• Journal of Audiology & Otology
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• v.25 no.2
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• pp.80-88
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• 2021

Background and Objectives: Non-linear frequency compression (NLFC) technology compresses and shifts higher frequencies into a lower frequency area that has better residual hearing. Because consonants are uttered in the high-frequency area, NLFC could provide better speech understanding. The aim of this study was to investigate the clinical effectiveness of NLFC technology on the perception of speech and music in patients with high-frequency hearing loss. Subjects and Methods: Twelve participants with high-frequency hearing loss were tested in a counter-balanced order, and had two weeks of daily experience with NLFC set on/off prior to testing. Performance was repeatedly evaluated with consonant tests in quiet and noise environments, speech perception in noise, music perception and acceptableness of sound quality rating tasks. Additionally, two questionnaires (the Abbreviated Profile of Hearing Aid Benefit and the Korean version of the International Outcome Inventory-Hearing Aids) were administered. Results: Consonant and speech perception improved with hearing aids (NLFC on/off conditions), but there was no significant difference between NLFC on and off states. Music perception performances revealed no notable difference among unaided and NLFC on and off states. The benefits and satisfaction ratings between NLFC on and off conditions were also not significantly different, based on questionnaires, however great individual variability preferences were noted. Conclusions: Speech perception as well as music perception both in quiet and noise environments was similar between NLFC on and off states, indicating that real world benefits from NLFC technology may be limited in Korean adult hearing aid users.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.42 no.3
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• pp.323-331
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• 2022

An experimental study was conducted to investigate the effect of applied tensile force and temperature on the permeability of magnetic flux in prestressing steel. The permeability of magnetic flux is the ratio at which the magnetic flux between two points passes. The prestressing steel used in these experiments included a 7-mm PS wire mainly used for cable-stayed bridges and a 12.7-mm PS strand for prestressed concrete bridges. The experiments to extract the permeability of the magnetic flux of steel wire and strand were conducted under various tensile levels and temperature conditions. From the experimental results, it was observed that the permeability of magnetic flux of the PS tension material was linearly proportional to the applied tensile stress level, and inversely proportional to the temperature. If the experimental relationship among the magnetic permeability, temperature, and prestressing ratio of a PS tension material is known in advance, the current tension stress level on PS members can be evaluated by measuring solely the magnetic permeability and temperature.

• Journal of Veterinary Clinics
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• v.39 no.2
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• pp.51-58
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• 2022

Quercetin, a flavonoid found in fruits and vegetables, exhibits a strong anti-inflammatory activity. The objective of this study was to examine the effect of quercetin on chemotactic activity of peripheral blood polymorphonuclear cells (PMNs) to culture supernatant from peripheral blood mononuclear cells (PBMCs) stimulated with lipopolysaccharide (LPS). In addition, we determined whether this effect is related to interleukin (IL)-8 and changes in cytoskeleton. The chemotactic activity of PMNs was evaluated by a modified Boyden chamber assay. Total cellular filamentous (F)-actin levels were measured by method of fluorescence microscopy. The levels of IL-8 mRNA and protein were measured by real time polymerase reaction method and enzyme-linked immunosorbent assay, respectively. Quercetin (0-50 µM) itself has no chemoattractant effect for PMNs. The culture supernatant from PBMCs (2 × 10⁶ cells/mL) treated with LPS (1 ㎍/mL) showed remarkable increase in chemotaxis of PMNs. However, this effect was reduced dose-dependently by treatment with quercetin. In addition, PBMCs treated with LPS revealed enhanced levels in IL-8 protein and mRNA. Co-treatment of LPS with quercetin (50 µM) in PBMCs decreased IL-8 production and expression. Treatment of quercetin (0-50 µM) on PMNs to rpIL-8 (10 nM) decreased dose-dependently the chemotactic activity of PMNs. Treatment of quercetin on PMNs to IL-8 also reduced their total cellular F-actin level. These results suggested that quercetin attenuates chemotactic activity of PMNs, which is mediated by down-regulation of IL-8 production from LPS-stimulated PBMCs and inhibition of F-actin polymerization in PMNs.

