• Journal of the Korean Society for Precision Engineering
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• v.30 no.1
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• pp.85-95
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• 2013

As the conventional hydraulic power steering system in the passenger vehicles is being rapidly replaced by EPS (Electric Power Steering) system, performance evaluation of the EPS system has become an important issue in the automotive industries. But the evaluation process takes significant expertise since steering conditions in the test protocols must be implemented with high accuracy. EPS HILS (Hardware-In the-Loop Simulation) system is developed together with robot steering system in this study. Main components of EPS HILS system include: C-EPS hardware, CarSim vehicle model, and road reaction force generation system powered by servo motor. The robot steering system, operated by another servo motor, was combined with EPS HILS system to substitute for steering efforts of human driver. The road reaction force generation system and the robot steering system were carefully validated by using the data obtained from vehicle tests. An on-center handling test was conducted by using EPS HILS system combined with the robot steering system. In the result of this study, robot-steered EPS HILS system developed with its high reliability and no need of skilled driver's, can be widely adopted to evaluate any performance of EPS system.

• Molecules and Cells
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• v.44 no.12
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• pp.883-892
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• 2021

Genome-wide chromosome conformation capture (3C)-based high-throughput sequencing (Hi-C) has enabled identification of genome-wide chromatin loops. Because the Hi-C map with restriction fragment resolution is intrinsically associated with sparsity and stochastic noise, Hi-C data are usually binned at particular intervals; however, the binning method has limited reliability, especially at high resolution. Here, we describe a new method called HiCORE, which provides simple pipelines and algorithms to overcome the limitations of single-layered binning and predict core chromatin regions with three-dimensional physical interactions. In this approach, multiple layers of binning with slightly shifted genome coverage are generated, and interacting bins at each layer are integrated to infer narrower regions of chromatin interactions. HiCORE predicts chromatin looping regions with higher resolution, both in human and Arabidopsis genomes, and contributes to the identification of the precise positions of potential genomic elements in an unbiased manner.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.4
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• pp.1854-1868
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• 2018

A wireless body-sensor network (WBSN) refers to a network-configured environment in which sensors are placed on both the inside and outside of the human body. The sensors are much smaller and the energy is more constrained when compared to traditional wireless sensor network (WSN) environments. The critical nature of the energy-constraint issue in WBSN environments has led to numerous studies on the reduction of energy consumption of WBSN sensors. The transmission-power-control (TPC) technique adjusts the transmission-power level (TPL) of sensors in the WBSN and reduces the energy consumption that occurs during communications. To elaborate, when transmission sensors and reception sensors are placed in various parts of the human body, the transmission sensors regularly send sensor data to the reception sensors. As the reception sensors receive data from the transmission sensors, real-time measurements of the received signal-strength indication (RSSI), which is the value that indicates the channel status, are taken to determine the TPL that suits the current-channel status. This TPL information is then sent back to the transmission sensors. The transmission sensors adjust their current TPL based on the TPL that they receive from the reception sensors. The initial TPC algorithm made linear or binary adjustments using only the information of the current-channel status. However, because various data in the WBSN environment can be utilized to create a more efficient TPC algorithm, many different types of TPC algorithms that combine human movements or fuse TPC with other algorithms have emerged. This paper defines and discusses the design and development process of an efficient TPC algorithm for WBSNs. We will describe the WBSN characteristics, model, and closed-loop mechanism, followed by an examination of recent TPC studies.

• Journal of Digital Contents Society
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• v.19 no.1
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• pp.113-122
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• 2018

In level 3 automated vehicles, drivers are expected to encounter transition of control when the system reaches its limit. Drivers need to refocus their attention on the road ahead and gain situational awareness. Appropriate information should be conveyed during this period in order to prevent human errors. In this paper, we defined the takeover process as 'in-the-middle-of-the-loop' and conducted Task Analysis and Work Domain Analysis to find out information requirements. As a result, we specified required information types and interface considerations. Moreover, we conducted an experimental study to find how the information types affect drivers on situation awareness, cognitive load and reaction time. Consequently, we found different information on system transparency should be conveyed depending on the urgency of takeover situation and driver guidance could help drivers with better situation awareness after the takeover.

• Journal of the Korea Computer Graphics Society
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• v.22 no.5
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• pp.27-36
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• 2016

As big data become more complex than ever, there has been a need for various techniques and approaches to better analyze and explore such big data. A research discipline of visual analytics has been proposed to help users' visual data analysis and decision-making. Since 2006 when the first symposium of visual analytics was held, the visual analytics research has become popular as the advanced technology in computer graphics, data mining, and human-computer interaction has been incorporated in visual analytics. In this work we introduce the visual analytics research by reviewing and surveying the papers published in IEEE VAST 2015 in terms of data and visualization techniques to help domestics researchers' understanding on visual analytics.

