• Journal of Microbiology and Biotechnology
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• v.17 no.7
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• pp.1204-1207
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• 2007

Structural analyses have shown that nucleotides at the positions 770 and 771 of Escherichia coli 16S rRNA are implicated in forming one of highly conserved intersubunit bridges of the ribosome, B2c. To examine a functional role of these residues, base substitutions were introduced at these positions and mutant ribosomes were analyzed for their protein synthesis ability using a specialized ribosome system. The results showed requirement of a pyrimidine at the position 770 for ribosome function regardless of the nucleotide identity at the position 771. Sucrose gradient profiles of ribosomes revealed that the loss of protein-synthesis ability of mutant ribosome bearing a base substitution from C to G at the position 770 stems from its inability to form 70S ribosomes. These findings indicate involvement of nucleotide at the position 770, not 771, in ribosomal subunit association and provide a useful rRNA mutation that can be used as a target to investigate the physical interaction between 16S and 23S rRNA.

• Proceedings of the Korea Technology Innovation Society Conference
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• 2017.05a
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• pp.473-487
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• 2017

본 논문은 대한민국의 제19대 대통령 선거와 관련하여 각 후보들의 과학기술정책 공약이 과학자들의 여론을 반영하였는지 알아본다. 이를 위해서, 주요 정당(더불어민주당, 국민의당, 바른정당, 정의당)의 후보들이 과학 언론인 동아사이언스로부터 받은 과학기술정책 공약에 대한 문의에 대해 답변한 내용과 사단법인 과학자 단체인 '변화를 꿈꾸는 과학기술인 네트워크(ESC)'가 발간한 '2017 대선 과학기술지원정책 타운미팅 - 우리는 대통령 후보에게 무엇을 묻고 요구할 것인가'라는 자료집에 대해 답변한 내용을 중심으로 하였다. ESC의 해당 자료집은 ESC 소속 회원들이 주관한 타운미팅에서 참가자들이 소속 및 직위에 의한 제한 없이 반대 의견에 부딪히지 않고 자유롭게 의견을 개진함으로써 발간된 것이기 때문에, 과학기술계의 여론을 가감 없이 반영했다고 볼 수 있다. 분석을 해본 결과, 국민의당 안철수 후보의 과학기술정책 공약이 과학기술계 여론을 가장 많이 반영하였으나, 과학기술 일자리 확충 및 과학기술인재 등용과 관련해서는 더불어민주당 문재인 대통령이, 과학문화 정책과 관련해서는 바른정당 유승민 후보 및 정의당 심상정 후보가 과학기술계 여론을 잘 반영한 것으로 나타났기에, 문재인 대통령이 세부 정책별로 다른 후보의 공약을 참고할 필요가 있는 것으로 파악되었다.

• The KIPS Transactions:PartD
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• v.11D no.7 s.96
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• pp.1483-1490
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• 2004

To accomplish a project successfuly, we have to estimate develpment effort accurately. But, development effort is different to software size and operation environment. Usually, we made use of function point for estimating development effort. In this paper. we make use of 789 project data. It is related to development projects in 1990`s. We investigate the variable affecting development effort. Also, we exedcute multiple liner regression analysis for looking linear relation about variables. We find the regression equation for multistage by dividing PDR that influ-enced development effort step by step.

• 한국정보디스플레이학회:학술대회논문집
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• 2007.08b
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• pp.1658-1660
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• 2007

We fabricate green device having unique life time characteristics of operating voltage reduction with time, ${\Delta}V_{op}$ <0. A green device needs lower voltage than initial voltage for sustaining constant current as life time goes on. It means there are two possible reasons; one is interface modification between anode and HIL due to oxygen plasma treatment and the other is bulk property modification due to combination of new green host and new green dopant. From these materials and oxygen plasma treatment, we can make white OLED device having the characteristics of low ${\Delta}V_{op}$ increasing.

