• Title/Summary/Keyword: Human vessels

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Anti-aggregation Effect of Artemether Through Regulation of PI3K/Akt and MAPK in U46619-induced Platelets (U46619-유도의 혈소판에서 PI3K/Akt 및 MAPK 조절을 통한 Artemether의 응집억제효과)

  • Park, Chang-Eun;Lee, Dong-Ha
    • Korean Journal of Pharmacognosy
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    • v.53 no.2
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    • pp.64-69
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    • 2022
  • When blood vessels are damaged, a rapid hemostatic response should occur in order to lower blood loss and keep normal circulation, and platelet activation and aggregation are essential. Nevertheless, abnormal or excessive platelet aggregation can be a reason of cardiovascular diseases including thrombosis, atherosclerosis, and stroke. Therefore, the screening for a substance which can regulate platelet activation and suppress aggregation reaction is very important for treatment and prevention of cardiovascular diseases. Artemether is a methyl ether derivative of artemisinin, which is isolated from the antimalarial plant Artemisia annua, but research on platelet aggregation or its mechanisms is still insufficient. This study identified the effects of artemether on U46619-induced human platelet aggregation and their granule secretion (ATP and serotonin release). In addition, the effects of artemether on the phosphorylation of PI3K/Akt or MAPK, which are related to signal transduction in platelet aggregation, were studied. As the results, artemether significantly lowered PI3K/Akt and MAPK phosphorylation, which inhibited platelet aggregation through granule secretion (ATP and serotonin release) dose-dependently. Therefore, we suggest that artemether is an antiplatelet substance that regulates PI3K/Akt and MAPK pathway and is of value as a therapeutic and preventive agent for platelet-derived cardiovascular diseases.

A Study on Management Status of Disposed FRP Fishing Boats and Competitive Advantages of Third Recycling Technology (FRP 폐어선 관리 실태와 재활용 기술 경쟁우위에 관한 연구)

  • Dong-Hun Go;Yeong-Tae Son
    • The Journal of Fisheries Business Administration
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    • v.54 no.3
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    • pp.93-114
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    • 2023
  • Around the 1980s, with government's promotion and dissemination policies for FRP (Fiberglass Reinforced Plastics) of the government as a main material of fishing boats, approximately 97% of the entire fishing boats in Korea have utilized FRP until now. Nevertheless, diverse social and environmental issues have emerged due to the susceptibility to fire and the generation of substances detrimental to human health during the construction process of FRP fishing vessels. Especially, the high disposal cost and the limitation of recycling technology in the disposal process of FRP fishing boats have elicited attention to circular economy. This research intended to grasp the management status and problems of disposed FRP fishing boats in Korea, and to assess the level of competitive advantage of FRP fishing boats' recycling technologies of FRP fishing boats based on VRIO (Value, Rarity, Imitability, Organization) analysis through domestic and foreign management policies and related recycling examples. According to the survey of 161 respondents, including the industry, stakeholders and experts related to the collection, treatment and recycling of fisheries wastes, it was revealed that FRP fishing boats' recycling technologies of FRP fishing boats are at the level of 'unused competitive advantage' that satisfied the level of value, rarity and imitability, but not the level of organization.

Industrialization possibilities of purified pig sperm hyaluronidase

  • Soojin Park;In-Soo Myeong;Gabbine Wee;Ekyune Kim
    • Journal of Animal Science and Technology
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    • v.65 no.6
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    • pp.1205-1213
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    • 2023
  • The goals of the present study were to develop a simple method for obtain highly purified pig sperm hyaluronidase (pHyase) and to assess its activity, function, and safety. In mammals, sperm-specific glycophosphatidylinositol (GPI)-anchored Hyase assists sperm penetration through the cumulus mass surrounding the egg and aids in the dispersal of the cumulus-oocyte complex. Recently, Purified bovine sperm hyaluronidase (bHyase) has been shown to enhance therapeutic drug transport by breaking down the hyaluronan barrier to the lymphatic and capillary vessels, thereby facilitating tissue absorption. Commercially available Hyase is typically isolated from bovine or ovine; which have several disadvantages, including the risk of bovine spongiform encephalopathy, low homology with human Hyase, and the requirement for relatively complex isolation procedures. This study successfully isolated highly purified pHyase in only two steps, using ammonium sulfate precipitation and fast protein liquid chromatography. The isolated Hyase had activity equal to that of commercial bHyase, facilitated in vitro fertilization, and effectively dissolved high molecule hyaluronic acid. This simple, effective isolation method could improve the availability of pHyase for research and clinical applications.

