• Genomics & Informatics
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• v.14 no.4
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• pp.138-148
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• 2016

The success of genome-wide association studies (GWASs) has enabled us to improve risk assessment and provide novel genetic variants for diagnosis, prevention, and treatment. However, most variants discovered by GWASs have been reported to have very small effect sizes on complex human diseases, which has been a big hurdle in building risk prediction models. Recently, many statistical approaches based on penalized regression have been developed to solve the "large p and small n" problem. In this report, we evaluated the performance of several statistical methods for predicting a binary trait: stepwise logistic regression (SLR), least absolute shrinkage and selection operator (LASSO), and Elastic-Net (EN). We first built a prediction model by combining variable selection and prediction methods for type 2 diabetes using Affymetrix Genome-Wide Human SNP Array 5.0 from the Korean Association Resource project. We assessed the risk prediction performance using area under the receiver operating characteristic curve (AUC) for the internal and external validation datasets. In the internal validation, SLR-LASSO and SLR-EN tended to yield more accurate predictions than other combinations. During the external validation, the SLR-SLR and SLR-EN combinations achieved the highest AUC of 0.726. We propose these combinations as a potentially powerful risk prediction model for type 2 diabetes.

• Nuclear Engineering and Technology
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• v.37 no.5
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• pp.491-502
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• 2005

Reliable human performance is a prerequisite in securing the safety of complicated process systems such as nuclear power plants. However, the amount of available knowledge that can explain why operators deviate from an expected performance level is so small because of the infrequency of real accidents. Therefore, in this study, a database that contains a set of useful information extracted from simulated emergencies was developed in order to provide important clues for understanding the change of operators' performance under stressful conditions (i.e., real accidents). The database was developed under Microsoft Windows TM environment using Microsoft Access $97^{TM}$ and Microsoft Visual Basic $6.0^{TM}$. In the database, operators' performance data obtained from the analysis of over 100 audio-visual records for simulated emergencies were stored using twenty kinds of distinctive data fields. A total of ten kinds of operators' performance data are available from the developed database. Although it is still difficult to predict operators' performance under stressful conditions based on the results of simulated emergencies, simulation studies remain the most feasible way to scrutinize performance. Accordingly, it is expected that the performance data of this study will provide a concrete foundation for understanding the change of operators' performance in emergency situations.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.10 no.1
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• pp.70-74
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• 2014

An Operating Experience Report(OER) has written about events and accidents happened at a Nuclear Power Plant(NPP). The purpose of publishing the OER is to prevent the similar event or accident repeatedly by spreading the experience of a single plant to other plants personnel. In this paper, it is analyses that the foreign NPPs' OERs on JIT published by the International Nuclear Agency(WANO, INPO, COG, BE). The analysis introduced in this paper is performed along with the various factors such as type of work, root-cause, and equipment. The root-cause analysis about the OERs shows that the Human-error is the major factor in foreign NPPs, but on the other hand equipment problem is the main part of the Domestic NPPs. The ratio of the foreign NPP's OERs on JIT according to the type of work was applied to KHNP-JIT developed nowadays for the first time in KOREA.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2003.06a
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• pp.1294-1297
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• 2003

With the development of medical field, many kinds of operations have been performed on human articulation. Arthroscopic surgery, which has Irrigation Pumping System for security of operator vision and washing spaces of operation, has been used for more merits than others. In this paper, it is presented that the research on a reliable control algorithm of the pumping system instrument for arthroscopic surgery. Before clinical operation, the flexible artificial articulation model is used for realizing the model the most same as human's and the algorithm has been exploited for it. This system is considered of the following; limited sensing point, dynamic effect by compliance, time delay by fluid flow and so on. The system is composed with a pressure controller, a regulator for keeping air pressure, an airtight tank that can have distilled water packs, artificial articulation and a measuring system, and has controlled by the feedback of pressure sensor on the artificial articulation. Also the system has applied to Smith Predictor for time delay and the parameter estimation method for the most suitable system with both the experiment data and modeling. In this paper, the pressure error that is between an air pressure tank and an artificial articulation was measured so that the system could be presumed and then the controller had developed for performing State-Feedback. Finally, the controller with a real microprocessor has realized. The confidence of system can be proved by applying this control algorithm to an artificial articulation experiment material.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.20 no.11
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• pp.3525-3537
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• 1996

This paper presents a CAD program develpoed on a microcomputer in order to support graphic and computational assessment of ergonomic problems associated with the design of a man-in-cab system. The program is coded to help workspace designers with ergonomic evaluations needed in the design stage. This paper proposed a biomechanical -ergonomic evaluations needed using man and workplace models. The human model is developed to have dimensions obtained from the Korean anthropometric data reported in 1992. Its graphical representation is based on a wire-frame model but, whenever necessary, body segments can be represented by a solid model with hidden line/faces removed and shaded. Workplace models are presented for cabs of the excavator, one of the most popular construction vehicles. A workplace model consists of an operator seat, a steering wheel. two control levers, two pedals, and a control panel. The workplace elements can be modified in their sizes, positions, and orientations by changing the reference point and design parameters. An algorithm for the view test is suggested and loaded to provide a visual evaluaiton of the overall layout of a workplace model.

