• Title, Summary, Keyword: Hypercholesterolemia

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Interreationship between the Subclinical Hypothyroidism and Serum Total Cholesterol, LDL-Cholesterol (불현성 갑상선 기능저하증과 혈청 총 콜레스테롤, 저밀도 콜레스테롤 농도와의 상관성)

  • Seok, Seong-Ja;Yoo, Wang-Keun
    • Journal of Society of Preventive Korean Medicine
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    • v.12 no.1
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    • pp.127-134
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    • 2008
  • This study was carried out in 14,443 subjects(8,706 men, 5,737 women, mean age $41.8{\pm}9.16$) who visited the health promotion center of one university hospital. Serum $T_3$, $T_4$ and TSH concentrations were measured with CIA using commercial kits on ADVIA Centaur Assay and Serum total cholesterol, triglyceride, and HDL-cholesterol were measured by auto-analyzer Hitach 7600 in enzyme method. 1. The prevalence of subclinical hypothyroidism was 12.6/1,000 population(men 6.0/1,000, women 22.7/1,000) and as high as about 4 times in women than in men. 2. In subclinical hypothyroidism, the values of total cholesterol and LDL-cholesterol were significantly high by 5.5 mg/dL, 4.6 mg/dL compared with normal group(p<0.05). 3. In all the tested hypercholesterolemia and hyperLDL-cholesterolemia, were correlated with TSH. There is higher correlation in women group than men group. These results indicate that the subclinical hypothyroidism and dyslipemia significantly correlated. Especially, it is very important to find that the hypercholesterolemia and hyperLDL-cholesterolemia are the high risk factors of atherosclerosis. Therefore, it is essential for the group of subclinical hypothyroidism to take the cholesterol, LDL-cholesterol and serum lipid test as well as thyroid function test.

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Effects of Cinnamomi Cortex on Hypercholesterolemia Induced by Estradiol Valerate in Rats (육계(肉桂)가 Estradiol valerate에 의하여 유발된 고콜레스테롤 혈증에 미치는 영향)

  • Choi, Eu-Gene;Kim, Hyung-Woo;Chung, Hee-Jin;Joung, Young-Min;Shin, Dong-Sung;Cho, Su-In
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.25 no.2
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    • pp.264-269
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    • 2011
  • This study was designed to investigate the effects of Cinnamomi Cortex extract (CC) on hypercholesterolemia induced by Estradiol valerate (EV) in female rats. We investigated the effects of CC on Changes in body weights for 5 weeks. In addition, we examined the effects on fasting blood glucose (FBS) and tested oral glucose tolerance test after oral administration of CC for 5 weeks. We also investigated the effects on levels of total cholesterol, HDL-cholesterol and LDL-cholesterol in serum. Treatment with CC restored weight gain rates suppressed by EV significantly. CC did not affect serum glucose level and glucose tolerance. Levels of total cholesterol and triglyceride were lowered by administration of CC compared to EV treated control respectively. These result suggest that CC can lower serum cholesterol level then prevent weight loss induced by EV. We also suggest the possibility as anti-hyperlipidemic agent of CC.

Dietary chitosan enhances hepatic CYP7A1 activity and reduces plasma and liver cholesterol concentrations in diet-induced hypercholesterolemia in rats

  • Moon, Min-Sun;Lee, Mak-Soon;Kim, Chong-Tai;Kim, Yang-Ha
    • Nutrition Research and Practice
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    • v.1 no.3
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    • pp.175-179
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    • 2007
  • The present study was performed to elucidate the hypocholesterolemic action of chitosan on the diet-induced hypercholesterolemia in rats. Male Sprague-Dawley rats (n=24) were fed with chitosan-free diet (Control), diets containing 2% or 5% chitosan for 4 weeks. Hypercholesterolemia was induced by adding 1% cholesterol and 0.5% cholic acid to all diets. Body weight gain and food intake of rats did not differ among the groups. The chitosan treated groups showed significant improvement in the plasma concentration of total cholesterol and LDL-cholesterol compared to the control group (p<0.05). Also, the chitosan treated groups decreased the liver concentration of total lipid and total cholesterol compared to the control group (p<0.05). The activity of hepatic cholesterol $7{\alpha}-hydroxylase$ (CYP7A1), the rate-limiting enzyme in the conversion of cholesterol to bile acids, was increased by 123% and 165% for the 2% or 5% chitosan diets, respectively. These findings suggest that enhancement of hepatic CYP7A1 activity may be a mechanism, which can partially account for the hypocholesterolemic effect of dietary chitosan in cholesterol metabolism.

