• The Korean Journal of Pain
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• 제26권1호
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• pp.89-93
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• 2013

Compensatory hyperhidrosis or reflex hyperhidrosis is the increase in sweating in the postoperative stage of thoracic sympathectomy or lumbar sympathectomy. It shares several features with anxiety disorders and has a negative impact on a patient's quality of life. Oralglycopyrrolate is one of the treatment options available. This study reviewed case notes in a series of 19 patients with compensatory hyperhidrosis. We made a comparison between the Milanez de Campos score of a pre-glycopyrrolate medication group and the Milanez de Campos score of a post-glycopyrrolate medication group. The Beck Depression Inventory (BDI) score, Beck Anxiety Inventory (BAI) score, and autonomic nervous system (ANS) scale score were also compared between the pre-medication and post-medication groups. In the post-glycopyrrolate medication group, there was decrease in the Milanez de Campos score, BAI score, and BDI score (P < 0.05). But no meaningful change was seen in the ANS score in the post-glycopyrrolate medication group (P > 0.05). Glycopyrrolate is an effective medication in the treatment of compensatory hyperhidrosis that, can alleviate anxiety and improve patients' quality of life.

• 한방안이비인후피부과학회지
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• 제35권4호
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• pp.123-138
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• 2022

Objectives : The purpose of this study is to see the effects of herbal medicines on hyperhidrosis treatment. Methods : We searched articles related to oriental treatment of hyperhidrosis through domestic and international databases. Articles were searched for RCT. The results were summarized in tables and graphs, and meta-analysis was performed. Results : As a result of setting the herbal medicine alone treatment as an intervention for hyperhidrosis and western medicine alone as the control group, total 8 articles were selected. We analyzed them and got the results. The efficient rate of the treatment group was statistically significantly higher than that of the control group. In addition, adverse events were significantly less in the treatment group than in the control group. Conclusions : We found that oriental herbal medicine was effective and safe for hyperhidrosis.

• The Korean Journal of Pain
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• 제18권2호
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• pp.171-175
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• 2005

Background: Hyperhidrosis is the troublesome disorder of excessive perspiration, which affects as much as 0.15-1% of the population. There are many methods for treating hyperhidrosis. In this report, we present our experience of dorsal percutaneous thoracic sympathetic ganglion block (TSGB) using 99.9% ethyl alcohol for treating palmar hyperhidrosis. Methods: Between March 1992 and July 2003, a total of 856 patients underwent TSGB for the treatment of palmar hyperhidrosis of which 625 were followed up for 2 years. There were 297 and 328 male and female patients, respectively, with a mean age of $23.9{\pm}7.7years$. TSGB was performed under fluoroscopic guidance using 99.9% ethyl alcohol at the T2 and T3 sympathetic ganglia. Results: In the 625 patients, the recurrence rates within the 1st and 2nd years were 29 and 8%, respectively. Compensatory sweating occurred in 42.1% of patients, which was severe in 7.5%. Of the 625 patients 21.0 and 36.9% were either very satisfied or relatively satisfied with the outcome, respectively. Conclusions: Our report confirms that TSGB may be a good alternative to endoscopic thoracic sympathectomy in the treatment of palmar hyperhidrosis.

• 대한한방내과학회지
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• 제33권3호
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• pp.327-337
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• 2012

Objectives : The purpose of this study was to report the clinical effect of short- term admission program on primary palmar/plantar hyperhidrosis in children and adolescents. Methods : Between January 2011 and January 2012, a total of 11 patients with clinical diagnosis of primary palmar/plantar hyperhidrosis were treated with hospitalization which consisted of iontophoresis, electro-acupuncture, herbal medicine, topical therapy and physical therapy. The effects were evaluated as quality of life with dermatology life quality index (DLQI), severity of discomfort using visual analogue scale (VAS), and the patients' subjective satisfaction. We analyzed the patients' improvement before and after admission treatment, as well as six month later. Results : After treatment, the 11 patients' quality of life and severity of discomfort improved significantly. They also were satisfied with oriental treatments for hyper hidrosis. Six months later, 6 of 11 patients had visited the hyperhidrosis clinic. Their symptoms had improved and remained stable. Conclusions : The short-term admission program is effective on primary palmar/plantar hyperhidrosis. Further studies with a larger number of cases will be needed in the future.

