• Archives of Pharmacal Research
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• v.27 no.7
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• pp.806-810
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• 2004

Metformin is a biguanide antihyperglycemic agent often used for the treatment of non-insulin dependent diabetics (NIDDM). In this study, the pharmacokinetics and pharmacodynamics of metformin were investigated in Korean healthy volunteers during a fasting state for over 10 h. In order to evaluate the amount of glucose-lowering effect of metformin, the plasma concentrations of glucose were measured for a period of 10 h followed by the administration of metformin (oral 500 mg) or placebo. In addition, the concentration of metformin in blood samples was determined by HPLC assay for the drug. All volunteers were consumed with 12 g of white sugar 10 minutes after drug intake to maintain initial plasma glucose concentration. The time courses of the plasma concentration of metformin and the glucose-lowering effect were analyzed by nonlinear regression analysis. The estimated $C_{max}$, $T_{max}$, $CL_{t}$/F (apparent clearance), V/F(apparent volume of distribution), and half-life of metformin were 1.42$\{pm}$0.07 $\mu\textrm{g}$/mL, 2.59$\{pm}$0.18h, 66.12$\{pm}$4.6 L/h, 26.63 L, and 1.54 h respectively. Since a significant counterclock-wise hysteresis was found for the metformin concentration in the plasma-effect relationship, indirect response model was used to evaluate pharmacodynamic parameters for metformin. The mean concentration at half-maximum inhibition $IC_{50}$, $k_{in}$, $k_{out}$ were 2.26 $\mu\textrm{g}$/mL, 83.26 $H^{-1}$, and 0.68 $H^{-1}$, respectively. Therefore, the pharmacokinetic-pharmacodynamic model may be useful in the description for the relationship between plasma concentration of metformin and its glucose-lowering effect.

• Journal of the Korea Concrete Institute
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• v.26 no.3
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• pp.351-360
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• 2014

The purpose of this research is to introduce the simplified equivalent frame model for the equivalent lateral force procedure, the response spectrum procedure and nonlinear procedure according to ASCE7-10 in order to reduce the time of performance and reasonably evaluate the effect of applying the damping system with the various conditions for the analysis and the variable. In this research, the seismic performance assessment and the design of the damping system were conducted through the nonlinear time history analysis based on the performance based seismic design in ASCE7-10 in regard to applying the damping system to apartment buildings which is lately issued. The optimal design based on the 75% of seismic base shear was performed for an apartment building. The seismic performance assessment were conducted to check the safety of the building, and the economic evaluation was performed by comparing the amount of resource for the optimal designed building with the amount of resource for the original building. In addition, hysteresis dampers was applied to the apartment building, and the suggested equivalent frame model was performed using the damping system design in ASCE7-10, then its control effects were proved in the full scale model of the apartment building which was used in this research.

• Structural Engineering and Mechanics
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• v.83 no.3
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• pp.305-326
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• 2022

To realize the recycling utilization of waste concrete and alleviate the shortage of resources, 11 specimens of steel reinforced recycled concrete (SRRC) filled circular steel tube columns were designed and manufactured in this study, and the cyclic loading tests on the specimens of columns were also carried out respectively. The hysteretic curves, skeleton curves and performance indicators of columns were obtained and analysed in detail. Besides, the finite element model of columns was established through OpenSees software, which considered the adverse effect of recycled coarse aggregate (RA) replacement rates and the constraint effect of circular steel tube on internal RAC. The numerical calculation curves of columns are in good agreement with the experimental curves, which shows that the numerical model is relatively reasonable. On this basis, a series of nonlinear parameters analysis on the hysteretic behaviors of columns were also investigated. The results are as follows: When the replacement rates of RA increases from 0 to 100%, the peak loads of columns decreases by 7.78% and the ductility decreases slightly. With the increase of axial compression ratio, the bearing capacity of columns increases first and then decreases, but the ductility of columns decreases rapidly. Increasing the wall thickness of circular steel tube is very profitable to improve the bearing capacity and ductility of columns. When the section steel ratio increases from 5.54% to 9.99%, although the bearing capacity of columns is improved, it has no obvious contribution to improve the ductility of columns. With the decrease of shear span ratio, the bearing capacity of columns increases obviously, but the ductility decreases, and the failure mode of columns develops into brittle shear failure. Therefore, in the engineering design of columns, the situation of small shear span ratio (i.e., short columns) should be avoided as far as possible. Based on this, the calculation model on the skeleton curves of columns was established by the theoretical analysis and fitting method, so as to determine the main characteristic points in the model. The effectiveness of skeleton curve model is verified by comparing with the test skeleton curves.

