• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.11 no.1
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• pp.40-53
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• 1998

Mast cells play an important role in the pathophysiologlcal changes observed in acute cutaneous and inflammatory diseases In order to see whether Kum-Hwang-San has an influence on mast cell- mediated immediate cutaneous reactions, the author has undertaken an animal study. Ears of mice were treated with a compound 48/80 solution topically at 30 min after the cutaneous application of Kum-Hwang-San. At each point, an ear swelling response was measured with a digimatic thickness micrometer. Ear swelling response induced by compound 48/80 was significantly suppressed dose-dependently by Kum-Hwang-San 30 min before topical application as compared with that in nonapplicated control mice, and the value returned to normal levels by 120 min. Compound 48/80- induced mast cell degranulation by Kum-Hwang-San was also remarkably decreased in accordance with the suppression in ear swelling response. Kum-Hwang-San dose-dependently inhibited histamine release from the rat peritoneal mast cells activated by compound 48/80. Another way to test acute cutaneous reaction is to induce passive cutaneous anaphylactic reaction. Kum-Hwang-San significantly inhibited passive cutaneous anaphylactic reaction activated by anti-dinitrophenyl IgE on both topical application and intradermal injection. Kum-Hwang-San also inhibited histamine release from the rat peritoneal mast cells induced by anti-DNP IgE. This study provides evidence that Kum-Hwang-San will be beneficial in the treatment of acute cutaneous diseases.

• (The)Study of the Eastern Classic
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• no.70
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• pp.33-58
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• 2018

The purpose of this paper is to clarify the life and poetry of Dokshok Hwang Hyok. In Chapter 2, we looked at the life of Hwang Hyok. There are two characteristics in the life of Hwang Hyok. First, Hwang Hyok had excellent literary talent. Secondly, Hwang Hyok wrote in an attempt to surrender during the Japanese Invasion of Japan. That is why he lived a 21 year detained life. In Chapter 3, we looked at poetry based on the life of Hwang Hyok. The features of poetry are as follows. First, the image of Somu and reality of Tiger and Dhole go around. Hwang Hyok lived a confined life because of the Japanese Invasion of Korea. Because of that, Hwang Hyok recognized the Japanese invasion of the Imperial Japan as a world where Dhole and tigers travel around. It symbolized the image of Sommu that he did not surrender. Second, Changsha, is the world and Gulwon images. Changsha is Gulwon the space of self-destruction. Hwang Hyok likened his dark life to Gulwon dead. This is because Hwang Hyok's life is similar to Gulwon's life. In other words, Hwang Hyok was most appropriate to compare his tough life to Gulwon, who drowned in Myeoglasu.

• The Journal of Internal Korean Medicine
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• v.24 no.2
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• pp.220-232
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• 2003

Objective : The purpose of this study was to analyze the effects of HwangRyunHaeDok-Tang and combinations of constituent herbs on the arterial contraction. Methods : In order to investigate the effects Scutellariae Radix. Coptidis Rhizoma, Phellodendri Cortex and Gardeniae Fructus, in which one of them, two of them, and all of them, were used to exam. Results : The results were summarized as follows; 1. HwangRyunHaeDok-Tang significantly inhibited the contraction of artery induced by Norepinephrine(NE). However the atonic effect was slightly blunted when the vascular endothelial cell was removed. No significant change in the atonic effect of HwangRyunHaeDok-Tang was found when $_L-NNA$ was used as a preliminary treatment. These results indicate that the vascular atonic effect by HwangRyunHaeDok-Tang is slightly dependent on the endothelial cell, and that the HwangRyunHaeDok-Tang works directly to the vascular smooth muscle in creating the vascular atonic effect. 2. The pretreatment of HwangRyunHaeDok-Tang extract significantly inhibited the contractile response to additive application of $Ca^{2+}$ in the strips which were contracted by NE in $Ca^{2+}$-free solution. 3. HwangRyunHaeDok-Tang extract increased the contraction of arterial smooth muscle induced by KCl. Therefore, it can be concluded that HwangRyunHaeDok-Tang may block the NE-receptor or receptor-operated $Ca^{2+}$ channel. 4. It was determined that Scutellariae Radix, Coptidis Rhizoma and Phellodendri Cortex among the ingredients of HwangRyunHaeDok-Tang have a vascular atonic effect. In addition, those ingredients plays a role in strengthening the atonic effect by working with other herbal medicines. Gardeniae Fructus causes the blood vessel to contract. but it does not influence the atonic effects of other herbal medicines. However Gardeniae Fructus tends to inhibit the vascular atonic effect of Phellodendri Cortex. Conclusion : Based on the above results, it can be said that HwangRyunHaeDok-Tang can be applied to cure hypertension considering those three herbs have significant effects of relaxation.

• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.4
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• pp.198-206
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• 2019

This study was conducted to evaluate the vasorelaxant effect of DangGuiSu-San and SamHwangSaSim-Tang extract on contracted rabbit carotid artery. To study the effect of DangGuiSu-San and SamHwangSaSim-Tang extract on contracted rabbit carotid arterial strips, arterial strips with intact or damaged endothelium were used for experiment using organ bath. The pre-contracted arterial strips with Phenylephrine(PE) was treated with various concentrations of DangGuiSu-San and SamHwangSaSim-Tang extract(0.01, 0.03, 0.1, 0.3 and $1.0mg/m{\ell}$). To determine the mechanisms of DangGuiSu-San and SamHwangSaSim-Tang-induced vasorelaxant, DangGuiSu-San and SamHwangSaSim-Tang extract were infused into contracted arterial rings which had been pretreated by indomethacin(IM), tetraethylammonium chloride(TEA), $N{\omega}$-nitro-L-arginine ($_L-NNA$), methylene blue(MB). And calcium chloride(Ca) 1 mM was infused into precontracted arterial ring induced by PE after treatment of DangGuiSu-San and SamHwangSaSim-Tang extract in $Ca^{2+}$-free krebs solution. DangGuiSu-San and SamHwangSaSim-Tang extract revealed significant relaxation on PE-induced arterial contraction. DangGuiSu-San and SamHwangSaSim-Tang extract also had an effective relaxation to the intact endothelium arterial ring. SamHwangSaSim-Tang extract on contracted rabbit carotid artery is related with NO-cGMP pathway. Pretreatment of DangGuiSu-San and SamHwangSaSim-Tang extract inhibited the contraction by influx of extracellular $Ca^{2+}$ in contracted arterial ring induced by NE. This study indicated that the relaxation effect of SamHwangSaSim-Tang extract on contracted rabbit carotid artery is related with NO-cGMP pathway. Pretreatment of DangGuiSu-San and SamHwangSaSim-Tang extract inhibited the contraction by influx of extracellular $Ca^{2+}$ in contracted arterial ring induced by NE.

• Korean Journal of Acupuncture
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• v.23 no.3
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• pp.37-50
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• 2006

Objectives : The aim of the study was to investigate the antihypertensive effect of Hwang-gu Acupuncture in hypertensive patients. Methods : We measured the blood pressure of the patients who were admitted in the Oriental Medical Clinic of Brother from 25th November 2005 to 27th March 2006. We included the patients only in case of the systolic blood pressure was over 140mmHg or diastolic blood pressure was over 90mmHg, Twenty two patients were treated by Hwang-gu Acupuncture. In order to evaluate the effect of the Hwang-gu Acupuncture, the blood pressure was measured before and after Acupuncture procedure total 4 times, 10times. Results : There were a significant decrease in the systolic blood pressure and significant decrease in the diastolic blood pressure by Hwang-gu Acupuncture 4 times. The effect of Hwang-gu Acupuncture by measurement time on blood pressure were follows: In a systolic blood pressure was gradually deceased significantly from 1st to 4th but diastolic blood pressure was significantly decreased after 2nd and 4th only. Conclusions : These results suggest that Hwang-gu Acupuncture is effective in decreasing the systolic and diastolic blood pressure.

