• 사상체질의학회지
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• 제2권1호
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• pp.149-166
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• 1990

In order to investigate experimented effects of Indongdeung Jigolpi-Tang, which is applied to Soyangin, to diabetes, the measurement, comparison and observation made on the contents of volumes of blood glucose, total cholesterol, triglyceride, phospholipid, total protein and electrolyte($K^+$, $Na^+$) in blood serum by giving a high blood glucose, induced by streptozotocin, to hyperglycemic rats, dosing the cooked liquid of I.J.T., and following conclusion was attained. 1. The volume of glucose urine, induced by streptozotocin to hyperglycemic rats, was shown an increase in comparision to a normal flock when $12.50m{\ell}/kg$ of I.J.T. dosed to the rats and checked after two and four weeks and thereby, a sinificant reduction in the volume of blood glucose was made. 2. The volume of total cholesterol of blood serum in the diabetic rats, induced by streptozotocin, was increased in comparision to the normal flock, and in the fouth week of dosing $1.25m{\ell}/kg$ of I.J.T., a significant reduction of total cholesterol volum was shown in the blood serum. 3. The volume of triglyceride in the blood serum of the diabetic rats, induced by the streptozotocin, was increased in comparision to the normal flock, and with dosing $1.25m{\ell}/kg$ and $12.50m{\ell}/kg$ of I.J.T., a significant reduction of triglyceride volium was shwon in the blood serum after second and fourth week. 4. The volume of phospholipid in the blood serum of the diabetic rats, induced by the streptozotocin, was somewhat reduced in comparision to the normal flock, and with dosing $1.25m{\ell}/kg$ of I.J.T., a significant reduction of phospholipid volium in the blood serum was shown after first and second week. 5. The volume of total protein in the blood serum of the diabetic rats, induced by the streptozotocin, was somewhat reduced in comparison to the normal flock however, with dosing the I.J.T., no significant change on the volium of total protein was made in the blood serum. 6. The volume of potassium in the blood serum of the diabetic rats, induced by the streptozotocin, was increased in comparision to the normal flock however, with dosing the I.J.T., no significant change of potassium content was made in the blood serum. 7. The volume of sodium in the blood serum of the diabetic rats, induced by the streptozotocin, was somewhat reduced in comparision to the normal flock, and with dosing $12.50m{\ell}/kg$ of the I.J.T., a significant increase was shown in the blood serum after first week. Soyangin, accompanying with a middle and upper heat, the I.J.T. - that has a merits of cleaning up fever, solving fever, solving poison, solving thirst and restoring exhaustion - can be proved that it has a blood sugar reduction effect and it is considered that it can be meritorious for strengthening vitality, further, many other exhausting diseases, and can actively used for the cases such as thirst causing disease and a disease that causes an abnormal food hunger, thirst causing and frequent going to pass urine, in particular.

• 대한핵의학회지
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• 제36권2호
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• pp.110-120
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• 2002

목적: FDG PET은 악성종양의 진단에 유용하게 쓰이고 있으나, 염증에도 섭취되어 진단에 어려움이 있다. 염증에서 F-18-FDG 섭취는 단핵세포에서 포도당대사가 항진되어 나타난다. 이 연구에서는 사람의 암세포와 단핵세포간에 포도당대사에 차이가 있는지 알아보고자 하였다. 대상 및 방법: 사람의 대장암 세포주(SNU-C2A, SNU-C4, SNU-C5)와 폐암 세포주(NCI-H522), 단핵세포를 포도당 농도가 다른 배지에서 각각 배양시키고, FDG 섭취와 포도당운반체 1(Glut1)의 발현, hexokinase 활성도의 변화를 비교 분석하였다. 결과: 포도당이 없는 배지에서는 암세포와 단핵세포 모두에서 FDG 섭취가 증가되나 포도당 고농도(16.7 mM)에서는 섭취가 감소하였다. 이 고농도에서 Glut1 mRNA의 발현은 대장암 세포주, 폐암 세포주에서 감소하였다. 고농도의 포도당 배지에서 Glut1 단백질의 발현도 4종류의 암세포에서 모두 감소하였으나, 단핵세포에서는 변화가 없었다. SNU-C2A, SNU-C4, NCI-H522 세포에서 hexokinase의 활성도는 비슷하였고, 단핵세포와 SNU-C5에서는 약간 증가하였다. 결론: 포도당 섭취에 있어서 사람의 암 세포주와 단핵세포는 서로 다른 기전을 보이고 있다. 대장암 세포는 포도당 농도에 의한 포도당 섭취 변화가 Glut1에 의하여 조절되나, 단핵세포는 다른 기전을 가지고 있다.