• Korean Journal of Soil Science and Fertilizer
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• v.36 no.4
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• pp.181-192
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• 2003

We developed a mathematical simulation model to portray the vertical distribution of soil water from the measured weather data and the known soil hydraulic properties, and then compared simulation results with the periodically measured soil water profiles obtained on Jungdong sandy loam to verify the model, In this model, we solved potential-based Richards' equation by the implicit finite difference method superimposed on the predictor-corrector scheme. We presumed that: soil hydraulic properties are homogeneous; soil water flows isothermally; hysteresis is not considered; no vapor flows; no heat transfers into the soil profiles; and water added to soil surface is distributed along the soil profile following partial displacement principle. The input data were broadly classified into two groups: (1) daily weather data such as rainfall, maximum and minimum air temperatures, relative humidity and solar radiation and (2) soil hydraulic data to approximate unsaturated hydraulic conductivity and water retention. Each hydraulic polynomial function approximated using the Chebyshev polynomial and least square difference technique in tandem showed a fairly good fit of the given set of data. Vertical distribution of soil water as approximations to the Richards' equation subject to changing surface and phreatic boundaries was solved numerically during 53 days with a comparatively large time increment, and this pattern agreed well with field neutron scattering data, except for the surface 0.1 m slab.

• Journal of the Earthquake Engineering Society of Korea
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• v.3 no.2
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• pp.87-96
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• 1999

To analyze the dynamic behavior of structure, direct integration and mode superposition may be utilized in time domain analysis. As finite number of frequencies can give relatively exact solutions, mode superposition is preferable in analyzing structural behavior. In non-linear analysis, however, mode superposition is seldom used since time-varying element stiffness changes stiffness matrix, and the change of stiffness matrix leads to the change of essential constants - natural frequencies and mode shapes. In spite of these difficulties, there are some attempts to adopt mode superposition because of low cost compared to direct integration, but the result is not satisfactory. In this paper, a method using mode superposition in non-linear analysis is presented by separating local element stiffness from global stiffness matrix with the difference between linear and non-linear restoring forces to the external force vectors included. Moreover, the hysteresis model changing with the relative deformation in each floor makes it possible to analyze non-linear behavior of structure. The proposed algorithm is applied to shear beam model and the maximum displacement is compared with the result using direct integration method.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.17 no.3
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• pp.329-338
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• 2019

Suction of unsaturated bentonite buffers is a very important input parameter for hydro-mechanical performance assessment and design of an engineered barrier system. This study analyzed suction measurement techniques and constitutive models of unsaturated porous media reported in the literature, and suggested suction measurement techniques and constitutive models suitable for bentonite buffer in an HLW repository. The literature review showed the suction of bentonite buffer to be much higher than that of soil, as measured by total suction including matric suction and osmotic suction. The measurement methods (RH-Cell, RH-Cell/Sensor) using a relative humidity sensor were suitable for suction measurement of the bentonite buffer; the RH-Cell /Sensor method was more preferred in consideration of the temperature change due to radioactive decay heat and measurement time. Various water retention models of bentonite buffers have been proposed through experiments, but the van Genuchten model is mainly used as a constitutive model of hydro-mechanical performance assessment of unsaturated buffers. The water characteristic curve of bentonite buffers showed different tendencies according to bentonite type, dry density, temperature, salinity, sample state and hysteresis. Selection of water retention models and determination of model input parameters should consider the effects of these controlling factors so as to improve overall reliability.

• Journal of the Korean Geotechnical Society
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• v.30 no.3
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• pp.47-58
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• 2014

To investigate the unsaturated characteristics of the tailings obtained from the waste dump at Imgi mine, matric suction and volumetric water content were measured in both drying and wetting processes using Automated Soil-Water Characteristics Curve Apparatus. Based on the measured result, Soil Water Characteristic Curves (SWCC) were estimated by van Genuchten model. According to the unsaturated soil classification method, the tailings of the waste dump correspond to clayey sand. As a result of Suction Stress Characteristic Curve (SSCC) by Lu and Likos model, SSCC has a shape of S which is similar to SWCC. The hysteresis phenomenon occurred in SSCCs, which means the suction stress of drying path is larger than that of wetting path in the same effective degree of saturation. The effective stress of unsaturated soil is equal to that of saturated soil when matric suction is less than Air Entry Value (AEV). However, the effective stress of unsaturated soil is larger than that of saturated soil when matic suction is more than AEV. Meanwhile, unsaturated hydraulic conductivity by van Genuchten model decreased with increasing matric suction, and the hydraulic conductivity of drying path is larger than that of wetting path.