• Journal of Chest Surgery
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• 제33권3호
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• pp.268-272
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• 2000

Thoracic sympathicotomy has been used safely and successfully to treat essential hyperhidrosis. However, it has been difficult to treat compansatory hyperhidrosis after thoracic sympathicotomy and focal hyperhidrosis. The sweat glands were innervated by post-ganglionic sympathetic fibers with acetylcholic serving as the transmitter. Botulinum A toxin has been reported to block neuro-transmission at the cholinergic autonomic nerve terminals. Prospecting its effect for the sweat gland, we treated 5 patients with focal hyperhidrosis with botulinum A toxin. Three patients received bilateral thoracic sympathectomy (1 case) and sympathicotomy(2 case) via VAT. The hyperhidrosis area was marked with betadine and was subdivided into squares of 2$\times$2 cm(4$\textrm{cm}^2$) each. Botulinum A toxin was injected intracutaneously in a dosage of 2.5U/0.1ml(100U/4ml) /4$\textrm{cm}^2$. A total dose of 100U of Botulinum A toxin was injected into the affected sites. Subjective assessment of sweat production by the patients using a visual analogue scale showed a 20~70% improvement. During the follow-up period, no toxic effects were observed.

• Journal of Chest Surgery
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• 제32권9호
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• pp.818-822
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• 1999

배경: 수장부 다한증에서 비디오 흉강경을 이용한 제 2번 흉부 교감신경절 차단술이 최근 들어 많이 이용되 어 왔으나, 보상성 다한증의 발현 및 안면 무한증 등의 부작용 발현 등으로 이를 변형시킨 Modified T2 sympathicotomy의 효과에 관하여 단기성적을 비교 분석하고자한다. 대상 및 방법: 건국대학교 의과대학 흉부 외과에서 1997년 1월부터 1998년 12월까지 수장부 본태성 다한증으로 수술 한 41명의 환자를 대상으로 Modified upper T2 sympathicotomy를 한 A군(24명)과 Modified lower T2 sympathicotomy를 한 B군(17명) 사이에 서 환자의 성별, 나이, 수술 시간, 수술후 부작용 발현 및 수술의 만족도 등을 비교 분석하였다. 결과: 모든 환자에 있어서 다한증 증세 호전을 보였으며, B군보다 A군에서 동공부동증과 안면무한증 발생율이 높고, 보 상성 다한증의 발현율이 많다. 전체적인 수술의 만족도는 A군 보다 B군에서 높게 나타난다. 결론: 변형된 T2 교감신경절 차단술 중에서 하부 제 2번 흉부(T2) 교감신경절 차단술이 수장부 다한증 환자 수술시 부작 용을 줄이고 만족도를 높이는 방법이 될 수 있다.

• 대한한방소아과학회지
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• 제36권3호
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• pp.75-86
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• 2022

Objectives The purpose of the study is to review the trend of clinical trials conducted in China with oral herbal medicine treatment on childhood primary hyperhidrosis. Methods We searched the randomized controlled trials (RCTs) with oral herbal medicine treatment on childhood primary hyperhidrosis from the China National Knowledge Infrastructure (CNKI). The demographic data, duration of illness, intervention, treatment period, outcome and composition of herbal medicine were analyzed for this study. Results A total of five RCTs were selected and analyzed. The effectiveness of the oral administration of herbal medicines on childhood primary hyperhidrosis was found to be significant. In one study, there was no statistical difference between the treatment group and the control group when curative effect was evaluated two weeks after the intervention; however, the treatment group showed a statistically higher curative effect than the control group at one and two months after intervention, and also one month after the intervention was terminated. Conclusions Oral herbal medicine has been shown to be an effective treatment for childhood primary hyperhidrosis, and it takes at least one month for the administered oral herbal medicines to take effect. However, further well-designed large-scale randomized controlled trials are needed to confirm the efficacy and safety of oral herbal medicines in childhood primary hyperhidrosis.

• 대한중풍순환신경학회지
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• 제19권1호
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• pp.31-40
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• 2018

■ Objectives The purpose of this case study is to report the effectiveness of Korean medicine in the treatment of chronic hyperhidrosis. ■ Methods The patient was diagnosed as a Soeumin Mang-yang Syndrome, and treated with Korean medical treatment such as Sungyangikgibuja-tang and acupuncture treatment. The severity of symptom was assessed using Numerical Rating Scale (NRS) and follow-up of Hyperhidrosis Quality of Life Index (HidroQOL) ■ Results After treatment, the severity of hyperhidrosis was decreased from NRS 10 to NRS 2, HidroQOL score was also decreased from 32 to 19. ■ Conclusion Korean medical treatment for hyperhidrosis was effective in decreasing the NRS and HidroQOL score. The results suggest that Korean medical combined treatment including Sungyangikgibuja-tang and acupuncture treatment can be a effective option for treating hyperhidrosis.