• Proceedings of the Korea Water Resources Association Conference
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• 2023.05a
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• pp.4-4
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• 2023

C-band SAR 센서를 탑재한 수자원위성은 한반도 수자원 모니터링을 위해 개발되어 2025년 발사가 계획되어 있으며, 수변환경 및 부유물 탐지 및 다양한 활용이 기대되고 있다. 그 중 수변환경은 수변 생태계 안정성을 유지하는 역할을 담당하여 이에 대한 모니터링은 중요하다. s현장 관측 기반 탐지 방법과 비교하여 위성 원격탐사는 광범위한 지역을 반복적으로 관측하여, 연속적인 수변환경 및 부유물 정보를 제공할 수 있다. 이러한 특성에 기반하여 다양한 다중분광 및 SAR (Synthetic Aperture Radar) 위성 원격탐사 자료를 바탕으로 수변환경 및 부유물의 탐지 연구가 이루어졌다. 특히 단일 영상만을 사용하는 기법에 비해 다중분광 및 SAR 영상을 융합하여 높은 정확도를 보인 바 있다. 초기 연구에서는 임계값 알고리즘 또는 현장관측 기반의 부유물 농도와 위성 자료간의 선형관계를 분석하는 단순한 알고리즘이 주를 이루었으나, 최근에는 RF, CNN 등 보다 복잡하고 다양한 인공지능 알고리즘이 적용되어 높은 정확도로 해당 문제들을 해결하고 있다. 본 연구에서는 수자원위성 활용을 위해 인공지능 기반 수변환경 및 부유물 탐지 알고리즘을 개발하고자 한다. 수자원위성의 대체 자료로 유럽우주국의 Sentinel-1 A/B 위성의 C-band SAR 영상을 이용하였으며, 보조자료로 Sentinel-2 다중분광 영상을 이용하였다. 개발된 알고리즘은 수자원 관리를 위한 환경변화 탐지에 유용한 정보로 활용될 수 있을 것으로 기대된다.

• BMB Reports
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• v.56 no.9
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• pp.520-525
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• 2023

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by cognitive decline. Several recent studies demonstrated that impaired adult neurogenesis could contribute to AD-related cognitive impairment. Adult subventricular zone (SVZ) neurogenesis, which occurs in the lateral ventricles, plays a crucial role in structural plasticity and neural circuit maintenance. Alterations in adult SVZ neurogenesis are early events in AD, and impaired adult neurogenesis is influenced by the accumulation of intracellular Aβ. Although Aβ-overexpressing transgenic 5XFAD mice are an AD animal model well representative of Aβ-related pathologies in the brain, the characterization of altered adult SVZ neurogenesis following AD progression in 5XFAD mice has not been thoroughly examined. Therefore, we validated the characterization of adult SVZ neurogenesis changes with AD progression in 2-, 4-, 8-, and 11-monthold male 5XFAD mice. We first investigated the Aβ accumulation in the SVZ using the 4G8 antibody. We observed intracellular Aβ accumulation in the SVZ of 2-month-old 5XFAD mice. In addition, 5XFAD mice exhibited significantly increased Aβ deposition in the SVZ with age. Next, we performed a histological analysis to investigate changes in various phases of adult neurogenesis, such as quiescence, proliferation, and differentiation, in SVZ. Compared to age-matched wild-type (WT) mice, quiescent neural stem cells were reduced in 5XFAD mice from 2-11 months of age. Moreover, proliferative neural stem cells were decreased in 5XFAD mice from 2 to 8 months of age. Furthermore, differentiations of neuroblasts were diminished in 5XFAD mice from 2-11 months of age. Intriguingly, we found that adult SVZ neurogenesis was reduced with aging in healthy mice. Taken together, our results revealed that impairment of adult SVZ neurogenesis appears with aging or AD progression.

