• Korean Journal of Community Nutrition
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• v.5 no.3
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• pp.461-474
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• 2000

The purpose of this study was to explore the difference in nutrient intakes between normocholesterolemia and hypercholesterolemia. The subjects were classified as normocholesterolemia and hypercholesterolemia based on The Guideline for Korean Hyperlipidemia. A semiquantitative food frequency questionnaire was used to measure the dietary intakes of the subjects. The results obtained are summarized as follows. Intakes of nutrients such as energy, carbohydrate, protein, fat, minerals, and antioxidant vitamins were not significantly different between the normocholesterolemia group and hypercholesterolemia group. However, antioxidant vitamins and folate intakes in the hypercholesterolemia group tended to be lower than those in the normocholesterolmia group. Intakes of vitamin A, vitamin E, and Ca in normocholesterolemia was much less than the RDA for those nutrients in normocholesterolemia. Cholesterol intake in the hypercholesterolemia group was significantly higher than that in the normochoesterolemia group. However, mean cholesterol intake(240 mg/day) of the hypercholesterolemia group was much less than that of Americans whose cholesterol intake was 400 - 500 me/day. Fatty acid intakes were not significantly different between normocholesterolemia and hypercholesterolemia groups but the hypercholesterolemia group tended to consume $\omega$3 fatty acids less than the normocholesterolemia group. Out data indicate that cholesterol intake is man important determinant of serum cholesterol levels in postmenopausal women. The results of this study provide information that is important in designing appropriate dietary guidelines for hypercholesterolemia in postmenopausal women.

• The Korea Journal of Herbology
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• v.25 no.3
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• pp.73-80
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• 2010

Objectives：The present study purposed to evaluate the effects of Leonuri Herba and Leonuri Semen on hypercholesterolemia and provide data for the appropriate clinical application of Leonuri Herba and Leonuri Semen. Methods：We applied the water extracts of Leonuri Herba and Leonuri Semen to rats with hypercholesterolemia induced by high-cholesteroldiet, and examined their effects. Results：The levels of the total cholesterol and LDL-cholesterol were reduced by the uptake of Leonuri Herba to rats with hypercholesterolemia, but there was no significant effect on the level of TG(triglyceride), HDLc(HDL-cholesterol), FFA(free fatty acid), and Fc(free cholesterol), while the amount of AST and ALT was inhibited. The application of Leonuri Semen brought about the decrease of the total cholesterol and Fc, the increase of TG, HDLc, and FFA, and the significant decrease of the activation of AST. Leonuri Herba had only a weak effect on hypercholesterolemia, while Leonuri Semen had a strong effect on the reduction of the symptoms of hypercholesterolemia. Conclusion：Based on the fact that Leonuri Herba had only a weak effect on hypercholesterolemia, while Leonuri Semen had a strong effect on the reduction of the symptoms of hypercholesterolemia, it is concluded that Leonuri Semen is a better solution for hypercholesterolemia than Leonuri Herba.

• Journal of Nutrition and Health
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• v.32 no.6
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• pp.713-725
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• 1999

Women have a greater incidence of coronary heart disease(CHD) after menopause. It relates to hormone imbalance-induced changes in known CHD risk factors, especially hyperlipidemia. Accordingly, once women are diagnosed, the rate of morbidity and mortality is greater than for men. Thus, preventive strategies are critical to improve the quality oflife in the later years for women. The purpose of ths study was to explore the difference of anthropometric, environmental factors and food behaviors between normocholesterolemia and hypercholesterolemia within postmenopausal women. The subjects were classified as normocholesterolemia and hypercholesterolemia based on the Guideline for Korean Hyperlipidemia. The results obtained are summarized as follows. The distributions of general characteristics such as age, family income, occupation status, age at menarche, and menopausal period were not significantly different between the normocholesterolemia group and hypercholesterolemia group. The anthropometric factors such as body mass index(BMI) and waist hip ratio(WHR) were not significantly different between the normocholesteroemia group and the hypercholesterolemia group but odds ratio of hypercholesterolemia group was higher than that of normocholesterolemia but not significant. Aerobic activity more than 1hours/day was significantly related to low serum cholesterol concentration. Eating behaviors related to regular meal time, regular breakfast habit, and slow meal speed were related to low serum cholesterol concentration. Eating the chicken without skin was significantly related to low serum cholesterol concentration. Our data indicate that desirable eating habit, aerobic activity more than 1hr/day are important factors of serum cholesterol concentrations in postmenopausal women. The result of this study provide information that is important in designing appropriate dietary guidelines for hypercholesterolemia in postmenopausal women.