A Study on the Information Management System Support for the Intelligent Autonomous Navigation Systems (지능형 자율운항시스템 지원을 위한 정보 관리 시스템에 관한 연구)

  • Kim, Eun-Kyoung;Kim, Yong-Gi
    • Journal of the Korean Institute of Intelligent Systems
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    • v.25 no.3
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    • pp.279-286
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    • 2015
  • The rapid increase of the current marine accidents is mainly due to the human execution errors. In an effort to address this, various kinds of researches such as construction of the digital vessels and vessel information monitoring systems have been conducted. But for safe navigation of vessels, it lack on systems study which can efficiently store, utilize and manage the mass data accepted by the vessel. In this paper, we propose a VWS(Virtual World System) that is based on the architecture of intelligent systems RVC(Reactive Layer-Virtual World-Considerative Layer) model of intelligent autonomous navigation system. VWS is responsible to store all the necessary information for safe navigation of the vessel and the information services to the sub-system of intelligent autonomous navigation system. VWS uses topology database to express the specific problem area, and utilizes a scheduling to reflect the characteristics of the real-time processing environment. Also, Virtual World defines API for the system to reflect the characteristics of the distributed processing environment. As a case study, the VWS is applied to a intelligent ship autonomous navigation system, and simulation is done to prove the effectiveness of the proposed system.

Detecting Regions of Stenosis and Aneurysm in a 3D Blood Vessel Model (3차원 혈관 모델에서 협착 및 팽창 영역 탐색 방안)

  • Park, Sang-Jin;Kim, Jae-Sung;Park, Hyungjun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.1
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    • pp.113-120
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    • 2018
  • Angiography and CT angiography are used widely for the examination of vascular diseases, but the diagnosis of such diseases is made mostly by the subjective judgment of the inspector. This paper proposes a method for detecting the suspicious regions of stenosis and aneurysm in the inner surfaces of 3D blood vessel models reconstructed from medical images. Initially, the 3D curve-skeletons of the blood vessel models and the contours at the nodes of the curve-skeletons were generated. Next, the 3D curve-skeletons were divided into a set of branches and the areas of normal contours of nodes located in each branch were calculated. The nodes whose contours contain suspicious regions were detected by taking into account the average area, maximum and minimum areas, and the area difference between the adjacent normal contours. The diagnosis of stenosis and aneurysm can be supported by properly visualizing the suspicious regions detected. The suspicious regions of the disease were identified by implementing and testing it using several data sets of human blood vessels, highlighting the usefulness of the proposed method.

Pirates in History and International Law Centering around the Viking Pirates (역사상 해적과 국제법상 해적 : 바이킹 해적을 중심으로)

