• 제목, 요약, 키워드: Hypercholesterolemia

검색결과 367건 처리시간 0.049초

Hypocholesterolemic Effects of Soybean Lecithin in Cholesterol-Fed Rats

  • Moon Min-Sun;Kwun In-Sook;Kim Yangha
    • Nutritional Sciences
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    • v.8 no.4
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    • pp.237-241
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    • 2005
  • The present study was performed to elucidate the hypocholesterolemic action of lecithin on the diet-induced hypercholesterolemia in rats. Male Sprague-Dawley rats (n=24) were fed lecithin-free (control) diet or diets containing $2\%\;or\;5\%$ lecithin for 4 weeks. Hypercholesterolemia was induced by adding $1\%$ cholesterol and $0.5\%$ cholic acid to all diets. No difference was found in food intake and body weight gain among groups. The lecithin treated groups showed significant improvement in the plasma levels of total cholesterol and LDL-cholesterol (p<0.05) compared to the control group, while the plasma triacylglyceride was not significantly affected 1he atherogenic index and HDL-cholesterol level were decreased in the lecithin groups. The diets with $2\%\;or\;5\%$ lecithin significantly decreased the activity of cholestetyl ester transfer protein (CETP) by $14\%\;or\;17\%$, respectively. Also, lecithin diets increased the activity of lecithin: cholesterol acyltransferase (LCAT). These results suggest that lecithin accounts for the hypocholesterolemic effect due to the decreased CETP activity and increased LCAT activity.

Purification and Identification of Squalene Synthase Inhibitor Isolated from Fermented Soybean Paste

  • Choi, Sung-Won;Kim, Dong-Seob;Hur, Nam-Youn;Park, Cheon-Seok;Baik, Moo-Yeol
    • Food Science and Biotechnology
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    • v.14 no.1
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    • pp.89-93
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    • 2005
  • Squalene synthase (SQS) inhibitors were screened from various plants and food extracts. Effective SQS inhibitor was purified from fermented soybean paste using ethanol extraction, HP-20 column chromatography, ethyl acetate extraction, silica gel column chromatography, and crystallization. Through UV spectrometry, $^1H$ NMR, $^{13}C$ NMR, and mass spectrometry, SQS inhibitor was identified as daidzein with molecular mass of 254 and molecular formula of $C_{15}H_{10}O_4$. Daidzein showed $IC_{50}$ value of 50 nmol/L against SQS, confirming its potential as therapeutic agent for hypercholesterolemia.

단순형과 혼합형 고콜레스테롤혈증 환자의 체위 및 혈장지질 특성 (Characteristics of the Anthropometry and Plasma Lipid Profiles of Patients with Simple and Combined Hypercholesterolemia)

  • 허영란;황금희;임현숙
    • 대한지역사회영양학회지
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    • v.4 no.2
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    • pp.186-193
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    • 1999
  • Recent epidemiologic and clinical students have shown that plasma cholesterol and triglyceride levels are independent risk factors for coronary heart disease. However, there is not much data on the characteristics of anthropometry and lipid profiles of hypercholesterolemia patients with hypertiglyceridemia. In this study, 112 hypercholesterolemic subjects$(T.C{\ge}240mg/dl)$ were divided into two groups by their plasma triglyceride levels. We compared the anthropometric measurements and lipid profiles of the subjects between the two groups : the simples hypercholesterolemic group(SHC, TG<200mg/dl) and the combined hypercholesterolemic group$(CHC, TG{\ge}250mg/dl)$. The distribution of the subjects into the SHC and CHC groups was 36.6% and 47.3%, respectively. The frequency of the CHC patients decreased with age. The subjects in this group had higher weight, BMI, HWR, cricumferences of mid arm, waist, hip and thigh, and skinfold thicknesses of biceps and triceps than those of the SHC subjects. The difference of plasma total cholesterol level was mainly due to the difference of VLDL-C levels. These differences resulted in the CHC subjects having higher atherogenic indexes and T-C/HDL-C ratios than those of the SHC subjects. Also, the former had higher Apo-B and insulin levels than those the latter. However, blood pressure, fasting blood glucose and HDL-C levels were not significantly different between the two groups. These results suggest that hypercholesterolemic patients with hypertriglyceridemia have riskier lipid profiles for CHD than those of patients with normal triglyceridemia. They also indicate that CHC is closely associated with glucose resistance syndrome(obesity, hyperglycemia, hyperinsulinemia and hypertriglyceridemia), and more prevalent in young people.

