• Transactions of the Korean Society of Automotive Engineers
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• v.22 no.1
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• pp.174-182
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• 2014

Recently, not only common types of hybrid electric vehicle (HEV) such as series or parallel but many other types of HEVs including 4WD hybrid electric vehicle have been developed and released. In this study, analysis of fuel economy and driving performance for 2WD and 4WD HEV are conducted using backward simulation based on dynamic programming. To analyze the characteristics of 4WD HEV, tire slip model based on vehicle dynamics was applied to the backward simulation program. As a result, 2WD HEV shows better fuel economy than 4WD HEV because of relatively simple configuration. However, in a severe road condition, 4WD HEV shows better driving performance that 2WD HEV had about 6% of impossible time to follow the driving cycle though the 4WD HEV had no impossible time.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.65 no.6
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• pp.962-968
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• 2016

The large scaled lead-acid battery is widely used for efficient operation of the photovoltaic system in many islands. However, lithium-ion battery is now being introduced to mitigate the fluctuation of wind power and to replace lead-acid battery. Therefore, hybrid ESS(Energy Storage system) that combines lithium-ion battery with lead-acid battery is being required because lithium-ion battery is costly in present stage. Under this circumstance, this paper presents the optimal algorithm to create composition rate of hybrid ESS by considering fixed and variable costs in order to maximize advantage of each battery. With minimization of total cost including fixed and variable costs, the optimal composition rate can be calculated based on the various scenarios such as load variation, life cycle and cost trend. From simulation results, it is confirmed that the proposed algorithms are an effective tool to produce a optimal composition rate.

• KEPCO Journal on Electric Power and Energy
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• v.2 no.1
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• pp.49-54
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• 2016

The large scaled lead-acid battery is widely used for efficient operation of the photovoltaic system in many islands. However, lithium-ion battery is now being introduced to mitigate the fluctuation of wind power and to replace lead-acid battery. Therefore, hybrid ESS (Energy Storage system) that combines lithium-ion battery with lead-acid battery is being required because lithium-ion battery is costly in present stage. Under this circumstance, this paper presents the optimal algorithm to create composition rate of hybrid ESS by considering fixed and variable costs in order to maximize advantage of each battery. With minimization of total cost including fixed and variable costs, the optimal composition rate can be calculated based on the various scenarios such as load variation, life cycle and cost trend. From simulation results, it is confirmed that the proposed algorithms are an effective tool to produce a optimal composition rate.

• Journal of Drive and Control
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• v.12 no.3
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• pp.18-24
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• 2015

The plug-in hybrid electric vehicle has a high fuel economy and can be driven long distances. Its different modes include the electric vehicle, hybrid electric vehicle, and only engine operating mode. A power management strategy is important to determine which mode should be selected. The strategy makes the vehicle more efficient using appropriate power sources for driving. However, the strategy usually needs a driving speed profile which is future driving cycle. If the profile is known, the strategy easily determines which mode is driven efficiently. However, it is difficult to estimate the speed profile for a real system. To address this problem, this paper proposes a new power distribution strategy using a neural network. The average speed and driving range are used as input parameters to train the neural network system. The strategy determines a limit for the use of the battery and the desired power is distributed between the engine and the motor simultaneously. Its fuel economy can increase by improving the basic strategy.

• Journal of the Korea Society for Simulation
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• v.25 no.3
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• pp.65-76
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• 2016

Self-adaptive software is software that adapts by itself to system requirements about the recognized problems without stopping the software cycle. In order to reduce the unnecessary adaptation in the system having the critical points, we propose proactive approach which can predict the future operation after a critical point. In this paper, we predict the future operation after a critical point using a hybrid model to deal with the characteristics of the observed data with the linear and non-linear pattern. The operation of the prediction method is determined on a timing decision indicator based on the prediction accuracy. The two main points of contributions of this paper are to reduce uncertainty about the future operation by predicting the situation after a critical point using hybrid model and to reduce unnecessary adaptation implementation by deciding a timing based on a timing decision indicator.

• Journal of Veterinary Science
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• v.22 no.3
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• pp.25.1-25.16
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• 2021

Background: Malignant lymphoma is the most common hematopoietic malignancy in dogs, and relapse is frequently seen despite aggressive initial treatment. In order for the treatment of these recurrent lymphomas in dogs to be effective, it is important to choose a personalized and sensitive anticancer agent. To provide a reliable tool for drug development and for personalized cancer therapy, it is critical to maintain key characteristics of the original tumor. Objectives: In this study, we established a model of hybrid tumor/stromal spheroids and investigated the association between canine lymphoma cell line (GL-1) and canine lymph node (LN)-derived stromal cells (SCs). Methods: A hybrid spheroid model consisting of GL-1 cells and LN-derived SC was created using ultra low attachment plate. The relationship between SCs and tumor cells (TCs) was investigated using a coculture system. Results: TCs cocultured with SCs were found to have significantly upregulated multidrug resistance genes, such as P-qp, MRP1, and BCRP, compared with TC monocultures. Additionally, it was revealed that coculture with SCs reduced doxorubicin-induced apoptosis and G2/M cell cycle arrest of GL-1 cells. Conclusions: SCs upregulated multidrug resistance genes in TCs and influenced apoptosis and the cell cycle of TCs in the presence of anticancer drugs. This study revealed that understanding the interaction between the tumor microenvironment and TCs is essential in designing experimental approaches to personalized medicine and to predict the effect of drugs.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.6
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• pp.288-296
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• 2019

