• Journal of the Korean Society of Manufacturing Process Engineers
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• v.21 no.8
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• pp.93-98
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• 2022

Adiabatic blanking is a method to improve productivity through an autocatalytic cycle that occurs repeatedly through plastic deformation and thermal softening caused by impact energy. In this study, an axisymmetric analysis model comprising a punch, die, holder, and specimen was developed to confirm the temperature and deformation characteristics caused by an impact load. Through this, the impact energy, diameter of the punch, gap between the punch and die, and the effect of the fillet were analyzed. Because this process occurs in a very short time, adiabatic analysis can be performed using the explicit time-integration method. The analysis, confirmed that it is necessary to design a structure capable of increasing the local temperature and plastic deformation by controlling the impact energy, working area, gap, and the fillet.

• BMB Reports
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• v.54 no.7
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• pp.335-343
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• 2021

Cancer stem cells (CSCs) are a subpopulation of cancer that can self-renew and differentiate into large tumor masses. Evidence accumulated to date shows that CSCs affect tumor proliferation, recurrence, and resistance to chemotherapy. Recent studies have shown that, like stem cells, CSCs maintain cells with self-renewal capacity by means of asymmetric division and promote cell proliferation by means of symmetric division. This cell division is regulated by fate determinants, such as the NUMB protein, which recently has also been confirmed as a tumor suppressor. Loss of NUMB expression leads to uncontrolled proliferation and amplification of the CSC pool, which promotes the Notch signaling pathway and reduces the expression of the p53 protein. NUMB genes are alternatively spliced to produce six functionally distinct isoforms. An interesting recent discovery is that the protein NUMB isoform produced by alternative splicing of NUMB plays an important role in promoting carcinogenesis. In this review, we summarize the known functions of NUMB and NUMB isoforms related to the proliferation and generation of CSCs.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.42
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• pp.38.1-38.7
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• 2020

Background: Lipomas are benign soft tissue neoplasms of mature adipose tissue commonly occurring in the trunk or extremities. But, intraoral lipomas are rare entities which may be only noticed during routine dental examinations. Especially intramuscular lipomas on the tongue have been reported very rarely. In this study, we report a case of intramuscular lipoma on tongue, with a review of the literature from 1978 to 2019, providing data on age, gender, location, presenting symptoms, size, surgical methods, and recurrence. Case presentation: A case of intramuscular lipoma occurring in tongue region in a 65-year-old male is reported. Surgical excision is the mainstay of treatment for the lesion. In order to decrease the deformity and discomfort after the excision, we tried to modify surgical technique using enveloped mucosal flap. This technique provided more comfortable healing procedure on the operative site without recurrence. Conclusion: This is a rare case of large intramuscular lipoma on tongue. Surgical excision with enveloped mucosal flap design was performed to diminish postoperative raw surface and discomfort and a 24-month follow-up showed excellent healing without any recurrence. A case of intramuscular lipoma on tongue and relevant literature reviews are presented in this study.

• Journal of Distribution Science
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• v.21 no.2
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• pp.7-20
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• 2023

Purpose: With the unique feature of O2O, consumers are now able to check the profile of the services and products online and then consume them in offline venues or vice versa. This study provides motivation and practical implications about online-to-offline (O2O) distribution channels and investigates the relationship between economic values, service consistency and brand identity attractiveness in the O2O distribution channel. Then identify the impact of brand identity attractiveness on the performance (reputation and reuse intention). Research design, data, and methodology: Structural equation modeling (SEM) has been used to investigate the relationship between economic value and brand identity attractiveness, which affects the reputation and reuse intention of services in O2O. Results: Empirical results show the positive and significant impact of economic value and service consistency on brand identity attractiveness which results the positive and significant impact on performance (reputation and reuse intention) in O2O. Conclusion: In the O2O distribution channel, economic value is an important aspect for the attractive image and brand identity. On the other side, brand identity attractiveness is important for the bright future of O2O services, continuous growth, achieving the distinct goal, keeping good promises with customers, and a better reputation of O2O services in distribution channels.

• Journal of Acupuncture Research
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• v.39 no.1
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• pp.64-69
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• 2022

The risk of stress fractures is associated with rheumatoid arthritis (RA), which can aggravate bone loss. We report the case of a patient who was on long-term medication for RA presenting with lower extremity pain on the left and swelling without trauma. Magnetic resonance imaging and plain radiographs at the previous hospital showed no signs of fracture, but radiographs performed later, revealed a stress fracture of the left distal tibia. The stress fracture may have occurred due to multiple reasons such as long-term use of methotrexate and glucocorticoids, active RA, postmenopausal state, and immobility. Suspicion of a stress fracture should not be ruled out especially in RA patients with persistent pain, even if the radiographical findings are normal. Additional imaging and follow-ups are essential. The patient's pain was relieved with Korean medicine treatments, which suggests their potential application for stress fractures in RA patients.

