• Molecules and Cells
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• v.41 no.8
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• pp.771-780
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• 2018

Angiogenesis must be precisely controlled because uncontrolled angiogenesis is involved in aggravation of disease symptoms. Vascular endothelial growth factor (VEGF)/VEGF receptor 2 (VEGFR-2) signaling is a key pathway leading to angiogenic responses in vascular endothelial cells (ECs). Therefore, targeting VEGF/VEGFR-2 signaling may be effective at modulating angiogenesis to alleviate various disease symptoms. Oleanolic acid was verified as a VEGFR-2 binding chemical from anticancer herbs with similar binding affinity as a reference drug in the Protein Data Bank (PDB) entry 3CJG of model A coordination. Oleanolic acid effectively inhibited VEGF-induced VEGFR-2 activation and angiogenesis in HUVECs without cytotoxicity. We also verified that oleanolic acid inhibits in vivo angiogenesis during the development and the course of the retinopathy of prematurity (ROP) model in the mouse retina. Taken together, our results suggest a potential therapeutic benefit of oleanolic acid for inhibiting angiogenesis in proangiogenic diseases, including retinopathy.

• Journal of Preventive Medicine and Public Health
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• v.49 no.3
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• pp.143-152
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• 2016

Objectives: Metabolic syndrome is a cluster of risk factors for type 2 diabetes mellitus and cardiovascular disease. Associations between metabolic syndrome and several types of cancer have recently been documented. Methods: We analyzed the sample cohort data from the Korean National Health Insurance Service from 2002, with a follow-up period extending to 2013. The cohort data included 99 565 individuals who participated in the health examination program and whose data were therefore present in the cohort database. The metabolic risk profile of each participant was assessed based on obesity, high serum glucose and total cholesterol levels, and high blood pressure. The occurrence of cancer was identified using Korean National Health Insurance claims data. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models, adjusting for age group, smoking status, alcohol intake, and regular exercise. Results: A total of 5937 cases of cancer occurred during a mean follow-up period of 10.4 years. In men with a high-risk metabolic profile, the risk of colon cancer was elevated (HR, 1.40; 95% CI, 1.14 to 1.71). In women, a high-risk metabolic profile was associated with a significantly increased risk of gallbladder and biliary tract cancer (HR, 2.05; 95% CI, 1.24 to 3.42). Non-significantly increased risks were observed in men for pharynx, larynx, rectum, and kidney cancer, and in women for colon, liver, breast, and ovarian cancer. Conclusions: The findings of this study support the previously suggested association between metabolic syndrome and the risk of several cancers. A high-risk metabolic profile may be an important risk factor for colon cancer in Korean men and gallbladder and biliary tract cancer in Korean women.

• Perspectives in Nursing Science
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• v.17 no.1
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• pp.12-27
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• 2020

Purpose: Bullying is a global problem, and various programs are under way to prevent it. The purpose of this study was to review school bullying interventions for Korean school-age children and adolescents. Methods: Online databases such as RISS, KISS, DBpia, NDSL and KMBASE were searched, identifying 32 intervention studies published from January 2009 to November 2018. Results: Thirty-two intervention studies were identified: 23 included school bullying prevention and 9 included school bullying treatment for victims or youth at high risk for bullying. The main purpose of preventive intervention was to decrease the bystander's attitude toward group bullying and treatment program was to improve the psychosocial adaptation of bullying victims. The school bullying interventions varied from group counseling, social skills training, art therapy, bibliotherapy using role-play, game & activities. Classroom environment variables and self-esteem, peer-related variables improved significantly after the school bullying prevention programs and school bullying treatment programs, respectively. Conclusion: There is potential for enhancing the outcomes of the behavioral, interpersonal psychological variable. Integrated interventions considering the individuality, gender and physical health of children and adolescents will also be needed. However, a rigorous study design is required to compensate for the methodological limitations.