Radiation cooling has used ceilings or floors as cooling surfaces. In such cases, to avoid moisture condensation on the surface, the surface temperature needs be higher than the dew point temperature or an additional dehumidifier is added. In this study, with a goal for residential application, intentional moisture condensation on the cooling surface was attempted, which increased the cooling capacity and improved the indoor comfortness. This method included two separate refrigeration cycles - convection-type dehumidifying cycle and the panel cooling cycle. Test results on the panel cooling cycle showed that, at the standard outdoor ($35^{\circ}C/24^{\circ}C$) and indoor ($27^{\circ}C/19.5^{\circ}C$) condition, the refrigerant flow rate was 8.8 kg/h, condensation temperature was $51^{\circ}C$, evaporation temperature was $8.8^{\circ}C$, cooling capacity was 376 W and COP was 1.75. Furthermore, the panel temperature was uniform within $1^{\circ}C$ (between $13^{\circ}C$ and $14^{\circ}C$). As the relative humidity decreased, the cooling capacity decreased. However, the power consumption remained approximately constant. In the convection-type dehumidification cycle, the refrigerant flow rate was 21.1 kg/h, condensation temperature was $61^{\circ}C$, evaporation temperature was $5.0^{\circ}C$, cooling capacity was 949 W and COP was 2.11 at the standard air condition. When both the radiation panel cooling and the dehumidification cycle operated simultaneously, the cooling capacity of the radiation panel cycle was 333 W and that of the dehumidification cycle was 894 W, and the COP was 1.89. As the fan flow rate decreased, both the cooling capacity of the radiation panel and the dehumidification cycle decreased, with that of the dehumidification cycle decreasing at a higher rate. Finally, a possible control logic depending on the change of the cooling load was proposed based on the results of the present study.

• Journal of Microbiology
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• v.39 no.4
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• pp.286-292
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• 2001

During mitosis. the proper segregation of duplicated chromosomes is corrdinated by a spindle check-point. The bifurcated spindle checkpoint blocks cell cycle progression at metaphase by monitoring unattached kinetochores and inhibits mitotic exit in response to the misorientation of the mitotic spin- dle Ibd1p/Bfa1p is a spindle checkpoint regulator of budding yeast in the Bub2p checkpoint pathway for mitotic exit and its disruption abolishes mitotic arrest when proper organization of the mitotic spin-dls inhibited. Ibd1p/Bfa1p localizes to the spindle pole body, a microtublue-organizing center in yeast, and its overexpression arrests the cell cycle in 80% of cells with an enlarged budy at mitosis and in 20 % of cells with multiple buds. In this study, we found that the C-terminus of Ibd1p/Bfa1p phys-ically interacts with Skp1p, a key component of SCF (Skp1/cullin/F-box) complex for ubiquition-medi-ated proteolysis of cel cycle regulatores as well as an evolutionally conserved kinetochore protein for cell cycle progression. A putative F-box motif was found in the C-terminus of Ibd1p/Bfa1p and its function was investigated by making mutants of conserved residues in the motif. These Ibd1p/Bfa1p mutants of a putative F-box interacted with SKp1p in vitro by two-hybrid assays as wild type Ibd1p/Bfa1p. Also these Ibd1p/Bfa1p utants displayed the overexpression phenotypes of wild type Ibd1p, when over-expressed under inducible promoters . These results suggest that a putative F-box motif of Ibd1p/Bfa1p is not essential for the interaction with SKp1p and its function in mitotic exit and cytokinesis.

• Journal of the Korean Institute of Gas
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• v.19 no.2
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• pp.66-73
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• 2015

The amount and quality of waste heat from a gas engine which is modified from an automobile gasoline engine is analyzed. Exhaust temperature is $573.8^{\circ}C$ and engine cooling water exit temperature is $85.7^{\circ}C$. The amount of waste heat of engine cooling water is double compared to that of exhaust gas. Organic Rankine cycle (ORC) system is designed for two different waste heat source of engine cooling water and engine exhaust and is thermodynamically analyzed.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.36 no.2
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• pp.81-90
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• 2013

Material flow control (MFC) is a kind of operational policy to control of the movement of raw materials, components, and products through the manufacturing lines. It is very important because it varies throughput, line cycle time, and work-in-process (WIP) under the same manufacturing environments. MFC can be largely categorized into three types such as Push, Pull, and Hybrid. In this paper, we set various manufacturing environments to compare five existing MFC mechanisms: Push, Pull, and Hybrid (CONWIP, Gated MaxWIP, Critical WIP Loops, etc). Three manufacturing environments, manufacturing policies (make to stock and make to order), demand (low, medium, high), and line balancing (balanced, unbalanced, and highly unbalanced) are considered. The MFCs are compared in the point of the five functional efficiencies and the proposed compounded efficiency. The simulation results shows that the Push is superior in the functional efficiency and GMWIP is superior in the compounded efficiency.