• Proceedings of the KIEE Conference
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• 2007.04a
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• pp.331-333
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• 2007

Robot manipulator is one of the important features in service robot area. Until now, there has been a lot of research on robot" manipulator that can imitate the functions of a human being by recognizing and grasping objects. In this paper, we present a robot arm based on the object recognition vision system. We have implemented closed-loop control that use the feedback from visual information, and used a sonar sensor to improve the accuracy. We have placed the web-camera on the top of the hand to recognize objects. We also present some vision-based manipulation issues and our system features.

• Journal of the Institute of Electronics and Information Engineers
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• v.52 no.7
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• pp.135-142
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• 2015

Human-powered self-generating devices have been attractive with its operation characteristic independent from outer environment such as weather condition and wind speed. However, conventional self-generators have low electric power output due to their weakly-coupled electromagnetic structure. More importantly, rotary crank motion which is usually adopted by conventional self-generator to generate electricity requires specific skeletal muscles to maintain large torque circular motion and consequently, causes fatigue on those muscles before it can generate enough amount of electricity for any practical application. Without improvement in electric power output and usability, the human-powered self-generator could not be used in everyday life. This study aims to develop a human-powered self-generator which realized a strong electromagnetic coupling in a closed-loop tubular structure (hula-hoop shape) for easy and steady long-term driving as well as larger electric output. The performance and usability of the developed human-powered generator is verified through experimental comparison with a commercial one. Additionally, human workload which is a key element of a human-powered generator but not often considered elsewhere, is estimated based on metabolic energy expenditure measured respiratory gas analyzer. Further study will focus on output and portability enhancement, which can contribute to the continuous power supply of mobile equipments.

• Korean Journal of Veterinary Service
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• v.36 no.2
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• pp.79-86
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• 2013

Mycobacterium (M.) bovis, a member of the M. tuberculosis complex (MTC), is a re-emerging, zoonotic agent of bovine tuberculosis whose prevalence probably depends on variations in direct exposure to cattle and ingestion of raw milk. Accurate species differentiation of M. bovis and M. tuberculosis is needed to distinguish between human and zoonotic tuberculosis. This study successfully developed a loop-mediated isothermal amplification (LAMP) assay for rapid detection and differentiation of M. bovis and M. tuberculosis, however showed negative reactions in eight non-tuberculous mycobacteria (NTM) samples and ten other bacterial species. Sensitivity of this assay for detection of genomic M. bovis DNA was 10 $fg/{\mu}l$. And this assay successfully detected M. bovis in bovine clinical specimens. In conclusion, the LAMP assay is a simple and powerful tool for rapid detection of M. bovis in both pure bacterial culture and in clinical samples.

• Genomics & Informatics
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• v.18 no.4
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• pp.40.1-40.8
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• 2020

Avian influenza (AIV) outbreaks can induce fatal human pulmonary infections in addition to economic losses to the poultry industry. In this study, we aimed to develop a rapid and sensitive point-of-care AIV test using loop-mediated isothermal amplification (LAMP) technology. We designed three sets of reverse transcription LAMP (RT-LAMP) primers targeting the matrix (M) and hemagglutinin (HA) genes of the H5 and H9 subtypes. RT-LAMP targeting the universal M gene was designed to screen for the presence of AIV and RT-LAMP assays targeting H5-HA and H9-HA were designed to discriminate between the H5 and H9 subtypes. All three RT-LAMP assays showed specific amplification results without nonspecific reactions. In terms of sensitivity, the detection limits of our RT-LAMP assays were 100 to 1,000 RNA copies per reaction, which were 10 times more sensitive than the detection limits of the reference reverse-transcription polymerase chain reaction (RT-PCR) (1,000 to 10,000 RNA copies per reaction). The reaction time of our RT-LAMP assays was less than 30 min, which was approximately four times quicker than that of conventional RT-PCR. Altogether, these assays successfully detected the existence of AIV and discriminated between the H5 or H9 subtypes with higher sensitivity and less time than the conventional RT-PCR assay.

• Molecules and Cells
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• v.45 no.8
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• pp.575-587
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• 2022

Human ABCB6 is an ATP-binding cassette transporter that regulates heme biosynthesis by translocating various porphyrins from the cytoplasm into the mitochondria. Here we report the cryo-electron microscopy (cryo-EM) structures of human ABCB6 with its substrates, coproporphyrin III (CPIII) and hemin, at 3.5 and 3.7 Å resolution, respectively. Metal-free porphyrin CPIII binds to ABCB6 within the central cavity, where its propionic acids form hydrogen bonds with the highly conserved Y550. The resulting structure has an overall fold similar to the inward-facing apo structure, but the two nucleotide-binding domains (NBDs) are slightly closer to each other. In contrast, when ABCB6 binds a metal-centered porphyrin hemin in complex with two glutathione molecules (1 hemin: 2 glutathione), the two NBDs end up much closer together, aligning them to bind and hydrolyze ATP more efficiently. In our structures, a glycine-rich and highly flexible "bulge" loop on TM helix 7 undergoes significant conformational changes associated with substrate binding. Our findings suggest that ABCB6 utilizes at least two distinct mechanisms to fine-tune substrate specificity and transport efficiency.