• 생명과학회지
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• 제14권2호
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• pp.245-251
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• 2004

본 연구는 streptozotocin으로 당뇨병을 유도하는 조건들을 농도에 따른 변화를 관찰하고, 적절한 조건에서 당뇨쥐에서의 저강도의 treadmill 운동이 체중과 혈중의 당, 인슐린 및 지질의 변화에 미치는 영향을 알아보고자 실시하였으며, 연구결과를 요약하면 다음과 같다. 실험 I에서 STZ 주사량이 40 mg/mg으로 높아질수록 정상군에 비해 혈당이 유의하게 증가하고, 반대로 체중과 인슐린 농도는 상대적으로 감소하였다. 실험II에서 STZ 주사를 한 모든 군에서 혈당이 유의하게 증가하지만 BE군은 C군에 비해 그 증가율이 유의하게 억제되었으며, 운동이 인슐린 농도와 혈중지질 농도를 정상적으로 유도하는 것으로 나타났다. 특히, 당뇨 유발 전부터 운동을 실시한 경우 그 효과가 더욱 유의하게 나타났으며, 앞으로 당뇨 유발의 정도와 운동 빈도 및 강도와 관련된 더욱 많은 연구가 이루어져야 할 것으로 사료된다.

• 한국식품과학회지
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• 제32권6호
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• pp.1418-1425
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• 2000

아가리쿠스 버섯(동결 건조, 온풍 건조)에서 추출한 ${\beta}-glucan$을 7주령의 db/db마우스에 5주간 음용수로 제공하고 식이섭취량 및 체중의 변화를 관찰하고 혈액내의 포도당, 인슐린, 당화 헤모글로빈, 소장의 glycosidase의 활성을 측정하고 중성지방농도, 혈중 지질조성을 측정하였으며 결과는 다음과 같다. db/db 마우스에서 Agari.F군과 Agari.H군은 식이섭취량에서 Control군보다 유의적으로 낮았고, 그에 따라 체중증가량도 낮았으며, 혈중 인슐린 농도와 당화헤모글로빈 농도는 Control군에 비해 Agari.F군, Agari.H군, Acarbose군이 유의적으로 낮은 수준이었다. 소장의 maltase, lactase, sucrase의 활성은 Control군에서 Lean군에 비해 세 효소의 활성이 매우 높게 관찰되었고, 시료투여군인 Agari.F군, Agari.H군은 maltase의 경우 proximal, middle 부위는 대조군보다 낮았고 distal 부위에서는 Agari.F군의 활성이 가장 높았다. Sucrase, lactase의 활성은 모든 부위에서 시료투여군이 Control군보다 낮은 수준이었다. 혈중 중성지방 농도는 Control군에 비해 Agari.F군, Agari.H군, Acarbose군은 유의적으로 낮은 수준이었다. 혈중 total cholesterol의 농도의 경우 Control군과 Agari.H군은 유의적인 차이가 없었지만 Agari.F군과 Acarbose군은 유의적으로 낮았다. 혈중 VLDL cholesterol의 경우는 Control군에 비해 Agari.F군, Agari.H군은 유의적으로 낮았고 Acarbose군은 유의적인 차이가 없었다. 혈중 LDL cholesterol의 농도는 Control군이 유의적으로 높았으며, Acarbose군이 가장 낮았다. 혈중 HDL cholesterol의 농도는 Agari.H군이 유의적으로 가장 높았고, Control군이 가장 낮았다.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 2002년도 학술대회지
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• pp.129-144
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• 2002

We investigated anti-hyperglycemic and anti-obese effects of Panax ginseng berry extract and its major constituent, ginsenoside Re, in obese diabetic C57BL/6J ob/ob mice and their lean littermates. Animals received daily intraperitoneal injections of Panax ginseng berry extract for 12 days. On Day 5, 150 mg/kg extract-treated ob/ob mice had significantly lower fasting blood glucose levels compared to vehicle-treated mice $(156{\pm}9.0\;mg/dl\;vs.\;243{\pm}15.8mg/dl,$ P<0.01). On Day 12, the extract-treated ob/ob mice became normoglycemic $(137{\pm}6.7\;mg/dl)$ and had significantly improved glucose tolerance. The overall glucose excursion during the two-hour intraperitoneal glucose tolerance test (IPGTT), calculated as area under the curve (AUC), decreased by $46\%$ (P<0.01) compared to vehicle-treated ob/ob mice. Glucose levels of lean mice were not significantly affected by the extract. The improvement in blood glucose levels in 150 mg/kg extracttreated ob/ob mice was associated with significant reduction in serum insulin levels of fed and fasting mice. Consistent with an improvement in insulin sensitivity, hyperinsulinemic euglycemic clamp study revealed a more than 2-fold increase in the rate of insulin-stimulated glucose disposal in treated ob/ob mice $(112{\pm}19.1\;vs.\;52{\pm}11.8{\mu}mol/kg/min$ for the vehicle group, P<0.01). In addition, 150 mg/kg extract-treated ob/ob mice, but not the lean mice, lost significant weight (from $51.7{\pm}1.9g\;on\;Day\;0\;to\;45.7{\pm}1.2$ on Day 12, P<0.01 compared to vehicle-treated ob/ob mice), associated with a significant reduction in food intake (P<0.05) and a very significant increase in energy expenditure (P<0.01) and body temperature (P<0.01). A 12-day treatment with 150 mg/kg Panax ginseng berry extract also significantly reduced plasma cholesterol levels in ob/ob mice. Additional studies demonstrated that ginsenoside Re, a major constituent of the ginseng berry, but not from the root, plays a significant role in anti-hyperglycemic action. This anti-diabetic effect of ginsenoside Re was not associated with body weight changes, suggesting that other constituents in the extract have distinct pharmacological mechanisms on energy metabolism. The identification of a significant anti-hyperglycemic activity in ginsenoside Re may provide an opportunity to develop a novel class of anti-diabetic agent.