• Journal of Institute of Control, Robotics and Systems
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• v.21 no.3
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• pp.243-249
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• 2015

In direct vehicle teleoperation, a human operator drives a vehicle at a distance through a pair of master and slave device. However, if there is time delay, it is difficult to remotely drive the vehicle due to slow response. In order to address this problem, we introduced a novel methodology of shared vehicle teleoperation using a virtual driving interface. The methodology was developed with four components: 1) virtual driving environment, 2) interface for virtual driving environment, 3) path generator based on virtual driving trajectory, 4) path following controller. Experimental results showed the effectiveness of the proposed approach in simple and cluttered driving environment as well. In the experiments, we compared two sampling methods, fixed sampling time and user defined instant, and finally merged method showed best remote driving performance in term of completion time and number of collision.

• Journal of Korean Institute of Industrial Engineers
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• v.23 no.1
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• pp.147-162
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• 1997

When designing workplaces or arranging controls on panel, devices and controls should be placed within the reach of operator's arm or foot to guarantee effective performances. Most of the existing research on the reach volume were based on measurements of a few subject's arm reach, and limited to Caucasian and Chinese populations. Furthermore, reach volume considering foot or trunk motion have not been investigated. Range of human joint motion and that of two degrees of freedom motion are needed to generate reach volume analytically using the sweeping algorithm. However, range of two degrees of freedom motion has not been measured up to now. Therefore, range of two degrees of freedom motion was measured in this research, where 47 college students were participated voluntarily as subjects. The results showed that the motion of one joint can be limited by the motion of another motion, that is to say, the shoulder flexion was decreased significantly when the shoulder was adducted or abducted. Second, new approximate algorithms generating reach volumes were suggested, in which range of two degrees of freedom motion was used as input data. Depending upon the body segment included such as trunk, arm and leg, three types of reach volume were provided, in which the human body was modeled as a multilink system based on the robot kinematics and the sweeping method was employed. Reach volume generated analytically in this study showed statistically reasonable results when compared with that obtained from direct measurement.

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2003.11a
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• pp.438-446
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• 2003

This paper presents the development of the remotely operated decontamination systems for use in a highly radioactive zone of the DUPIC Fuel Development facility of the Irradiated Material Examination Facility at the Korea Atomic Energy Research Institute. The remotely operated decontamination systems were designed to completely eliminate human interaction with hazardous radioactive contaminants. These decontamination systems are mainly classified into three systems depending on the task environment - a fabrication equipment decontamination system, a hot-cell floor decontamination system, and an isolation room floor decontamination system. A decontamination system for contaminated fabrication equipment utilizes dry ice pellet blasting method to decontaminate contaminated surface of the equipment. The decontamination systems for the hot-cell floor and isolation room floor employ a vacuum cleaning method to decontaminate the contaminated floor and collect loose dry spent nuclear fuel debris and other radioactive waste placed on the floor. The human operator from the out-of-cell performs a series of decontamination tasks remotely by manipulating decontamination systems located in-cell via a handcontroller with the aid of vision feedback information. The environmental, functional and mechanical design considerations, control system and capabilities of the remotely operated decontamination systems at a high radioactive environment are also described.

• Restorative Dentistry and Endodontics
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• v.15 no.1
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• pp.129-139
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• 1990

In order to determine if GK-101E(N-monochloro-DL-2-aminobutyrate) solution was effective in the removal of carious dentin, this study was conducted on 75 extracted human carious teeth. GK-101E solution was compared in effectiveness to saline solution.75 extracted human carious teeth were randomly assigned to two groups accordingly : (1) 50 teeth were treated with GK-101E solution : and (2) 25 teeth were treated with saline solution. Teeth in each group were divided into the medium or medium-hard consistency. Treatment consisted of directing the pulsating stream of each coded test solution utilizing the Caridex$^{TM}$ Caries Removal System against the carious surface for 4 mimutes. One operator treated all teeth with corded solution, and four investigators scored on the treated teeth based on visual examination and tactile evaluation with a dental explorer in conjunction with staining method with Caries Detector$^{TM}$ The results were as follows : 1. All groups showed various effect of carious dentin removal. 2. GK-101E solution was statistically superior to physiologic saline solution in the removal of carious dentin, regardless of carious consistency. 3. GK-101E solution in the medium-hard consistency was statistically superior to that in the medium consistency in the caries removal(p=0.001). 4. Saline solution in the medium consistency was equivalent to that in the medium-hard consistency in caries removal(p>0.1).

• The Transactions of the Korean Institute of Electrical Engineers D
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• v.49 no.2
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• pp.74-80
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• 2000

In this paper, we present a control method of mobile power assist systems. Most of mobile power assist systems have a heavy base for preventing easy tumbling, so continual movement of the base during operations causes high energy consumption and gives the high risk of human injury. Furthermore, the slow dynamics of the base limits the frequency bandwidth of the whole system. Thus we propose a cooperation control method of the mobile base and manipulator, which removes the unnecessary movements of the base. In our scheme, the mobile base does not move until the center of gravity(C.G) of the system goes outside a safety region. When C.G. reaches the boundary of the safety region, the base starts moving to recover the manipulator's initial configuration. By varying the parameters of a human impedance controller, the operator is warned by a force feedback that C.G. is on the marginal safety region. Our scheme is implemented by assigning a nonlinear mass-damper-spring impedance to the tip of the manipulator. Our scheme is implemented by a nonlinear mass-spring impedance to the tip of the manipulator. The experimental results show the efficacy of the proposed control method.