• Toxicological Research
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• 제12권1호
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• pp.87-91
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• 1996

LB00013, a newly developed recombinant human Interferon $\beta$, was tested for primary eye and skin irritation in male New Zealand White rabbits. In the primary eye irritation test, 0.1 ml of a solution of LB00013 was instilled into the eye. In the rinsing group, the eye was washed with water at 30 seconds after instillation. No reaction was produced at the cornea, iris and conjunctivae by LB00013. In the primary skin irritation test, LB00013 was applied to the back of rabbits for 24 hours. Primary irritation index was "0" in test and control sites of all animals. Thus LB00013 was evaluated as a non-irritant on the basis of the criteria of Draize et al. (1944).l. (1944).

• 자동차안전학회지
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• 제4권2호
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• pp.37-43
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• 2012

The purpose of this research is to obtain and analyze dynamic responses from human volunteers for the development of the human-like mechanical or mathematical model for Korean males in automotive rear collisions. This paper focused on the introduction to a low-speed rear impact sled test involving Korean male subjects, and the accumulation of the motion of head and neck. A total of 50 dynamic rear impact sled tests were performed with 50 human volunteers, who are 30-50 year-old males. Each subject can be involved in only one case to prevent any injury in which he was exposed to the impulse that was equivalent to a low-speed rear-end collision of cars at 5-8 km/h for change of velocity, so called, ${\Delta}V$. All subjects were examined by an orthopedist to qualify for the test through the medical check-up of their necks and low backs prior to the test. The impact device is the pendulum type, tuned to simulate the crash pulse of a real vehicle. All motions and impulses were captured and measured by motion capture systems and pressure sensors on the seat. Dynamic responses of head and T1 were analyzed in two cases(5 km/h, 8 km/h) to compare with the results in the previous studies. After the experiments, human subjects were examined to check up any change in the post medical analysis. As a result, there was no change in MRI and no injury reported. Six subjects experienced a minor stiffness on their back for no more than 2 days and got back to normal without any medical treatment.

• Biomolecules & Therapeutics
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• 제6권1호
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• pp.56-62
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• 1998

Mutagenicity of recombinant human erythropoietin (rhEPO) was examined in the reverse mutation test on bacteria, in the chromosomal aberration test on cultured mammalian cells and in the micronucleus test on mice. The reverse mutation test was performed by a plate incorporation method with or wothout a metabolic activation system (59 Mix) using Salmonella typhimurium strain TA100, TA1535, TA98 and TA 1537. The rhEPO did not significantly increase revertant colonies in any of the test strains under any conditions at dose levels ranging from 1000 H/ml to 62.5 lu/plate, compared with the vehicle control. In the chromosomal aberration test using cultured Chinese Hamster Lung (CHL) cells, the number of aberrant cells was not increased in the presence or absence of 59 Mix at concentrations of 1000 lU/ml to 250 lU/ml, compared with the vehicle control. In the micronucleus test, male ICR mice were given rhEPO intraperitoneally at a dose level of 25000, 12500 and 6250 lU/kg. The incidence of bone marrow micronucleated polychromatic erythrocytes was not different from that of the vehicle control. From these results, rhEPO is considered to be non-mutagenic under the present test conditions.

• 대한간호학회지
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• 제42권2호
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• pp.217-225
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• 2012

Purpose: This study was conducted to examine the factors associated with HPV (Human Papillomavirus) related stigma, shame and intent to have HPV test among adult women. Methods: Data were collected from December 1, 2009 to January 31, 2010, and participants were 324 women who visited an obstetric gynecologic clinic. They anticipated testing positive for HPV. Then HPV related stigma, shame, intent to have HPV testing and HPV knowledge were measured. Descriptive statistics, Mann-Whitney U test, Kruskal Wallis test and multivariate adjusted logistic regression were used for data analysis. Results: The levels of stigma and shame were higher than average. Intent to have HPV test was high and HPV knowledge was low. Women who answered that HPV is not sexually transmitted had lower HPV stigma than did women who answered they didn't know (OR=0.20, 95%CI 0.06-0.68). Women with lower stigma showed lower intent to have HPV test than women with higher stigma (OR=0.46, 95%CI 0.26-0.82). Conclusion: Basic HPV information should be fully understood for women especially prior to HPV test. Normalizing HPV stigma is necessary for women who perceive HPV as sexually transmitted and women intending to have HPV test.