Isolation and Structural Determination of Squalene Synthase Inhibitor from Prunus mume Fruit

  • Choi, Sung-Won;Hur, Nam-Yoon;Ahn, Soon-Cheol;Kim, Dong-Seob;Lee, Jae-Kwon;Kim, Dae-Ok;Park, Seung-Kook;Kim, Byun-Yong;Baik, Moo-Yeol
    • Journal of Microbiology and Biotechnology
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    • v.17 no.12
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    • pp.1970-1975
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    • 2007
  • Squalene synthase plays an important role in the cholesterol biosynthetic pathway. Inhibiting this enzyme in hypercholesterolemia can lower not only plasma cholesterol but also plasma triglyceride levels. A squalene synthase inhibitor was screened from Prunus mume fruit, and then purified via sequential processes of ethanol extraction, HP-20 column chromatography, ethyl acetate extraction, silica gel column chromatography, and crystallization. The squalene synthase inhibitor was identified as chlorogenic acid with a molecular mass of 354 Da and a molecular formula of $C_{16}H_{18}O_9$ based on UV spectrophotometry, $^1H$ and $^{13}C$ NMRs, and mass spectrometry. Chlorogenic acid inhibited the squalene synthase of pig liver with an $IC_{50}$ level of 100 nM. Since chlorogenic acid was an effective inhibitor against the squalene synthase of an animal source, it may be a potential therapeutic agent for hypercholesterolemia.

Effects of Adipokine Retnla on the Regulation of High-Density Lipoprotein Metabolism

  • Lee, Mi-Ran
    • Journal of the Korea Society of Computer and Information
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    • v.21 no.12
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    • pp.139-145
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    • 2016
  • In this paper, we propose to evaluate the effect of Resistin-like molecule alpha (Retnla) on the expression of transporters involved in modulating concentrations of peripheral cholesterol and plasma high-density lipoprotein (HDL) cholesterol. High levels of blood cholesterol are a well-recognized risk factor for atherosclerosis and are eliminated via the process of reverse cholesterol transport (RCT). We recently showed that Retnla ameliorates hypercholesterolemia and atherosclerosis by increasing biliary cholesterol secretion, the final step of the process, in low-density lipoprotein receptor-deficient mice. However, the role of Retnla in HDL-mediated cholesterol efflux, initial step of RCT pathway, is not yet clear. To identify cholesterol transport genes regulated by Retnla, we performed an extensive microarray-based gene expression screen using livers from Retnla-overexpressing (Tg) mice and control animals. The most significant change in Retnla-Tg mice was an upregulation of ATP-binding cassette sub-family G member 4 (Abcg4) transport and was validated using quantitative RT-PCR. The validated gene was also induced by treatment of purified Retnla protein in RAW 264.7 cells incubated with acetylated low-density lipoprotein and Hepa1c1c7 cells. Taken together, these results indicates that Retnla might also accelerate initial step of RCT pathway, suggesting therapeutic value of Retnla in the treatment of hypercholesterolemia and atherosclerosis.

The $Sst$ I Restriction Fragment Length Polymorphism of the Apolipoprotein C-III Gene in Korean Subjects

  • Youk, Hyei-Soo;Kim, In-Sik;Kang, Sang-Sun;Kang, Hee-Gyoo;Hyun, Sung-Hee
    • Biomedical Science Letters
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    • v.17 no.4
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    • pp.347-353
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    • 2011
  • The definite mechanism in the control of triglyceride metabolism is not well understood. Nowadays, it has been known that the polymorphism of apolipoprotein C-III $Sst$ I was an important candidate for contributing to the control of triglyceride metabolism. In 298 Korean women aged 30 years or more, the genotypes of apolipoprotein C-III $Sst$ I were statistically compared with total blood cholesterol, triglyceride, high density lipoprotein, fasting blood sugar and hemoglobin A1c. Multiple logistic regression analysis was carried out to compare the odd-ratios of hypertriglyceridemia, hypercholesterolemia and diabetes mellitus with them. The differences among the polymorphic types ($S_1S_1$, $S_1S_2$, and $S_2S_2$) were not statistically significant in the distribution of triglyceride, total cholesterol, high density lipoprotein, fasting blood sugar, and hemoglobin A1c. There were not statistically significant in the odds ratios of the hypertriglyceridemia, hypercholesterolemia, and diabetes mellitus, neither. Those were not statistically significant. This study did not show that there was any association between the polymorphism of apolipoprotein C-III $Sst$ I and various laboratory values-total blood cholesterol, triglyceride, high density lipoprotein, fasting blood sugar and hemoglobin A1c.

Cardiovascular Risk Factors Predicting Endothelial Dysfunction in Patients with Variant Angina (이형협심증 환자의 혈관내피세포 기능저하에 영향을 미치는 심혈관질환 위험인자)