  • Kim, Joo-Sik
    • Strategy21
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    • s.30
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    • pp.263-285
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    • 2012
  • History, demonstrating convincingly that pirates have arisen continuously for a lengthy period of time throughout the world, is able to become a cooperative study of international law in terms of pirates matters ; Viking pirates. There are beneficial topics for the study of true nature of viking activities and the settlement of present pirates matters ; How were the pirates activities of Vikings, What sort of relations do they have between Vikings and other pirates which have arisen in world history, What are the differences compared to present concept of pirates. There were active pirates activities in the coast and waters of Scandinavia even before the period of the Migration Age because of geographical condition. With those experiences, Vikings began to ambush Britain Islands sailing across the North Sea since the late 8C, ages of migration in earnest. They ambushed all coasts of the European Continent expending boundary until the late of 11C. Pirate activities in a sort of guerrilla operations were operated when they encountered Islams in the Iberian Peninsula and the coast of North Africa. They showed twofold attitudes ; if the defence of the region and sea was weak, they plundered, or if strong, traded. In plundered europeans' position, Vikings were pirates with cruelty and barbarians. In vikings position, they were normal human beings who did a pirate activity to lead a better life. Viking pirates showed different characteristics in terms of three aspects ; area and aspect of action, activity after piracy. Meanwhile, Viking pirates showed several differences with pirates defined in terms of modern international law. Among the satisfying conditions of pirates, required by the international law of the sea, Vikings fulfilled animus furandi, desire for gain, activities for hatred and revenge, and private ends. Other conditions including attacking authority of the vessels, activities toward private ships, activities in the coast and the land, and illegal terroristic activities toward ships are found in viking pirates. However, Viking pirates do not show the activities in high seas and in the outside of a State's jurisdiction. In addition, it cannot be excluded that they pirated with vessels of regional leaders and the Sovereign, not private ships. Contrary to the definition of concept in terms of modern international law toward pirates, Viking invaded foreign waters, came on shore to foreign land and island, went up-stream the rivers to the back of interior, and attacked churches and abbeys. Strangely, they sometimes settled down in the places where they had pirated. Today, pirates appearing in history and defined in international law exist simultaneously and separately. It means, the historical nature and the nature under the international law are turning up differently. Historical cases of pirates should be reflected to modern international law. If so, it seems that the clue to solve pirate problems can be arranged. History is the immortal living thing, which not just existed as a past but reflects present.

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Plasma Vascular Endothelial Growth Factors A and C in Patients undergoing Prostatic Biopsy and TURP for Suspected Prostatic Neoplasia

  • Singh, A.N.;Gautam, Kirti A.;Dalela, D.;Sankhwar, S.N.;Natu, S.M.;Sankhwar, P.L.;Srivastava, A.N.
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.3
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    • pp.2053-2058
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    • 2013
  • Background: Formation of new blood vessels is necessary for the development and spread of neoplasms more than 1 mm3 in volume, angiogenesis being responsible for formation of new from pre-existing blood vessels. Vascular endothelial growth factor (VEGF) is pivotal and the best studied angiogenic factor in all human cancers. Therefore we designed this study to investigate the role of VEGF-A and VEGF-C in prostate cancer in comparison with BPH controls in a north Indian population. Methods: In this case-control study a total of 100 subjects were included on the basis of confirmed histopathological reports, out of which 50 were prostate cancer patients and the other 50 were BPH patients with PSA levels >2 ng/ml and abnormal digital rectal examination (DRE) findings during September 2009 to August 2011 from the Department of Urology, KGMU, Lucknow, India. Plasma levels of VEGF were determined using quantitative immunoassay (ELISA-enzyme linked immunosorbent assay). Statistical analysis was carried out using SPSS 15.0 version. Results: The mean age of prostate cancer ($67.6{\pm}5.72$) patients was significantly higher (p=0.005) than BPH ($63.6{\pm}7.92$) patients. Expression of VEGF-A was not significantly higher in disease stage C1 than D1 or D2 and A or B (p=0.13) while the level of VEGF-A was significantly higher (p=0.04) in prostate cancer as compared to BPH subjects (PCa=13.0 pg/ml, BPH=6.8 pg/ml). Levels of VEGF-C were similar in both groups (PCa=832.6 pg/ml, BPH=823.7 pg/ml). In ROC curve, the area under curve (AUC) was 0.70 (95%CI: 0.60-0.80) and the cut-off value for which a higher proportion of patients was correctly classified (20%) was 26.0 pg/mL. Conclusion: Although VEGF-A is increased in cancer prostate patients a statistically significant correlation could not be established in this study. VEGF-C was not found to be a useful biomarker.

