• 한국전산유체공학회:학술대회논문집
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• 1999.11a
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• pp.115-126
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• 1999

A two-dimensional Navier-Stokes solver using hybrid meshes is parallelized with a domain decompostion method. The focus of this paper is placed on minimizing the amount of effort in parallelizing the serial version of the solver, and this is achieved by adding an additional layer of cells to each decomposed domain. Most subroutines of the serial solver are used without modification, and the information exchange between neighboring domains is achieved using MPI(Message Passing Interface) library. Load balancing among the processors and scheduling of the message passing are implemented to reduce the overhead of parallelization, and the speed-up achieved by parallelization is measured on the transonic invisicd and turbulent flow problems. The parallelization efficiencies of the explicit Runge-Kutta scheme and the implicit point-SGS scheme are compared and the effects of various factors on the results are also studied.

• Biomedical Science Letters
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• v.13 no.4
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• pp.305-311
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• 2007

cAMP-dependent protein kinase A (PKA) is the best-characterized protein kinases and has served as a model of the structure and regulation of cAMP-binding protein as well as of protein kinases. To determine the function of PKA in development, we employed the yeast two-hybrid system to screen for catalytic subunit of PKA $(C\alpha)$ interacting partners in a cDNA library from mouse embryo. A Testis-brain RNA-binding protein (TB-RBP), specifically bound to $C\alpha$. This interaction was verified by several biochemical analysis. Our findings indicate that $C\alpha$ can modulate nucleic acid binding proteins of TB-RBP and provide insights into the diverse role of PKA.

• Journal of Korean Library and Information Science Society
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• v.27
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• pp.457-483
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• 1997

This study was intended to compare the effectiveness of the Savvy search and Metacrawler in terms of the total number of relevant documents retrieved, precision, recall, and the number of deadlines. In addition, this study measured whether the Meta-search engine and general web search engines retrieved different web documents. As a result, Savvy search produced a higher precision and recall as compared with motacrawler search engine while the metacrawler had lower deadlines ration than savvy search, Also, Meta search engine was more effective than the general web search engine, The results show that the hybrid methodology of integrating a variety of web search engines can help solve retrieval effectiveness problems on the Internet.

• Structural Engineering and Mechanics
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• v.32 no.5
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• pp.667-683
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• 2009

FE model-based dynamic analysis has been widely used to predict the dynamic characteristics of civil structures. In a physical point of view, an FE model is unavoidably different from the actual structure as being formulated based on extremely idealized engineering drawings and design data. The conventional model updating methods such as direct method and sensitivity-based parameter estimation are not flexible for model updating of complex and large structures. Thus, it is needed to develop a model updating method applicable to complex structures without restriction. The main objective of this paper is to present the model updating method based on the hybrid genetic algorithm (HGA) by combining the genetic algorithm as global optimization method and modified Nelder-Mead's Simplex method as local optimization method. This FE model updating method using HGA does not need the derivation of derivative function related to parameters and without application of complicated inverse analysis methods. In order to allow its application on diversified and complex structures, a commercial FEA tool is adopted to exploit previously developed element library and analysis algorithms. Moreover, an output-level objective function making use of measurement and analytical results is also presented to update simultaneously the stiffness and mass of the analysis model. The numerical examples demonstrated that the proposed method based on HGA is effective for the updating of the FE model of bridge structures.

• Animal cells and systems
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• v.12 no.3
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• pp.143-148
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• 2008

Heterogeneous nuclear ribonucleoprotein E1(hnRNP E1) is one of the primary pre-mRNA binding proteins in human cells. It consists of 356 amino acid residues and harbors three hnRNP K homology(KH) domains that mediate RNA-binding. The hnRNP E1 protein was shown to play important roles in mRNA stabilization and translational control. In order to enhance our understanding of the cellular functions of hnRNP E1, we searched for interacting proteins through a yeast two-hybrid screening while using HeLa cDNA library as target. One of the cDNA clones was found to be human ribosomal protein L18a cDNA(GenBank accession number BC071920). We demonstrated in this study that human ribosomal protein L18a, a constituent of ribosomal protein large subunit, interacts specifically with hnRNP E1 in the yeast two-hybrid system. Such an interaction was observed for the first time in this study, and was also verified by biochemical assay.

