophate dehydrogenase (G6PDH) tended to be reduced with high cholesterol diets and dropped markedly by 15% using additional prosomillet powder. Those of the liver cytoxolic malic enzyme had a similar tendency to those of G6PDH. The results indicate that certain active components in prosmillet other than fiber have the potential to exert hypolipidemic effects via regulating cholesterol excretions and lipogenesis.

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Characterization of the Deposited Layer Obtained by Direct Laser Melting of Fe-Cr Based Metal Powder (Fe-Cr계 금속 분말의 직접 레이저 용융을 통해 형성된 적층부 특성 분석)

  • Jang, Jeong-Hwan;Joo, Byeong-Don;Jeon, Chan-Hu;Moon, Young-Hoon
    • Korean Journal of Metals and Materials
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    • v.50 no.2
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    • pp.107-115
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    • 2012
  • Direct laser melting (DLM) is a powder-based additive manufacturing process to produce parts by layer-by-layer laser melting. As the properties of the manufactured parts depend strongly on the deposited laser-melted bead, deposited layers obtained by the DLM process were characterized in this study. This investigation used a 200 W fiber laser to produce single-line beads under a variety of different energy distributions. In order to obtain a feasible range for the two main process parameters (i.e. laser power and scan rate), bead shapes of single track deposition were intensively investigated. The effects of the processing parameters, such as powder layer thickness and scan spacing, on geometries of the deposited layers have also been analyzed. As a result, minimum energy criteria that can achieve a complete melting have been suggested at the given powder layer thickness. The surface roughnesses of the deposited beads were strongly dependent on the overlap ratio of adjacent beads and on the energy distributions of laser power. Through microstructural analysis and hardness measurement, the morphological and mechanical properties of the deposited layers at various overlapped beads have also been characterized.

A Comparative Study on the Spacing and Discharge Performance of Subsurface Drainage Culvert to Increase Drainage Efficiency (배수효율이 높은 지하암거의 간격과 주름유공관의 통수능 비교분석)

  • KIM, Hyuntai;RYU, Jeonyong;JUNG, Kiyuol;PARK, Youngjun
    • Journal of The Korean Society of Agricultural Engineers
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    • v.61 no.6
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    • pp.67-72
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    • 2019
  • This study compared the theory of a culvert spacing and analytical results of the seepage flow for the subsurface drainage. i) If culvert spacing (Sc) is within 5 m, the unit drainage (q) is very larger; in contrast, if Sc is 5 m or more, there is very little drainage in the middle between drains. Therefore, the drain spacing should be within 5 m to ensure high drainage efficiency. ii) Since the planned culvert drainage increases linearly with the soil's permeability coefficient (k), k must be taken into account when determining the drain diameter by the planned culvert drainage. iii) As a result of analyzing the drainage performance of the absorbing culvert, the drainage performance is sufficient with the diameter of the corrugated drain pipe Dc = 50 mm at the length of the drain Lc = 100 m. iv) Therefore, if the drain spacing (Sc) is less than 5 m using the low-cost non-excavated drainage pipe method (${\Phi}50mm$ the corrugated drain pipe and fiber mat) rather than the conventional trench drain method (Sc > 10 m, Dc > 100 mm), uniform and high drainage efficiency can be ensured as well as low construction cost. v) The sub-irrigation+drainage culvert requires narrower drain spacing (Sc < 2-3 m) for irrigation. As a result of examining the condition of 35 mm in diameter (Dc) and 2~3 m in drain spacing, it is possible to apply the non-excavated drainage pipe method to the sub-irrigation+drainage culvert because drainage performance is sufficient at the drain length Lc = 50 m.