• Journal of the Korean Dietetic Association
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• v.7 no.4
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• pp.373-384
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• 2001

The purpose of this study was to compare with in fatty acid intakes between hypercholesterolemia group and normocholesterolemia group, aged between 30 to 65 years old in women. The subjects were classified as hypercholesterolemia group and normocholesterolemia group based on The Guideline for Korean Hyperlipidemia. Dietary intakes of fatty acids were by means of a 24-hr recall method with food models and measuring tools. We analyzed both data sets together using analysis of variance the chi-square test and student's t-test(SPSS for WINDOWS, version 7.5). Significance was defied as a P value <0.05. The results obtained are summarized as follows. Mean age, BMI and percentage of postmenopausal women in hypercholesterolemia group were significantly higher than those of normocholesterolemia group. Percent of total energy from fat in hypercholesterolemia group tended to be higher than that in normocholesterolemia group. C16:0(Palmitic acid) and saturated fatty acids(SFA) intake of hypercholesterolemia group was significantly higher than that of normocholesterolemia group. Therefore, women who suffered from hypercholesterolemia were recommended to control body weight and consume foods containing low SFA and cholesterol.

• Quality Improvement in Health Care
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• v.4 no.2
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• pp.230-240
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• 1997

Background : Hypercholesterolemia is a major independent risk factor of coronary heart disease. Practice guidelines for management of hypercholesterolemia had been made in several developed countries. This study was undertaken to assess the effect of practice guideline reminders and flow-sheets to improve the quality of management of hypercholesterolemia. Methods: Practice guideline reminders and flow-sheets based on National Cholesterol Education Program Adult Treatment Panel II guidelines, were placed on the office desks of outpatient department of family medicine at the Asan Medical Center. Before this intervention, we educated the doctors to use these reminders and flow-sheets. The charts of all patients who had cholesterol levels greater than or equal to 240 mg/dl during 4 months before and after introduction of reminders and flow-sheets, were reviewed retrospectively. We compared the performances of physicians about management of hypercholesterolemia between pre-intervention period and post-intervention period. Results: The detection rate of hypercholesterolemia in post-intervention period was increased to 83.2% compared by 71.5% in pre-intervention period. Risk factor analysis for coronary heart disease increased significantly from 16.9% to 68.7%. Adequacy of management was 19.2% in pre-intervention period and 78.0% in post-intervention period. It showed statistically significant improvement in management of hypercholesterolemia. Conclusion : This study suggested that practice guideline reminders and flow-sheets were the effective methods in improving the quality in management of hypercholesterolemia.

• Korean Journal of Community Nutrition
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• v.6 no.5
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• pp.819-829
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• 2001

The purpose of this study was to investigate the difference of general characteristics, menopause status, dietary patterns and nutrient intakes between women aged from 30 to 65 years old with a hypercholesterolemia group and normocholesterolemia group. The subjects were classified as belonging to the hypercholesterolemia group or normocholesterolemia group barred on The Guidelines for Korean Hyperlipidemia. Dietary intakes of fatty acids were measured by means of a 24-hr recall method with food models and measuring tools. We analyzed both data sets together using analysis of variance chi-square test and student's t-test(SPSS for WINDOWS, version 7.5). Significance was defied as a p value < 0.05. The results obtained are summarized as follows. Mean age and BMI of the hypercholesteroemia group were significantly higher than those of the normocholesterolemia group. Intakes of cereal, vegetables, mushrooms and sea food in the normocholesterolemia group were significantly higher than those in the hypercholesterolemia group. Most of the nutrient intakes were not significantly different between the normocholesterolemia group and the hypercholesterolemia group. However, vitamin E intake of the normocholesterolemia group was significantly higher than that of the hypercholesterolemia group. There was a significant negative correlation between vitamin E intake and serum TC(r = -.363, p < 0.001) and LDL-C(r = -.359, p < 0.001). In addition, Serum TG had significantly correlation with carbohydrate(r = 0.137, p < 0.001) and vitamin E intake(r = -0.134, p < 0.001). Therefore, women who suffered from hypercholesterolemia were recommended to control body weight, and to consume foods containing high vitamin E and foods containing high dietary fiber such as vegetables, mushrooms, and sea food.

• Physical Therapy Korea
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• v.15 no.1
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• pp.54-60
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• 2008

The purpose of the study was to investigate the effectiveness of self-paced walking exercises in elderly women with hypertension, hyperglycemia, and hypercholesterolemia. Thirty-eight elderly women with hypertension, hyperglycemia, and hypercholesterolemia (16 hypertension, 11 hyperglycemia, 11 hypercholesterolemia), aged between 65 and 80, were invited to participate in this study. Each subject participated in a self-paced walking exercise five times a week for twelve weeks from 26 June to 16 September 2006. The changes between pre- and post-exercise were analyzed using the analysis of a paired t-test with the SPSS version 12.0 package program. There were significant decreases in systolic blood pressure (p<.01) and diastolic blood pressure (p<.05), blood glucose(p<.05), and cholesterol in the blood (p<.01). These results show that self-paced walking exercises may be helpful in treating elderly women with hypertension, hyperglycemia, and hypercholesterolemia.