• International Journal of Fuzzy Logic and Intelligent Systems
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• v.6 no.4
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• pp.304-313
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• 2006

This paper describes a novel way of applying capacitive sensing technology to a mobile user interface. The key idea is to use grip-pattern, which is naturally produced when a user tries to use the mobile device, as a clue to determine an application to be launched. To this end, a capacitive touch sensing system is carefully designed and installed underneath the housing of the mobile device to capture the information of the user's grip-pattern. The captured data is then recognized by dedicated recognition algorithms. The feasibility of the proposed user interface system is thoroughly evaluated with various recognition tests.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.19 no.6
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• pp.579-585
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• 2006

We fabricated BSCCO-2212 (2212) rod by the melt casting process (MCP) and evaluated the effect of the melt flowing on the critical current ($I_c$) by using vertical and tilt casting. It was observed that the $2212-SrSO_4$ rod processed by the tilt casting method with homogeneous pre-heating temperature of the mold had a higher $I_c$ than that processed by the vertical casting method. We also evaluated the influence of the strontium sulfates ($SrSO_4$) addition on the texture, microstructure, critical current and temperature, and mechanical hardness of the $2212-SrSO_4$ rods. It was observed that the addition of $SrSO_4$ improved the critical current ($I_c$) and mechanical hardness of the 2212. The $I_c$ of the 2212 increased as the $SrSO_4$ content increased and reached a peak value (260 A at 77 K) at an $SrSO_4$ content of 6 wt.%. In addition, the addition of $SrSO_4$ had a beneficial effect on the mechanical hardness of the 2212. We studied the possible cause of the variation in the $I_c$ with the melt flowing and the $SrSO_4$ content based on the XRD, EPMA analysis and the microstructural observation.

• IMMUNE NETWORK
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• v.11 no.6
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• pp.348-357
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• 2011

Background: N-myc downstream-regulated gene 2 (NDRG2), a member of a newly described family of differentiation-related genes, has been characterized as a regulator of dendritic cells. However, the role of NDRG2 on the expression and activation of transcription factors in blood cells remains poorly understood. In this study, we investigated the effects of NDRG2 overexpression on GATA-1 expression in PMAstimulated U937 cells. Methods: We generated NDRG2-overexpressing U937 cell line (U937-NDRG2) and treated the cells with PMA to investigate the role of NDRG2 on GATA-1 expression. Results: NDRG2 overexpression in U937 cells significantly induced GATA-1 expression in response to PMA stimulation. Interestingly, JAK2/STAT and BMP-4/Smad pathways associated with the induction of GATA-1 were activated in PMA-stimulated U937-NDRG2 cells. We found that the inhibition of JAK2 activation, but not of BMP-4/Smad signaling, can elicit a decrease of PMA-induced GATA-1 expression in U937-NDRG2 cells. Conclusion: The results reveal that NDRG2 promotes the expression of GATA-1 through activation of the JAK2/STAT pathway, but not through the regulation of the BMP-4/Smad pathway in U937 cells. Our findings further suggest that NDRG2 may play a role as a regulator of erythrocyte and megakaryocyte differentiation during hematopoiesis.

• The Bulletin of The Korean Astronomical Society
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• v.36 no.1
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• pp.30.1-30.1
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• 2011

2010년 11월 05일부터 11월 29일 중 총 12일간 진천 소재 충북대학교 천문대의 60cm 반사망원경과 ST-8 CCD 카메라를 이용하여 BD And의 BVR CCD 측광 관측을 수행하여 처음으로 BVR 광도 곡선을 완성하였다. 또한, 극심시각 결정을 위한 측광관측이 레몬산 천문대 1m 반사 망원경과 충북대학교 천문대의 35cm 망원경으로 수행되었다. 우리의 관측을 통하여 모두 19개의 극심시각을 새로이 결정하였다. 새로운 관측은 이 별의 공전주기가 이전까지 알려진 0.4629일이 아니라 그 두 배인 0.9258일이며, 기산점도 반주기 바뀌어야 함을 보여준다. BD And의 광도요소를 $MinI=HJD2434962.8602+0.^d9258054E$으로 새롭게 개정하였다. 이 광도요소로 작성한 우리의 BVR 광도곡선은 제1식과 제2식의 깊이가 거의 비슷하며, 식바깥 부분에 잘 발달된 파형 모양을 보인다. 이는 BD And가 짧은 주기의 RS CVn형 식쌍성임을 나타내는 것이다. 우리의 극심시각을 포함한 총 130개의 극심시각에 대한 (O-C)도를 작성한 결과, BD And의 공전주기가 규칙적으로 변화하는 것을 발견하였다. 이 변화를 보이지 않는 제3천체에 의한 광시간 효과로 가정하여, 궤도이심율이 0.78이며, 9.19년의 주기를 가진 광시간 궤도를 결정하였다. 우리의 광도곡선을 2003년 Wilson-Devinney 쌍성 모형으로 분석하여 광도곡선 해를 질량비 q=0.094, 궤도경사각 $i=85.^{\circ}4$, $T_1=6365(K)$, $T_2=6250(K)$, $R_1=1.132(Rsun)$, $R_2=1.304(Rsun)$와 같이 산출하였다. 식바깥에서 나타나는 파형 모양의 변화는 주성의 표면에 매우 큰 흑점으로 잘 설명되며, BVR 광도곡선에서 각전체 광도의 각 8.3%, 10.0%, 11.7%에 해당되는 제3 광도가 검출되었다. 이는 주기연구에서 제안된 제3천체의 존재 가능성을 더 공고히 한다.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.27 no.3
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• pp.501-519
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• 2017