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고콜레스테롤혈증 치료 약물들에 대한 비용-효과 분석 (Cost-effectiveness Analysis of Pharmacologic Treatment in Hypercholesterolemia)

  • 정경래;문옥륜
    • 보건행정학회지
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    • v.9 no.3
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    • pp.70-94
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    • 1999
  • This paper was performed for a cost-effectiveness analysis of pharmacologic treatment of hypercholesterolemia. Agents modeled were cholestyramine, gemfibrozil. bezafibrate, lovastatin, pravastatin, simvastatin. Pharmacologic effectiveness was estimated by regression from reported clinical trials. Pharmacologic effects were expressed as the percent change of blood cholesterol level. Cost estimates included patients' travel expenses and time loss as well as resource consumption in the health care sector. Bezafibrate was the most efficient agent for reducing total cholesterol levels, having an cost over 1 year of ₩31.400 per percent reduction in total cholesterol. Simvastatin (10mg/d) was also efficient(₩33,100 per percent reduction). Chole styramine(8g/d) was least efficient at ₩90,200. For low-density lipoprotein cholesterol. simvastatin(10mg/d) was most efficient, at ₩23,200 per percent reduction, followed by lovastatin(20mg/d) at ₩28,000. Gemfibrozil was least efficient at ₩77,800 per percent reduction. For high-density lipoprotein cholesterol. bezafibrate(400mg/d) was most efficient at ₩39,300 per percent increase of high-density lipoprotein cholesterol. Cholestyramine was least efficient at ₩514,700. Analyses combining low-density lipoprotein cholesterol and high-density cholesterol effects suggest that bezafibrate(600mg/d) and simvastatin (10mg/d) were most efficient for reducing cardiovascular risk. The cost-effectiveness analysis results show that both simvastatin and bezafibrate could be efficient treatment. Simvastatin provide more effective treatment at higher cost, whereas bezafibrate is more cost-effective, as it may be less effective, at lower cost. Therefore, clinicians should choose reasonable treatment according to the patient's needs This pharmacoeconimc analysis will provide a guideline for efficient pharmacologic treatment and also be reference data for pricing new drugs.

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한국인의 고지혈증에 관한 연구 -I. 고콜레스테롤혈증 소견자의 신체 특성과 그 위험인자를 중심으로- (A Study of Hyperlipidemia in Koreans -I. Specially Related to physical Characteristics and It's Risk Factors for Hypercholesterolemia-)

  • 허영란
    • 한국식품영양학회지
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    • v.12 no.3
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    • pp.279-289
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    • 1999
  • This study was conducted to investigate the physical characteristics and risk factors for hyperchol-esterolemia (HC) in Korean. 344 adult men who took the annual health check-ups at D or J hospitals were participated in this cross-sectional study. The subjects were grouped by plasma total cholesterol level in to three groups: normal cholesterolemic (n=139) borderline hypercholesterolemic(n=93) and hypercholesterolemic (n=112) groups. The data of height weight and plasma cholesterol level were col-lected from medical records. Body circumferences(midarm, waist, hip, and thight) skinfold thicknesses (biceps, triceps, subcostal, abdomen, and suprailic), and body composition (fat mass and fat free mass) were measured. Body mass index (BMI) height/weight ratio (HWR) waist/hip circumference ratio (WHR) waist/ thigh circumference ratio (WTR) central skinfold thickenss (CSF) and peripheral skin-fold thickness were calculated. The subjects with HC had significantly higher weight BMI waist cir-cumference skinfold thickness and body fat mass than those of the normal subjects. The relative and attributable risks on HC were 1.61 and 0.17 for obesity (BMI$\geq$25) 1,30 and 0.11 for upper body obesity (WTR$\geq$1.30) and 1.54 and 0.18 for central body obesity (CSF$\geq$95.7). Plasma total cholesterol level was positively correlated with several antropometric parameters: BMI (p<0.001) weight(p<0.001) waist circumference(p<0.001) and skinfold thickness of abdomen (p<0.001) spraillic (p<0.01) triceps(p<0.01) subcostal (p<0.01) and biceps (p<0.05) In conclusion the major influencing factors to plasma cholesterol level was BMI. Among the each physical parameters the circumference of waist the skinfol-d thickness of abdomen and the percentage of body fat were closely related to plasma cholesterol level. The important risk factor for hypercholesterolemia was obesity specially upper body obesity and central body obesity.