• Journal of Haehwa Medicine
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• v.17 no.2
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• pp.101-116
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• 2008

In order to investigate the effect of HGCS on Hypercholesterolemia in rats diagnosed with hypertension, changes of related factors in blood and tissues of animal models were studied. The results are as following: At 250 ${\mu}g/m{\ell}$ or lower doses of HGCS, human fibroblast cells showed a survival rate of more than 90%. HGCS significantly reduced the total cholesterol and LDL cholesterol levels in blood observed in hypercholesterolemia rats. On the other hand, HGCS signicantly increased the blood HDL cholesterol level, compared to that of the control group. HGCS significantly reduced triglycerides caused by hypercholesterolemia. However, glucose level was decreased insignificantly. Significant decrease of hyperoxidative lipid level in tissues due to hypercholesterolemia was observed in HGCS treated group. Significant increase of SOD and catalase activities in tissues due to hypercholesterolemia were observed in HGCS treated group. From the results above, the anti-hypercholesterolemic effect of clinically used HGCS has been experimentally proved. More active prescription of HGCS to hypercholesterolemia and related patients should be available in the future.

• Korean Journal of Community Nutrition
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• v.25 no.5
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• pp.396-405
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• 2020

Objectives: This study was conducted to compare the nutrient intake of normal healthy adults with those having hypercholesterolemia. Methods: We analyzed data from the 6th Korea National Health and Nutrition Examination Survey (KNHANES VI). A total of 12,636 adults (5,223 males and 7,413 females) aged 19 or older were included in the study. Results: Males with hypercholesterolemia were older and had a higher waist circumference, body mass index, fasting blood sugar levels (FBS) and serum triglyceride (TG) concentrations compared to the normal group. Females with hypercholesterolemia were older and had higher FBS levels and serum TG concentrations compared to the normal group. While comparing nutrient intake by the 24-hour recall method, the male normal group showed a higher intake of fat, saturated fatty acid (SFA), monounsaturated fatty acid (MUFA), vitamin A and thiamin compared to the hypercholesterolemic group. However, the male normal group had a lower intake of iron and vitamin C compared to the hypercholesterolemic group. The female normal group had a higher intake of energy, protein, fat, SFA, MUFA, polyunsaturated fatty acids, cholesterol, riboflavin, and niacin compared to the hypercholesterolemic group, but had a lower intake of iron compared to the hypercholesterolemic group. A comparison of nutrient intake by food frequency questionnaire (FFQ) showed the following: There was no significant difference in nutrient intake between the normal men and women and those with hypercholesterolemia. After adjustment for confounding factors, nutrient intake by FFQ of the male normal group showed higher levels of n-3 fatty acid and vitamin C compared to the group with hypercholesterolemia. However, there was no significant difference in nutrient intake between the two groups of women. Conclusions: The average intake of n-3 fatty acids and vitamin C of the male group with hypercholesterolemia was lower than that of the normal group. However, since KNHANES is a cross-sectional study, prospective cohort studies are required to analyze the risk factors of hypercholesterolemia.

• Clinics in Shoulder and Elbow
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• v.25 no.4
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• pp.296-303
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• 2022

Background: A previous study reported that hyperlipidemia increases the incidence of tears in the rotator cuff tendon and affects healing after repair. The aim of our study was to compare the gene and protein expression of torn rotator cuff tendons in patients both with and without hypercholesterolemia. Methods: Thirty patients who provided rotator cuff tendon samples were classified into either a non-hypercholesterolemia group (n=19, serum total cholesterol [TC] <200 mg/dL) and hypercholesterolemia group (n=11, serum TC ≥240 mg/dL) based on their concentrations of serum TC. The expression of various genes of interest, including COL1A1, IGF1, IL-6, MMP2, MMP3, MMP9, MMP13, TNMD, and TP53, was analyzed by real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). In addition, Western blot analysis was performed on the proteins encoded by interleukin (IL)-6 and TP53 that showed significantly different expression levels in real-time qRT-PCR. Results: Except for IGF1, the gene expression levels of IL-6, MMP2, MMP9, and TP53 were significantly higher in the hypercholesterolemic group than in the non-hypercholesterolemia group. Western blot analysis confirmed significantly higher protein levels of IL-6 and TP53 in the hypercholesterolemic group (p<0.05). Conclusions: We observed an increase in inflammatory cytokine and matrix metalloproteinase (MMP) levels in hypercholesterolemic patients with rotator cuff tears. Increased levels of IL-6 and TP53 were observed at both the mRNA and protein levels. We suggest that the overexpression of IL-6 and TP53 may be a specific feature in rotator cuff disease patients with hypercholesterolemia.