Platinum-Catalyzed and Ion-Selective Polystyrene Fibrous Membrane by Electrospinning and In-Situ Metallization Techniques

  • Hong, Seung-Hee;Lee, Sun-Ae;Nam, Jae-Do;Lee, Young-Kwan;Kim, Tae-Sung;Won, Sung-Ho
    • Macromolecular Research
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    • v.16 no.3
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    • pp.204-211
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    • 2008
  • A platinum-catalyzed polyelectrolyte porous membrane was prepared by solid-state compression of electrospun polystyrene (PS) fibers and in-situ metallization of counter-balanced ionic metal sources on the polymer surface. Using this ion-exchange metal-polymer composite system, fiber entangled pores were formed in the interstitial space of the fibers, which were surrounded by sulfonic acid sites ($SO_3^-$) to give a cation-selective polyelectrolyte porous bed with an ion exchange capacity ($I_{EC}$) of 3.0 meq/g and an ionic conductivity of 0.09 S/cm. The Pt loading was estimated to be 16.32 wt% from the $SO_3^-$ ions on the surface of the sulfonated PS fibers, which interact with the cationic platinum complex, $Pt(NH_3)_4^{2+}$, at a ratio of 3:1 based on steric hindrance and the arrangement of interacting ions. This is in good agreement with the Pt loading of 15.82 wt% measured by inductively coupled plasma-optical emission spectroscopy (ICP-OES). The Pt-loaded sulfonated PS media showed an ionic conductivity of 0.32 S/cm. The in-situ metallized platinum provided a nano-sized and strongly-bound catalyst in robust porous media, which highlights its potential use in various electrochemical and catalytic systems.

Effect of Alloying Element Addition on the Microstructure and Wear Properties of Die-casting ADC12 Alloy (ADC12 다이캐스팅 합금의 미세조직 및 기계적 특성에 미치는 개량 원소 첨가의 영향)

  • Kang, Y.J.;Yoon, S.I.;Kim, D.H.;Lee, K.A.
    • Transactions of Materials Processing
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    • v.28 no.1
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    • pp.34-42
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    • 2019
  • In this study, various alloying elements (Cr, Sr, Ca, Cd) were added to improve the mechanical properties of ADC12 fabricated by a die casting process. The effect of alloying elements on the microstructure and mechanical properties were investigated. The phase analysis results of the modified ADC12 alloy with conventional ADC12 alloy, showed the similar characteristics of Al matrix, Si phase, $CuAl_2$ phase and the Fe intermetallic phase. As a result of the microstructure observation, the secondary dendrite arm spacing (SDAS) was shown to have decreased after the addition of the alloying elements. The eutectic Si phase, which existed as flake form in the conventional ADC12 alloy, was modified finely as a fiber form in the modified ADC12 alloy. It was observed that the $CuAl_2$ phase as the strengthening phase was relatively finely distributed in the modified ADC12 alloy. The Fe intermetallic appeared as a Chinese script shaped $Al_6$ (Mn,Fe) which is detrimental to mechanical properties in conventional ADC12 alloy. On the other hand, in the modified ADC12 alloy, polyhedral ${\alpha}-Al_{15}Si_2$ $(Fe,Mn,Cr)_3$ was observed. The tensile properties were improved in the modified ADC12 alloy. The yield strength and tensile strength increased by 12.4% and 10.0%, respectively, in the modified ADC12 alloy, and the elongation was also seen to have been increased. As a result of the pin on disk wear test, the wear resistance properties were also improved by up to about 7% in the modified ADC12 alloy. It is noted that the wear deformation microstructures were also observed, and it was found that the fine eutectic Si and strengthening phases greatly improved abrasion resistance.

Review of Carbon Materials Used in Fuel cell Components (연료 전지 구성요소에 사용되는 탄소 재료에 관한 고찰)

  • Jang, Min-Hyeok;Kang, Yu-Jin;Jo, Hyung-Kun;Park, Cho-I;Sim, Hye-Soo;Park, Joo-Il
    • Journal of the Korea Convergence Society
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    • v.12 no.2
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    • pp.193-200
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    • 2021
  • As the degree of environmental pollution caused by the use of fossil fuels intensifies, many countries continue to invest in the development of alternative energy. PEMFC, one of the alternative energies, consists of four main components: bipolor plate, electrolyte, gas diffusion layer, and electrode. Among them, bipolor plate, the gas diffusion layer, and electrode are generally manufactured using carbon materials such as carbon black and carbon fiber. These carbon materials are expensive in manufacturing process or have disadvantages such as corrosion, and research is being conducted in many fields to improve this. This paper collects several research results conducted to improve the shortcomings of these three components and examines the trends of PEMFC by grasping what problems have been and how they have improved.