A Study on the Implementation of Intelligent Navigational Risk Assessment System for High-risk Vessel using IoT Sensor Gateway (IoT 센서연계장치를 이용한 고위험선박의 지능형 운항위험 분석 시스템 개발에 대한 연구)

  • Kim, Do-Yeon;Kim, Kil-Yong;Park, Gyei-Kark;Jeong, Jung-Sik
    • Journal of the Korean Institute of Intelligent Systems
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    • v.26 no.3
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    • pp.239-245
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    • 2016
  • In the midst of continuing international recession, the rate of maritime traffic and marine leisure markets are consistently growing. The Republic of Korea controls the marine traffic volume through vessel traffic centers and various other management facilities. Nevertheless, the continuous growth and complexity of marine traffic is resulting in repeated occurrences of marine accidents. Recovery is very difficult in cases of human injuries or deaths caused by marine accidents due to its nature, and the scale of marine accidents is also becoming greater with advanced ship building technologies. Passenger ships, oil tankers, and other such vessels used for specific purposes requires a more detailed navigational status surveillance and analysis, and numerous research has been conducted with an objective for monitoring such special purpose vessels. However, the data elements transmitted from the ocean to the shore station are limited to AIS and ARPA. We are implementing IoT ship sensor collection and a syncing system capable of transmitting various ship sensing data to the shore station, and also proposing a Safe Navigation Status Analysis System utilizing the collected data.

Auto-Segmentation Algorithm For Liver-Vessel From Abdominal MDCT Image (복부 MDCT 영상으로부터 간혈관 자동 추출 알고리즘)

  • Park, Seong-Me;Lee, You-Jin;Park, Jong-Won
    • Journal of Korea Multimedia Society
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    • v.13 no.3
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    • pp.430-437
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    • 2010
  • It is essential for living donor liver transplantation that surgeon must understand the hepatic vessel structure to improve the success rate of operation. In this paper, we extract the liver boundary without other surrounding structures such as heart, stomach, and spleen using the contrast enhanced MDCT liver image sequence. After that, we extract the major hepatic veins (left, middle, right hepatic vein) with morphological filter after review the basic structure of hepatic vessel which reside in segmented liver image region. The purpose of this study is provide the overall status of transplantation operation with size estimation of resection part which is dissected along with the middle hepatic vein. The method of liver extraction is as follows: firstly, we get rid of background and muscle layer with gray level distribution ratio from sampling process. secondly, the coincident images match with unit mesh image are unified with resulted image using the corse coordinate of liver and body. thirdly, we extract the final liver image after expanding and region filling. Using the segmented liver images, we extract the hepatic vessels with morphological filter and reversed the major hepatic vessels only with a results of ascending order of vessel size. The 3D reconstructed views of hepatic vessel are generated after applying the interpolation to provide the smooth view. These 3D view are used to estimate the dissection line after identify the middle hepatic vein. Finally, the volume of resection region is calculated and we can identify the possibility of successful transplantation operation.

Analysis on the Dynamic Responses of Fishing Vessels in a Seaway (파랑중 어선의 동력학 해석)

  • 이희상
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.36 no.1
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    • pp.33-44
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    • 2000
  • Ships in a seaway will encounter dangerous situation, such as slamming, stranding, and capsizing. The number of capsizing is small, but the loss due to them is very large from the viewpoint of human life, property, and the environmental pollution. The number of capsizing of fishing vessels is about 62% of total number of capsizing, and the half of them is originated from the operational mistake in a seaway. So the dynamics and the capsizing phenomena are to be studied, and the guide for the safe operation of a fishing vessel in a seaway are to be specified. The hydrodynamic forces consist of radiation forces (which are due to the motion of a ship), Froude-Krylov forces (which is due to the incoming waves), and diffraction forces (which is due to the wave and ship interaction). These forces are calculated by well-known strip method. Using the calculated forces, the motion of a ship in a regular sea is obtained. In the real seaway, the waves are very irregular, therefore the statistical analysis is very helpful. In this paper, using the results of the motion in a regular seaway and the wave spectrum, the motion in a irregular seaway are obtained and analyzed.

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