• Journal of Information Science Theory and Practice
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• v.4 no.1
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• pp.30-48
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• 2016

The study tested a hybrid model with constructs drawn from the Technology Acceptance Model (TAM) and Diffusion of Innovation (DOI) theory in order to examine the moderating effect of productivity and relative advantage (RA) on perceived usefulness (PU) vis-à-vis electronic information resources (EIR) adoption in private university libraries in Ogun and Osun States of Nigeria. The descriptive research design was adopted in the study. The population consisted of 61 (55.0%) librarians and 50 (45.0%) library officers (totaling 116—100%) in Babcock University, Bells University, Covenant University, Bowen University, Oduduwa University, and Redeemer's University. Purposive sampling procedure was adopted after which total enumeration was used since the total population is small. The questionnaire was used for data collection. Of the 116 copies of the questionnaire administered, 111 (95.7%) were found usable. The instrument was structured based on a 4-point Likert agreement scale of Strongly Agree, Agree, Disagree, and Strongly Disagree. Data were analyzed using descriptive statistics like tables of frequency counts and percentage. The findings revealed that productivity and relative advantage are significant moderators of perceived usefulness of EIR adoption in private university libraries in Ogun and Osun States, Nigeria.

• Journal of Life Science
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• v.14 no.1
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• pp.26-31
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• 2004

Redox factor-1 (Ref-1), known as a redox regulator, controls the DNA binding of AP-1 and is activated in HT29 colon cancer cells by hypoxia in vitro. REF-1 also increases tile DNA binding affinity of Hypoxia-inducible Factor-lalpha$ (HIF-lalpha$), HIF-like Factor (HLF) and early growth response-1 (Egr-1) which induce expression of the genes involved in angiogenesis, so that we speculate that REF-1 may play a role in hypoxia-induced angiogenesis. In this research we tried to detect novel proteins interacting with REF-1 using Yeast two-hybrid system using full-length REF-1 cDNA as bait. As result of such screening we detected 3 positive clones. DNA sequencing and GeneBank search revealed that one of the clones contained the same sequences as M.musculus cDNA for tioredoxin.

• Journal of the Korean Society for Library and Information Science
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• v.39 no.4
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• pp.71-98
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• 2005

Recently, the speed of changes surrounding university libraries requires a hybrid library environment that supports integrated services, combining a virtual space with physical space of traditional libraries. Through changes, university libraries have faced the need to review their missions and visions, laying stress on the core values of university libraries. This study analyzed the central keywords in the contents of mission and vision statements of university libraries in America, England, Canada, and Australia. The research was acquired from mission and vision statements containing core values of developed university libraries. Core values are present in each area such as correction and information resources, services, place, people, environment and infrastructure, community, and parent-university relations. Ultimately, this study tried to provide the directions and the basic materials for the establishment of missions and visions for university libraries in Korea.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.23 no.4
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• pp.71-91
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• 2012

As the smartphone market has expanded and university students in their twenties account for the largest portion of the market, university libraries need to provide mobile library services to keep up with students' growing demand in mobile services. The purpose of this study is to analyze the status and trends of mobile services in Korean university libraries. This study investigated mobile services of 434 university libraries in Korea and 114 ones which are members of ARL during the months of September and November in 2012. As a result, this study found that university libraries in Korea were offering 55 mobile Web and 29 mobile application services with 11.2 and 10.7 contents respectively. In addition, on the basis of the identified current problems, this study suggested further steps for developing and improving mobile services in Korean university libraries.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.31 no.1
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• pp.89-113
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• 2020

Libraries are one of the essential living infrastructures in urban regeneration. Beyond its meaning as a basic living infrastructure, it is necessary to first understand the role, nature and forms of participation in existing urban regeneration projects in order for libraries to perform their functions and roles effectively as participants of urban regeneration. Therefore, this study investigates the contents related to libraries in the contents of the strategic plan related to urban regeneration projects, and considers them in terms of the role of the library and the form of participation. Through this, the city's library would seek to maximize its role and function as a participant in urban regeneration. As a result, the library in urban regeneration is expected to improve the quality of living environment, Urban vitality, culturally, educationally, socially/welfare role closely related to life, and the role of community as a hub. In addition, the types of library participation could be largely divided into regional and geographical libraries, hybrid libraries combined with various services, libraries based on community cooperation and linkage, and regional community hub libraries based on community participation. In the future, the library needs to promote a more active role change based on the five roles expected as participants in urban regeneration. In addition, more detailed discussions on librarians, services, and programs, which are the main subjects of library services, will be needed in developing urban regeneration plans in order for libraries to successfully fulfill their role as urban regeneration centers.