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침습, 비침습 혈관레이저에 의한 고콜레스테롤혈증의 치료효과 비교 (Comparison between the Effect of Intravascular Laser Irradiation Therapy with the Exterior Vascular Laser Irradiation Therapy on Hypercholesterolemia)

  • 권미정;윤현민;김영균;김원일
    • Journal of Acupuncture Research
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    • v.22 no.5
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    • pp.121-132
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    • 2005
  • Objectives : The purpose of study was to compare and analyze the effect of the Intravascular Laser Irradiation Therapy and the Exterior vascular Laser Irradiation Therapy on Hypercholesterolemia. Methods : The 73 Sam-se-han-bang hospital patients who were irradiated to the Intravascular Laser and the 57 Sam-se-han-bang hospital patients who were irradiated to the Exterior vascular Laser were the study group. They had the treatment two or three times a week, and had checked total cholesterol before and after the ten times irradiation therapy. Results : Both the Intravascular Laser Irradiation Therapy and the Exterior vascular Laser Irradiation Therapy were effective on decreasing total cholesterol. The effect on decreasing total cholesterol was more definite at the abnormal group than the border line group, and the border line group than the normal group. The effect on decreasing total cholesterol was more definite at the Exterior vascular Laser Irradiation Therapy than the Intravascular Laser Irradiation Therapy, but this result was unavailable in the statistics. Conclusion : Both the Intravascular Laser Irradiation Therapy and the Exterior vascular Laser Irradiation Therapy had available effect on decreasing total cholesterol.

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폐경기 여성의 항산화 비타민 영양 상태와 혈중 지질 및 MDA 농도와의 관계 (Correlation of the Nutritional Status of Antioxidant Vitamins and Serum Lipids and MDA Levels in Postmenopausal Women)

  • 김상연;정경아
    • 동아시아식생활학회지
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    • v.16 no.2
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    • pp.145-155
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    • 2006
  • This study investigated the correlation of the nutritional status of antioxidant vitamins and serum lipids and MDA levels in postmenopausal women. Data about general characteristics, dietary intakes and biochemical parameters, including serum lipids, MDA and antioxidant vitamins levels, were collected from 85 postmenopausal women. The subjects were classified into three groups according to their serum total cholesterol level: normocholesterolemia group (NC, < 200 mg/dL), moderate hypercholesterolemia group (MC, $200{\sim}239mg/dL$) and hypercholesterolemia group(HC, ${\geq}240mg/dL$). The results are as follows. 1) General characteristics and serum MDA levels were not significantly different among the three groups. 2) Daily nutrients intakes adjusted to energy intake were not significantly different among the three groups, and were compatible with dietary reference intakes (DRIs) for Koreans. 3) Dietary Vt. A, ${\beta}-carotene$, Vt. C and Vt. E intake were not significantly different among the groups, while Vt. E intake was positively related with serum TC (r=0.288, p<0.05) and triglyceride (r=0.341, p<0.001) levels. 4) Serum Vt. A level standardized by serum TC level was significantly low and serum Vt. E level was significantly high in the HC group. Serum Vt. E level was positively related with serum TC level (r=0.389, p<0.001). 5) Dietary Vt. E intake was negatively correlated to serum MDA level (r=-0.242 p<0.05). Serum Vt. C and Vt. E levels were also negatively correlated to serum MDA level (r=-0.312, p<0.001 and r=-0.299, p<0.05). When the correlation was analyzed only in the group with hypercholesterolemia, correlation coefficients between the antioxidant vitamin and serum MDA level were higher. We concluded that intakes of antioxidant vitamins can contribute to decreasing the risk of cardiovascular disease by decreasing the oxidative stress of body rather than by controlling serum lipid levels.

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Inhibitory Effects of Hwao-tang on the Atherosclerosis and the Venous Thrombosis

  • Hong Mun Yoob;Choi Dall Yoong;Kim Cherl Ho;Kim Beob Jin;Kim Han Geu;Ahan Jong Chan;Lee Soo Kyung;Chung Tae Wook;Park Won Hwan
    • 동의생리병리학회지
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    • v.16 no.2
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    • pp.380-388
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    • 2002
  • The inhibitory effects of the traditional herbal medicine Hwao-tang on the progression of the atherosclerotic lesions were studied using the spontaneous familial hypercholesterolemia (FH) model, Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits. Hwao-tang is activate blood circulation, vital energy and regulate menstruation, etc. Nowadays, Hwao-tang is mainly used for the treatment of inflammation, hyperlipemia and arteriosclerosis. However, pharmacological mechanisms of Hwao-tang on lipid metabolism and atherosclerosis formation are poorly understood. We have investigated the pharmacological effects of Hwao-tang on hypercholesterolemia and atherosclerosis using a spontaneous experimental model. In conclusion, the protection of extracts of HOT and its herbs on the ischemic infarction induced artificially might be related to their inhibitory effects on DIC, platelet coagulation and thrombic action. These suggest that Hwao-tang has inhibitory effects on the development of atheromatous plaque formation in spontaneous FH model rabbits. It is possible that the anti oxidative effects of Hwao-tang on LDL led to the beneficial effects observed in this study.