• Proceedings of the National Institute of Ecology of the Republic of Korea
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• v.3 no.4
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• pp.221-226
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• 2022

A filarial nematode was found in a blood sample of an Anas falcata individual collected in South Korea in 2018. Phylogenetic analysis based on partial cytochrome C oxidase subunit I (COI) sequences placed the nematode as a novel genus of the family Onchocercidae and as closely related to Mansonella species, Chandlerella quiscali, and filarial nematodes recently reported in avian species. However, different phylogenetic relationship was observed in the NADH dehydrogenase subunit 5 and 12S rRNA-based phylogenetic trees, which might indicate the filarial nematode found in this study was not defined to belong to the known specific genera of the family Onchocercidae. The screening of 105 additional avian blood samples retrieved only one 12S rRNA-targeting polymerase chain reaction (PCR)-positive sample, which indicates that filarial nematode infection is rare in wild birds or that it occurs below the detection limit of PCR in blood samples. Nevertheless, considering the recent findings about ancient interactions between birds and human pathogenic filarial nematodes and their pathogenic potential in several avian species, additional exploration of novel filarial nematodes in wild birds remains necessary.

• Molecules and Cells
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• v.45 no.12
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• pp.869-876
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• 2022

Methylglyoxal (MG) is a dicarbonyl compound formed in cells mainly by the spontaneous degradation of the triose phosphate intermediates of glycolysis. MG is a powerful precursor of advanced glycation end products, which lead to strong dicarbonyl and oxidative stress. Although divergent functions of MG have been observed depending on its concentration, MG is considered to be a potential antitumor factor due to its cytotoxic effects within the oncologic domain. MG detoxification is carried out by the glyoxalase system. Glyoxalase 1 (Glo1), the ubiquitous glutathionedependent enzyme responsible for MG degradation, is considered to be a tumor promoting factor due to it catalyzing the removal of cytotoxic MG. Indeed, various cancer types exhibit increased expression and activity of Glo1 that closely correlate with tumor cell growth and metastasis. Furthermore, mounting evidence suggests that Glo1 contributes to cancer stem cell survival. In this review, we discuss the role of Glo1 in the malignant progression of cancer and its possible use as a promising therapeutic target for tumor therapy. We also summarize therapeutic outcomes of Glo1 inhibitors as prospective treatments for the prevention of cancer.

• Annual Conference of KIPS
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• 2010.11a
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• pp.603-604
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• 2010

본 연구는 이미지 필터링 효과를 적용한 이미지들을 3D tomogram으로 만들었을 때 어느 정도의 효과적인 복원이 가능하고 또 어떤 해상도의 필터를 사용했을 때 더 나은 결과를 얻어 낼 수 있는 지 확인하기 위해 진행하였다. 전자현미경으로 2D tilted image들을 찍는 과정에는 고전압의 사용으로 인한 다소의 오류들이 발생한다. 따라서 이러한 오류를 상쇄시키고 3D tomogram의 질적 향상을 위하여 Gaussian low-pass filtering을 사용하였다. 또한 Gaussian low-pass filtering 내에서도 어떤 해상도 값의 필터링을 사용해야 더 나은 결과를 얻을 수 있는 지 확인하였다.

• Journal of Korean society of Dental Hygiene
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• v.23 no.4
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• pp.303-309
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• 2023

Objectives: According to the Korea Education Development Institute, the college admission quota is expected to exceed the number of high school graduates, leading to an anticipated expansion in the gap between them. This paper aims to conduct an empirical analysis of the variables previously studied, with a specific focus on the admission competition rate for the department of dental hygiene. Methods: The research methodology is the multiple linear regression analysis. The research data contains the structured data from academy information, and the web-based unstructured data collected over the past 3 years. Results: After conducting the analysis, it was newly discovered that the university's online recognition and its location in the metropolitan area were statistically significant factors influencing the admission competition rate for the department of dental hygiene. Conclusions: The findings of this study are expected to be helpful in formulating admission strategies for universities to attract new students and identifying the factors that influence student attraction.

• Journal of Korean Association for Spatial Structures
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• v.23 no.3
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• pp.71-78
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• 2023

Recently, Free-Form and Irregular Shape high-rise buildings are constructed by IT technology development. Tilted shaped high-rise building which is one of Irregular shape high-rise buildings can cause lateral displacement by gravity load and lateral load due to tilted elevation shape. Therefore, it is necessary to review the behavior and structural aspects of the Tilted shape high-rise building by gravity load. In this paper, the dynamic characteristics of a tilted structure with a dual-core were analyzed with the core location as a design variable, and response behavior, vulnerable members, and vulnerable layers to earthquake loads were analyzed. As a result of the analysis, as the location of the core moved in an tilted direction, the eccentric distance and eccentric load decreased, reducing the axial force of the vertical members. However, the location of the core had little effect on the response.