• 한국시뮬레이션학회:학술대회논문집
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• 한국시뮬레이션학회 2005년도 춘계학술대회 논문집
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• pp.149-153
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• 2005

In the cardiovascular system, the waveform of the pulsatory blood pressure appears variously due to the cardiac impulse and compliance of blood vessels and arm tissue. We have constructed a blood pressure simulator to investigate effects of mechanical properties of artery walls and tissue on blood pressure measurements. The blood pressure simulator is designed to reproduce wave forms of blood pressure in human arteries. To minimize tracking error, we use a linear control valve, and adapt a hybrid control scheme which consists of a feedback controller and a feedforward controller. Any form of the pressure wave can be reproduced, changing function of the wave form in the computer connected to the simulator for control. From experiments, it has been shown that the simulator reproduces wave forms very well, and that the hybrid scheme adapted is superior to the feedback controller.

• Steel and Composite Structures
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• 제22권6호
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• pp.1391-1415
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• 2016

Limit load of pressure bearing structures was reviewed in this article. By means of the finite element analysis, limit load of pressurized cylinder with nozzle was taken as an example. Stress classification method and Elastic-plastic finite element analysis combining with limit load determination methods were used to determine limit load of cylinder with nozzle. Comparison of limit load determined by different methods, the results indicated that limit load determined by linearization method was the smallest. Limit load determined by twice elastic slope criterion was the nearest than experimental results. Elastic-plastic finite element analysis had comparably computational precision, but required time consuming. And then the requirements of computer processing and storage capacity by power system became higher and higher. Most of criteria for limit load estimation included any human factors based on a certain substantive characteristics of experimental results. The reasonable criterion should be objective and operational.

• 한국항해학회지
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• 제16권1호
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• pp.14-35
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• 1992

The recently-developed automated vessels require a system which evaluates the operating conditions of the ship at present position from weather information as well as sensors ; forecasting the operations condition in the state to come in foreseeable future ; and suggests the optimum course and speed for ship's safety. According to a study, deck wetness, propeller racing, slamming. rolling, vertical acceleration, lateral acceleration, vertical bending moment at midship etc. were chosen as the factors for evaluating seakeeping performance. As a matter of act, there is no developing the hardware of a system which could consider all the factors on seakeeping performance. This study introduces a theoretical method which makes it possible to evaluate the seakeeping performance by applying a theory from reliability engineering, and thereby establishing a safety space. The author adopts rolling and pitching as the factors on seakeeping performance by clarifying the correlation of stochastic processes the factors presently adopted for evaluation system in consideration of the safety of human being, cargoes and the ship. This method of evaluation shall be of much use in developing the practical system of seakeeping performance of a ship in waves.

• 한국항해학회지
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• 제21권4호
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• pp.1-9
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• 1997

A study on theergonomic design of the automated ship's bridge and console layout was carried out through this paper. The goal of this study is to find out the effective and ergonomic optimal design solutions of bridge layout hence to reduce the duty officier's workload and increase the safety of navigation. The conventional bridge layouts and modernized Integrated bridge layouts were compared using several factors. To use human factors, an ergonomic control panel layout system based on constraint satisfaction algorithm wa squoted. And the integrated ergonomic bridge layout was converged and applied to the redesign of the navigational console layout.

• 한국항해항만학회지
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• 제35권2호
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• pp.131-136
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• 2011

As the faithful performance of ISPS of IMO, nowadays actually applicable an integrated safety and security system in and out of vessel should be organized in views of seafarers. Therefore, this paper is aimed to design a fundamental system for ship's integrated safety and security. The system of integrated grabbing will affect efficiently in any maritime field of material and human flow. Therefore this research will be expected to affect economical side by securing all the risk of maritime issues. In addition to the passenger ship and merchant vessel, it is applicable to other public and private vessels either. As a result of this paper, the system designed collecting various data through integrating the system including RFID reader, PIR sensor, and CMOS camera by putting an individual number into each unit that could be control at easy.

• Genomics & Informatics
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• 제19권2호
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• pp.13.1-13.8
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• 2021

Ranked in the topmost position among the deadliest diseases in the world, cardiovascular diseases (CVDs) are a global burden with alterations in heart and blood vessels. Early diagnostics and prognostics could be the best possible solution in CVD management. OMICS (genomics, proteomics, transcriptomics, and metabolomics) approaches could be able to tackle the challenges against CVDs. Genome-wide association studies along with next-generation sequencing with various computational biology tools could lead a new sight in early detection and possible therapeutics of CVDs. Human cardiac proteins are also characterized by mass spectrophotometry which could open the scope of proteomics approaches in CVD. Besides this, regulation of gene expression by transcriptomics approaches exhibits a new insight while metabolomics is the endpoint on the downstream of multi-omics approaches to confront CVDs from the early onset. Although a lot of challenges needed to overcome in CVD management, OMICS approaches are certainly a new prospect.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제35권2호
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• pp.66-73
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• 2009