• Journal of Chest Surgery
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• 제38권8호
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• pp.570-575
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• 2005

배경: 다한증의 치료에 있어서 흉강내시경을 이용한 흉부교감신경절단술은 매우 중요한 역할을 한다. 하지만 액와부 다한증의 경우 술 후 보상성 발한 및 액와부의 재발한으로 인해 술 후 만족도가 높지 못하다 이에 흥부교감신경의 차단범위에 따른 증상의 호전 및 만족도를 비교 평가하여 수술방법의 선택에 도움을 주려하였다. 대상 및 방법: 2001년 1월부터 2003년 12월까지 액와부 다한증으로 흥부 교감신경차단술을 시행한 70명의 환자 중 술 후 추적이 가능했던 57명을 대상으로 하였다. 제 3, 4, 5번 늑골상연에서 교감신경절간신경을 차단한 25예(1군)와 제 3, 4번 늑골 상연에서 교감신경절간신 경을 차단한 32예(2군)로 나누어서 수술 후 만족도의 변화와 보상성 발한의 정도를 비교하였다 결과: 두 군간의 연령 및 성별, 가족력, 동반된 다한증, 술 후 추적기간에 있어서 유의한 차이는 없었으나, 수술 후 만족도에 있어서는 1군에서 $88.0\%$, 2군에서는 $56.3\%$의 만족도를 보여 유의한 차이를 보였다 (p=0.02). 일상생활에 불편함을 초래하는 중등도 이상의 보상성발한은 1군에서 25예 중 13예$(52.0\%)$, 2군에서 32예 중 20예$(62.5\%)$였으나 통계적으로 유의한 차이를 보이지는 않았다. 걸론: 액와부다한증 을 동반한 일차성 다한증의 수술 치료에 있어서 R3, 4, 5 교감신경 차단술이 R3, 4 교감신경 차단술에 비해서 보상성 발한에 차이가 없고 술 후 만기추적상의 만족도가 높았다.

• Journal of Chest Surgery
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• 제32권5호
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• pp.456-460
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• 1999

배경: 다한증에 대한 흉부교감신경절제술은 흉강경기구 및 수술술기 발달로 효과적인 치료방법으로 인식되고 있으나 보상성 다한증으로 그 만족도가 떨어지고 있다. 따라서 저자들은 수술결과 및 보상성 다한증을 분석하고자 하였으며 수술전후 손과 발의 온도 차이 그리고 상지와 하지의 혈류량을 측정하였다. 대상 및 방법: 1995년 12월부터 1998년 7월까지 강남성모병원에서 총 47명의 다한증환자를 흉강경하에 교감신경절제술을 시행하였다. 수술전후로 손가락 및 발가락에서 온도변화를 측정하였고, 혈류량 측정은 도플러 초음파검사로 손가락동맥, 요골동맥, 그리고 족배동맥에서 측정하였다. 결과: 수술사망은 없었으며, 기흉 7건, 재발 3건, 안검하수 1건등의 합병증이 있었다. 보상성 다한증은 수술한 환자의 95%에서 있었으며 이중 5명이 수술을 후회하였다. 족부 다한증은 흉부교감신경절제술후 46%에서 향상되었고, 수술전후 온도변화는 우측 손에서 1$^{\circ}C$, 좌측 손에서 1.9$^{\circ}C$였고 통계적으로 의미있게 증가하였다. 그러나 족부 다한증에서는 의미있는 온도차이가 없었다. 혈류량은 손에서 의미있게 증가하였으나 발에서는 차이가 없었다. 결론: 다한증의 흉부 교감신경절제술은 안전하고 효과적인 치료이지만 그 만족도는 보상성 다한증에 의해 감소하고 있으므로 수술전에 보상성 다한증에 대하여 충분히 설명하는 것이 중요하다. 족부 다한증은 생리적 변화에 의한 것이라기 보다는 정신적 안정에 의한 것으로 보인다.