An experimental and analytical study into the strength of hooked-end steel fiber reinforced HVFA concrete

  • Shariq, M.;Pal, S.;Chaubey, R.;Masood, A.
    • Advances in concrete construction
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    • v.13 no.1
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    • pp.35-43
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    • 2022
  • The experimental investigations into hooked-end round steel fibers (HSF) effect on the age-dependent strengths of high volume fly ash (HVFA) concrete is studied. The concrete was prepared with class F fly ash used as partial cement replacement varied from 0% to 70% on an equal weight basis. Two percentages of HSF (i.e., 0.5% and 1.5% by volume fraction) of 50 mm length were added in plain, and 50% fly ash concrete mixes. The compressive and flexural tensile strength was determined at 7, 28, 56, and 90 days. The strength results of fly ash concrete mixes with and without steel fibers were compared with the plain concrete strength. The test results indicated that the strength of fly ash concrete is comparable with the plain concrete strength and further increases with an increase in the percentage of steel fibers. The maximum flexure strength of HVFA concrete is found with 0.5% steel fibers. It is concluded that the HVFA concrete with steel fibers of 50 mm length can effectively be used in concrete construction. The analytical models are proposed to predict the age-dependent compressive and flexural tensile strength of HVFA concrete with and without HSF. The compressive and tensile strength of HVFA concrete with HSF can be predicted using these models when the 28-day compressive strength of plain concrete is known. The present study will be helpful in the design and construction of reinforced and pre-stressed concrete structures made with HVFA and HSF.

The Treatment Effect of Ulcerative Colitis of Supercritical Heat-Treated Radish Extracts

  • Kim, Hyun-Kyoung
    • International Journal of Internet, Broadcasting and Communication
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    • v.13 no.2
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    • pp.145-155
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    • 2021
  • With the recent rapid improvement in the standards of life and westernization of dietary lifestyles, the consumption of high-calorie diets such as high-fat and high-protein red meat and instant foods has increased, while less vegetables containing dietary fiber are consumed. In addition to that, stress, erroneous dietary behaviors, and contaminated environments are linked to the risk of developing ulcerative colitis, which is on the rise. Another cause of ulcerative colitis is that involve laxative abuse, including repeated, frequent use of laxatives, and include such conditions as deteriorated bowel function, irritable bowel syndrome, diarrhea, intestinal inflammation, etc. The present study aimed to investigate the comparative evaluation of pharmacological efficacy between sulfasalazine alone and combination with herbal medicine on dextran sodium sulfate (DSS)-induced UC in mice. Balb/c mice received 5% DSS in drinking water for 7 days to induce colitis. Animals were divided into five groups (n = 9): group I-normal group, group II-DSS control group, group III-DSS + sulfasalazine (30 mg/kg), group IV-DSS + sulfasalazine (60 mg/kg), group V-DSS + sulfasalazine (30 mg/kg) + Radish Extract mixture (30 mg /kg) (SRE). DSS-treated mice developed symptoms similar to those of human UC, such as severe bloody diarrhea and weight loss. SRE supplementation, as well as sulfasalazine, suppressed colonic length and mucosal inflammatory infiltration. In addition, SRE treatment significantly reduced the expression of pro-inflammatory signaling molecules through suppression both mitogen-activated protein kinases (MAPK) and nuclear factor-kappa B (NF-κB) signaling pathways, and prevented the apoptosis of colon. Moreover, SRE administration significantly led to the up-regulation of antioxidant enzyme including SOD and Catalase. This is the first report that Radish extract mixture combined with sulfasalazine protects against experimental UC via the inhibition of both inflammation and apoptosis, very similar to the standard-of-care sulfasalazine.