• 디지털융복합연구
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• 제14권4호
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• pp.355-362
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• 2016

본 연구는 간호대학생의 인권감수성 변화를 확인하기 위하여 간호대학생과 일반대학생의 1학년과 4학년 간 인권감수성 수준의 횡단적 차이를 파악하기 위한 서술적 비교 조사연구이다. 본 연구는 전라북도와 충청북도, 충청남도 소재 5개 대학교에 재학 중인 간호대학생 93명과 일반대학생 85명, 총 178명을 대상으로, 문용린의 대학생용 인권감수성 도구를 이용하여 자료수집을 실시하였다. 수집된 자료는 빈도와 백분율, 평균과 표준편차, t-test, chi-square test, ANCOVA로 분석하였다. 본 연구결과, 간호대학생과 일반대학생 모두 1학년과 4학년 간 인권감수성의 점수가 통계적으로 유의한 차이는 없는 것으로 나타났다. 간호대학생과 일반대학생의 1학년과 4학년 간 에피소드 별 인권감수성 수준 차이 간호대학생은 정신질환자 사생활권(t=-2.94, p=.004)과 환경권(t=2.16, p=.034) 에피소드에서 1학년과 4학년 간의 인권감수성 점수가 통계적으로 유의한 차이가 있는 것으로 나타났다. 또한 일반대학생에서는 장애우 신체의 자유권(t=2.41, p=.018) 에피소드에서만 1학년과 4학년 간의 인권감수성 점수가 통계적으로 유의한 차이가 있는 것으로 나타났다. 이러한 연구결과를 토대로 간호대학생의 인권감수성 증진을 위한 교육프로그램 개발의 필요성을 제시하였으며, 간호윤리 관련 교육과정에 인권감수성에 대한 내용이 포함되어야 할 것으로 사료된다.

• 대한안전경영과학회지
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• 제6권2호
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• pp.1-9
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• 2004

The chemical factory deals with dangerous element and more advance, human-error analyzes and becomes effective research for the country and region. This paper analysis the form of work-miss on human-error according to a safety accident for domestic chemical factory from 1999-2002. It include the present contents and raise issues human knowledge, behavior, judgment, sensibility as an important counter plan that makes the safety solution of work miss. For the point of view of human knowledge, it takes color standard for works to be effective in work place. For behavior, the test has been for risk Point of work place and infra worker movement, also the workers performed professional work as classify according to work. For judgement, the valuation sheet is reflected to minimize the human-error and the 3rd supervisor does a cross-check audit beforehand. For sensibility, it is applicable for human relations, information, communication by program to the consciousness and an attitude of worker-supervisor.

• 대한안전경영과학회:학술대회논문집
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• 대한안전경영과학회 2004년도 춘계학술대회
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• pp.33-39
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• 2004

The chemical factory deals with dangerous element and more advance, human-error analyzes and becomes effective research for the country and region, this paper analyes the form of work-miss on human-error according to a safety accident for domestic chemical factory from 1999-2002. It include the present contents and raise issues human knowledge, behavior, judgment, sensibility as an important counterplan that makes the safety solution of work miss. For the point of view of human knowledge, it takes color standard for works to be effective in work place. for behavior, the test has been for risk point of work place and infra worker movement, also the workers performed professional work as classify according to work. for judgement, the valuation sheet is reflected to minimize the human -error and the 3rd supervisor does a cross-check audit beforehand. For sensibility, it is applicable for human relations, information, communication by program to the consciousness and an attitude of worker-supervisor.

• Journal of Mechanical Science and Technology
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• 제15권7호
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• pp.995-1001
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• 2001

The finite element human head model is developed for traumatic injury assessment. The model is constructed based on the precise anatomical geometry and validated with test results. In this paper, structural and physiologic explanation of human head will be introduced as well as the modeling methodology. Some of simulation results are also chosen to present major features of the model.