• Korean Journal of Veterinary Service
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• v.46 no.1
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• pp.59-66
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• 2023

Wild boar is closely related to domestic pigs in terms of genetic homogeneity and the possibility of a source of infection by contact. This study investigated the prevalence of viral diseases from wild boars inhabiting Gyeongsangnam-do, South Korea. A total of 374 blood samples were collected and subjected to antigen tests to detect African swine fever virus (ASFV), Porcine circovirus type-2 (PCV2), Porcine reproductive and respiratory syndrome virus (PRRSV). For seroprevalence, PCV2, PRRS, classical swine fever virus (CSFV), Aujezsky's disease (ADV), and foot and mouth disease virus (FMDV) were investigated. The antigenic analysis revealed 73 positive cases (19.5%) for PCV2, while no positive cases for ASFV and PRRSV. For the antibody test, 225 (60.2%), 2 (0.5%), and 48 (12.8%) cases were detected against PCV2, PRRSV, and CSFV, respectively. There were no antibodies detected against both ADV and FMDV. Our results suggest that the viruses infecting both wild boar and domestic pig, mainly PCV2, are circulating in the wild boar population thus, the consistent monitoring of prevalence in wild boar will be needed for transboundary spillover to the domestic pig.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.2A
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• pp.215-222
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• 2008

This paper introduces an experimental verification of a tension estimation method based on system identification approach for a double hanger system on a suspension bridge. A laboratory model of such double hanger system has been made for this study. Total nine cases of the vibration tests have been conducted with respect to three levels of applied tension and three cases of the location of clamp. For a set of the collected acceleration response data, modal analysis has been followed in order to extract the natural frequencies and mode shapes of the selected cable systems. For the extracted modal parameters, the existing tension estimation methods based on the string theory and axially loaded beam theory have been firstly applied to estimate the tensile force on the double hanger cable system. Next, the tensile force on cables has been estimated by the system identification approach. It is seen that the errors in the tension estimation using the frequency-based system identification technique are about 3% for all cases while the estimation error using the existing method is up to 53.1%.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.5A
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• pp.631-639
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• 2008

This paper reports the mode shapes of Seohae cable-stayed bridge extracted by TDD technique. In order to record total 72 acceleration points in the vertical direction of the bridge deck, a custom made data acquisition system with LAN communication has been especially developed and a set of ambient vibration tests has been conducted. For the measured acceleration responses, total twenty four mode shapes up to 2Hz has been extracted by TDD technique. The extracted mode shapes include many new modes that have not been identified in the current on-line health monitoring system installed in the bridge. It is confirmed that TDD technique is the most effective in extracting the high resolution mode shapes on a particularly long span bridge.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.6A
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• pp.581-590
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• 2010

This study introduces a layered sectional analysis for a PSC girder with a vaiable cross section and curved tendons. To consider the shear equilibrium at a concrete layer with curved tendons, the shear stress distribution has been computed at each section. In addition, to improve the convergence to the solution, a system identification technique is newly adopted in the solution process for strain computation. To examine the feasibility of the proposed approach, a static load test has been conducted for a full scale PSC girder with variable cross section. The prediction shows a good agreement with experiment. It is seen that a uniform cross section has the same moment capacity with a variable cross section while the variable cross section has more shear capacity than the uniform cross section. It is also noted that the maximum displacement of a variable cross section is a little smaller than a uniform cross section.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.34 no.4
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• pp.5-27
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• 2023

Gagné proposed nine instructional events, gain attention of the students, inform students of the objectives, stimulate recall of prior learning, present the content, provide learning guidance, elicit performance(practice), provide feedback, assess performance, enhance retention and transfer for effective teaching & learning practice. Gagné's theory is widely applied in various subjects because it increases student participation and allows classes to be developed systematically. The purpose of this study is to develop a lesson plans for the 'library and information life' subjects in middle school using Gagné's nine instructional events theory, conduct actual instructions, and verify its effectiveness. The research procedure was conducted as follows. Development of lesson plan that using Gagné's theory to Section III (Information Analysis and Interpretation) of 'Library and Information Life' in middle school. Actual instruction were conducted and student survey, peer teacher assessment, and instructor self-assessment were conducted. Based on the evaluation results, a elements to revise and improve the lesson plan was presented.