• Journal of Biomedical Engineering Research
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• v.37 no.5
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• pp.168-177
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• 2016

In this paper we present an implantable pressure sensor to measure real-time blood pressure by monitoring mechanical movement of artery. Sensor is composed of inductors (L) and capacitors (C) which are formed by microfabrication and direct bonding on two biocompatible substrates (quartz). When electrical potential is applied to the sensor, the inductors and capacitors generates a LC resonance circuit and produce characteristic resonant frequencies. Real-time variation of the resonant frequency is monitored by an external measurement system using inductive coupling. Structural and electrical simulation was performed by Computer Aided Engineering (CAE) programs, ANSYS and HFSS, to optimize geometry of sensor. Ultrafast laser (femto-second) cutting and MEMS process were executed as sensor fabrication methods with consideration of brittleness of the substrate and small radial artery size. After whole fabrication processes, we got sensors of $3mm{\times}15mm{\times}0.5mm$. Resonant frequency of the sensor was around 90 MHz at atmosphere (760 mmHg), and the sensor has good linearity without any hysteresis. Longterm (5 years) stability of the sensor was verified by thermal acceleration testing with Arrhenius model. Moreover, in-vitro cytotoxicity test was done to show biocompatiblity of the sensor and validation of real-time blood pressure measurement was verified with animal test by implant of the sensor. By integration with development of external interrogation system, the proposed sensor system will be a promising method to measure real-time blood pressure.

• Journal of the Korean Society of Propulsion Engineers
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• v.14 no.6
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• pp.38-44
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• 2010

The shock wave and boundary layer interaction patterns in an over-expanded rocket nozzle are associated with the production of undesirable side-forces during the start-up and shut-down processes of the engine. In the present work, a computational study is carried out to investigate the effect of the transient nozzle pressure ratio (NPR) on the flow fields inside the nozzle. The unsteady, compressible, axisymmetric, Navier-Stocks equations with SST k-${\omega}$ turbulence model are solved using a fully implicit finite volume scheme. NPR is varied from 2.0 to 10.0, in order to simulate the start-up and shut-down processes of the rocket engine. It is observed that the interaction patterns and the hysteresis phenomenon strongly depend on the time variation of NPR, leading to significantly different characteristics in the lateral forces.

• Steel and Composite Structures
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• v.34 no.5
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• pp.625-641
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• 2020

The realistic modeling of the beam-column semi-rigid connection in steel frames attracted the attention of many researchers in the past for the seismic analysis of semi-rigid frames. Comparatively less studies have been made to investigate the behavior of steel frames with semi-rigid connections under different types of earthquake. Herein, the seismic behavior of semi-rigid steel frames is investigated under both far and near-field earthquakes. The semi-rigid connection is modeled by the multilinear plastic link element consisting of rotational springs. The kinematic hysteresis model is used to define the dynamic behavior of the rotational spring, describing the nonlinearity of the semi-rigid connection as defined in SAP2000. The nonlinear time history analysis (NTHA) is performed to obtain response time histories of the frame under scaled earthquakes at three PGA levels denoting the low, medium and high-level earthquakes. The other important parameters varied are the stiffness and strength parameters of the connections, defining the degree of semi-rigidity. For studying the behavior of the semi-rigid frame, a large number of seismic demand parameters are considered. The benchmark for comparison is taken as those of the corresponding rigid frame. Two different frames, namely, a five-story frame and a ten-story frame are considered as the numerical examples. It is shown that semi-rigid frames prove to be effective and beneficial in resisting the seismic forces for near-field earthquakes (PGA ≈ 0.2g), especially in reducing the base shear to a considerable extent for the moderate level of earthquake. Further, the semi-rigid frame with a relatively weaker beam and less connection stiffness may withstand a moderately strong earthquake without having much damage in the beams.