• Journal of Chest Surgery
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• 제17권1호
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• pp.157-166
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• 1984

These biologic test procedures are designed to test the suitability of P.V.C. made in Korea intended for parenteral preparation, which were based on the U.S. Pharmacopeia XIX "Biologic Test-Plastic Container", Official from July 1, 1975. Healthy adult human blood and rabbits weighing 2\ulcorner.2Kg were used for test materials. Sample P.V.C. were sampled from the medical equipments made in Korea randomly and Control P.V.C. were sampled from the standardized Cobe and Polystan P.V.C. tubes. P.V.C. extract was prepared from a homogeneous P.V.C. samples by incubating 60 square centimeters of the sample per 20 millimeters of sterile pyrogen-free saline at 70\ulcorner for 72 hours or autoclaving at 120\ulcorner for 1 hour. The Implantation Test was designed to evaluate the reaction of living tissue to the plastic by the method of the implantation of the Sample itself into animal tissue. The Systemic Injection Test, the Intracutaneous Test, and the remainders were designed to determine the biological response of animals to plastics by the single-dose injection of specific extracts prepared from a Sample. The results are as follows; 1.Implantation Test - No significant difference for reactions was noted between the Sample treated animal and the Control after 72 hours of implantation. 2.Systemic Toxicity Injection Test - No sign of toxicity and/or death immediately after injection and at 4, 24, 48 hours respectfully after injection. 3.Intracutaneous Test - None of the animals treated with the Sample showed a significantly greater reaction than the observed in the animals treated with Blank. 4.Pyrogen Assay-Only one animal treated with the Sample showed the maximal rise of rectal temperature about 0.2\ulcorner after 3 hours of injection, but remainders showed no change. 5.Hemolytic Index - The positive Control tube of distilled water exhibited complete hemolysis while the negative Control tube and P.V.C. extract were negative demonstrating no hemolysis. 6.Cell Morphology of Erythrocytes and Leukocytes on Stored, Heparinized Human Blood -- There was no significant difference in the morphology of either the Control or Sample extract. 7.Clotting Mechanism of Human Blood in vitro - After allowing to the P.V.C. extract at room temperature for 5 Hours and at 10\ulcorner for 24 hours, there was no appreciable difference in Prothrombin Time under these conditions. 8.Clotting Mechanism of Rabbit in vivo - At the termination of 5 days after intraperitoneal injection of the P.V.C. extract, no significant changes in Clotting Time were observed. According to the above results, it could be concluded that the P.V.C. made in Korea was acceptable for parenteral preparation, especially treated with physiologic saline and/or human blood.man blood.

• 한국융합학회논문지
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• 제8권10호
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• pp.95-104
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• 2017

본 연구의 목적은 미혼여성의 자궁경부암 예방활동에 따른 자궁경부암 지식과 자궁경부암 예방행위 의도를 융합적으로 파악하기 위함이다. 216명의 여성을 대상으로 자가보고 설문지를 통해 수집한 자료는 SPSS 프로그램을 사용하여 분석하였다. 연구 결과, 미혼여성의 33.9%가 HPV 예방접종을 시행하였고 7.9%가 Pap test를 시행하였다. Pap test와 HPV 예방접종을 모두 시행한 그룹은 6.7%, Pap test 또는 HPV 예방접종을 시행한 그룹은 28.5%이었다. 자궁경부암 예방활동에 따라 자궁경부암 가족력, 자궁경부암 예방행위에 대한 주관적 규범, 지각된 행위통제, 행위의도의 차이가 있었다. 따라서 미혼 여성의 자궁경부암 예방활동에 대한 감수성을 높이는 것이 중요하며, 미혼 여성의 자궁경부암 예방을 위해 건강 전문가가 가장 의미 있는 지원시스템을 수행하는 것이 중요하다. 또한 미혼 여성이 자궁경부암 예방에 보다 적극적으로 참여할 수 있도록 다양한 정책을 적극적으로 홍보하고 지원해야 한다.