• 대한화학회지
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• 제34권4호
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• pp.377-383
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• 1990

용매 존재하에서 2-hydroxyethylmethacrylate와 acrylamide, N, N-dimethylamide 및 methylmethacrylate를 함량에 따라 3종류의 공중합체 수화겔막을 제조한 다음 이들 막에 알코올용질의 투과 및 분배계수를 측정하였으며, 이 측정값들을 이용하여 용질의 투과 메카니즘을 논의하였다. 수화겔막에서 유기용질의 투과계수는 그 분자의 크기에 주로 의존하였다. 그러나 수화겔막 내에 존재하는 물의 함량이 낮아지면 막에 대한 용질의 용해도가 점차 중요해짐을 또한 알 수 있었다. 분배계수의 측정 결과에 의하면 수화겔막에서의 용질의 분배는 주로 막과 용질사이에 존재하는 소수성 상호작용에 의해 조절되었다. 그리고 수화겔막에 유기용질의 확산은 전적으로 빈자리에 의존하며, 물분자와 용질 사이에 극성-편극성 및 수소결합도 부분적으로 영향을 미치나 그 정도가 아주 미약함을 확인하였다.

• Restorative Dentistry and Endodontics
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• 제26권5호
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• pp.399-408
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• 2001

Tooth bleaching has been prevailing recently for its ability to recover the color and shape of natural teeth without reduction of tooth material. However, it has been reported that bleaching procedure adversely affects the adhesive bond strength of composite resin to tooth. At the same time the bond strength was reported to be regained by application of some chemical agents. The purpose of this in vitro study was to investigate the effect of the removal of residual peroxide on the composite- enamel adhesion and also evaluated fracture mode between resin and enamel after bleaching. Sixty extracted human anterior and premolars teeth were divided into 5 groups and bleached by combined technique using of office bleaching with 35 % hydrogen peroxide and matrix bleaching with 10% carbamide peroxide for 4 weeks. After bleaching, the labial surfaces of each tooth were treated with catalase, 70% ethyl alcohol, distilled water and filled with composite resin. Shear bond strength was tested and the fractured surfaces were also examined with SEM. Analysis revealed significantly higher bond strength values. (p＜0.05) for catalase-treated specimens, but water-treated specimens showed reduction of bond strength, alcohol- treated specimens had medium value between the two groups(p＜0.05). The fracture mode was shown that the catalase group and the alcohol group had cohesive failure but the water sprayed group had adhesive failure. It was concluded that the peroxide residues in tooth after bleaching seems to be removed by gradual diffusion and the free radical oxygen from peroxide prevents polymerization by combining catalyst in the resin monomer. Therefore it may be possible to eliminate the adverse effect on the adhesion of composite resin to enamel after bleaching by using water displacement solution or dentin bonding agent including it for effective removal of residual peroxide.

• Journal of Ginseng Research
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• 제47권2호
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• pp.228-236
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• 2023

Background: QiShen YiQi pills (QSYQ) is a Traditional Chinese Medicine (TCM) formula, which has a significant effect on the treatment of patients with myocardial infarction (MI) in clinical practice. However, the molecular mechanism of QSYQ regulation pyroptosis after MI is still not fully known. Hence, this study was designed to reveal the mechanism of the active ingredient in QSYQ. Methods: Integrated approach of network pharmacology and molecular docking, were conducted to screen active components and corresponding common target genes of QSYQ in intervening pyroptosis after MI. Subsequently, STRING and Cytoscape were applied to construct a PPI network, and obtain candidate active compounds. Molecular docking was performed to verify the binding ability of candidate components to pyroptosis proteins and oxygen-glucose deprivation (OGD) induced cardiomyocytes injuries were applied to explore the protective effect and mechanism of the candidate drug. Results: Two drug-likeness compounds were preliminarily selected, and the binding capacity between Ginsenoside Rh2 (Rh2) and key target High Mobility Group Box 1 (HMGB1)was validated in the form of hydrogen bonding. 2 μM Rh2 prevented OGD-induced H9c2 death and reduced IL-18 and IL-1β levels, possibly by decreasing the activation of the NLRP3 inflammasome, inhibiting the expression of p12-caspase1, and attenuating the level of pyroptosis executive protein GSDMD-N. Conclusions: We propose that Rh2 of QSYQ can protect myocardial cells partially by ameliorating pyroptosis, which seems to have a new insight regarding the therapeutic potential for MI.

• 생명과학회지
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• 제24권4호
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• pp.437-446
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• 2014

트립탄 계열의 약물을 경구 복용 시에 트립탄은 소화 시스템에 의하여 생물학적 이용도가 감소되며, 혈중 약물 농도가 시간의 경과에 따라 급격히 감소되고, 위장 장애의 가능성 등이 있다는 문제들을 나타낸다. 일반 겔 패치의 부작용을 개선하기 위하여 패치는 하이드로겔 형태로 제조하였다. 하이드로겔 패치의 주가 되는 메트릭스의 고분자는 PVA를 사용하였고, PEG는 PVA의 분자 간/분자 내 수소결합을 유도하기 위해 첨가물로서 사용되었고 알모트립탄 약물이 부가되었다. 또한 PVA 체인간의 미세 상분리를 가속하기 위해 매우 낮은 온도에서 액체질소가 사용되었다. FT-IR 분석에서 PVA, PEG 그리고 알모트립탄의 흡수 밴드를 확인하였다. PEG 함량이 증가함에 따라 결정화도, 수분흡수력과 인장강도들은 증가하였다. 약물방출 실험에서 약물 방출량은 PEG의 함량이 높은 하이드로겔이 약물 방출 시에 팽윤이 더 잘 이루어져 증가하였다. 본 실험에서 10 wt%의 PEG를 첨가하여 제조된 하이드로겔의 약물 방출량이 가장 좋았다. 또한 10 wt%의 PEG가 함유된 하이드로겔은 2시간째까지 전체 약물의 약 60%가 방출됨을 확인하였고, 24시간째까지도 방출이 계속되었다. 따라서 제조된 하이드로겔은 triptan의 1차 투여 이후 24시간 이내에 재발하는 편두통 환자들을 대상으로 한 트립탄의 2차 투여를 위한 경피흡수형 패치로서 적합하다.