• Proceedings of the KIEE Conference
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• 2006.07d
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• pp.2177-2178
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• 2006

학습 행동에서의 뇌파 측정은 실시간으로 두뇌 기능 상태를 연구하는데 유용한 연구 방법이며 대뇌의 부위 중 전두엽은 새로움에 대한 지향 반응과 사고 활동에 중요한 역할을 한다. 본 연구에서는 중학교 2학년 학생에게 새로운 시청각 학습 자료를 제시하고 5회의 반복학습이 이루어지는 과정에서의 전두부($Fp_2,Fp_2$)의 뇌파를 측정하고 Fourier, Wavelet 변환을 하여 정량적으로 분석하였다. 주의 집중, 정서 등 인지와 관련지어 특정파의 조절 능력 및 파의 특성을 이용한 여러 연구들을 종합해보면, 기억력, 주의지속과 연관되어 알파파, 베타파와 세타파가 발생되는 것을 볼 수 있다. 이 중 알파파는 기존의 뇌 상태를 동기화시키고 주의나 기억의 과정에 영향을 미칠 수 있는 것으로 증명되었다. 본 논문에서는 신호 처리에 높은 효율을 보이는 Wavelet 변환을 이용하여, 학습이 됨에 따라 변화하는 EEG 신호 가운데 알파파의 패턴과 활성도를 분석하고자 한다.

• Journal of KIISE:Computing Practices and Letters
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• v.16 no.2
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• pp.157-162
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• 2010

Previous process for issuing and messaging tax-invoice needs too much cost and has risky problems such as loss or forgery. A rule for an electronic tax-invoice can make up for the weak points. In the tax-invoice system based on web environment, the messaging electronic tax-invoices is more important than the issuing it. Therefore, a messaging system should be developed for submitting tax-invoice efficiently and safely. In this paper, we implement an electronic tax-invoice messaging system based on Hermes 2 which is an open source framework for electronic document messaging.

• YAKHAK HOEJI
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• v.50 no.2
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• pp.124-128
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• 2006

Astrocyte has emerged as an active regulator of brain function, which connects between blood vessels and neurons as well as is a structural component of the blood-brain barrier, From its structural characteristics, astrocyte seems to sensitively respond to oxygen tension, and, in turn, generate diverse cellular cascades. Therefore, to reveal astrocytlc events by oxygen change, we screened genes whose expressions are upregulated under reoxygenation after hypoxic stress using cDNA representational difference analysis (RDA) technique. Meteorin that regulates glial differentiation was isolated from primary cultured rat astrocytes as a hypoxia/reoxygenation regulatory factor. We cloned rat version of Meteorin (rMe-teorin) and determined full-size sequences of rMeteorin. In addition, RT-PCR analysis revealed that Meteorin was increased under reoxygenation in astrocytes and highly expressed in the developing brain. Collectively, these results suggest that Meteorin may regulate astrocyte-mediated effects in response to the change of oxygen tension in the pathophysiological states.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.272.2-273
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• 2002

The safety of blood and blood products is ensured by careful selection of donors. screening of donated blood and the use of validated viral inactivation and/or removal steps during the manufacture of blood products. Serologic screening procedures have substantially reduces the risk of transmission of blood-bone viruses. However, there are still residual risks despite these measures due to the inclusion of 'window period'donations. (omitted)

• YAKHAK HOEJI
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• v.54 no.4
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• pp.316-321
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• 2010

Adefovir dipivoxil which was originally developed by Gilead Sciences has been used as treatments of HIV and HBV, especially a therapeutics for HBeAg positive and negative chronic patients. We developed highly efficient purification method using reverse phase column chromatography for mass production and a stable amorphous Adefovir dipivoxil using solid dispersion method. Reverse phase column chromatography led to highly pure product, more than 99.7% by HPLC and can be used for mass production compared with normal column chromatography. Solid dispersion method containing watersoluble polymer and Isomalt showed improved stability of amorphous Adefovir dipivoxil against heat and moisture.

• Journal of Ginseng Research
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• v.37 no.1
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• pp.94-99
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• 2013

Proteinuric conditions demonstrate structural and compositional changes of the foot processes and slit diaphragms between podocytes. p130Cas in podocytes serves as an adapter protein anchoring glomerular basement membrane to actin filaments of podocyte cytoskeleton. To investigate the effect of ginseng total saponin (GTS) on the pathologic changes of podocyte p130Cas induced by diabetic conditions, we cultured mouse podocytes under: 1) normal glucose (5 mM, control); 2) high glucose (HG, 30 mM); 3) advanced glycosylation endproducts (AGE)-added; or 4) HG plus AGE-added conditions and treated with GTS. In confocal imaging, p130Cas colocalized with zonula occludens-1 and synaptopodin connecting to F-actin. However, diabetic conditions relocalized p130Cas molecules at perinuclear cytoplasmic area and reduced the intensity of p130Cas. In Western blotting, diabetic conditions, especially HG plus AGE-added condition, decreased cellular p130Cas protein levels at 24 and 48 h. GTS improved such quantitative and qualitative changes. These findings imply that HG and AGE have an influence on the redistribution and amount of p130Cas of podocytes, which can be reversed by GTS.