• Title/Summary/Keyword: Hwan

Search Result 63,222, Processing Time 0.071 seconds

Effects of Sedang-hwan on Experimental Diabetic Rats induced by Streptozotocin (세당환(世糖丸)이 Streptozotocin으로 유발된 흰쥐의 실험적 당뇨에 미치는 영향)

  • Bae, Chul-Ho;Soh, Kyeong-Sun;Jeong, Chan-Gil
    • Journal of Pharmacopuncture
    • /
    • v.9 no.1
    • /
    • pp.33-44
    • /
    • 2006

  • Objectives : We performed this study in order to investigate the effects of Sedang-hwan(世糖丸) on the diabetes mellitus. Methods : We injected a vein with 65mg/kg of streptozotocin(STZ) on the rats. And then administered Sedang-hwan; 18.7mg/kg/day to sample groups and observed the weight and glucose level, insulin, C-peptide, triglyceride, albumin, T-protein, BUN(Blood Urea Nitrogen) and creatinine in blood. Results : 1. The sample groups showed a high suppressive effect of weight loss(P=0.002). 2. The sample groups' glucose level showed a effective in lowering level(P=0.001). 3. The sample groups showed a higher insulin level than control groups. 4. The sample groups showed a higher C-peptide level than control groups(P=0.001). 5. The sample groups' triglyceride level showed a effective in lowering level. 6. The sample groups showed a higher HDL-cholesterol level than control groups(P<0.001). 7. The sample groups showed a higher T-protein level than control groups(P=0.04). 8. The sample groups showed a higher albumin level than control groups(P<0.001). 9. The sample groups' creatinine level showed a effective in lowering level(P=0.04). 10. The sample groups' BUN level showed a effective in lowering level(P=0.03). Conclusions : Conclusively, Sedang-hwan was recognized to have decrease effect of serum glucose, triglyceride, creatinine, BUN of the diabetic rats induced by streptozotocin. It was suggested that Sedang-hwan can be used for effective diabetes mellitus medical treatment. It is also required to study further about detailed principles of blood-sugar dropping effect by Sedang-hwan, and recovery by diabetes mellitus.

  • https://doi.org/10.3831/KPI.2006.9.1.033 인용 PDF

Study of Anti-inflammatory Effect of Ohmae-hwan Water Extract (오매환(烏梅丸) 물추출물의 항염증 활성에 관한 연구)

  • Kim, Young-Hwan;Song, Aejin;Sung, Sun Heui;Kwon, Dong Yeul;Chong, Myongsoo
    • Journal of Physiology & Pathology in Korean Medicine
    • /
    • v.30 no.4
    • /
    • pp.266-273
    • /
    • 2016

  • Ohmae-hwan has been used to treat the symptoms of loose stools mixed with blood accompanied by abdominal pain due to heat dysentery in Korean medicine. However, its mechanism of action on inflammatory disease using macrophages was not known. The author was to find out about the influence of Ohmae-hwan water extract on expressions of NO, cytokine IL-6 and TNF-α in LPS-stimulated RAW 264.7 cell, on expressions of mRNA of iNOS, IL-6 and COX-2 and on suppression of expressions of protein of iNOS and COX-2, and was to find out about the mechanism. As a result of the study, it was found that Ohmae-hwan suppressed generation of NO activated by LPS depending on its concentrations, suppressed expressions of cytokine IL-6, and TNF-α and suppressed expressions of mRNA of iNOS, IL-6, and COX-2 and suppressed expressions of protein of iNOS, COX-2. Considering the above results, it can be known that Ohmae-hwan water extract has anti-inflammatory effect against inflammatory response mediated by macrophages by suppressing generation of NO, TNF-α, and IL-6 and expressions of iNOS, COX-2 as it acts on macrophages.

  • https://doi.org/10.15188/kjopp.2016.08.30.4.266 인용 PDF KSCI KPUBS HTML