• Natural Product Sciences
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• 제10권1호
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• pp.11-15
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• 2004

The leaves of Rhizophora apiculata, a plant belonging to the family Rhizophoraceae were collected from the mangrove forest of Sunderbans, West Bengal, India. Alcoholic extract of the leaves of this plant was prepared and hypoglycemic/anti-hyperglycemic activity was studied in fed rats, glucose loaded rats and streptozotocin induced diabetic rats. The results of this study reveal that this plant extract has potential hypoglycemic action.

• Asian-Australasian Journal of Animal Sciences
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• 제4권1호
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• pp.41-45
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• 1991

Insulin responsiveness to glucose and tissue responsiveness to insulin, using the hyperglycemic clamp and the hyperinsulinemic euglycemic clamp techniques, were compared among cows, sheep and pigs. The plasma insulin concentrations during the hyperglaycemic clamp period were highest (p < 0.05) in cows, followed by sheep and pigs. The glucose infusion rate in the hyperinsulinemic euglycemic clamp technique was greater (p < 0.01) in pigs than in cows and sheep. These results suggest responsiveness to insulin is higher in pigs than in cows and sheep.

• 생약학회지
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• 제32권3호통권126호
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• pp.248-252
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• 2001

The present study was undertaken to elucidate the hypoglycemic effect and inhibitory effect of Cudrania tricuspidata root bark on aldose reductase activity. C. tricuspidata MeOH ext. 1,000 mg/kg showed a significant blood glucose lowering effect on alloxan-induced hyperglycemic rats and increasing body weight. C. tricuspidata MeOH ext. showed a potent inhibitory effect on bovine lens aldose reductase.

• Natural Product Sciences
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• 제8권4호
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• pp.111-126
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• 2002

The chemistry of secondary products from Acanthopanax species and their pharmacological activities were reviewed. A nitrogenous compound, a furan compound, a quinoid, benzoids, coumarins, phenylpropanoids, lignans, flavonoids, terpenoids, phytosterols, polyacetylenes, a pyrimidine, cyclitols, monosaccharides and an aliphatic alcohol have been isolated from Acanthopanax species and have been shown to have various levels of activities such as anti-bacterial, anti-cancer, anti-gout, anti-hepatitis, anti-hyperglycemic, anti-inflammatory, anti-leishmanicidic, anti-oxidant, anti-pyretic, anti-xanthine oxidase, choleretic, hemostatic, hypocholesterolemic, immunostimulatory and radioprotectant effects, etc.

• 대한약리학회지
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• 제15권1_2호
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• pp.21-27
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• 1979

It is well known that picrotoxin, an amaroid substance of Anamirta cocculus, is a classic stimulant on the central nervous system accompanying convulsive activity, and it liberates catecholameine from the adrenal mdulla through its central action to increase blood sugar level. Schou reported that lithium and alcohol have the similar inhibitory property on the $Na^+,\;K^+$-ATPase activity, and recently, the therapeutic efficacies of lithium on the alcohol withdrawal syndrome and the chronic alcoholics have been studied. Many studies about the hypoglycemic effect of lithium and alcohol were reported but the interaction between those hypoglycemic action is little known. Therefore, in this paper, the hypoglycemic effect of lithium and ethanol on the hyperglycemia induced with picrotoxin, and the interaction of them in those hypoglycemic action were investigated with reference to the anticonvulsive action of them. The results were obtained as follows: 1. The convulsive dose (: $CD__{50}$) of picrotoxin in mice was slightly increased by the pretreatment of lithium or ethanol. 2. The blood sugar level was markedly increased by picrotoxin but the level was sugar level was significantly decreased by lithium, ethanol or both. 3. The hyperglycemic effect of picrotoxin was significantly potentiated by the lithium pretreatment, but the potentiation effect of lithium was markedly suppressed by the additional injection of ethanol after lithium injection and more markedly suppressed by the premedication of ethanol before lithium injection 4. The hyperglycemic effect of picrotoxin was markedly inhibited by the ethanol pretreatment, and the inhibitory effect of ethanol was significantly strenthened by the additional injection of lithium after ethanol injection, but on the contrary, the inhibitory effect was completely disappeared by the premedication of lithium before ethanol injection.