Tumor angiogenesis is a process leading to formation of blood vessels within tumors and is crucial for maintaining a supply of oxygen and nutrients to support tumor growth and metastasis. Vascular endothelial growth factor(VEGF) plays a key role in tumor angiogenesis including induction of endothelial cell proliferation, migration, survival and capillary tube formation. VEGF binds to two distinct receptors on endothelial cells. VEGFR-2 is considered to be the dominant signaling receptor for endothelial cell permeability, proliferation, and differentiation. Bevacizumab(Avastin, Genetech, USA) is a monoclonal antibody against vascular endothelial growth factor. It is used in the treatment of cancer, where it inhibits tumor growth by blocking the formation of new blood vessels. The goal of this study is to identify the anti-tumor effect of Bevacizumab(Avastin) for oral squamous cell carcinoma cell lines. Human squamous cell carcinoma cell line(HN4) was used in this study. We examined the sensitivity of HN4 cell line to Bevacizumab(Avastin) by using in vitro proliferation assays. The results were as follows. 1. In the result of MTT assay according to concentration of Bevacizumab(Avastin), antiproliferative effect for oral squamous cell carcinoma cell lines was observed. 2. The growth curve of cell line showed the gradual growth inhibition of oral squamous cell carcinoma cell lines after exposure of Bevacizumab(Avastin). 3. In the apoptotic index, groups inoculated Bevacizumab(Avastin) were higher than control groups. 4. In condition of serum starvation, VEGFR-2 did not show any detectable autophosphorylation, whereas the addition of VEGF activated the receptor. Suppression of phosphorylated VEGFR-2 and phosphorylated MAPK was observed following treatment with Bevacizumab(Avastin) in a dose-dependent manner. 5. In TEM view, dispersed nuclear membrane, scattered many cytoplasmic vacuoles and localized chromosomal margination after Bevacizumab(Avastin) treatment were observed. These findings suggest that Bevacizumab(Avastin) has the potential to inhibit MAPK pathway in proliferation of oral squamous cell carcinoma cell lines via inhibition of VEGF-dependent tumor growth.

• The Korean Journal of Pain
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• 제9권1호
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• pp.46-56
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• 1996

Many surgeons and anesthesiologists prefer using vasoconstrictor mixed with local anesthetic agent to reduce the incidence of side effects and prolong the duration of analgesia because most local anesthetic agents, except cocaine, were believed to possess vasodilating effect. However, some investigators recently reported vasoconstricting effect of local anesthetic agents. There is still controversy on the vasoactive effect of local anesthetic agents. So this study is aimed to clarify the vasoactive effect of local anesthetics in the animal model resembling clinical settings. Rabbits were anesthesized with ketamine and haloghane, and respirations were controlled with Harvard animal ventilator. Lidocaine (0.5%, 1.0%, 1.5%) and bupivacaine (0.125%, 0.25% and 0.5%) with or without 1:100,000 epinephrine were subdermaly injected on the femoral bupivacaine of the femoral artery were measured with Doppler flow meter in vivo. The mean arterial pressure, pulse rate, arterial blood gases, pH and level of serum electrolytes were measured at every 2 minute interval for 30 minutes. Results were as follows: 1) There was no significant vasoconstriction with 0.5% lidocaine and 0.125% bupivacaine. 2) Statistically significant (p<0.05) vasodilations were observed with lidocaine (1.0~2.0%) and bupivacaine (0.25~0.5%). 3) There were no changes on the duration of vasodilation induced by local anesthetic agents of various concentrations. 4) Onset of vasodilation induced by local anesthetic agents of high concentration were faster than that of lower concentrations. 5) In the mixed injection group of epinephrine and local anesthetic agent, the vasoconstriction induced by epinephrine was completely reversed by local anesthetics, approximately 5 minutes later. In conclusion, local anesthetic agents at dose exceeding 1.0% lidocaine and 0.25% bupivacaine increase local blood flow significantly in animal study in vivo which is applicable in human clinical settings. The increase blood flow may be due to dilatation of blood vessel. Further study on the analysis of association between amount of absorbed local anesthetics in blood vessels and dilatation of blood vessels is needed.

• 한국압력기기공학회 논문집
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• 제7권3호
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• pp.61-66
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• 2011

The integrity of the SG(Steam Generator) tubes has been challenged by numerous factors such as flaws, operation, atmosphere, inherently degraded materials, loose parts and even human errors. Of the factors, loose parts(or foreign materials) on the secondary side of the tubes can bring about volumetric defects and even leakage from the primary to the secondary side in a short period of time. More serious concerns about the loose parts are their unknown influx path and rapid growth rate of the defects affected by the loose parts. Therefore it is imperative to detect and characterize the foreign materials and the defects. As a part of the measures for loose part detection, TTS(Top of Tubesheet) MRPC(Motorized Rotating Pancake Coils) ECT has been carried out especially to the restricted high probability area of the loose part. However, in the presence of loose parts in the other areas, wide range loose part detection techniques are required. In this study, loose part standard tube was presented as a way to accurately detect and characterize loose part signals. And the SG tube ECT bobbin coil and MRPC ISI(In-service Inspection) data of domestic OPR-1000 and Westinghouse Model F(W_F) were reviewed and consequently, comprehensive loose part detection technique is derived especially by applying bobbin coil signals

• 대한의용생체공학회:의공학회지
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• 제29권1호
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• pp.40-45
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• 2008

Therapeutic ultrasound which is developed for rehabilitation therapy have already been used for healing joint contracture, synechia, acute and chronic inflammatory diseases. Medical devices for pain-relief and healing using therapeutic ultrasound are actively being developed. This study measured the change of PTT with the transmitted ultrasound through the human body to find out the increase of compliance of blood vessels. Measurement method of PTT in this study is employed as useful ways to acquire physiological information of patients in the clinical case in order to measure the change of mechanical characteristics of blood vessels. This study confirmed the PTT change of rehabilitation patients through the thermal effects of ultrasound by using PTT and also found that it is possible to increase PTT by adjusting the warm water and ultrasound. The increase of PTT means the decrease of the pulse wave velocity from the cardiovascular system to the peripheral arteries. The physiological effects occurred using the warm water and ultrasound.