Fenofibrate Reduces Age-related Hypercholesterolemia in Normal Rats on a Standard Diet

  • Han, Ying;Do, Mi-Hyang;Kim, Mi-Sun;Seo, Eun-Hui;Park, Mi-Kyoung;Kim, Duk Kyu;Lee, Hye-Jeong;Seo, Su-Yeong
    • The Korean Journal of Physiology and Pharmacology
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    • v.14 no.2
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    • pp.77-81
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    • 2010
  • Plasma cholesterol is increased in normal aging in both rodents and humans. This is associated with reduced elimination of cholesterol and decreased receptor-mediated clearance of plasma low-density lipoprotein (LDL) cholesterol. The aims of this study were: (1) to determine age-related changes in plasma lipid profiles, and (2) to determine the effect of fenofibrate, an activator of peroxisome proliferator activated receptor alpha (PPAR $\alpha$), on plasma lipid profiles in normal rats on a standard diet. Male Sprague-Dawley (SD) rats (n=15) were fed standard chow and water from 10 to 25 weeks of age. During that period, we measured daily food intake, body weight, fasting and random blood glucose levels, plasma total cholesterol (TC), triglycerides (TG), and free fatty acid (FFA) levels. At 20 weeks of age, all rats were randomly divided into two groups: a fenofibrate group (in which rats were gavaged with 300 mg/kg/day of fenofibrate) and a control group (gavaged with water). Fenofibrate treatment lasted 5 weeks. There were no significant changes in daily food intake, blood glucose, and plasma TG level with age. Body weight, plasma TC, and FFA levels were significantly increased with age. Fenofibrate significantly decreased plasma concentrations of TC and FFA, which had been increased with age. However, fenofibrate did not influence the plasma concentration of TG, which had not increased with age. These results suggest that fenofibrate might have a novel role in preventing age-related hypercholesterolemia in SD rats on a normal diet.

Effects of Portulaca oleracea Powder on the Lipid Levels of Rats Fed a Hypercholesterolemia Inducing Diet

  • Lee, Soo-Jung;Shin, Jung-Hye;Kang, Min-Jung;Kim, Mi-Ju;Kim, Sung-Hee;Sung, Nak-Ju
    • Preventive Nutrition and Food Science
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    • v.16 no.3
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    • pp.202-209
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    • 2011
  • This study was initiated to investigate the effects of lyophilized purslane (Portulaca oleracea) powder (5% and 10%) on lipid levels in rats fed a hypercholesterolemia-inducing diet (1% cholesterol). During the four week study, there were no significant differences in either weight change or the food efficiency ratio between the group fed the hypercholesterol diet alone (HC) and the groups fed the purslane powder (HCPO-I and HCPO-II, 5% and 10% purslane, respectively). In serum, the levels of total lipid, total cholesterol and LDL-C decreased significantly for the group fed the 10% purslane powder (HCPO-II) in comparison with the group fed the 5% purslane powder (HCPO-I). The atherogenic index (AI) was reduced by about 51% for the group fed the 10% purslane powder (1.47) in comparison with the HC group (3.03). The activities of GOT, GPT, ALP and LDH decreased significantly for the groups fed the purslane powder in comparison with the HC group. Regarding liver tissue, the levels of total lipid, total cholesterol and triglyceride decreased significantly for the purslane powder-fed rats compared to the HC group. The fecal lipid profiles increased significantly as the amount of purslane powder was increased. Compared to the HC group, the fecal total cholesterol and triglyceride levels were higher in the group fed the 10% purslane powder by about 2.8 times and 2.3 times, respectively. For the serum and liver tissue, the content of lipid peroxide decreased significantly in the groups fed purslane powder compared to the HC group. The data from this experiment show an increase in the lipid levels discharged in feces, suggesting that the supplementation of purslane powder to a hypercholesterolemia-inducing diet reduces lipid levels.