Anti-inflammatory and antioxidant activities of Sargassum horneri extract in RAW264.7 macrophages

  • Kim, Min Ju;Jo, Hee Geun;Ramakrishna, Chilakala;Lee, Seung-Jae;Lee, Dong-Sung;Cheong, Sun Hee
    • Korean Journal of Exercise Nutrition
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    • v.25 no.4
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    • pp.45-53
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    • 2021
  • [Purpose] In this study, we investigated whether a 70% ethanolic (EtOH) extract of Sargassum horneri had antioxidant and anti-inflammatory effects in lipopolysaccharide (LPS)-stimulated macrophage-like RAW 264.7 cells. [Methods] The proximate composition, fatty acids, amino acids, and dietary fiber of S. horneri, various biologically active compounds, and antioxidant activity were analyzed. [Results] The DPPH and ABTS free radical scavenging activities, as well as the reduction power, of the S. horneri extract used here were significantly increased in a concentration-dependent manner. This indicates that S. horneri contains bioactive compounds, such as phenols and flavonoids, that have excellent antioxidant activity. The cellular viability and metabolic activity results confirmed that the extract had no discernible toxicity at concentrations up to 100 ㎍/mL. The levels of nitrites and cytokines (PGE2, TNF-α and IL-6), which mediate pro-inflammatory effect, were significantly inhibited by treatment with either 50 or 100 ㎍/mL S. horneri extract, whereas that of IL-1β was significantly inhibited by treatment with 100 ㎍/mL of the extract. Similarly, the expression of iNOS and COX-2 proteins also decreased according to 50 or 100 ㎍/mL extract concentrations. NF-κB binding to DNA was also significantly inhibited by treatment with 100 ㎍/mL of extract. [Conclusion] These results suggest that 70% EtOH extracts of S. horneri can relieve inflammation caused by disease or high intensity exercise.

Finite element modeling of RC columns made of inferior concrete mix strengthened with CFRP sheets

  • Khaled A. Alawi, Al-Sodani;Muhammad Kalimur ,Rahman;Mohammed A., Al-Osta;Omar S. Baghabra, Al-Amoudi
    • Earthquakes and Structures
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    • v.23 no.5
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    • pp.403-417
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    • 2022
  • Reinforced concrete (RC) structures with low-strength RC columns are rampant in several countries, especially those constructed during the early 1960s and 1970s. The weakness of these structures due to overloading or some natural disasters such as earthquakes and building age effects are some of the main reasons to collapse, particularly with the scarcity of data on the impact of aspect ratio and corner radius on the confinement effectiveness. Hence, it is crucial to investigate if these columns (with different aspect ratios) can be made safe by strengthening them with carbon fiber-reinforced polymers (CFRP) sheets. Therefore, experimental and numerical studies of CFRP-strengthened low-strength reinforced concrete short rectangular, square, and circular columns were studied. In this investigation, a total of 6 columns divided into three sets were evaluated. The first set had two circular cross-sectional columns, the second set had two square cross-section columns, and the third set has two rectangular cross-section columns. Furthermore, FEM validation has been conducted for some of the experimental results obtained from the literature. The experimental results revealed that the confinement equations for RC columns as per both CSA and ACI codes could give incorrect results for low-strength concrete. The control specimen (unstrengthened ones) displayed that both ACI and CSA equations overestimate the ultimate strength of low-strength RC columns by order of extent. For strengthened columns with CFRP, the code equations of CSA and ACI code overestimate the maximum strength by around 6 to 13% and 23 to 29%, respectively, depending on the cross-section of the column (i.e., square, rectangular, or circular). Results of finite element models (FEMs) showed that increasing the layer number of new commonly CFRP type (B) from one to 3 for circular columns can increase the column's ultimate loads by around eight times compared to unjacketed columns. However, in the case of strengthened square and rectangular columns with CFRP, the increase of the ultimate loads of columns can reach up to six times and two times, respectively.