• Journal of Sasang Constitutional Medicine
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• v.13 no.3
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• pp.8-14
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• 2001

1. Purpose A branch of acupuncture is to be tender at the sasang contitutional medicine. So studying 『HwangJeNaiKyung』, we find the commencement of sasangin-acupuncture that Dong-Mu was not discovered. 2. Method We select the constitutional acupuncture of 『HwangJeNaiKyung』, and analysis that. 3. Result We can find the constitutional acupuncture of 『HwangJeNaiKyung』 as follows. The first, Acu-point of each constitution is not mentioned. The second, Acupuncture comparing with HyungJiGoRak(形志苦樂) of 『HwangJeNaiKyung』 is effective at mind-treatment. The third, the response of acupuncture supply the commencement that can devide YangIn(陽人) and EumIn(陰人). The forth, according to the fatness and the thinness it must be different with the depth of acupuncture and the time of acupuncture. The fifth, according to the HanYeulHeuSil(寒熱虛實) of constitution, there can be different the depth of acupuncture, the time of acupuncture and the count of acupuncture. But throuth 『HwangJeNaiKyung』 we can not find the commencement of the theory of Dong-Mu's SeungGangWanSok(升降緩束).

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.281.3-282
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• 2002

Hwang-Chil. a natural resources of Korea. doesn't have a side effects and has excellent bone cell proliferation. We will be able to use Hwang-Chil to cure and develop various disease that require tissue regeneration. such as osteoporosis and bone fracture and be used in the orthopedic area. In this study. we observed the effect of Hwang-Chil extract and concentration on osteoblast proliferation. alkaline phosphatase(ALP) activity and calcification. (omitted)

• The Journal of the Acoustical Society of Korea
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• v.16 no.4
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• pp.90-93
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• 1997

In Korean traditional music, the frequency of Hwang-Jong tone is not known precisely, to say nothing of the temperament. So we measured the frequency of Hwang-Jong tone in solo pieces for the woodwind instruments such as daegum, piri and danso. According to the results of the measurement, the frequency of Hwang-Jong tone is about 328Hz, which is closer to the frequency of E$_3$(330Hz) than that of E$^b_3$(311Hz). This result is different from the existing theory that the frequency of Hwang-Jong tone is close to that of E$^b_3$.

• Journal of The Korean Society of Agricultural Engineers
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• v.52 no.5
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• pp.53-60
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• 2010

The effects of blast furnace slag, hwang-toh, and reinforcing fiber on the physical and mechanical properties of porous concrete using blast furnace slag coarse aggregates have been evaluated in this study. The effect of the depending on replacement ratio of blast furnace slag to cement was investigated such that the replacement ratio was varied to 0 %, 25 % and 50 %. Also, the replacement ratios of hwang-toh were 0, 20 and 30 %. The polyvinyl alcohol fiber was used for the reinforcing fiber. A series of pH, unit mass, and void ratio tests have been performed to study the physical properties of the porous concrete using blast furnace slag coarse aggregates with the polyvinyl alcohol fiber and the replacement ratios of blast furnace slag, hwang-toh, while a series of compressive tests have been performed to evaluate the strength property depending on polyvinyl alcohol fiber and the replacement ratios of blast furnace slag, hwang-toh. The test results indicated that the physical and mechanical properties of porous concrete using blast furnace slag coarse aggregates is affected by the replacement ratio of blast furnace slag, and the fiber contents. According to the tests with polyvinyl alcohol fiber contents, the void ratio was decreased and the compressive strength was upgraded.

• KIEAE Journal
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• v.7 no.3
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• pp.89-96
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• 2007

The purpose of this experimental study is to investigate the compressive strength, shear strength, bending strength, and crack control by the mixture of the hwang-toh. The size of compressive specimens is $200{\times}200{\times}400(mm)$, and the size of shear, bending specimens is $200{\times}200{\times}600(mm)$. Finally, crack control specimens for comparative comparison is $200{\times}200{\times}15(mm)$. The mixture of the hwang-toh is as follows; Hwangtoh( H)+Water(W), H+W+Sand(S), H+W+S+sTraw(0.5%), H+W+S+sT(1.0%). The actual height, width, and the length are measured at the center of all specimens. The main parameters are mixture ratio of hwang-toh, straw and age of specimens. The test results are as follows. (1) The compressive strength is linearly increased until 15 weeks according to specimen ages. (2) About crack control, the specimen added in 1% straw is the most effective.