  • Cho, Sook-Hee;Hwang, Seon-Young;Jeong, Myung-Ho
    • Korean Journal of Adult Nursing
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    • v.21 no.5
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    • pp.477-488
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    • 2009
  • Purpose: This study was conducted to identify the clinical characteristics and risk factors on the occurrence of variant angina, and to examine the predicting factors on the vascular endothelial dysfunction of the patients with variant angina. Methods: A total of 134 patients diagnosed with variant angina were recruited from 2006 to 2008. The degrees of endothelial dysfunction were measured and recorded by the researcher using the values of flow-mediated vasodilation of their brachial arteries and Nitroglycerine-mediated dilation. Subjects' demographic data and risk factors were gathered after obtaining informed consent, and their electronic medical records were reviewed to collect laboratory data. Results: The mean age was $54.2{\pm}9.6$ years and 52% was male patients. More than 50% of the male patients were cigarette smokers and had hypercholesterolemia. 84% of the male patients and 70% of the female patients had more than one risk factor of cardiovascular disease. A stepwise multiple regression analysis showed that smoking and hypercholesterolemia predicted the decrease of flow-mediated vasodilation (Adjusted $R^2$ = .204, p < .001). Conclusion: Tailored educational interventions for smoking cessation and cholesterol management are needed to prevent recurrence of angina attack for patients with variant angina and to prevent cardiovascular disease for middle-aged workers.

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Minimizing the risk of perioperative cardiovascular complications in homozygous familial hypercholesterolemia: a case report

  • Khan, Saad;Min, Samuel;Willard, Garrett;Lo, Iris;D'Souza, Rachael;Park, Aaron
    • Journal of Dental Anesthesia and Pain Medicine
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    • v.20 no.1
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    • pp.39-44
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    • 2020
  • Homozygous familial hypercholesterolemia (HoFH) is a rare inherited disorder that presents as abnormally elevated levels of low-density lipoprotein cholesterol and premature heart disease, requiring frequent intervention through lipid apheresis for management. The risk of perioperative cardiac events is higher in patients with HoFH because of its pathophysiological manifestations in the vascular system. Careful cardiac precautions and anesthetic assessments are necessary to ensure patient safety. In the following case report, we discuss the clinical course and anesthetic considerations for a 14-year-old girl with HoFH undergoing sedation for dental extractions and mandibular molar uprighting in an outpatient oral surgery clinic. Considerations included the use of heparin in the patient's weekly plasma lipid apheresis treatment. In order to reduce the risks of peri- and postoperative bleeding and perioperative cardiac events, the operation was scheduled for 4 days after apheresis. This allowed for adequate heparin clearance, while also reducing the likelihood of possible cardiac events. A literature review revealed no results for the outpatient management of patients with HoFH undergoing sedation for noncardiac procedures. Our reported case serves as a clinical example for physicians to be utilized in the future.

Body Mass Index and Subsequent Risk of Hypertension, Hyperglycemia and Hypercholesterolemia in Health Checkup Examinees (건강검진 수검자들의 비만도와 고혈압, 고혈당 및 고콜레스테롤혈증과의 관련성)

  • Wang, Seong-Bae;Cho, Young-Chae
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.12 no.6
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    • pp.2677-2684
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    • 2011
  • This study was conducted to clarify relationships between BMI and the incidence of hypertension, hyperglycemia and hypercholesterolemia among health checkup examinees. The study sample consists of 3,402 adults aged 30s - 60s years, who underwent health check-up at a university hospital. during the Jan. 2007 to Dec. 2008.As a results, blood pressure level at the base line, ORs(95% CI) of hypertension compared with BMI category of 18.5-22.9(normal group) were 1.7(1.2-3.8) for obesity group I, and 2.9(1.7-6.2) for obesity group II. After adjusting for age and sex, ORs(95% CI) of hypertension compared with BMI category of normal group were 1.3(1.0-1.7) for obesity group I, 1.8(1.3-2.4) for obesity group II. Serum total cholesterol level at the base line, ORs(95% CI) of hypercholesterolemia compared with BMI category of normal group were 1.7(1.5-4.9) for obesity group I, and 2.8(1.8-5.3) for obesity group II. After adjusting for age and sex, ORs(95% CI) of hypercholesterolemia compared with BMI category of normal group were 1.5(1.1-1.9) for obesity group I, and 2.3(1.7-3.1) for obesity group II.

Influence of Crude Drugs on Serum Total Cholesterol Contents in Rabbits (수종생약(數種生藥)이 Rabbit의 혈청(血淸) Total Cholesterol 치(値)에 미치는 영향)

  • Ko, Geon-Il
    • Journal of Pharmaceutical Investigation
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    • v.13 no.4
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    • pp.196-201
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    • 1983
  • Banggi, Banggi Whanggi Tang and Gami Jodeung San have been used to prevent and treat arteriosclerosis in oriental medicine. In order to investigate preventive and therapeutic effects of its crude drugs, this research was studied in cholesterol induced hypercholesterolemia rabbits. The rusults were as follows. 1) By concurrent administeration of Banggi or Banggi Whanggi Tang with cholesterol, serum total cholesterol contents were increased more slowly than control group. But in the case of Gami Jodeung San, serum total cholesterol contents were increased as well as control group. 2) By administration of Banggi Whanggi Tang or Gami Jodeung San on induced hydercholesterol rabbits, serum total cholesterol contents were decreased faster than control group. According to this result, it is suggested that Banggi and Banggi Whanggi Tang have preventive and therapeutic effects on hypercholesterolemia rabbits and that Gami Jodeun San has not preventive effect but therapeutic effect.

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