With the revolution of IT technology, cyber threats and crimes are also increasing. In the recent years, many large-scale APT attack executed domestically and internationally. Specially, many of the APT incidents were not recognized by internal organizations, were noticed by external entities. With fourth industrial revolution(4IR), advancement of IT technology produce large scale of sensitive data more than ever before; thus, organizations invest a mount of budget for various methods such as encrypting data, access control and even SIEM for analyzing any little sign of risks. However, enhanced intelligent APT it's getting hard to aware or detect. These APT threats are too much burden for SMB, Enterprise and Government Agencies to respond effectively and efficiently. This paper will research what's the limitation and weakness of current defense countermeasure base on Cyber Kill Chain process and will suggest effective and efficient APT defense operation model with considering of organization structure and human resources for operation.

• Journal of Navigation and Port Research
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• v.38 no.5
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• pp.503-509
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• 2014

In this study, a new concept perforated breakwater is proposed, which is having resonant channels. In the channel, perforated plate is installed for dissipating wave energy induced by flow separations. The breakwater has two advantages compared with conventional perforated breakwater having wave chamber with slotted walls. One is easy to control the target wave condition for dissipating wave energy, and the other is having the high structural safety because the structural members are not exposed to impact waves, directly. To evaluate wave reflection characteristics of the proposed breakwater, numerical experiment was carried out by using Galerkin's finite element model based on the linear potential theory. The results indicated that considerable energy dissipation occurs near the resonant period of channel, and wave reflection characteristics are affected by channel shape, location and opening ratio.

• 한국IT서비스학회:학술대회논문집
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• 2008.05a
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• pp.425-430
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• 2008

USN의 발전으로 인해 인간 중심의 정보화 사회에서 사물 간에도 정보들을 유기적으로 결합하여 활용하는 유비쿼터스 컴퓨팅 사회로 급격히 변모하고 있다. 이러한 유비쿼터스 컴퓨팅 인프라를 성공적으로 구축하기 위해서는 센서노드에 대한 기술의 발전과 함께 USN 미들웨어에 대한 연구가 필요하다. USN의 핵심기술 중 하나인 USN 미들웨어는 시스템 소프트웨어로써 USN 응용에서 USN 계층의 자원과 데이타를 쉽게 활용할 수 있도록 다양한 기본 서비스를 제공한다. USN 디렉토리 서비스는 이와 같은 USN 미들웨어의 핵심 컴포넌트로서 USN 응용이 필요로 하는 USN 자원에 대한 정보를 검색하는 기능을 수행한다. 분산된 USN 자원에 대한 메타데이타의 효율적인 검색은 분산된 환경에서의 USN 디렉토리 서비스의 핵심요소이며 최근 이에 대한 연구가 보이고 있다. 분산 USN 디렉토리 서비스에서의 메타데이타 검색 모델은 크게 중앙 집중식(Centralized) 모델, 계층식(Hierarchical) 모델, P2P(Peer-to-Peer) 모델이 있다. 그러나 현재 메타데이타 검색 모델에 대한 연구는 원하는 메타데이타를 찾기 위한 서버 검색 회수만을 대상으로 하고 있으며 실제 단말 간 응답시간에 영향을 미치는 지연시간은 고려하지 않고 있다. 본 논문은 실제 단말 간 응답시간에 영향을 미치는 검색회수와 지연시간을 고려한 하이브리드 모델을 제안하고, 하이브리드 모델이 계층 모델에서 검색 시 불필요한 검색횟수의 증가와 P2P 모델의 광범위한 지역에서 응답시간이 증가하게 되는 단점을 개선할 수 있음을 보인다.